Objective:To investigate the distribution of health literacy(HL)levels and the association of HL with proactive personality in patients with permanent colostomy.Methods:A cross-sectional study was conducted to measure...Objective:To investigate the distribution of health literacy(HL)levels and the association of HL with proactive personality in patients with permanent colostomy.Methods:A cross-sectional study was conducted to measure proactive personality and HL using validated scales.A total of 172 patients with permanent colostomy were selected from January 2021 to May 2022 in Yantai City,China.Descriptive statistics,t-test,ANOVA,Pearson correlation analysis,and multiple linear regression analysis techniques were used.Results:The results obtained from the study showed that the HL status of the participants was moderate.The correlation between participants’total HL scores and proactive personality scores was 0.417(P-value<0.001).In addition,HL showed statistically significant differences according to education level,place of residence,profession,and average monthly household income.Conclusions:This study showed that patients with higher proactive personality scores had higher HL.The key stakeholders require several positive strategies to improve the HL of patients with permanent colostomy by cultivating their proactive personalities,and these important policies will help to improve patient health and quality of life.展开更多
In the rapidly evolving landscape of Industry 4.0(I4.0),the convergence of information and operational technologies necessitates real-time communication and collaboration across cyber-physical systems and the Internet...In the rapidly evolving landscape of Industry 4.0(I4.0),the convergence of information and operational technologies necessitates real-time communication and collaboration across cyber-physical systems and the Internet of Things(IoT).Rapid data transmission is particularly critical within enterprises(vertically)and among stakeholders(horizontally)in this complex,heterogeneous ecosystem.While current research has focused on data application,processing,and storage within the cloud-edge-device continuum,cross-edge transmission has received less attention,resulting in challenges such as suboptimal routing and excessive delays in horizontal communications.To address the above issues,this paper introduces a Connection-As-Required Scheme(CARS)specifically designed for delay-sensitive IoT and Cyber-Physical System(CPS)applications,where low-latency communication is essential for operational efficiency.CARS leverages Lyapunov optimization and backpressure algorithms to optimize traffic scheduling and routing,minimizing communication delay between entities.Benchmarking against state-of-the-art solutions,CARS reduces Round-Trip Time(RTT)to approximately 47.0%of conventional methods and decreases delay by 24.5%in TCP-based and 26.0%in UDP-based applications.These results highlight the potential of CARS to facilitate effective,low-latency collaboration in diverse I4.0 environments.展开更多
High-quality clinical evidence is the basis of evidence-based medical practice.Acupuncture is the most widely used complementary and alternative medicine in the world.However,the improvement in the quality of acupunct...High-quality clinical evidence is the basis of evidence-based medical practice.Acupuncture is the most widely used complementary and alternative medicine in the world.However,the improvement in the quality of acupuncture clinical research does not match the rapid increase in the number of acupuncture clinical research in recent years.At present,the number of high-quality acupuncture clinical research in the world remains low.Taking the trial of acupuncture for chronic spontaneous urticaria published in Annals of Internal Medicine as an example,this paper discusses the factors that contribute to producing high-quality clinical evidence for acupuncture from the aspects of selecting the topic of study,formulating the study method,designing the study plan,controlling the study process,writing the study report,and selecting the journal in the process of before,during,and after the research.It emphasizes the necessity to start from the benefit of global people's health,take practical clinical problems as guidance,cleverly choose the research entry point,and conduct high-quality research with clinical value.After the accomplishment of the study,the results must be faithfully described,the scientific conclusions accurately sublimated,and appropriate scientific journals selected for publication.展开更多
Lily-Ziziphi Spinosae Semen decoction(LZ)is known for its blood nourishing,mind calming,body sedation,and sleep promoting effects in traditional Chinese medicine.However,its material basis and underlying mechanisms ha...Lily-Ziziphi Spinosae Semen decoction(LZ)is known for its blood nourishing,mind calming,body sedation,and sleep promoting effects in traditional Chinese medicine.However,its material basis and underlying mechanisms have not yet been clearly defined.This study applies liquid chromatography-mass spectrometry,network pharmacology,and animal studies to reveal the material basis and sleep-improving mechanisms of LZ.The mixed decoction(LZ-ME)and single decoction(LZ-SE)were prepared to study their chemical components.Network pharmacology was used to predict the sleep-improving targets and signaling pathways of LZ.ICR mice were intragastrically administered saline(NC),melatonin(positive control group,0.50 mg/kg),low(12.90 g/kg),medium(25.70 g/kg),and high(38.60 g/kg)dose of LZ-ME and LZ-SH for 30 days.The results showed that LZ-ME could prolong the sleep duration and shorten the sleep latency in sodium barbiturate induced mice model.The results of chemical composition showed that total polysaccharides,total flavonoids,total saponins,and total alkaloids in LZ-ME were significantly higher than those in LZ-SE(177.20%,82.34%,30.58%,and 11.66%,respectively).A total of 58 chemical components were identified by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-QTOF-MS),and 8 representative difference components of LZ-ME and LZ-SE were found.LZ-ME significantly increased tumor necrosis factor-α(TNF-α)in mice serum and neurotransmitterγ-aminobutyric acid(GABA)levels in mice hippocampus,decreased dopamine(DA)and glutamate(Glu)levels in mice hippocampus(P<0.05).Furthermore,LZ-ME up-regulated the abundance of the beneficial bacteria Lactobacillus and Eubacterium_R,down-regulated the abundance of the harmful bacteria Lachnospiraceae etc.The polysaccharides,flavonoids(spinosin and 6‴-feruloylspinosin)and saponins(jujuboside A and jujuboside B)were the main material bases for the sleep-promoting effects of LZ.These compounds may directly enhance levels of the GABA,reduced levels of Glu and DA and improve TNF-αlevels.And they also may indirectly regulate GABA levels by influencing the relative abundance of Lactobacillus and Eubacterium.展开更多
Since the plasticity of soil and the irregular shape of the excavation,the efficiency and stability of the traditional local radial basis function(RBF)collocation method(LRBFCM)are inadequate for analyzing three-dimen...Since the plasticity of soil and the irregular shape of the excavation,the efficiency and stability of the traditional local radial basis function(RBF)collocation method(LRBFCM)are inadequate for analyzing three-dimensional(3D)deformation of deep excavation.In this work,the technique known as the direct method,where the local influence nodes are collocated on a straight line,is introduced to optimize the LRBFCM.The direct method can improve the accuracy of the partial derivative,reduce the size effect caused by the large length-width ratio,and weaken the influence of the shape parameters on the LRBFCM.The mapping technique is adopted to transform the physical coordinates of a quadratic-type block to normalized coordinates,in which the deformation problem can easily be solved using the direct method.The stability of the LRBFCM is further modified by considering the irregular shape of 3D excavation,which is divided into several quadratic-type blocks.The soil’s plasticity is described by the Drucker-Prager(D-P)model.The improved LRBFCM is integrated with the incremental method to analyze the plasticity.Five different examples,including strip excavations and circular excavations,are presented to validate the proposed approach’s efficiency.展开更多
The Yangtze-Huaihe River Valley(YHRV)experienced a record-breaking mei-yu season during the summer of 2020,prompting investigation into the role of regional ocean-atmosphere coupling in simulating this extreme event.T...The Yangtze-Huaihe River Valley(YHRV)experienced a record-breaking mei-yu season during the summer of 2020,prompting investigation into the role of regional ocean-atmosphere coupling in simulating this extreme event.Through comparative analysis of regional ocean-atmosphere coupled(CP)and atmosphere-only(WRF)simulations,the aim of this study was to elucidate the mechanisms underlying this phenomenon.Results indicate that CP effectively reproduced the observed sea surface temperature spatial distribution and its daily variation during the period from 25 June to 25 July 2020,and notably reduced the wet biases over the YHRV when compared to WRF simulations.This improvement in representation was manifested in the observed rainfall spatial distribution and daily variability.The wet biases simulated by WRF were associated with a stronger 200-hPa westerly jet and a more westward-positioned western North Pacific subtropical high(WNPSH)with more intense 500-hPa winds and a stronger 850-hPa circulation.However,these biases were significantly reduced in CP simulations.Mechanism analysis revealed that regional ocean-atmosphere coupling over the western Northwest Pacific influenced surface turbulent heat fluxes and atmospheric instability,thereby modulating the intensity and position of the WNPSH and associated circulation subsystems at different levels.Moreover,adjustments in land-sea thermal contrast induced by ocean-atmosphere coupling impacted YHRV precipitation by altering East Asian circulation systems.These findings highlight the significant role of regional ocean-atmosphere coupling in enhancing the simulation and understanding of extreme mei-yu events over East Asia.展开更多
AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellular carcinogenesisand their clinical significance.METHODS SP immunohistochemistry was usedto dete...AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellular carcinogenesisand their clinical significance.METHODS SP immunohistochemistry was usedto detect the expression of p42/44MAPK, p-Stat3,c-fos and c-jun proteins in 55 hepatocellularcarcinomas (HCC) and their surrounding livertissues.RESULTS The positive rates and expressionlevels of p42/44MAPK, p-Stat3, c-fos and c-junproteins in HCCs were significantly higher thanthose in pericarcinomatous liver tissues (PCLT).A positive correlation was observed between theexpression of p42/44MAPK and c-fos proteins, andbetween p-Stat3 and c-jun, but there was nosignificant correlation between p42/44MAPK and p-Stat3 in HCCs and their surrounding livertissues.CONCLUSION The abnormalities of Ras/Rat/MAPK and JAKs/ Stat3 cascade reaction maycontribute to malignant transformation ofhepatocytes. Hepatocytes which are positive forp42/ 44MAPK, c-fos or c-jun proteins may bepotential malignant pre-cancerous cells.Activation of MAPK and Stat3 proteins may be anearly event in hepatocellular carcinogenesis.展开更多
Background: Insomnia is a common complaint that is closely related to gastrointestinal symptoms, which is consistent with the traditional Chinese medicine classical theory of ‘‘stomach disharmony leading to restless...Background: Insomnia is a common complaint that is closely related to gastrointestinal symptoms, which is consistent with the traditional Chinese medicine classical theory of ‘‘stomach disharmony leading to restless sleep." Acupuncture is an effective complementary and alternative medicine therapy to improve gastrointestinal function and restore the normal sleep-wake cycle. However, studies on the effectiveness of acupuncture for insomnia due to spleen-stomach disharmony syndrome are limited to case reports and few randomized controlled trials; deeper research on its mechanism is still lacking. This randomized controlled trial aims to assess the treatment efficacy of ‘‘harmonizing stomach to tranquilize mind"acupuncture for insomnia and its influence on the intestinal microbiome.Methods/design: This is a randomized, single-blind, parallel-group study. Sixty eligible patients with insomnia due to spleen-stomach disharmony syndrome will be randomly divided into two groups(1:1 allocation ratio). The intervention group will use ‘‘harmonizing stomach to tranquilize mind"acupuncture, and the control group will receive sham acupuncture. Participants will receive 5 acupuncture treatment sessions per week for 4 consecutive weeks. The Pittsburgh Sleep Quality Index will be used to evaluate the clinical efficacy of acupuncture treatment by making assessments at baseline, the end of treatment and the end of the follow-up. High-throughput 16 S ribosomal ribonucleic acid gene sequencing will be performed to detect changes in the intestinal microbial composition before and after treatment.Discussion: The results of this trial are expected to confirm that ‘‘harmonizing stomach to tranquilize mind" acupuncture can effectively relieve insomnia and alter the intestinal microbiome.展开更多
The newly-discovered supergiant Huayangchuan uranium(U)-polymetallic(Sr,Se,REEs,Ba,Nb and Pb)deposit is located in the Qinling Orogen,central China.The deposit underwent multistage mineralization,with the main carbona...The newly-discovered supergiant Huayangchuan uranium(U)-polymetallic(Sr,Se,REEs,Ba,Nb and Pb)deposit is located in the Qinling Orogen,central China.The deposit underwent multistage mineralization,with the main carbonatite ore stage being the most important for the U,Nb,REE,Sr and Ba endowments.According to the mineral assemblages,the main carbonatite ore stage can be divided into three substages,i.e.,sulfate(Ba-Sr),alkali-rich U and REE-U mineralization.Main-stage titanite from the Huayangchuan igneous carbonatite are rich in high field strength elements(HFSEs,e.g.,Zr,Nb and REEs),and show clear elemental substitutions(e.g.,Ti vs.Nb+Fe+Al and Ca+Ti vs.Fe+Al+REE).High-precision LA-ICP-MS titanite dating yielded a U-Pb age of 209.0±2.9 Ma,which represents the mainstage mineralization age at Huayangchuan,and is coeval with the local carbonatite dyke intrusion.This mineralization age is further constrained by the Re-Os dating of molybdenite from the Huayangchuan carbonatite,which yielded a weighted mean age of 196.8±2.4 Ma.Molybdenite Re contents(337.55-392.75 ppm)and C-OSr-Nd-Pb isotopic evidence of the Huayangchuan carbonatite both suggest a mantle origin for the carbonatite.Our study supports that the Late Triassic carbonatite magmatism was responsible for the world-class U-Mo-REE mineralization in the Qinling Orogen,and that the regional magmatism and ore formation was likely caused by the closure of the Mianlue ocean and the subsequent North China-South China continent-continent collision.展开更多
文摘Objective:To investigate the distribution of health literacy(HL)levels and the association of HL with proactive personality in patients with permanent colostomy.Methods:A cross-sectional study was conducted to measure proactive personality and HL using validated scales.A total of 172 patients with permanent colostomy were selected from January 2021 to May 2022 in Yantai City,China.Descriptive statistics,t-test,ANOVA,Pearson correlation analysis,and multiple linear regression analysis techniques were used.Results:The results obtained from the study showed that the HL status of the participants was moderate.The correlation between participants’total HL scores and proactive personality scores was 0.417(P-value<0.001).In addition,HL showed statistically significant differences according to education level,place of residence,profession,and average monthly household income.Conclusions:This study showed that patients with higher proactive personality scores had higher HL.The key stakeholders require several positive strategies to improve the HL of patients with permanent colostomy by cultivating their proactive personalities,and these important policies will help to improve patient health and quality of life.
基金supported by the National Natural Science Foundation of China under Grant No.62271040,and 62341102the Fundamental Research Funds for the Central Universities under Grant No.2023JBGP004.
文摘In the rapidly evolving landscape of Industry 4.0(I4.0),the convergence of information and operational technologies necessitates real-time communication and collaboration across cyber-physical systems and the Internet of Things(IoT).Rapid data transmission is particularly critical within enterprises(vertically)and among stakeholders(horizontally)in this complex,heterogeneous ecosystem.While current research has focused on data application,processing,and storage within the cloud-edge-device continuum,cross-edge transmission has received less attention,resulting in challenges such as suboptimal routing and excessive delays in horizontal communications.To address the above issues,this paper introduces a Connection-As-Required Scheme(CARS)specifically designed for delay-sensitive IoT and Cyber-Physical System(CPS)applications,where low-latency communication is essential for operational efficiency.CARS leverages Lyapunov optimization and backpressure algorithms to optimize traffic scheduling and routing,minimizing communication delay between entities.Benchmarking against state-of-the-art solutions,CARS reduces Round-Trip Time(RTT)to approximately 47.0%of conventional methods and decreases delay by 24.5%in TCP-based and 26.0%in UDP-based applications.These results highlight the potential of CARS to facilitate effective,low-latency collaboration in diverse I4.0 environments.
基金Supported by Sichuan Province science and technology education joint fund project:2024NSFSC1976Science and Technology Research Project of Sichuan Ad-ministration of Traditional Chinese Medicine:2021MS320.
文摘High-quality clinical evidence is the basis of evidence-based medical practice.Acupuncture is the most widely used complementary and alternative medicine in the world.However,the improvement in the quality of acupuncture clinical research does not match the rapid increase in the number of acupuncture clinical research in recent years.At present,the number of high-quality acupuncture clinical research in the world remains low.Taking the trial of acupuncture for chronic spontaneous urticaria published in Annals of Internal Medicine as an example,this paper discusses the factors that contribute to producing high-quality clinical evidence for acupuncture from the aspects of selecting the topic of study,formulating the study method,designing the study plan,controlling the study process,writing the study report,and selecting the journal in the process of before,during,and after the research.It emphasizes the necessity to start from the benefit of global people's health,take practical clinical problems as guidance,cleverly choose the research entry point,and conduct high-quality research with clinical value.After the accomplishment of the study,the results must be faithfully described,the scientific conclusions accurately sublimated,and appropriate scientific journals selected for publication.
基金supported by the Province Natural Science Foundation of Hunan,China(2022JJ50048)Hunan Agriculture Research System(HARS-11).
文摘Lily-Ziziphi Spinosae Semen decoction(LZ)is known for its blood nourishing,mind calming,body sedation,and sleep promoting effects in traditional Chinese medicine.However,its material basis and underlying mechanisms have not yet been clearly defined.This study applies liquid chromatography-mass spectrometry,network pharmacology,and animal studies to reveal the material basis and sleep-improving mechanisms of LZ.The mixed decoction(LZ-ME)and single decoction(LZ-SE)were prepared to study their chemical components.Network pharmacology was used to predict the sleep-improving targets and signaling pathways of LZ.ICR mice were intragastrically administered saline(NC),melatonin(positive control group,0.50 mg/kg),low(12.90 g/kg),medium(25.70 g/kg),and high(38.60 g/kg)dose of LZ-ME and LZ-SH for 30 days.The results showed that LZ-ME could prolong the sleep duration and shorten the sleep latency in sodium barbiturate induced mice model.The results of chemical composition showed that total polysaccharides,total flavonoids,total saponins,and total alkaloids in LZ-ME were significantly higher than those in LZ-SE(177.20%,82.34%,30.58%,and 11.66%,respectively).A total of 58 chemical components were identified by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-QTOF-MS),and 8 representative difference components of LZ-ME and LZ-SE were found.LZ-ME significantly increased tumor necrosis factor-α(TNF-α)in mice serum and neurotransmitterγ-aminobutyric acid(GABA)levels in mice hippocampus,decreased dopamine(DA)and glutamate(Glu)levels in mice hippocampus(P<0.05).Furthermore,LZ-ME up-regulated the abundance of the beneficial bacteria Lactobacillus and Eubacterium_R,down-regulated the abundance of the harmful bacteria Lachnospiraceae etc.The polysaccharides,flavonoids(spinosin and 6‴-feruloylspinosin)and saponins(jujuboside A and jujuboside B)were the main material bases for the sleep-promoting effects of LZ.These compounds may directly enhance levels of the GABA,reduced levels of Glu and DA and improve TNF-αlevels.And they also may indirectly regulate GABA levels by influencing the relative abundance of Lactobacillus and Eubacterium.
基金supported by grants from the National Natural Science Foundation of China(Nos.12172159 and 12362019).
文摘Since the plasticity of soil and the irregular shape of the excavation,the efficiency and stability of the traditional local radial basis function(RBF)collocation method(LRBFCM)are inadequate for analyzing three-dimensional(3D)deformation of deep excavation.In this work,the technique known as the direct method,where the local influence nodes are collocated on a straight line,is introduced to optimize the LRBFCM.The direct method can improve the accuracy of the partial derivative,reduce the size effect caused by the large length-width ratio,and weaken the influence of the shape parameters on the LRBFCM.The mapping technique is adopted to transform the physical coordinates of a quadratic-type block to normalized coordinates,in which the deformation problem can easily be solved using the direct method.The stability of the LRBFCM is further modified by considering the irregular shape of 3D excavation,which is divided into several quadratic-type blocks.The soil’s plasticity is described by the Drucker-Prager(D-P)model.The improved LRBFCM is integrated with the incremental method to analyze the plasticity.Five different examples,including strip excavations and circular excavations,are presented to validate the proposed approach’s efficiency.
基金the National Key Scientific and Technological Infrastructure project “Earth System Science Numerical Simulator Facility (EarthLab)” for its support of our studyjointly supported by the National Key Research and Development Program of China (Grant No. 2023YFF0805501)+2 种基金the Key Laboratory of Meteorological Disaster (KLME) of the Ministry of Education, and the Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD) at Nanjing University of Information Science & Technology, Nanjing, China (Grant No. KLME202204)the NSFC program (42141017)support from the China Scholarship Council.
文摘The Yangtze-Huaihe River Valley(YHRV)experienced a record-breaking mei-yu season during the summer of 2020,prompting investigation into the role of regional ocean-atmosphere coupling in simulating this extreme event.Through comparative analysis of regional ocean-atmosphere coupled(CP)and atmosphere-only(WRF)simulations,the aim of this study was to elucidate the mechanisms underlying this phenomenon.Results indicate that CP effectively reproduced the observed sea surface temperature spatial distribution and its daily variation during the period from 25 June to 25 July 2020,and notably reduced the wet biases over the YHRV when compared to WRF simulations.This improvement in representation was manifested in the observed rainfall spatial distribution and daily variability.The wet biases simulated by WRF were associated with a stronger 200-hPa westerly jet and a more westward-positioned western North Pacific subtropical high(WNPSH)with more intense 500-hPa winds and a stronger 850-hPa circulation.However,these biases were significantly reduced in CP simulations.Mechanism analysis revealed that regional ocean-atmosphere coupling over the western Northwest Pacific influenced surface turbulent heat fluxes and atmospheric instability,thereby modulating the intensity and position of the WNPSH and associated circulation subsystems at different levels.Moreover,adjustments in land-sea thermal contrast induced by ocean-atmosphere coupling impacted YHRV precipitation by altering East Asian circulation systems.These findings highlight the significant role of regional ocean-atmosphere coupling in enhancing the simulation and understanding of extreme mei-yu events over East Asia.
文摘AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellular carcinogenesisand their clinical significance.METHODS SP immunohistochemistry was usedto detect the expression of p42/44MAPK, p-Stat3,c-fos and c-jun proteins in 55 hepatocellularcarcinomas (HCC) and their surrounding livertissues.RESULTS The positive rates and expressionlevels of p42/44MAPK, p-Stat3, c-fos and c-junproteins in HCCs were significantly higher thanthose in pericarcinomatous liver tissues (PCLT).A positive correlation was observed between theexpression of p42/44MAPK and c-fos proteins, andbetween p-Stat3 and c-jun, but there was nosignificant correlation between p42/44MAPK and p-Stat3 in HCCs and their surrounding livertissues.CONCLUSION The abnormalities of Ras/Rat/MAPK and JAKs/ Stat3 cascade reaction maycontribute to malignant transformation ofhepatocytes. Hepatocytes which are positive forp42/ 44MAPK, c-fos or c-jun proteins may bepotential malignant pre-cancerous cells.Activation of MAPK and Stat3 proteins may be anearly event in hepatocellular carcinogenesis.
基金supported by a grant from the Science and Technology Planned Project of Sichuan Province,China (No.18YYJC0949)
文摘Background: Insomnia is a common complaint that is closely related to gastrointestinal symptoms, which is consistent with the traditional Chinese medicine classical theory of ‘‘stomach disharmony leading to restless sleep." Acupuncture is an effective complementary and alternative medicine therapy to improve gastrointestinal function and restore the normal sleep-wake cycle. However, studies on the effectiveness of acupuncture for insomnia due to spleen-stomach disharmony syndrome are limited to case reports and few randomized controlled trials; deeper research on its mechanism is still lacking. This randomized controlled trial aims to assess the treatment efficacy of ‘‘harmonizing stomach to tranquilize mind"acupuncture for insomnia and its influence on the intestinal microbiome.Methods/design: This is a randomized, single-blind, parallel-group study. Sixty eligible patients with insomnia due to spleen-stomach disharmony syndrome will be randomly divided into two groups(1:1 allocation ratio). The intervention group will use ‘‘harmonizing stomach to tranquilize mind"acupuncture, and the control group will receive sham acupuncture. Participants will receive 5 acupuncture treatment sessions per week for 4 consecutive weeks. The Pittsburgh Sleep Quality Index will be used to evaluate the clinical efficacy of acupuncture treatment by making assessments at baseline, the end of treatment and the end of the follow-up. High-throughput 16 S ribosomal ribonucleic acid gene sequencing will be performed to detect changes in the intestinal microbial composition before and after treatment.Discussion: The results of this trial are expected to confirm that ‘‘harmonizing stomach to tranquilize mind" acupuncture can effectively relieve insomnia and alter the intestinal microbiome.
基金supported by the Type-B Strategic Pilot Science and Special Technology Program,Chinese Academy of Sciences(XDB18030206)Academician Workstation of Sino Shaanxi Nuclear Industry Group(ZSH-YS180101 and YS190101)。
文摘The newly-discovered supergiant Huayangchuan uranium(U)-polymetallic(Sr,Se,REEs,Ba,Nb and Pb)deposit is located in the Qinling Orogen,central China.The deposit underwent multistage mineralization,with the main carbonatite ore stage being the most important for the U,Nb,REE,Sr and Ba endowments.According to the mineral assemblages,the main carbonatite ore stage can be divided into three substages,i.e.,sulfate(Ba-Sr),alkali-rich U and REE-U mineralization.Main-stage titanite from the Huayangchuan igneous carbonatite are rich in high field strength elements(HFSEs,e.g.,Zr,Nb and REEs),and show clear elemental substitutions(e.g.,Ti vs.Nb+Fe+Al and Ca+Ti vs.Fe+Al+REE).High-precision LA-ICP-MS titanite dating yielded a U-Pb age of 209.0±2.9 Ma,which represents the mainstage mineralization age at Huayangchuan,and is coeval with the local carbonatite dyke intrusion.This mineralization age is further constrained by the Re-Os dating of molybdenite from the Huayangchuan carbonatite,which yielded a weighted mean age of 196.8±2.4 Ma.Molybdenite Re contents(337.55-392.75 ppm)and C-OSr-Nd-Pb isotopic evidence of the Huayangchuan carbonatite both suggest a mantle origin for the carbonatite.Our study supports that the Late Triassic carbonatite magmatism was responsible for the world-class U-Mo-REE mineralization in the Qinling Orogen,and that the regional magmatism and ore formation was likely caused by the closure of the Mianlue ocean and the subsequent North China-South China continent-continent collision.
