Chemical allergy can take a variety of forms. Those of greatest relevance to toxicology are skin sensitisation resulting in allergic contact dermatitis, and sensitisation of the respiratory tract associated with aller...Chemical allergy can take a variety of forms. Those of greatest relevance to toxicology are skin sensitisation resulting in allergic contact dermatitis, and sensitisation of the respiratory tract associated with allergic rhinitis and asthma. Both represent important health issues and there is a need for effective hazard characterisation and risk assessment.展开更多
The no-observed-effect level (NOEL) in a study of carcinogenicity for compounds that are both genotoxic and carcinogenic represents the limit of detection in that bioassay, rather than an estimate of a possible thresh...The no-observed-effect level (NOEL) in a study of carcinogenicity for compounds that are both genotoxic and carcinogenic represents the limit of detection in that bioassay, rather than an estimate of a possible threshold. Therefore, for those genotoxic and carcinogenic contaminants (e.g. acrylamides, PAHs, etc.) in foods it is not possible to develop health-based guidance values (e.g. ADI or PTWI) using the traditional NOEL and safety/uncertainty factors.展开更多
文摘Chemical allergy can take a variety of forms. Those of greatest relevance to toxicology are skin sensitisation resulting in allergic contact dermatitis, and sensitisation of the respiratory tract associated with allergic rhinitis and asthma. Both represent important health issues and there is a need for effective hazard characterisation and risk assessment.
文摘The no-observed-effect level (NOEL) in a study of carcinogenicity for compounds that are both genotoxic and carcinogenic represents the limit of detection in that bioassay, rather than an estimate of a possible threshold. Therefore, for those genotoxic and carcinogenic contaminants (e.g. acrylamides, PAHs, etc.) in foods it is not possible to develop health-based guidance values (e.g. ADI or PTWI) using the traditional NOEL and safety/uncertainty factors.
