A carotid web is considered a localized form of fibromuscular dysplasia,carrying a heightened risk of stroke due to blood stagnation and subsequent clot formation downstream from the web.These abnor-malities typically...A carotid web is considered a localized form of fibromuscular dysplasia,carrying a heightened risk of stroke due to blood stagnation and subsequent clot formation downstream from the web.These abnor-malities typically affect the rear outer wall of the carot-id artery,and their exact developmental origin remains a topic of debate.This case report details the presentation of a young male with altered mental status,ultimately di-agnosed with an acute stroke using magnetic resonance imaging(MRI).Brain MRI revealed an ischemic stroke affecting the distribution of the left middle cerebral artery(MCA),with linear filling defects resembling shelves in the carotid bulbs on a computed tomography angiogra-phy(CTA)of the head and neck,consistent with bilateral carotid web confirmed by catheter angiography.Bilateral carotid web cases are also relatively uncommon in clin-ical practice but should not be dismissed as a potential cause of unexplained strokes.Bilateral carotid webs were identified using head and neck CTA,cerebral angiogra-phy,and carotid artery Doppler ultrasound.The patient was then treated with enteric-coated aspirin,clopidogrel,and high-intensity statins,followed by carotid endarterec-tomy after a 2-month follow-up,revealing fibromuscular hyperplasia upon pathology examination.展开更多
Background： Primary angle-closure glaucoma （PACG） is a common eye disease and a common cause of blindness. Inappropriate medical decisions severely affect the prognosis. This study investigated decision-making unde...Background： Primary angle-closure glaucoma （PACG） is a common eye disease and a common cause of blindness. Inappropriate medical decisions severely affect the prognosis. This study investigated decision-making under risk in PACG patients.Methods： Thirty patients with first acute attack of PACG before surgery and thirty healthy controls were included in the study. Decision-making under risk was evaluated with the game of dice task （GDT）. The results of Eysenck Personality Questionnaire （EPQ） and GDT between PACG patients and healthy controls were compared. Results： Risky decisions in PACG patients were more than those in healthy controls as measured by mean score ofGDT （ 12.47 ±5.72 vs. 4.33± 3.30, P 〈 0.001）. Higher neuroticism score in EPQ was found in PACG patients compared to healthy controls （14.97 ± 3.93 vs. 9.90 ± 4.49, P 〈 0.001 ）. Neuroticism scores in EPQ were associated with decision-making performance （r = 0.417, P = 0.001 ）. Conclusions： Neuroticism positively correlated with risky decisions. Decision-making might be influenced by neuroticism. Future studies will show whether therapy compliance will be improved by emotional management and psychological intervention in PACG patients.展开更多
Stimulated Reservoir Volume(SRV)fracturing is a key technology of unconventional oil and gas exploration and development.To gain a deeper understanding of tight sandstone reservoirs and draw on the development experie...Stimulated Reservoir Volume(SRV)fracturing is a key technology of unconventional oil and gas exploration and development.To gain a deeper understanding of tight sandstone reservoirs and draw on the development experience of hydraulic fracturing,the authors conduct a large number of detailed investigations of geological characteristics in the regions that have implemented SRV fracturing.Based on the data of rock mechanics parameters,insitu stress characteristics,brittleness characteristics and natural fractures,the influencing factors of SRV fracturing in tight oil reservoirs were analyzed.The results show that the SRV fracturing is suitable for geological reservoirs with the characteristics of medium to high elastic modulus,low to medium Poisson’s ratio,low stress difference,medium to high brittleness and naturally fractured reservoirs,where natural fractures have a significant impact.Region A,a tight sandstone region,has moderate elastic modulus,low Poisson’s ratio,low ground stress difference and medium brittleness,and has the feasibility of volume fracturing.The field case of the Y325 well shows that SRV fracturing technology has obvious effect on increasing production.This technology is applicable to the Region A.展开更多
Hydraulic fracturing(HF)is a commonly used technique to stimulate low permeability formations such as shale plays and tight formations.However,this method of well stimulation has also been used in high permeable uncon...Hydraulic fracturing(HF)is a commonly used technique to stimulate low permeability formations such as shale plays and tight formations.However,this method of well stimulation has also been used in high permeable unconsolidated sandstone formations to bypass near-wellbore formation damage and prevent sand production at some distance apart from the wellbore wall.The treatment is called frac-pack completion,where a short length but wide width fracture is formed by injecting aggressive concentrations of proppant into the fracture plane.This operation is known as tip screen-out(TSO).Detailed design of fluid and proppant,including an optimal pump schedule,is required to achieve satisfactory TSO.In this study,we first assess the lattice-based numerical method's capabilities for simulating hydraulic fracturing propagation in elastoplastic formation.The results will be compared with the same case simulation results using a pseudo 3D(P3D)model and analytical model.Second,we explore the Nolte(1986)design for frac-pack and TSO treatment using lattice-based software and the P3D model.The results showed that both models could simulate the hydraulic fracturing propagation in soft formation and TSO operation,while some differences were observed in generated geometry,the tip screenout time and net pressure profiles.The results are presented.It was noted that fracture propagation regime(viscosity/toughness),nonlocality and nonlinearity had an influence on the different geometries.The advantages of each model will be discussed.展开更多
文摘A carotid web is considered a localized form of fibromuscular dysplasia,carrying a heightened risk of stroke due to blood stagnation and subsequent clot formation downstream from the web.These abnor-malities typically affect the rear outer wall of the carot-id artery,and their exact developmental origin remains a topic of debate.This case report details the presentation of a young male with altered mental status,ultimately di-agnosed with an acute stroke using magnetic resonance imaging(MRI).Brain MRI revealed an ischemic stroke affecting the distribution of the left middle cerebral artery(MCA),with linear filling defects resembling shelves in the carotid bulbs on a computed tomography angiogra-phy(CTA)of the head and neck,consistent with bilateral carotid web confirmed by catheter angiography.Bilateral carotid web cases are also relatively uncommon in clin-ical practice but should not be dismissed as a potential cause of unexplained strokes.Bilateral carotid webs were identified using head and neck CTA,cerebral angiogra-phy,and carotid artery Doppler ultrasound.The patient was then treated with enteric-coated aspirin,clopidogrel,and high-intensity statins,followed by carotid endarterec-tomy after a 2-month follow-up,revealing fibromuscular hyperplasia upon pathology examination.
基金This study was supported by grants from the National Basic Research Program of China （973 Program No. 2015CB856405） and the National Natural Science Foundation of China （No. 81471117 and No. 81671354）.
文摘Background： Primary angle-closure glaucoma （PACG） is a common eye disease and a common cause of blindness. Inappropriate medical decisions severely affect the prognosis. This study investigated decision-making under risk in PACG patients.Methods： Thirty patients with first acute attack of PACG before surgery and thirty healthy controls were included in the study. Decision-making under risk was evaluated with the game of dice task （GDT）. The results of Eysenck Personality Questionnaire （EPQ） and GDT between PACG patients and healthy controls were compared. Results： Risky decisions in PACG patients were more than those in healthy controls as measured by mean score ofGDT （ 12.47 ±5.72 vs. 4.33± 3.30, P 〈 0.001）. Higher neuroticism score in EPQ was found in PACG patients compared to healthy controls （14.97 ± 3.93 vs. 9.90 ± 4.49, P 〈 0.001 ）. Neuroticism scores in EPQ were associated with decision-making performance （r = 0.417, P = 0.001 ）. Conclusions： Neuroticism positively correlated with risky decisions. Decision-making might be influenced by neuroticism. Future studies will show whether therapy compliance will be improved by emotional management and psychological intervention in PACG patients.
基金The research was financially supported by National NaturalScience Foundation of China (No.51774093).
文摘Stimulated Reservoir Volume(SRV)fracturing is a key technology of unconventional oil and gas exploration and development.To gain a deeper understanding of tight sandstone reservoirs and draw on the development experience of hydraulic fracturing,the authors conduct a large number of detailed investigations of geological characteristics in the regions that have implemented SRV fracturing.Based on the data of rock mechanics parameters,insitu stress characteristics,brittleness characteristics and natural fractures,the influencing factors of SRV fracturing in tight oil reservoirs were analyzed.The results show that the SRV fracturing is suitable for geological reservoirs with the characteristics of medium to high elastic modulus,low to medium Poisson’s ratio,low stress difference,medium to high brittleness and naturally fractured reservoirs,where natural fractures have a significant impact.Region A,a tight sandstone region,has moderate elastic modulus,low Poisson’s ratio,low ground stress difference and medium brittleness,and has the feasibility of volume fracturing.The field case of the Y325 well shows that SRV fracturing technology has obvious effect on increasing production.This technology is applicable to the Region A.
文摘Hydraulic fracturing(HF)is a commonly used technique to stimulate low permeability formations such as shale plays and tight formations.However,this method of well stimulation has also been used in high permeable unconsolidated sandstone formations to bypass near-wellbore formation damage and prevent sand production at some distance apart from the wellbore wall.The treatment is called frac-pack completion,where a short length but wide width fracture is formed by injecting aggressive concentrations of proppant into the fracture plane.This operation is known as tip screen-out(TSO).Detailed design of fluid and proppant,including an optimal pump schedule,is required to achieve satisfactory TSO.In this study,we first assess the lattice-based numerical method's capabilities for simulating hydraulic fracturing propagation in elastoplastic formation.The results will be compared with the same case simulation results using a pseudo 3D(P3D)model and analytical model.Second,we explore the Nolte(1986)design for frac-pack and TSO treatment using lattice-based software and the P3D model.The results showed that both models could simulate the hydraulic fracturing propagation in soft formation and TSO operation,while some differences were observed in generated geometry,the tip screenout time and net pressure profiles.The results are presented.It was noted that fracture propagation regime(viscosity/toughness),nonlocality and nonlinearity had an influence on the different geometries.The advantages of each model will be discussed.
