Selenium is an essential trace element for human health,but its nutritional application is limited by uneven global distribution and poor bioavailability of conventional supplements.Selenium-rich peptides(SePPs),compl...Selenium is an essential trace element for human health,but its nutritional application is limited by uneven global distribution and poor bioavailability of conventional supplements.Selenium-rich peptides(SePPs),complexes of selenium and bioactive peptides,have demonstrated remarkable synergistic effects and bio-activities,becoming a high-value focus in nutrition and functional foods.Artificial intelligence(AI)technologies encompassing machine learning(ML),deep learning(DL),molecular docking(MD),and so on,are driving revolutionary advances in SePPs research.This review comprehensively summarizes the latest progress on AIfacilitated SePPs,focusing on their synthesis,characterization,biological activity,pharmacological mecha-nisms,food industrial applications,and development prospects.Major preparation approaches include extraction from natural sources,chemical synthesis,and biosynthesis.Advanced techniques enable accurate structural identification,stability evaluation,and bioavailability assessment of SePPs.SePPs indicate multiple bioactivities such as antioxidant,immunomodulatory,thyroid-regulating,and neuroprotective effects with potential health benefits against cancer and cardiovascular disease.AI has been increasingly integrated into biosynthesis,virtual screening,activity prediction,and mechanism exploration of SePPs,although its application is still in the early stage.Current research is abundant in antioxidant properties but limited in clinical translation and diseasespecific mechanisms,especially regarding thyroid and cardiovascular regulation.This review further discusses current challenges,future research directions,and regulatory considerations for the application of AI-facilitated SePPs.Overall,AI-assisted development and application of SePPs offer great promise for functional food inno-vation and the advancement of precision nutrition,providing a rational basis for the design and application of next-generation selenium supplements.展开更多
基金supported by Key Research and Development Project of Henan Province(231111310700)Key Research and Development Project of Henan Province(241111310500)+2 种基金Henan Provincial Key Science&Technology Special Project(231100110300)supported by Henan Provincial Postdoctoral Research Project Funding(HN2025152)Cultivation Program for Young Backbone Teachers in Henan University of Technology and Student Innovation and Entrepreneurship Training Program(202510463007).
文摘Selenium is an essential trace element for human health,but its nutritional application is limited by uneven global distribution and poor bioavailability of conventional supplements.Selenium-rich peptides(SePPs),complexes of selenium and bioactive peptides,have demonstrated remarkable synergistic effects and bio-activities,becoming a high-value focus in nutrition and functional foods.Artificial intelligence(AI)technologies encompassing machine learning(ML),deep learning(DL),molecular docking(MD),and so on,are driving revolutionary advances in SePPs research.This review comprehensively summarizes the latest progress on AIfacilitated SePPs,focusing on their synthesis,characterization,biological activity,pharmacological mecha-nisms,food industrial applications,and development prospects.Major preparation approaches include extraction from natural sources,chemical synthesis,and biosynthesis.Advanced techniques enable accurate structural identification,stability evaluation,and bioavailability assessment of SePPs.SePPs indicate multiple bioactivities such as antioxidant,immunomodulatory,thyroid-regulating,and neuroprotective effects with potential health benefits against cancer and cardiovascular disease.AI has been increasingly integrated into biosynthesis,virtual screening,activity prediction,and mechanism exploration of SePPs,although its application is still in the early stage.Current research is abundant in antioxidant properties but limited in clinical translation and diseasespecific mechanisms,especially regarding thyroid and cardiovascular regulation.This review further discusses current challenges,future research directions,and regulatory considerations for the application of AI-facilitated SePPs.Overall,AI-assisted development and application of SePPs offer great promise for functional food inno-vation and the advancement of precision nutrition,providing a rational basis for the design and application of next-generation selenium supplements.
