Achieving precise,localized drug delivery within the brain remains a major challenge due to the restrictive nature of the blood-brain barrier and the risk of systemic toxicity.Here,we present a fully soft neural inter...Achieving precise,localized drug delivery within the brain remains a major challenge due to the restrictive nature of the blood-brain barrier and the risk of systemic toxicity.Here,we present a fully soft neural interface incorporating a thermo-pneumatic peristaltic micropump integrated with asymmetrically tapered microchannels for targeted,on-demand wireless drug delivery.All structural and functional components are fabricated from soft materials,ensuring mechanical compatibility with brain tissue.The system employs sequential actuation of microheaters to generate unidirectional airflow that drives drug infusion from an on-board reservoir.The nozzle-diffuser geometry of the microchannels minimizes backflow while enabling controlled,continuous delivery without mechanical valves.Fluid dynamics simulations guided the optimization of the microfluidic design,resulting in robust forward flow with minimal reflux.Benchtop validation in brain-mimicking phantoms confirmed consistent and programmable drug infusion.This platform represents a significant advancement in neuropharmacological research and therapeutic delivery for central nervous system disorders.展开更多
The use of water-based chemistry in photolithography during semiconductor fabrication is desirable due to its cost-effectiveness and minimal environmental impact,especially considering the large scale of semiconductor...The use of water-based chemistry in photolithography during semiconductor fabrication is desirable due to its cost-effectiveness and minimal environmental impact,especially considering the large scale of semiconductor production.Despite these benefits,limited research has reported successful demonstrations of water-based photopatterning,particularly for intrinsically water-soluble materials such as Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)due to significant challenges in achieving selective dissolution during the developing process.In this paper,we propose amethod for the direct patterning of PEDOT:PSS in water by introducing an amphiphilic Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)(PEO-PPO-PEO,P123)block copolymer to the PEDOT:PSS film.The addition of the block copolymer enhances the stretchability of the composite film and reduces the hydrophilicity of the film surface,allowing for water absorption only after UV exposure through a photoinitiated reaction with benzophenone.We apply this technique to fabricate tactile and wearable biosensors,both of which benefit fromthe mechanical stretchability and transparency of PEDOT:PSS.Our method represents a promising solution for water-based photopatterning of hydrophilic materials,with potential for wider applications in semiconductor fabrication.展开更多
基金supported by the National Research Foundation of Korea(NRF)funded by Ministry of Science and ICT(RS-2023-00234581)the Technology Innovation Program(RS-2025-08672969)funded by the Ministry of Trade Industry and Energy(MOTIE,Korea).
文摘Achieving precise,localized drug delivery within the brain remains a major challenge due to the restrictive nature of the blood-brain barrier and the risk of systemic toxicity.Here,we present a fully soft neural interface incorporating a thermo-pneumatic peristaltic micropump integrated with asymmetrically tapered microchannels for targeted,on-demand wireless drug delivery.All structural and functional components are fabricated from soft materials,ensuring mechanical compatibility with brain tissue.The system employs sequential actuation of microheaters to generate unidirectional airflow that drives drug infusion from an on-board reservoir.The nozzle-diffuser geometry of the microchannels minimizes backflow while enabling controlled,continuous delivery without mechanical valves.Fluid dynamics simulations guided the optimization of the microfluidic design,resulting in robust forward flow with minimal reflux.Benchtop validation in brain-mimicking phantoms confirmed consistent and programmable drug infusion.This platform represents a significant advancement in neuropharmacological research and therapeutic delivery for central nervous system disorders.
基金supported by the Korean government(the Ministry of Science and ICT,the Ministry of Trade,Industry,and Energy,the Ministry of Health&Welfare,and the Ministry of Food and Drug Safety).(Nos.2022R1C1C101007112,RS-2023-00221295,HR22C183201,RS-2020-KD000093,RS-2023-00234581,23-SENS-01).
文摘The use of water-based chemistry in photolithography during semiconductor fabrication is desirable due to its cost-effectiveness and minimal environmental impact,especially considering the large scale of semiconductor production.Despite these benefits,limited research has reported successful demonstrations of water-based photopatterning,particularly for intrinsically water-soluble materials such as Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)due to significant challenges in achieving selective dissolution during the developing process.In this paper,we propose amethod for the direct patterning of PEDOT:PSS in water by introducing an amphiphilic Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)(PEO-PPO-PEO,P123)block copolymer to the PEDOT:PSS film.The addition of the block copolymer enhances the stretchability of the composite film and reduces the hydrophilicity of the film surface,allowing for water absorption only after UV exposure through a photoinitiated reaction with benzophenone.We apply this technique to fabricate tactile and wearable biosensors,both of which benefit fromthe mechanical stretchability and transparency of PEDOT:PSS.Our method represents a promising solution for water-based photopatterning of hydrophilic materials,with potential for wider applications in semiconductor fabrication.
