静止卫星具有可连续高频率观测的特点,被广泛应用于数值天气预报中,以获得更精细、更真实的数值模式初始条件。基于WRF框架的陕西省区域数值模式系统,针对2022年7月陕西一次强降水过程,利用三维变分直接同化方法,协同常规观测资料,同化...静止卫星具有可连续高频率观测的特点,被广泛应用于数值天气预报中,以获得更精细、更真实的数值模式初始条件。基于WRF框架的陕西省区域数值模式系统,针对2022年7月陕西一次强降水过程,利用三维变分直接同化方法,协同常规观测资料,同化风云四号A星所探测的两个水汽通道辐射率资料。通过设计三组对比试验:(1)不同化任何资料的控制试验(CTRL);(2)仅同化常规观测资料的试验(CONV);(3)同化常规观测与AGRI水汽通道的试验(AGRI),系统评估了晴空区FY-4A卫星两个水汽通道辐射资料同化对降水预报的改进效果。结果表明,经过一系列的质量控制和偏差订正,通道9(10)同化前观测亮温和背景场亮温差值(observation minus background,简称OMB)的平均值由0.76(0.78)K减小到0.04(-0.02)K,同化后观测亮温和分析场亮温差值(observation minus analysis,简称OMA)的平均值进一步缩小为0.01(0.01)K;通道9(10)同化前观测亮温和背景场场亮温差OMB标准差为0.83(0.84)K,同化后观测亮温和分析场亮温差OMA的标准差为0.43(0.49)K,说明同化AGRI水汽通道辐射资料改善了模式的初始场。通过协同同化FY-4A AGRI水汽通道辐射率资料与常规观测资料,显著改善了降水预报性能,常规观测资料通过调整风场优化了天气系统配置,使降水落区与实况更加接近,AGRI水汽通道资料同化修正了中高层比湿场,使强降水中心的强度预报误差降低20%。展开更多
目的分析产后抑郁(postpartum depression,PPD)污名化的概念发展及应用、属性、前因、结果及典型案例,以期为PPD心理求助相关研究提供理论参考,为母婴健康照护实践提供依据。方法系统检索数据库知网、万方、维普、Sinomed、Embase、Pub...目的分析产后抑郁(postpartum depression,PPD)污名化的概念发展及应用、属性、前因、结果及典型案例,以期为PPD心理求助相关研究提供理论参考,为母婴健康照护实践提供依据。方法系统检索数据库知网、万方、维普、Sinomed、Embase、PubMed、Scopus、CINAHL和Web of Science收录的所有有关PPD污名化的文献,以Walker-Avant经典概念分析法为理论框架进行分析。结果共纳入文献40篇,归纳总结出PPD污名化定义属性包括3个方面:消极情绪体验、负面认知评价以及歧视倾向;其前因包括4个方面:个人障碍、社会障碍、卫生保健障碍及公众障碍;其后果是对患者生理心理均产生不利影响。结论界定PPD污名化有助于医护人员开展相关理论研究,编制相关适用测评量表及制定相应的干预措施,提高对PPD污名化的识别及干预能力,为提升围生产期精神卫生保健利用率提供参考依据。展开更多
BACKGROUND Although chemotherapy is effective for treating advanced gastric carcinoma(aGC),it may lead to an adverse prognosis.Establishing a highly effective and low-toxicity chemotherapy regimen is necessary for imp...BACKGROUND Although chemotherapy is effective for treating advanced gastric carcinoma(aGC),it may lead to an adverse prognosis.Establishing a highly effective and low-toxicity chemotherapy regimen is necessary for improving efficacy and outcomes in aGC patients.AIM To determine the efficacy and safety of cetuximab(CET)combined with the FOLFOX4 regimen(infusional fluorouracil,folinic acid,and oxaliplatin)as firstline therapy for patients with aGC,who received evidence-based care(EBC).METHODS A total of 117 aGC patients who received EBC from March 2019 to March 2022 were enrolled.Of these,60 in the research group(RG)received CET+FOLFOX4 as first-line therapy,whereas 57 in the control group(CG)received FOLFOX4.The efficacy[clinical response rate(RR)and disease control rate(DCR)],safety(liver and kidney dysfunction,leukopenia,thrombocytopenia,rash,and diarrhea),serum tumor marker expression[STMs;carbohydrate antigen(CA)19-9,CA72-4,and carcinoembryonic antigen(CEA)],inflammatory indicators[interleukin(IL)-2 and IL-10],and quality of life(QOL)of the two groups were compared.RESULTS A markedly higher RR and DCR were observed in the RG compared with the CG,with an equivalent safety profile between the two groups.RG exhibited notably reduced CA19-9,CA72-4,CEA,and IL-2 levels following treatment,which were lower than the pre-treatment levels and those in the CG.Post-treatment IL-10 was statistically increased in RG,higher than the pre-treatment level and the CG.Moreover,a significantly improved QOL was evident in the RG.CONCLUSION The CET+FOLFOX4 regimen is highly effective as first-line treatment for aGC patients receiving EBC.It facilitates the suppression of STMs,ameliorates the serum inflammatory microenvironment,and enhances QOL,without increased adverse drug effects.展开更多
文摘静止卫星具有可连续高频率观测的特点,被广泛应用于数值天气预报中,以获得更精细、更真实的数值模式初始条件。基于WRF框架的陕西省区域数值模式系统,针对2022年7月陕西一次强降水过程,利用三维变分直接同化方法,协同常规观测资料,同化风云四号A星所探测的两个水汽通道辐射率资料。通过设计三组对比试验:(1)不同化任何资料的控制试验(CTRL);(2)仅同化常规观测资料的试验(CONV);(3)同化常规观测与AGRI水汽通道的试验(AGRI),系统评估了晴空区FY-4A卫星两个水汽通道辐射资料同化对降水预报的改进效果。结果表明,经过一系列的质量控制和偏差订正,通道9(10)同化前观测亮温和背景场亮温差值(observation minus background,简称OMB)的平均值由0.76(0.78)K减小到0.04(-0.02)K,同化后观测亮温和分析场亮温差值(observation minus analysis,简称OMA)的平均值进一步缩小为0.01(0.01)K;通道9(10)同化前观测亮温和背景场场亮温差OMB标准差为0.83(0.84)K,同化后观测亮温和分析场亮温差OMA的标准差为0.43(0.49)K,说明同化AGRI水汽通道辐射资料改善了模式的初始场。通过协同同化FY-4A AGRI水汽通道辐射率资料与常规观测资料,显著改善了降水预报性能,常规观测资料通过调整风场优化了天气系统配置,使降水落区与实况更加接近,AGRI水汽通道资料同化修正了中高层比湿场,使强降水中心的强度预报误差降低20%。
文摘目的分析产后抑郁(postpartum depression,PPD)污名化的概念发展及应用、属性、前因、结果及典型案例,以期为PPD心理求助相关研究提供理论参考,为母婴健康照护实践提供依据。方法系统检索数据库知网、万方、维普、Sinomed、Embase、PubMed、Scopus、CINAHL和Web of Science收录的所有有关PPD污名化的文献,以Walker-Avant经典概念分析法为理论框架进行分析。结果共纳入文献40篇,归纳总结出PPD污名化定义属性包括3个方面:消极情绪体验、负面认知评价以及歧视倾向;其前因包括4个方面:个人障碍、社会障碍、卫生保健障碍及公众障碍;其后果是对患者生理心理均产生不利影响。结论界定PPD污名化有助于医护人员开展相关理论研究,编制相关适用测评量表及制定相应的干预措施,提高对PPD污名化的识别及干预能力,为提升围生产期精神卫生保健利用率提供参考依据。
文摘BACKGROUND Although chemotherapy is effective for treating advanced gastric carcinoma(aGC),it may lead to an adverse prognosis.Establishing a highly effective and low-toxicity chemotherapy regimen is necessary for improving efficacy and outcomes in aGC patients.AIM To determine the efficacy and safety of cetuximab(CET)combined with the FOLFOX4 regimen(infusional fluorouracil,folinic acid,and oxaliplatin)as firstline therapy for patients with aGC,who received evidence-based care(EBC).METHODS A total of 117 aGC patients who received EBC from March 2019 to March 2022 were enrolled.Of these,60 in the research group(RG)received CET+FOLFOX4 as first-line therapy,whereas 57 in the control group(CG)received FOLFOX4.The efficacy[clinical response rate(RR)and disease control rate(DCR)],safety(liver and kidney dysfunction,leukopenia,thrombocytopenia,rash,and diarrhea),serum tumor marker expression[STMs;carbohydrate antigen(CA)19-9,CA72-4,and carcinoembryonic antigen(CEA)],inflammatory indicators[interleukin(IL)-2 and IL-10],and quality of life(QOL)of the two groups were compared.RESULTS A markedly higher RR and DCR were observed in the RG compared with the CG,with an equivalent safety profile between the two groups.RG exhibited notably reduced CA19-9,CA72-4,CEA,and IL-2 levels following treatment,which were lower than the pre-treatment levels and those in the CG.Post-treatment IL-10 was statistically increased in RG,higher than the pre-treatment level and the CG.Moreover,a significantly improved QOL was evident in the RG.CONCLUSION The CET+FOLFOX4 regimen is highly effective as first-line treatment for aGC patients receiving EBC.It facilitates the suppression of STMs,ameliorates the serum inflammatory microenvironment,and enhances QOL,without increased adverse drug effects.
