As urban landscapes evolve and vehicular volumes soar,traditional traffic monitoring systems struggle to scale,often failing under the complexities of dense,dynamic,and occluded environments.This paper introduces a no...As urban landscapes evolve and vehicular volumes soar,traditional traffic monitoring systems struggle to scale,often failing under the complexities of dense,dynamic,and occluded environments.This paper introduces a novel,unified deep learning framework for vehicle detection,tracking,counting,and classification in aerial imagery designed explicitly for modern smart city infrastructure demands.Our approach begins with adaptive histogram equalization to optimize aerial image clarity,followed by a cutting-edge scene parsing technique using Mask2Former,enabling robust segmentation even in visually congested settings.Vehicle detection leverages the latest YOLOv11 architecture,delivering superior accuracy in aerial contexts by addressing occlusion,scale variance,and fine-grained object differentiation.We incorporate the highly efficient ByteTrack algorithm for tracking,enabling seamless identity preservation across frames.Vehicle counting is achieved through an unsupervised DBSCAN-based method,ensuring adaptability to varying traffic densities.We further introduce a hybrid feature extraction module combining Convolutional Neural Networks(CNNs)with Zernike Moments,capturing both deep semantic and geometric signatures of vehicles.The final classification is powered by NASNet,a neural architecture search-optimized model,ensuring high accuracy across diverse vehicle types and orientations.Extensive evaluations of the VAID benchmark dataset demonstrate the system’s outstanding performance,achieving 96%detection,94%tracking,and 96.4%classification accuracy.On the UAVDT dataset,the system attains 95%detection,93%tracking,and 95%classification accuracy,confirming its robustness across diverse aerial traffic scenarios.These results establish new benchmarks in aerial traffic analysis and validate the framework’s scalability,making it a powerful and adaptable solution for next-generation intelligent transportation systems and urban surveillance.展开更多
Seawater zinc-air batteries are promising energy storage devices due to their high energy density and utilization of seawater electrolytes.However,their efficiency is hindered by the sluggish oxygen reduction reaction...Seawater zinc-air batteries are promising energy storage devices due to their high energy density and utilization of seawater electrolytes.However,their efficiency is hindered by the sluggish oxygen reduction reaction(ORR)and chlorideinduced degradation over conventional catalysts.In this study,we proposed a universal synthetic strategy to construct heteroatom axially coordinated Fe–N_(4) single-atom seawater catalyst materials(Cl–Fe–N_(4) and S–Fe–N_(4)).X-ray absorption spectroscopy confirmed their five-coordinated square pyramidal structure.Systematic evaluation of catalytic activities revealed that compared with S–Fe–N_(4),Cl–Fe–N_(4) exhibits smaller electrochemical active surface area and specific surface area,yet demonstrates higher limiting current density(5.8 mA cm^(−2)).The assembled zinc-air batteries using Cl–Fe–N_(4) showed superior power density(187.7 mW cm^(−2) at 245.1 mA cm^(−2)),indicating that Cl axial coordination more effectively enhances the intrinsic ORR activity.Moreover,Cl–Fe–N_(4) demonstrates stronger Cl−poisoning resistance in seawater environments.Chronoamperometry tests and zinc-air battery cycling performance evaluations confirmed its enhanced stability.Density functional theory calculations revealed that the introduction of heteroatoms in the axial direction regulates the electron center of Fe single atom,leading to more active reaction intermediates and increased electron density of Fe single sites,thereby enhancing the reduction in adsorbed intermediates and hence the overall ORR catalytic activity.展开更多
The abundancy of defect sinks in the microstructure of laser powder bed fusion(LPBF) processed austenitic stainless steels was found to be beneficial for helium resistance.In the current study,the influence of the nov...The abundancy of defect sinks in the microstructure of laser powder bed fusion(LPBF) processed austenitic stainless steels was found to be beneficial for helium resistance.In the current study,the influence of the novel microstructure in LPBF processed 304 L on the helium bubble growth behaviour was investigated using transmission electron microscopy in samples implanted with He^(+) ion and post-irradiation annealing treated at 600℃ for 1 h.Two variants of LPBF processed 304 L samples were used,one in as-built condition and the other solution-annealed.The comparison between the two samples indicated that the helium bubble growth was inhibited and remained stable in the as-built sample but coarsened significantly in the solution-annealed sample.The sub-grain boundaries and oxide nano-inclusions acted as defect sinks to trap helium atoms and inhibited the growth of helium bubble in the as-built sample under the post-irradiation annealing conditions used.展开更多
We have carefully read the description of the proposed mechanisms of hamstring muscle strain injury by Liu et al.1and noticed that they suggest that hamstring strain injuries may be associated with extensive muscle fo...We have carefully read the description of the proposed mechanisms of hamstring muscle strain injury by Liu et al.1and noticed that they suggest that hamstring strain injuries may be associated with extensive muscle force and occur during the early stance phase of sprinting when the hamstrings are thought to work concentrically.We did not find any evidence in our extensive literature review to support this展开更多
The tight sandstone reservoirs in the first sub-member of Chang 7 member(Chang 71)of Triassic Yanchang Formation in the Jiyuan area,Ordos Basin,show significant variations in microscopic pore-throat structure(PTS)and ...The tight sandstone reservoirs in the first sub-member of Chang 7 member(Chang 71)of Triassic Yanchang Formation in the Jiyuan area,Ordos Basin,show significant variations in microscopic pore-throat structure(PTS)and fluid mobility due to the influences of the northeast and northwest dual provenance systems.This study performed multiple experimental analyses on nine samples from the area to determine the petrological and petrophysical properties,as well as the PTS characteristics of reservoirs in different provenance-controlled regions.On this basis,the pore-throat size distribution(PSD)obtained from high-pressure mercury injection(HPMI)was utilized to convert the NMR movable fluid T2spectrum,allowing for quantitative characterization of the full PSD and the occurrence characteristics of movable fluids.A systematic analysis was conducted on the primary controlling factors affecting fluid mobility in the reservoir.The results indicated that the lithology in the eastern and western regions is lithic arkose.The eastern sandstones,being farther from the provenance,exhibit higher contents of feldspar and lithic fragments,along with the development of more dissolution pores.The reservoir possesses good petrophysical properties,low displacement pressure,and high pore-throat connectivity and homogeneity,indicating strong fluid mobility.In contrast,the western sandstones,being nearer to the provenance,exhibit poor grain sorting,high contents of lithic fragments,strong compaction and cementation effects,resulting in poor petrophysical properties,and strong pore-throat heterogeneity,revealing weak fluid mobility.The range of full PSD in the eastern reservoir is wider than that in the western reservoir,with relatively well-developed macropores.The macropores are the primary space for occurrence of movable fluids,and controls the fluid mobility of the reservoir.The effective porosity of movable fluids(EPMF)quantitatively represents the pore space occupied by movable fluids within the reservoir and correlates well with porosity,permeability,and PTS parameters,making it a valuable parameter for evaluating fluid mobility.Under the multi-provenance system,the eastern and western reservoirs underwent different sedimentation and diagenesis processes,resulting in differential distribution of reservoir mineral components and pore types,which in turn affects the PTS heterogeneity and reservoir quality.The composition and content of reservoir minerals are intrinsic factors influencing fluid mobility,while the microscopic PTS is the primary factor controlling it.Low clay mineral content,welldeveloped macropores,and weak pore-throat heterogeneity all contribute to the storage and seepage of reservoir fluids.展开更多
The in-flight calibration and performance of the Solar Disk Imager(SDI),which is a pivotal instrument of the LyαSolar Telescope onboard the Advanced Space-based Solar Observatory mission,suggested a much lower spatia...The in-flight calibration and performance of the Solar Disk Imager(SDI),which is a pivotal instrument of the LyαSolar Telescope onboard the Advanced Space-based Solar Observatory mission,suggested a much lower spatial resolution than expected.In this paper,we developed the SDI point-spread function(PSF)and Image Bivariate Optimization Algorithm(SPIBOA)to improve the quality of SDI images.The bivariate optimization method smartly combines deep learning with optical system modeling.Despite the lack of information about the real image taken by SDI and the optical system function,this algorithm effectively estimates the PSF of the SDI imaging system directly from a large sample of observational data.We use the estimated PSF to conduct deconvolution correction to observed SDI images,and the resulting images show that the spatial resolution after correction has increased by a factor of more than three with respect to the observed ones.Meanwhile,our method also significantly reduces the inherent noise in the observed SDI images.The SPIBOA has now been successfully integrated into the routine SDI data processing,providing important support for the scientific studies based on the data.The development and application of SPIBOA also paves new ways to identify astronomical telescope systems and enhance observational image quality.Some essential factors and precautions in applying the SPIBOA method are also discussed.展开更多
Multiple active components in steel slags can optimize soil texture and catalyze the thermal desorption of refractory organic pollutants,especially polycyclic aromatic hydrocarbons(PAHs).In this study,a safety and ris...Multiple active components in steel slags can optimize soil texture and catalyze the thermal desorption of refractory organic pollutants,especially polycyclic aromatic hydrocarbons(PAHs).In this study,a safety and risk assessment was conducted on toxic metals present in collected steel slags,and the refining slag with a high content of free-CaO from the XG iron and steel plant(XGRS)was selected and used to regulate the plasticity index(PI)of clay soils.For the clay soil with high liquid limit and high plasticity(CH),the PI reduced from 34.3%to 24.8%with steel slags at an addition ratio of 10%(mass percent),and for the clay soil with low liquid limit(CL),the PI decreased from 22.8%to 16.5%,resulting in silt soil with optimal thermal properties.The thermal removal efficiency of PAHs in CH decreased from 81.9%to 74.0%at 350℃ as the soil water content increased from 0 to 150 g kg^(-1),due to the hydration and swelling of clay minerals and the heat loss associated with dehydroxylation and dehydration.The efficiency further decreased to 68.7%using 2%(mass percent)CaO as an additive due to the delayed dehydr(oxyl)ation of clay minerals and enhanced aromatization of soil organic matter.In contrast,addition of 2%high-content titania-bearing slag(HTBS)enhanced the removal efficiency of high-ring PAHs,with the efficiency increasing for 5-ring from 52.6%to 59.7%and for 6-ring from 76.6%to 81.8%.This is due to the presence of amorphous TiO_(2) and crystalline CaTiO_(3) in HTBS,which can degrade water to produce reactive oxygen species.The 2%XGRS addition facilitated the complete removal of PAHs by air-supplemented lattice oxygen,leading to the oxidation of C–C bonds in CH to C–O,C=O,and O–C=O functional groups.This study provides valuable insights into the use of additives to enhance the thermal remediation of PAH-contaminated clay soils via activating oxygen species and oxidizing C–C bonds in organo-mineral complexes within clay soils.展开更多
Evaluation of damage evolution effects in biodegradable pure Mg was carried out,using transmission electron microscope as surrogate irradiation for high-energy radionuclide β decay in Brachytherapy.Time-dependent qua...Evaluation of damage evolution effects in biodegradable pure Mg was carried out,using transmission electron microscope as surrogate irradiation for high-energy radionuclide β decay in Brachytherapy.Time-dependent quantitative defect production,evolution dynamics,and evolution statistics were revealed in-situ for two prism foils(z=[1.210],[10.10]),in as-received and heat-treated pure Mg,after 300 keV electron irradiation up to 0.468 dpa at R.T.Preferred nucleation of basal-plane interstitial-type 1/6<20.23>loops was confirmed,in addition to a small portion of prism-plane 1/3<11.20>loops.No cavities were found.A higher yield of point defect concentration and a more evident trend of defect coarsening were identified in[1.210]than in[10.10].Pre-existing dislocations(on the orders of 10^(13)−10^(14) m^(−2))in pure Mg resulted in a delay of the first occurrence of visible defects.Defect migration and elastic interactions governed the microstructural evolution of electron irradiation damage in pure Mg,giving rise to events of loop coalescence,growth,and sometimes rotation of habit plane.The influence of incident electron energy can be correlated to the rates of point defect production,and is quantifiable;however,interfered by defect cluster stability,defect mobility,and defect interactions.This forms an important theoretical basis for the application of Mg subjected to MeV-level β-decay radiation in Brachytherapy.The paper concludes with a brief comparison between Mg and conventional Ti casing,outlines the advantages and challenges,and provides reference points for the validation of Mg/Mg-alloys in Brachytherapy seed application.展开更多
Objective:Limb ischemia-reperfusion injury(LIRI)may lead to tissue necrosis and loss of function,even life-threatening.Our previous study found that Tao-Hong-Si-Wu decoction(THSWD)had some efficacy in treating of LIRI...Objective:Limb ischemia-reperfusion injury(LIRI)may lead to tissue necrosis and loss of function,even life-threatening.Our previous study found that Tao-Hong-Si-Wu decoction(THSWD)had some efficacy in treating of LIRI.Quercetin,the major component of THSWD,was selected further to uncover the molecular mechanism underlying its treatment of LIRI.Methods:In this study,myoblasts were isolated fromrat gastrocnemiusmuscle tissue,and an in vitro LIRI model was established.The cell counting kit-8(CCK-8)and colony formation assay were used to evaluate the impact of quercetin on LIRI-induced myoblast viability and proliferation.Lactate dehydrogenase(LDH)activity wasmeasured to detectmyoblast injury in the LIRI model.Theapoptosis ofmyoblasts was evaluated byHoechst staining and flow cytometry.In addition,molecular docking analysis was performed to predict the interaction between quercetin and NADPH oxidase 2(NOX-2).Subsequently,we investigated the molecular mechanism of quercetin in LIRI-induced myoblasts by overexpressing NOX-2.Results:The myogenic marker Desmin was highly expressed in isolatedmyoblasts.In the LIRImodel,myoblast viability and proliferation were decreased,and cell injury and apoptosis levels were increased.In addition,NOX-2 was highly expressed in the LIRI model.At the same time,LIRI induction promoted the up-regulation of oxidative stress and inflammatory response.Quercetin significantly reversed the effects of LIRI treatment on myoblasts in a concentration-dependent manner.Molecular docking suggested an interaction between quercetin and NOX-2.Further overexpression of NOX-2 inhibited the effect of quercetin on LIRI-induced myoblasts.Conclusion:Quercetin could reduce inflammatory response and oxidative stress by inhibiting NOX-2,thus playing a therapeutic role in treating LIRI.展开更多
Hepatocellular carcinoma(HCC)is one of the most common malignant tumors globally and is the most prevalent type of primary liver cancer,posing a heavy burden on global health.Surgical resection and liver transplantati...Hepatocellular carcinoma(HCC)is one of the most common malignant tumors globally and is the most prevalent type of primary liver cancer,posing a heavy burden on global health.Surgical resection and liver transplantation are the gold standard for the radical treatment of HCC.However,due to the heterogeneity and high invasiveness of HCC,the rates of local and distant recurrence are extremely high,with over 70%of patients experiencing recurrence within 5 years after treatment,significantly impacting the long-term quality of life.Therefore,researchers are exploring other treatment methods to reduce tumor recurrence and improve patient survival.To date,extensive research has concentrated on new alternative therapies,including radiotherapy(e.g.,selective internal radiotherapy),targeted drug therapy(e.g.,sorafenib and lenvatinib),and immunotherapy(e.g.,immune checkpoint inhibitors),which have played an integral role in the comprehensive treatment of HCC.This review mainly focuses on the cutting-edge advancements in these treatment methods for HCC and their potential role in reducing HCC recurrence.展开更多
As one of the most prevalent malignant tumors,hepatocellular carcinoma(HCC)represents a major global public health burden.Traditionally,HCC pathogenesis has been attributed to chronic liver diseases(viral hepatitis,ci...As one of the most prevalent malignant tumors,hepatocellular carcinoma(HCC)represents a major global public health burden.Traditionally,HCC pathogenesis has been attributed to chronic liver diseases(viral hepatitis,cirrhosis)and aflatoxin exposure.However,with evolving lifestyles and environmental changes,sleep disorders have become increasingly prevalent.Emerging evidence suggest that sleep disorders may contribute to hepatocarcinogenesis through multiple mechanisms,including immunity environment disorder,oxidative stress,metabolic dysregulation,disruption of gut microbiota,and circadian rhythm disruption,thereby influencing disease progression and patient prognosis.This review summarizes epidemiological evidence on the relationship between sleep disorders and HCC incidence,explores the underlying mechanisms through which sleep disorders contribute to HCC,and discusses clinical challenges and potential intervention strategies.Our objective is to provide novel insights into HCC prevention and therapeutic approaches.展开更多
基金funded by the Open Access Initiative of the University of Bremen and the DFG via SuUB BremenThe authors extend their appreciation to the Deanship of Research and Graduate Studies at King Khalid University for funding this work through Large Group Project under grant number(RGP2/367/46)+1 种基金This research is supported and funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2025R410)Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘As urban landscapes evolve and vehicular volumes soar,traditional traffic monitoring systems struggle to scale,often failing under the complexities of dense,dynamic,and occluded environments.This paper introduces a novel,unified deep learning framework for vehicle detection,tracking,counting,and classification in aerial imagery designed explicitly for modern smart city infrastructure demands.Our approach begins with adaptive histogram equalization to optimize aerial image clarity,followed by a cutting-edge scene parsing technique using Mask2Former,enabling robust segmentation even in visually congested settings.Vehicle detection leverages the latest YOLOv11 architecture,delivering superior accuracy in aerial contexts by addressing occlusion,scale variance,and fine-grained object differentiation.We incorporate the highly efficient ByteTrack algorithm for tracking,enabling seamless identity preservation across frames.Vehicle counting is achieved through an unsupervised DBSCAN-based method,ensuring adaptability to varying traffic densities.We further introduce a hybrid feature extraction module combining Convolutional Neural Networks(CNNs)with Zernike Moments,capturing both deep semantic and geometric signatures of vehicles.The final classification is powered by NASNet,a neural architecture search-optimized model,ensuring high accuracy across diverse vehicle types and orientations.Extensive evaluations of the VAID benchmark dataset demonstrate the system’s outstanding performance,achieving 96%detection,94%tracking,and 96.4%classification accuracy.On the UAVDT dataset,the system attains 95%detection,93%tracking,and 95%classification accuracy,confirming its robustness across diverse aerial traffic scenarios.These results establish new benchmarks in aerial traffic analysis and validate the framework’s scalability,making it a powerful and adaptable solution for next-generation intelligent transportation systems and urban surveillance.
基金funded by the Innovative Research Group Project of the National Natural Science Foundation of China(52121004)the Research Development Fund(No.RDF-21-02-060)by Xi’an Jiaotong-Liverpool University+1 种基金support received from the Suzhou Industrial Park High Quality Innovation Platform of Functional Molecular Materials and Devices(YZCXPT2023105)the XJTLU Advanced Materials Research Center(AMRC).
文摘Seawater zinc-air batteries are promising energy storage devices due to their high energy density and utilization of seawater electrolytes.However,their efficiency is hindered by the sluggish oxygen reduction reaction(ORR)and chlorideinduced degradation over conventional catalysts.In this study,we proposed a universal synthetic strategy to construct heteroatom axially coordinated Fe–N_(4) single-atom seawater catalyst materials(Cl–Fe–N_(4) and S–Fe–N_(4)).X-ray absorption spectroscopy confirmed their five-coordinated square pyramidal structure.Systematic evaluation of catalytic activities revealed that compared with S–Fe–N_(4),Cl–Fe–N_(4) exhibits smaller electrochemical active surface area and specific surface area,yet demonstrates higher limiting current density(5.8 mA cm^(−2)).The assembled zinc-air batteries using Cl–Fe–N_(4) showed superior power density(187.7 mW cm^(−2) at 245.1 mA cm^(−2)),indicating that Cl axial coordination more effectively enhances the intrinsic ORR activity.Moreover,Cl–Fe–N_(4) demonstrates stronger Cl−poisoning resistance in seawater environments.Chronoamperometry tests and zinc-air battery cycling performance evaluations confirmed its enhanced stability.Density functional theory calculations revealed that the introduction of heteroatoms in the axial direction regulates the electron center of Fe single atom,leading to more active reaction intermediates and increased electron density of Fe single sites,thereby enhancing the reduction in adsorbed intermediates and hence the overall ORR catalytic activity.
基金sponsored by the National Natural Science Foundation of China(Grant No.52073176)。
文摘The abundancy of defect sinks in the microstructure of laser powder bed fusion(LPBF) processed austenitic stainless steels was found to be beneficial for helium resistance.In the current study,the influence of the novel microstructure in LPBF processed 304 L on the helium bubble growth behaviour was investigated using transmission electron microscopy in samples implanted with He^(+) ion and post-irradiation annealing treated at 600℃ for 1 h.Two variants of LPBF processed 304 L samples were used,one in as-built condition and the other solution-annealed.The comparison between the two samples indicated that the helium bubble growth was inhibited and remained stable in the as-built sample but coarsened significantly in the solution-annealed sample.The sub-grain boundaries and oxide nano-inclusions acted as defect sinks to trap helium atoms and inhibited the growth of helium bubble in the as-built sample under the post-irradiation annealing conditions used.
文摘We have carefully read the description of the proposed mechanisms of hamstring muscle strain injury by Liu et al.1and noticed that they suggest that hamstring strain injuries may be associated with extensive muscle force and occur during the early stance phase of sprinting when the hamstrings are thought to work concentrically.We did not find any evidence in our extensive literature review to support this
文摘The tight sandstone reservoirs in the first sub-member of Chang 7 member(Chang 71)of Triassic Yanchang Formation in the Jiyuan area,Ordos Basin,show significant variations in microscopic pore-throat structure(PTS)and fluid mobility due to the influences of the northeast and northwest dual provenance systems.This study performed multiple experimental analyses on nine samples from the area to determine the petrological and petrophysical properties,as well as the PTS characteristics of reservoirs in different provenance-controlled regions.On this basis,the pore-throat size distribution(PSD)obtained from high-pressure mercury injection(HPMI)was utilized to convert the NMR movable fluid T2spectrum,allowing for quantitative characterization of the full PSD and the occurrence characteristics of movable fluids.A systematic analysis was conducted on the primary controlling factors affecting fluid mobility in the reservoir.The results indicated that the lithology in the eastern and western regions is lithic arkose.The eastern sandstones,being farther from the provenance,exhibit higher contents of feldspar and lithic fragments,along with the development of more dissolution pores.The reservoir possesses good petrophysical properties,low displacement pressure,and high pore-throat connectivity and homogeneity,indicating strong fluid mobility.In contrast,the western sandstones,being nearer to the provenance,exhibit poor grain sorting,high contents of lithic fragments,strong compaction and cementation effects,resulting in poor petrophysical properties,and strong pore-throat heterogeneity,revealing weak fluid mobility.The range of full PSD in the eastern reservoir is wider than that in the western reservoir,with relatively well-developed macropores.The macropores are the primary space for occurrence of movable fluids,and controls the fluid mobility of the reservoir.The effective porosity of movable fluids(EPMF)quantitatively represents the pore space occupied by movable fluids within the reservoir and correlates well with porosity,permeability,and PTS parameters,making it a valuable parameter for evaluating fluid mobility.Under the multi-provenance system,the eastern and western reservoirs underwent different sedimentation and diagenesis processes,resulting in differential distribution of reservoir mineral components and pore types,which in turn affects the PTS heterogeneity and reservoir quality.The composition and content of reservoir minerals are intrinsic factors influencing fluid mobility,while the microscopic PTS is the primary factor controlling it.Low clay mineral content,welldeveloped macropores,and weak pore-throat heterogeneity all contribute to the storage and seepage of reservoir fluids.
基金supported by the National Natural Science Foundation of China(NSFC)under grant No.12233012,the Strategic Priority Research Program of the Chinese Academy of Sciences,grant No.XDB0560102the National Key R&D Program of China 2022YFF0503003(2022YFF0503000)。
文摘The in-flight calibration and performance of the Solar Disk Imager(SDI),which is a pivotal instrument of the LyαSolar Telescope onboard the Advanced Space-based Solar Observatory mission,suggested a much lower spatial resolution than expected.In this paper,we developed the SDI point-spread function(PSF)and Image Bivariate Optimization Algorithm(SPIBOA)to improve the quality of SDI images.The bivariate optimization method smartly combines deep learning with optical system modeling.Despite the lack of information about the real image taken by SDI and the optical system function,this algorithm effectively estimates the PSF of the SDI imaging system directly from a large sample of observational data.We use the estimated PSF to conduct deconvolution correction to observed SDI images,and the resulting images show that the spatial resolution after correction has increased by a factor of more than three with respect to the observed ones.Meanwhile,our method also significantly reduces the inherent noise in the observed SDI images.The SPIBOA has now been successfully integrated into the routine SDI data processing,providing important support for the scientific studies based on the data.The development and application of SPIBOA also paves new ways to identify astronomical telescope systems and enhance observational image quality.Some essential factors and precautions in applying the SPIBOA method are also discussed.
基金sponsored by the National Key R&D Program of China(No.2018YFC1802101)the National Natural Science Foundation of China(No.52170149)。
文摘Multiple active components in steel slags can optimize soil texture and catalyze the thermal desorption of refractory organic pollutants,especially polycyclic aromatic hydrocarbons(PAHs).In this study,a safety and risk assessment was conducted on toxic metals present in collected steel slags,and the refining slag with a high content of free-CaO from the XG iron and steel plant(XGRS)was selected and used to regulate the plasticity index(PI)of clay soils.For the clay soil with high liquid limit and high plasticity(CH),the PI reduced from 34.3%to 24.8%with steel slags at an addition ratio of 10%(mass percent),and for the clay soil with low liquid limit(CL),the PI decreased from 22.8%to 16.5%,resulting in silt soil with optimal thermal properties.The thermal removal efficiency of PAHs in CH decreased from 81.9%to 74.0%at 350℃ as the soil water content increased from 0 to 150 g kg^(-1),due to the hydration and swelling of clay minerals and the heat loss associated with dehydroxylation and dehydration.The efficiency further decreased to 68.7%using 2%(mass percent)CaO as an additive due to the delayed dehydr(oxyl)ation of clay minerals and enhanced aromatization of soil organic matter.In contrast,addition of 2%high-content titania-bearing slag(HTBS)enhanced the removal efficiency of high-ring PAHs,with the efficiency increasing for 5-ring from 52.6%to 59.7%and for 6-ring from 76.6%to 81.8%.This is due to the presence of amorphous TiO_(2) and crystalline CaTiO_(3) in HTBS,which can degrade water to produce reactive oxygen species.The 2%XGRS addition facilitated the complete removal of PAHs by air-supplemented lattice oxygen,leading to the oxidation of C–C bonds in CH to C–O,C=O,and O–C=O functional groups.This study provides valuable insights into the use of additives to enhance the thermal remediation of PAH-contaminated clay soils via activating oxygen species and oxidizing C–C bonds in organo-mineral complexes within clay soils.
基金National Natural Science Foundation of China for funding support via grant No 12175013the Interdisciplinary Research Project for Young Researchers of USTB and the Youth Teacher International Exchange&Growth Program of USTB(Fundamental Research Funds for the Central Universities,China)for funding support via grant No FRF-IDRY-21–018 and QNXM20250033,respectively.
文摘Evaluation of damage evolution effects in biodegradable pure Mg was carried out,using transmission electron microscope as surrogate irradiation for high-energy radionuclide β decay in Brachytherapy.Time-dependent quantitative defect production,evolution dynamics,and evolution statistics were revealed in-situ for two prism foils(z=[1.210],[10.10]),in as-received and heat-treated pure Mg,after 300 keV electron irradiation up to 0.468 dpa at R.T.Preferred nucleation of basal-plane interstitial-type 1/6<20.23>loops was confirmed,in addition to a small portion of prism-plane 1/3<11.20>loops.No cavities were found.A higher yield of point defect concentration and a more evident trend of defect coarsening were identified in[1.210]than in[10.10].Pre-existing dislocations(on the orders of 10^(13)−10^(14) m^(−2))in pure Mg resulted in a delay of the first occurrence of visible defects.Defect migration and elastic interactions governed the microstructural evolution of electron irradiation damage in pure Mg,giving rise to events of loop coalescence,growth,and sometimes rotation of habit plane.The influence of incident electron energy can be correlated to the rates of point defect production,and is quantifiable;however,interfered by defect cluster stability,defect mobility,and defect interactions.This forms an important theoretical basis for the application of Mg subjected to MeV-level β-decay radiation in Brachytherapy.The paper concludes with a brief comparison between Mg and conventional Ti casing,outlines the advantages and challenges,and provides reference points for the validation of Mg/Mg-alloys in Brachytherapy seed application.
基金supported by National Natural Science Foundation of China(Grant 82274541&81674008)Key Project of Hunan Provincial Health Commission(Grant 202204072465)Natural Science Foundation of Hunan Province(Grant 2020JJ4070).
文摘Objective:Limb ischemia-reperfusion injury(LIRI)may lead to tissue necrosis and loss of function,even life-threatening.Our previous study found that Tao-Hong-Si-Wu decoction(THSWD)had some efficacy in treating of LIRI.Quercetin,the major component of THSWD,was selected further to uncover the molecular mechanism underlying its treatment of LIRI.Methods:In this study,myoblasts were isolated fromrat gastrocnemiusmuscle tissue,and an in vitro LIRI model was established.The cell counting kit-8(CCK-8)and colony formation assay were used to evaluate the impact of quercetin on LIRI-induced myoblast viability and proliferation.Lactate dehydrogenase(LDH)activity wasmeasured to detectmyoblast injury in the LIRI model.Theapoptosis ofmyoblasts was evaluated byHoechst staining and flow cytometry.In addition,molecular docking analysis was performed to predict the interaction between quercetin and NADPH oxidase 2(NOX-2).Subsequently,we investigated the molecular mechanism of quercetin in LIRI-induced myoblasts by overexpressing NOX-2.Results:The myogenic marker Desmin was highly expressed in isolatedmyoblasts.In the LIRImodel,myoblast viability and proliferation were decreased,and cell injury and apoptosis levels were increased.In addition,NOX-2 was highly expressed in the LIRI model.At the same time,LIRI induction promoted the up-regulation of oxidative stress and inflammatory response.Quercetin significantly reversed the effects of LIRI treatment on myoblasts in a concentration-dependent manner.Molecular docking suggested an interaction between quercetin and NOX-2.Further overexpression of NOX-2 inhibited the effect of quercetin on LIRI-induced myoblasts.Conclusion:Quercetin could reduce inflammatory response and oxidative stress by inhibiting NOX-2,thus playing a therapeutic role in treating LIRI.
基金Supported by the National Natural Science Foundation of China,No.82270634Third Affiliated Hospital of Naval Medical University,No.tf2024yzyy01.
文摘Hepatocellular carcinoma(HCC)is one of the most common malignant tumors globally and is the most prevalent type of primary liver cancer,posing a heavy burden on global health.Surgical resection and liver transplantation are the gold standard for the radical treatment of HCC.However,due to the heterogeneity and high invasiveness of HCC,the rates of local and distant recurrence are extremely high,with over 70%of patients experiencing recurrence within 5 years after treatment,significantly impacting the long-term quality of life.Therefore,researchers are exploring other treatment methods to reduce tumor recurrence and improve patient survival.To date,extensive research has concentrated on new alternative therapies,including radiotherapy(e.g.,selective internal radiotherapy),targeted drug therapy(e.g.,sorafenib and lenvatinib),and immunotherapy(e.g.,immune checkpoint inhibitors),which have played an integral role in the comprehensive treatment of HCC.This review mainly focuses on the cutting-edge advancements in these treatment methods for HCC and their potential role in reducing HCC recurrence.
基金Supported by National Natural Science Foundation of China,No.82270634.
文摘As one of the most prevalent malignant tumors,hepatocellular carcinoma(HCC)represents a major global public health burden.Traditionally,HCC pathogenesis has been attributed to chronic liver diseases(viral hepatitis,cirrhosis)and aflatoxin exposure.However,with evolving lifestyles and environmental changes,sleep disorders have become increasingly prevalent.Emerging evidence suggest that sleep disorders may contribute to hepatocarcinogenesis through multiple mechanisms,including immunity environment disorder,oxidative stress,metabolic dysregulation,disruption of gut microbiota,and circadian rhythm disruption,thereby influencing disease progression and patient prognosis.This review summarizes epidemiological evidence on the relationship between sleep disorders and HCC incidence,explores the underlying mechanisms through which sleep disorders contribute to HCC,and discusses clinical challenges and potential intervention strategies.Our objective is to provide novel insights into HCC prevention and therapeutic approaches.
