Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their development.The primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid ...Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their development.The primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid boron.In this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B system.This approach can be adopted to form various low-melting-point AM–Mg–B–O growth systems.These growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN chains.These findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.展开更多
Background: Resistance exercise leads to improved muscle function and metabolic homeostasis.Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive.Methods: Human volunteers w...Background: Resistance exercise leads to improved muscle function and metabolic homeostasis.Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive.Methods: Human volunteers were subjected to 4 weeks of resistance training protocols at different times of day to assess training outcomes and their associations with myokine irisin.Based on rhythmicity of Fibronectin type III domain containing 5(FNDC5/irisin),we trained wild type and FNDC5 knockout mice at late active phase(high FNDC5/irisin level)or late rest phase(low FNDC5/irisin level)to analyze exercise benefits on muscle function and metabolic homeostasis.Molecular analysis was performed to understand the regulatory mechanisms of FNDC5 rhythmicity and downstream signaling transduction in skeletal muscle.Results: In this study,we showed that regular resistance exercises performed at different times of day resulted in distinct training outcomes in humans,including exercise benefits and altered plasma metabolomics.We found that muscle FNDC5/irisin levels exhibit rhythmicity.Consistent with human data,compared to late rest phase(low irisin level),mice trained chronically at late active phase(high irisin level)gained more muscle capacity along with improved metabolic fitness and metabolomics/lipidomics profiles under a high-fat diet,whereas these differences were lost in FNDC5 knockout mice.Mechanistically,Basic helix-loop-helix ARNT like 1(BMAL1)and Peroxisome proliferative activated receptor,gamma,coactivator 1 alpha 4(PGC1α4)induce FNDC5/irisin transcription and rhythmicity,and the signaling is transduced viaαV integrin in muscle.Conclusion: Together,our results offered novel insights that exercise performed at distinct times of day determines training outcomes and metabolic benefits through the rhythmic regulation of the BMAL1/PGC1α4-FNDC5/irisin axis.展开更多
BACKGROUND At the end of 2019,a new epidemic of viral pneumonia emerged in China and was determined to be caused by a novel coronavirus,which was named coronavirus disease 2019(COVID-19)by the World Health Organizatio...BACKGROUND At the end of 2019,a new epidemic of viral pneumonia emerged in China and was determined to be caused by a novel coronavirus,which was named coronavirus disease 2019(COVID-19)by the World Health Organization.The epidemic quickly spread,causing a worldwide pandemic.Scientists and clinicians across the globe have shifted their research efforts towards understanding the virus itself and its epidemiology.CASE SUMMARY In mid-January 2020,a Chinese family made a visit to a local city,and within the next 2 wk one after another fell ill with COVID-19.At the beginning of their first illness onset,the family had eaten in a restaurant,which led to the subsequent illness onset in another two families.All cases were diagnosed as COVID-19 by real-time fluorescent reverse transcription-polymerase chain reaction.Epidemiological investigation showed that the transmission chain was complete.CONCLUSION This chain of social exposure highlights the danger of group aggregative behavior for spread of COVID-19.展开更多
Collective cell migration plays critical roles in various developmental,physiological,and pathological processes such as morphogenesis,wound healing,and tumor metastasis(Friedl and Gilmour,2009).During collective migr...Collective cell migration plays critical roles in various developmental,physiological,and pathological processes such as morphogenesis,wound healing,and tumor metastasis(Friedl and Gilmour,2009).During collective migration,each coherent group of associated cells needs to interpret external directional signal and convert it into a front-back asymmetry across a collective group(Rorth,2011).But the underlying mechanism for the establishment and maintenance of front-back asymmetry during collective migration is still not well understood.展开更多
This erratum clarifies information in the Letter to the Editor“Actin polymerization induces mitochondrial distribution during collective cell migration”by Qu et al.(2023).In the section for the list of author names,...This erratum clarifies information in the Letter to the Editor“Actin polymerization induces mitochondrial distribution during collective cell migration”by Qu et al.(2023).In the section for the list of author names,“Chen Qu,Yating Kan,Hui Zuo,Mengqi Wu,Zhixiang Dong,Xinyi Wang,Qing Zhang,Heng Wang,Dou Wang,Jiong Chen”should be“Chen Qu,Yating Kan,Xinyi Wang,Hui Zuo,Mengqi Wu,Zhixiang Dong,Qing Zhang,Heng Wang,Dou Wang,Jiong Chen”.展开更多
Bahu lotus root is a specialty of Hedong District,Linyi City,Shandong Province.It was recognized as a national product of geographical indication in 2011.This article describes the specific production area,unique prod...Bahu lotus root is a specialty of Hedong District,Linyi City,Shandong Province.It was recognized as a national product of geographical indication in 2011.This article describes the specific production area,unique production environment,rich cultural history and unique quality of Bahu lotus root,and summarizes its unique production from four aspects:selection of origin,selection of variety,production management and timely harvest,aiming to maintain the brand of Bahu lotus root to the greatest extent and further enhance the brand value and influence.展开更多
基金supported by the National Natural Science Foundation of China(No.51972162)the Fundamental Research Funds for the Central Universities(No.2024300440).
文摘Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their development.The primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid boron.In this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B system.This approach can be adopted to form various low-melting-point AM–Mg–B–O growth systems.These growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN chains.These findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.
基金supported by funds from National Key Research and Development Program of China (2019YFA0904500 to LX, 2023YFA1800400 to LX, and 2018YFE0113500 to JX)the National Natural Science Foundation of China (82301777 to MG, 32222024 to LX, 32325024 to XM, 32071148 to LX, and 91957116 to CX)+6 种基金Fundamental Research Funds for the Central Universities, Science and Technology Commission of Shanghai Municipality (21140904300 to XM and 22ZR1421200 to LX)Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-09-E00042 to JX)Key Project of 2022 Higher Education Scientific Research Planning Project of China Association of Higher Education (22TY0218 to FS)Youth Fund for Humanities and Social Sciences Research of the Ministry of Education (22YJC890023 to FS)Postdoctoral Fellowship Program of CPSF (GZB20230219 to MG)China Postdoctoral Science Foundation (2023M741183 to MG)ECNU public platform for Innovation (011).
文摘Background: Resistance exercise leads to improved muscle function and metabolic homeostasis.Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive.Methods: Human volunteers were subjected to 4 weeks of resistance training protocols at different times of day to assess training outcomes and their associations with myokine irisin.Based on rhythmicity of Fibronectin type III domain containing 5(FNDC5/irisin),we trained wild type and FNDC5 knockout mice at late active phase(high FNDC5/irisin level)or late rest phase(low FNDC5/irisin level)to analyze exercise benefits on muscle function and metabolic homeostasis.Molecular analysis was performed to understand the regulatory mechanisms of FNDC5 rhythmicity and downstream signaling transduction in skeletal muscle.Results: In this study,we showed that regular resistance exercises performed at different times of day resulted in distinct training outcomes in humans,including exercise benefits and altered plasma metabolomics.We found that muscle FNDC5/irisin levels exhibit rhythmicity.Consistent with human data,compared to late rest phase(low irisin level),mice trained chronically at late active phase(high irisin level)gained more muscle capacity along with improved metabolic fitness and metabolomics/lipidomics profiles under a high-fat diet,whereas these differences were lost in FNDC5 knockout mice.Mechanistically,Basic helix-loop-helix ARNT like 1(BMAL1)and Peroxisome proliferative activated receptor,gamma,coactivator 1 alpha 4(PGC1α4)induce FNDC5/irisin transcription and rhythmicity,and the signaling is transduced viaαV integrin in muscle.Conclusion: Together,our results offered novel insights that exercise performed at distinct times of day determines training outcomes and metabolic benefits through the rhythmic regulation of the BMAL1/PGC1α4-FNDC5/irisin axis.
基金The Guangzhou Science and Technology Program Key Projects,No.201704030132.
文摘BACKGROUND At the end of 2019,a new epidemic of viral pneumonia emerged in China and was determined to be caused by a novel coronavirus,which was named coronavirus disease 2019(COVID-19)by the World Health Organization.The epidemic quickly spread,causing a worldwide pandemic.Scientists and clinicians across the globe have shifted their research efforts towards understanding the virus itself and its epidemiology.CASE SUMMARY In mid-January 2020,a Chinese family made a visit to a local city,and within the next 2 wk one after another fell ill with COVID-19.At the beginning of their first illness onset,the family had eaten in a restaurant,which led to the subsequent illness onset in another two families.All cases were diagnosed as COVID-19 by real-time fluorescent reverse transcription-polymerase chain reaction.Epidemiological investigation showed that the transmission chain was complete.CONCLUSION This chain of social exposure highlights the danger of group aggregative behavior for spread of COVID-19.
基金supported by grants from the National Natural Science Foundation of China(31970743)the Fundamental Research Funds for the Central Universities(021414380524)to JC+1 种基金grants from the National Natural Science Foundation of China(31900563)Natural Science Foundation of Jiangsu Province(BK20190303)to HW。
文摘Collective cell migration plays critical roles in various developmental,physiological,and pathological processes such as morphogenesis,wound healing,and tumor metastasis(Friedl and Gilmour,2009).During collective migration,each coherent group of associated cells needs to interpret external directional signal and convert it into a front-back asymmetry across a collective group(Rorth,2011).But the underlying mechanism for the establishment and maintenance of front-back asymmetry during collective migration is still not well understood.
文摘This erratum clarifies information in the Letter to the Editor“Actin polymerization induces mitochondrial distribution during collective cell migration”by Qu et al.(2023).In the section for the list of author names,“Chen Qu,Yating Kan,Hui Zuo,Mengqi Wu,Zhixiang Dong,Xinyi Wang,Qing Zhang,Heng Wang,Dou Wang,Jiong Chen”should be“Chen Qu,Yating Kan,Xinyi Wang,Hui Zuo,Mengqi Wu,Zhixiang Dong,Qing Zhang,Heng Wang,Dou Wang,Jiong Chen”.
基金Supported by Subsidy Project for Reform and Construction of Grassroots Agricultural Technology Extension System(Lu Nong Cai Zi[2017]77).
文摘Bahu lotus root is a specialty of Hedong District,Linyi City,Shandong Province.It was recognized as a national product of geographical indication in 2011.This article describes the specific production area,unique production environment,rich cultural history and unique quality of Bahu lotus root,and summarizes its unique production from four aspects:selection of origin,selection of variety,production management and timely harvest,aiming to maintain the brand of Bahu lotus root to the greatest extent and further enhance the brand value and influence.
