Dear Editor,Solute carrier family 26 member 8(SLC26A8)gene belongs to the solute carrier 26(SLC26)family.It demonstrates distinct expression in male spermatozoa.This gene potentially plays a role in the formation of t...Dear Editor,Solute carrier family 26 member 8(SLC26A8)gene belongs to the solute carrier 26(SLC26)family.It demonstrates distinct expression in male spermatozoa.This gene potentially plays a role in the formation of the sperm annulus,a circular structure linking the midpiece and principal piece of mature sperm flagella.1 Studies in mice have shown that the deficiency of Slc26A8 leads to compromised sperm motility,capacitation,and structural anomalies.These include disarray in the mitochondrial sheath,abnormalities in the annulus,and bending of the flagella.2,3 Nevertheless,our comprehension of SLC26A8 mutations in male infertility is still restricted,with only a limited number of studies addressing this aspect.4-6 Therefore,further research is crucial to elucidate the functional significance of mutations in SLC26A8.展开更多
Yield stress,as the key parameter to characterize the network strength of waxy oil,is important to the petroleum pipeline safety.Reducing the yield stress of waxy oil is of great significance for flow assurance.In thi...Yield stress,as the key parameter to characterize the network strength of waxy oil,is important to the petroleum pipeline safety.Reducing the yield stress of waxy oil is of great significance for flow assurance.In this study,the effect of alternating magnetic field(intensity,frequency)on the yield stress of a waxy model oil with nanocomposite pour point depressant(NPPD)is systematically investigated.An optimum magnetic field intensity and frequency is found for the reduction in yield stress.When adding with NPPD,the heterogeneous nucleation of NPPD contributes to the reduction in yield stress for waxy model oil.Interestingly,the magnetic field is helpful for the modification of yield stress at a lower frequency and intensity before the optimal value;however,the modification is found to be weakened when the magnetic field is further increased after the optimal value.Possible explanation is proposed that the aggregation morphology of wax crystal would be altered and results in the release of wrapped oil phase from the network structure under the magnetic field.展开更多
In the present work,the interaction mechanism of specific polyelectrolyte multilayers(PEMs),fabricated by layer-by-layer deposition of polydiallyldimethylammonium chloride(PDDA)and poly(sodium 4-styrenesulfonate)(PSS)...In the present work,the interaction mechanism of specific polyelectrolyte multilayers(PEMs),fabricated by layer-by-layer deposition of polydiallyldimethylammonium chloride(PDDA)and poly(sodium 4-styrenesulfonate)(PSS),is studied using atomic force microscopy.The underwater oil-repellency of PS S-capped PEMs was further explored by measuring the interaction forces between tetradecane droplets and PEMs-coated silica substrates under various salinities.The force curves were analyzed following the Stokes-Reynolds-Young-Laplace theoretical model.Desirable consistency was achieved between the experimental and theoretical calculations at low NaCl concentrations(0.1 mM and 1 mM);however,underestimation of the attractive force was found as the NaCl concentration increases to moderate(10 mM)and high(100 mM)levels.Discrepancy analyses and incorporated features toward a reduced surface charge density were considered based on the previous findings of the orientation of anionic benzenesulfonate moieties(Liu et al.in Angew Chem Int Ed 54(16):4851-4856,2015.https://doi.org/10.1002/anie.201411992).Short-range steric hindrance interactions were further introduced to simulate"brush"effect stemming from nanoscale surface roughness.It is demonstrated in our work that the PSS-capped PEMs remains a stable underwater lipophobicity against high salinity,which renders it potential application in surface wetting modification and anti-fouling.展开更多
BACKGROUND Primary intratracheal schwannoma is an extremely rare type of benign airway tumor,especially in adolescents.The presenting symptoms are typically prolonged cough and wheezing that can be misdiagnosed as ast...BACKGROUND Primary intratracheal schwannoma is an extremely rare type of benign airway tumor,especially in adolescents.The presenting symptoms are typically prolonged cough and wheezing that can be misdiagnosed as asthma in adolescent patients.CASE A 16-year-old adolescent girl admitted to a local hospital with symptoms of an irritating cough and wheezing was diagnosed with bronchial asthma and treated with budesonide and formoterol.Over the next year,the patient's wheezing and coughing symptoms gradually worsened and the antiasthma treatment was ineffective.One week prior to this admission,the patient developed dyspnea after catching a cold and was transferred to our hospital with a diagnosis of severe asthma.However,chest computed tomography and bronchoscopy showed a mass in the trachea.Primary intratracheal schwannoma was diagnosed by biopsy.Her symptoms were relieved by endoscopic resection by electrosurgical snaring combined with argon plasma coagulation.No relapse occurred during an 18 mo follow-up.CONCLUSION Primary intratracheal schwannoma should be considered in the differential diagnosis in adolescents with recurrent asthma-like attacks.展开更多
基金support from grants provided by the Gansu Provincial Natural Science Foundation of China(23JRRA1046)the Gansu Association for Science and Technology(GSHZTS 2022-04)the National College Student Innovation and Entrepreneurship Training Program(202310730222).
文摘Dear Editor,Solute carrier family 26 member 8(SLC26A8)gene belongs to the solute carrier 26(SLC26)family.It demonstrates distinct expression in male spermatozoa.This gene potentially plays a role in the formation of the sperm annulus,a circular structure linking the midpiece and principal piece of mature sperm flagella.1 Studies in mice have shown that the deficiency of Slc26A8 leads to compromised sperm motility,capacitation,and structural anomalies.These include disarray in the mitochondrial sheath,abnormalities in the annulus,and bending of the flagella.2,3 Nevertheless,our comprehension of SLC26A8 mutations in male infertility is still restricted,with only a limited number of studies addressing this aspect.4-6 Therefore,further research is crucial to elucidate the functional significance of mutations in SLC26A8.
基金the National Natural Science Foundation of China(51774303,51422406,51534007)the National Science&Technology Specific Project(2016ZX05028-004-001)+1 种基金111 Project(B18054)Science Foundation of China University of Petroleum,Beijing(C201602)for providing support for this work
文摘Yield stress,as the key parameter to characterize the network strength of waxy oil,is important to the petroleum pipeline safety.Reducing the yield stress of waxy oil is of great significance for flow assurance.In this study,the effect of alternating magnetic field(intensity,frequency)on the yield stress of a waxy model oil with nanocomposite pour point depressant(NPPD)is systematically investigated.An optimum magnetic field intensity and frequency is found for the reduction in yield stress.When adding with NPPD,the heterogeneous nucleation of NPPD contributes to the reduction in yield stress for waxy model oil.Interestingly,the magnetic field is helpful for the modification of yield stress at a lower frequency and intensity before the optimal value;however,the modification is found to be weakened when the magnetic field is further increased after the optimal value.Possible explanation is proposed that the aggregation morphology of wax crystal would be altered and results in the release of wrapped oil phase from the network structure under the magnetic field.
基金the National Natural Science Foundation of China(51774303,51422406,51534007)the National Science and Technology Specific Project(2016ZX05028-004001)111 Project(B18054)for providing support for this research。
文摘In the present work,the interaction mechanism of specific polyelectrolyte multilayers(PEMs),fabricated by layer-by-layer deposition of polydiallyldimethylammonium chloride(PDDA)and poly(sodium 4-styrenesulfonate)(PSS),is studied using atomic force microscopy.The underwater oil-repellency of PS S-capped PEMs was further explored by measuring the interaction forces between tetradecane droplets and PEMs-coated silica substrates under various salinities.The force curves were analyzed following the Stokes-Reynolds-Young-Laplace theoretical model.Desirable consistency was achieved between the experimental and theoretical calculations at low NaCl concentrations(0.1 mM and 1 mM);however,underestimation of the attractive force was found as the NaCl concentration increases to moderate(10 mM)and high(100 mM)levels.Discrepancy analyses and incorporated features toward a reduced surface charge density were considered based on the previous findings of the orientation of anionic benzenesulfonate moieties(Liu et al.in Angew Chem Int Ed 54(16):4851-4856,2015.https://doi.org/10.1002/anie.201411992).Short-range steric hindrance interactions were further introduced to simulate"brush"effect stemming from nanoscale surface roughness.It is demonstrated in our work that the PSS-capped PEMs remains a stable underwater lipophobicity against high salinity,which renders it potential application in surface wetting modification and anti-fouling.
基金Natural Science Foundation of Gansu Province,China,No.20JR5RA335.
文摘BACKGROUND Primary intratracheal schwannoma is an extremely rare type of benign airway tumor,especially in adolescents.The presenting symptoms are typically prolonged cough and wheezing that can be misdiagnosed as asthma in adolescent patients.CASE A 16-year-old adolescent girl admitted to a local hospital with symptoms of an irritating cough and wheezing was diagnosed with bronchial asthma and treated with budesonide and formoterol.Over the next year,the patient's wheezing and coughing symptoms gradually worsened and the antiasthma treatment was ineffective.One week prior to this admission,the patient developed dyspnea after catching a cold and was transferred to our hospital with a diagnosis of severe asthma.However,chest computed tomography and bronchoscopy showed a mass in the trachea.Primary intratracheal schwannoma was diagnosed by biopsy.Her symptoms were relieved by endoscopic resection by electrosurgical snaring combined with argon plasma coagulation.No relapse occurred during an 18 mo follow-up.CONCLUSION Primary intratracheal schwannoma should be considered in the differential diagnosis in adolescents with recurrent asthma-like attacks.
