After several years of evolution,SARS-CoV-2 is now not considered a virus that easily causes death or severe complications.Most COVID-19 cases are mild to moderate,making the development of alternative therapies to ma...After several years of evolution,SARS-CoV-2 is now not considered a virus that easily causes death or severe complications.Most COVID-19 cases are mild to moderate,making the development of alternative therapies to manage symptoms a critical priority.Bacillus coagulans DSM33893 and Lactobacillus plantarum DSM33894,which have previously shown promising results in reducing PM2.5-induced lung inflammation and damage,were considered utilization in this study due to their potential immunomodulatory and anti-inflammatory effects targeting upper respiratory tract.Our results showed that the combination of these two strains improved airway resistance,and helped mitigate lymphopenia and delayed type I interferon.Furthermore,the combination was more effective than using either strain alone in reducing the levels of pro-inflammatory cytokines,such as IFN-γ(by 89.8%),IL-4(by 78.6%),and IL-17(by 62.4%),and increasing the levels of the antiviral cytokine IFN-β(by 68.7%)and anti-inflammatory cytokine TGF-β(by 10.3%),compared to the SARS-CoV-2 group.展开更多
文摘After several years of evolution,SARS-CoV-2 is now not considered a virus that easily causes death or severe complications.Most COVID-19 cases are mild to moderate,making the development of alternative therapies to manage symptoms a critical priority.Bacillus coagulans DSM33893 and Lactobacillus plantarum DSM33894,which have previously shown promising results in reducing PM2.5-induced lung inflammation and damage,were considered utilization in this study due to their potential immunomodulatory and anti-inflammatory effects targeting upper respiratory tract.Our results showed that the combination of these two strains improved airway resistance,and helped mitigate lymphopenia and delayed type I interferon.Furthermore,the combination was more effective than using either strain alone in reducing the levels of pro-inflammatory cytokines,such as IFN-γ(by 89.8%),IL-4(by 78.6%),and IL-17(by 62.4%),and increasing the levels of the antiviral cytokine IFN-β(by 68.7%)and anti-inflammatory cytokine TGF-β(by 10.3%),compared to the SARS-CoV-2 group.
