Human-wildlife conflict(HWC)and its socioeconomic impacts are a pressing global issue.Accurately quantifying HWCs and their interaction with residential development is crucial for rural revitalization and biodiversity...Human-wildlife conflict(HWC)and its socioeconomic impacts are a pressing global issue.Accurately quantifying HWCs and their interaction with residential development is crucial for rural revitalization and biodiversity conservation efforts.This study investigates the interplay between rural residential expansion(RRE)with humanelephant conflict(HEC)in southern Yunnan Province using high-accuracy yearly land use/land cover data and Asian elephant accident data.A piecewise regression along with several metrics,including expansion intensity,rate of rural residential land,and residential density,were employed to analyze the spatial-temporal change characteristics of RRE.Then,a geographical detector and a bivariate spatial autocorrelation model were used to reveal the driving mechanisms of RRE,with particular emphasis on the spatial relations between RRE and HECs.The results indicate that HECs had a significant negative impact on RRE,exhibiting higher expansion intensity and rate of rural residential land in non-HEC areas than in HEC areas.High spatiotemporal consistency between accelerated RRE and intensified HECs occurred from 2010 onwards,which aligns with the year when the trend of settlement area expansion changed.RRE activities and ensuing land use conversions led to increased occurrences of HECs,which negatively affected the RRE.Compared to HECs,topography and locational factors exhibited a secondary effect on RRE activities.The findings underscore reciprocal feedback mechanisms between RRE and HECs and the elevated risk of adverse interactions between humans and elephants within the range of China’s wild elephants,providing theoretical support for coordinating conservation initiatives for Asian elephants with rural revitalization in the border areas of Southwest China.展开更多
Cancer vaccines have garnered significant attention in cancer immunotherapy because they trigger tumor-specific immune responses.However,their effectiveness is hindered by inefficient antigen and adjuvant delivery at ...Cancer vaccines have garnered significant attention in cancer immunotherapy because they trigger tumor-specific immune responses.However,their effectiveness is hindered by inefficient antigen and adjuvant delivery at the subcellular level,which is essential to stimulate a robust CD8^(+)T cell response.This study presents PAR/OVA,a cancer nanovaccine developed by combining imiquimod(R837)-modified polyamidoamine dendrimers with the model protein antigen ovalbumin(OVA).Within the nanovaccine,R837 is an adjuvant for the Toll-like receptor 7(TLR7)pathway and a structural component that facilitates OVA loading.In dendritic cells(DCs),the high cytoplasmic glutathione levels triggered the breakdown of PAR/OVA,releasing OVA and R837,which induced DC activation and antigen cross-presentation.Furthermore,PAR/OVA vaccination showed a protective effect and effectively inhibited B16-OVA tumor progression,indicating its potential in cancer immunotherapy.Combining this vaccine with an immune checkpoint blockade enhanced antitumor efficacy by improving the ability of cytotoxic T lymphocytes to target cancer cells within the tumor microenvironment.These findings underscore the potential of this adjuvant/antigen-delivering nanovaccine in cancer immunotherapy.展开更多
Alcoholic liver disease(ALD)is the most frequent liver disease worldwide,resulting in severe harm to personal health and posing a serious burden to public health.Based on the reported antioxidant and anti-inflammatory...Alcoholic liver disease(ALD)is the most frequent liver disease worldwide,resulting in severe harm to personal health and posing a serious burden to public health.Based on the reported antioxidant and anti-inflammatory capacities of scutellarin(SCU),this study investigated its protective role in male BALB/c mice with acute alcoholic liver injury after oral administration(10,25,and 50 mg/kg).The results indicated that SCU could lessen serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels and improve the histopathological changes in acute alcoholic liver;it reduced alcohol-induced malondialdehyde(MDA)content and increased glutathione peroxidase(GSH-Px),catalase(CAT),and superoxide dismutase(SOD)activity.Furthermore,SCU decreased tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and IL-1βmessenger RNA(mRNA)expression levels,weakened inducible nitric oxide synthase(iNOS)activity,and inhibited nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome activation.Mechanistically,SCU suppressed cytochrome P450 family 2 subfamily E member 1(CYP2E1)upregulation triggered by alcohol,increased the expression of oxidative stress-related nuclear factor erythroid 2-related factor 2(Nrf2)and heme oxygenase-1(HO-1)pathways,and suppressed the inflammation-related degradation of inhibitor of nuclear factor-κB(NF-κB)-α(IκBα)as well as activation of NF-κB by mediating the protein kinase B(AKT)and p38 mitogen-activated protein kinase(MAPK)pathways.These findings demonstrate that SCU protects against acute alcoholic liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and suppressing inflammation by regulating the AKT,p38 MAPK/NF-κB pathways.展开更多
Solid oxide fuel cells(SOFCs)are an all-solid energy conversion device from the chemical energy of fuels to electric energy at intermediate and high temperatures.Up to now,massive efforts have been made in developing ...Solid oxide fuel cells(SOFCs)are an all-solid energy conversion device from the chemical energy of fuels to electric energy at intermediate and high temperatures.Up to now,massive efforts have been made in developing different components of solid oxide fuel cells,including electrolyte,anode,cathode and interconnect materials.Rare earth elements play an indispensable role in different components of SOFCs which have been extensively studied in the recent decades.In this review,we concentrate upon the rare earth application and recent advances in SOFCs and related materials.Materials structure involves perovskites,Ruddlesden-Popper,fluorite,spinel,pyrochlore,apatite and so on.Moreover,the effects of rare earth based oxides as matrix or dopants in different components are also discussed.Structures and properties of the materials are related to the element type,valence,coordination and ion radius.This article will provide a comprehensive research direction towards SOFCs components for their composition,structural design and mechanisms research.展开更多
Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem services.Capturing long-term forest disturbance and drivers at a regional scale is cruci...Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem services.Capturing long-term forest disturbance and drivers at a regional scale is crucial for sustainable forest management and biodiversity conservation.Methods:We used 30-m resolution Landsat time series images and the LandTrendr algorithm on the Google Earth Engine cloud platform to map forest disturbances at an annual time scale between 1990 and 2020 and attributed causal agents of forest disturbance,including fire,logging,road construction and insects,using disturbance properties and spectral and topographic variables in the random forest model.Results:The conventional and area-adjusted overall accuracies(OAs)of the forest disturbance map were 92.3% and 97.70%±0.06%,respectively,and the OA of mapping disturbance agents was 85.80%.The estimated disturbed forest area totalled 3313.13 km^(2)(approximately 2.31% of the total forest area in 1990)from 1990 to 2020,with considerable interannual fluctuations and significant regional differences.The predominant disturbance agent was fire,which comprised approximately 83.33% of the forest area disturbance,followed by logging(12.2%),insects(2.4%)and road construction(2.0%).Massive forest disturbances occurred mainly before 2000,and the post-2000 annual disturbance area significantly dropped by 55% compared with the pre-2000 value.Conclusions:This study provided spatially explicit and retrospective information on annual forest disturbance and associated agents in the HDMR.The findings suggest that China’s logging bans in natural forests combined with other forest sustainability programmes have effectively curbed forest disturbances in the HDMR,which has implications for enhancing future forest management and biodiversity conservation.展开更多
Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related...Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related deaths were reported(Rudd et al.,2020).Inflammation,oxidative stress,and apoptosis are the most common pathologies seen in sepsis.Liensinine(LIE)is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera.Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects.It can exert anti-carcinogenicactivityby regulating cell.展开更多
Drinking culture has high significance in both China and the world,whether in the entertainment sector or in social occasions;according to the World Health Organization's 2018 Global Alcohol and Health Report,abou...Drinking culture has high significance in both China and the world,whether in the entertainment sector or in social occasions;according to the World Health Organization's 2018 Global Alcohol and Health Report,about 3 million people died from excessive drinking in 2016,accounting for 5.3%of the total global deaths that year.Oxidative stress and inflammation are the most common pathological phenomena caused by alcohol abuse(Snyder et al.,2017).展开更多
To store energy from the grid into spiral torsion spring(STS)smoothly and efficiently via PMSM,a multi-objective control problem of flexible load’s vibration,PMSM’s torque ripple,and electrical loss is raised,where ...To store energy from the grid into spiral torsion spring(STS)smoothly and efficiently via PMSM,a multi-objective control problem of flexible load’s vibration,PMSM’s torque ripple,and electrical loss is raised,where the current studies on vibration and torque ripple are mostly addressed separately,not to mention electrical loss.This research attempts to propose a multi-objective integrative control scenario that can simultaneously solve these problems satisfactorily in a unitary nonlinear control framework.Firstly,a dynamic mathematical model of PMSM is built under stator current vector orientation,and then the model of PMSM is combined with the vibration model of STS to establish the overall system model of STS driven by PMSM with considering motor’s electrical loss.Then,a backstepping control principle-based multi-objective integrative control approach is proposed to realize the suppression of flexible load’s vibration and the reduction of PMSM’s torque ripple and electrical loss concurrently.Meanwhile,this research also designs a wide range speed identification method based on the least square algorithm with a forgetting factor.Simulation and experimental results have verified that the proposed integrative control method enables the state variables to track their respective references quickly and accurately,both torque ripple and load vibration are effectively suppressed,and the operating efficiency of the whole system is improved.展开更多
Power transformer is a core equipment of power system, which undertakes the important functions of power transmission and transformation, and its safe and stable operation has great significance to the normal operatio...Power transformer is a core equipment of power system, which undertakes the important functions of power transmission and transformation, and its safe and stable operation has great significance to the normal operation of the whole power system. Due to the complex structure of the transformer, the use of single information for condition-based maintenance (CBM) has certain limitations, with the help of advanced sensor monitoring and information fusion technology, multi-source information is applied to the prognostic and health management (PHM) of power transformer, which is an important way to realize the CBM of power transformer. This paper presents a method which combine deep belief network classifier (DBNC) and D-S evidence theory, and it is applied to the PHM of the large power transformer. The experimental results show that the proposed method has a high correct rate of fault diagnosis for the power transformer with a large number of multi-source data.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.41971239)the Second Tibetan Plateau Scientific Expedition and Research Program(Grant No.2019QZKK0402)+1 种基金Lancang-Mekong Cooperation Project on China-Laos Cross-border Asian Elephant Habitat Quality Assessment(Grant No.102169221100000009022)the Graduate Research Innovation Project of Yunnan University(Grant No.2021Y368).
文摘Human-wildlife conflict(HWC)and its socioeconomic impacts are a pressing global issue.Accurately quantifying HWCs and their interaction with residential development is crucial for rural revitalization and biodiversity conservation efforts.This study investigates the interplay between rural residential expansion(RRE)with humanelephant conflict(HEC)in southern Yunnan Province using high-accuracy yearly land use/land cover data and Asian elephant accident data.A piecewise regression along with several metrics,including expansion intensity,rate of rural residential land,and residential density,were employed to analyze the spatial-temporal change characteristics of RRE.Then,a geographical detector and a bivariate spatial autocorrelation model were used to reveal the driving mechanisms of RRE,with particular emphasis on the spatial relations between RRE and HECs.The results indicate that HECs had a significant negative impact on RRE,exhibiting higher expansion intensity and rate of rural residential land in non-HEC areas than in HEC areas.High spatiotemporal consistency between accelerated RRE and intensified HECs occurred from 2010 onwards,which aligns with the year when the trend of settlement area expansion changed.RRE activities and ensuing land use conversions led to increased occurrences of HECs,which negatively affected the RRE.Compared to HECs,topography and locational factors exhibited a secondary effect on RRE activities.The findings underscore reciprocal feedback mechanisms between RRE and HECs and the elevated risk of adverse interactions between humans and elephants within the range of China’s wild elephants,providing theoretical support for coordinating conservation initiatives for Asian elephants with rural revitalization in the border areas of Southwest China.
基金supported by the Guangdong Medical Science and Technology Research Fund Project(Nos.A2022124 and B2023148)the Guangdong Provincial Administration of Traditional Chinese Medicine Research Project(No.20231222)+3 种基金the National Natural Science Foundation of China(No.52403185)Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011493)the Open Fund of Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction(No.2023B121203001)the National Famous Old Traditional Chinese Medicine Experts Inheritance Studio Construction Program of the National Administration of TCM(No.(2022)75).
文摘Cancer vaccines have garnered significant attention in cancer immunotherapy because they trigger tumor-specific immune responses.However,their effectiveness is hindered by inefficient antigen and adjuvant delivery at the subcellular level,which is essential to stimulate a robust CD8^(+)T cell response.This study presents PAR/OVA,a cancer nanovaccine developed by combining imiquimod(R837)-modified polyamidoamine dendrimers with the model protein antigen ovalbumin(OVA).Within the nanovaccine,R837 is an adjuvant for the Toll-like receptor 7(TLR7)pathway and a structural component that facilitates OVA loading.In dendritic cells(DCs),the high cytoplasmic glutathione levels triggered the breakdown of PAR/OVA,releasing OVA and R837,which induced DC activation and antigen cross-presentation.Furthermore,PAR/OVA vaccination showed a protective effect and effectively inhibited B16-OVA tumor progression,indicating its potential in cancer immunotherapy.Combining this vaccine with an immune checkpoint blockade enhanced antitumor efficacy by improving the ability of cytotoxic T lymphocytes to target cancer cells within the tumor microenvironment.These findings underscore the potential of this adjuvant/antigen-delivering nanovaccine in cancer immunotherapy.
基金supported by the Basic Science(Natural Science)Research Project of Higher Education of Jiangsu Province(Nos.21KJB230001 and 21KJB350019)the Open Foundation of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening(No.HY202101)+1 种基金the Postdoctoral Science Foundation of Lianyungang(No.LYG20220013)the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
文摘Alcoholic liver disease(ALD)is the most frequent liver disease worldwide,resulting in severe harm to personal health and posing a serious burden to public health.Based on the reported antioxidant and anti-inflammatory capacities of scutellarin(SCU),this study investigated its protective role in male BALB/c mice with acute alcoholic liver injury after oral administration(10,25,and 50 mg/kg).The results indicated that SCU could lessen serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels and improve the histopathological changes in acute alcoholic liver;it reduced alcohol-induced malondialdehyde(MDA)content and increased glutathione peroxidase(GSH-Px),catalase(CAT),and superoxide dismutase(SOD)activity.Furthermore,SCU decreased tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and IL-1βmessenger RNA(mRNA)expression levels,weakened inducible nitric oxide synthase(iNOS)activity,and inhibited nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome activation.Mechanistically,SCU suppressed cytochrome P450 family 2 subfamily E member 1(CYP2E1)upregulation triggered by alcohol,increased the expression of oxidative stress-related nuclear factor erythroid 2-related factor 2(Nrf2)and heme oxygenase-1(HO-1)pathways,and suppressed the inflammation-related degradation of inhibitor of nuclear factor-κB(NF-κB)-α(IκBα)as well as activation of NF-κB by mediating the protein kinase B(AKT)and p38 mitogen-activated protein kinase(MAPK)pathways.These findings demonstrate that SCU protects against acute alcoholic liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and suppressing inflammation by regulating the AKT,p38 MAPK/NF-κB pathways.
基金Project supported by Fundamental Research Funds for Central Universities of the China University of Geosciences Beijing(590121038)Cultivation Project of the State Key Laboratory of Green Development and High-value Utilization of Ionic Rare Earth Resources in Jiangxi Province(20194AFD44003)。
文摘Solid oxide fuel cells(SOFCs)are an all-solid energy conversion device from the chemical energy of fuels to electric energy at intermediate and high temperatures.Up to now,massive efforts have been made in developing different components of solid oxide fuel cells,including electrolyte,anode,cathode and interconnect materials.Rare earth elements play an indispensable role in different components of SOFCs which have been extensively studied in the recent decades.In this review,we concentrate upon the rare earth application and recent advances in SOFCs and related materials.Materials structure involves perovskites,Ruddlesden-Popper,fluorite,spinel,pyrochlore,apatite and so on.Moreover,the effects of rare earth based oxides as matrix or dopants in different components are also discussed.Structures and properties of the materials are related to the element type,valence,coordination and ion radius.This article will provide a comprehensive research direction towards SOFCs components for their composition,structural design and mechanisms research.
基金jointly funded by the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK04020103)National Natural Science Foundation of China(41971239)programme for provincial innovative team of the climate change study of the Greater Mekong Subregion(2019HC027).
文摘Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem services.Capturing long-term forest disturbance and drivers at a regional scale is crucial for sustainable forest management and biodiversity conservation.Methods:We used 30-m resolution Landsat time series images and the LandTrendr algorithm on the Google Earth Engine cloud platform to map forest disturbances at an annual time scale between 1990 and 2020 and attributed causal agents of forest disturbance,including fire,logging,road construction and insects,using disturbance properties and spectral and topographic variables in the random forest model.Results:The conventional and area-adjusted overall accuracies(OAs)of the forest disturbance map were 92.3% and 97.70%±0.06%,respectively,and the OA of mapping disturbance agents was 85.80%.The estimated disturbed forest area totalled 3313.13 km^(2)(approximately 2.31% of the total forest area in 1990)from 1990 to 2020,with considerable interannual fluctuations and significant regional differences.The predominant disturbance agent was fire,which comprised approximately 83.33% of the forest area disturbance,followed by logging(12.2%),insects(2.4%)and road construction(2.0%).Massive forest disturbances occurred mainly before 2000,and the post-2000 annual disturbance area significantly dropped by 55% compared with the pre-2000 value.Conclusions:This study provided spatially explicit and retrospective information on annual forest disturbance and associated agents in the HDMR.The findings suggest that China’s logging bans in natural forests combined with other forest sustainability programmes have effectively curbed forest disturbances in the HDMR,which has implications for enhancing future forest management and biodiversity conservation.
基金the National Natural Science Foundation of China(No.81773968)the Basic Science(Natural Science)Research Project of Higher Education of Jiangsu Province(No.21KJB230001)+1 种基金the Open-End Funds of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening(No.HY202101)the Priority Academic Program Development of Jiangsu Higher Education Institutions of China。
文摘Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related deaths were reported(Rudd et al.,2020).Inflammation,oxidative stress,and apoptosis are the most common pathologies seen in sepsis.Liensinine(LIE)is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera.Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects.It can exert anti-carcinogenicactivityby regulating cell.
基金This work was supported by the Basic Science(Natural Science)Research Project of Higher Education of Jiangsu Province(No.21KJB230001)the Open Foundation of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening(No.HY202101)the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
文摘Drinking culture has high significance in both China and the world,whether in the entertainment sector or in social occasions;according to the World Health Organization's 2018 Global Alcohol and Health Report,about 3 million people died from excessive drinking in 2016,accounting for 5.3%of the total global deaths that year.Oxidative stress and inflammation are the most common pathological phenomena caused by alcohol abuse(Snyder et al.,2017).
基金supported in part by the Natural Science Foundation of Hebei Province in China under Grant E2019502163in part by“Double-First Class”Scientific Research Project in School of Electrical and Electronic Engineering of North China Electric Power University under Grant 180718in part by the Headquarter of Science and Technology Project for Sate Grid Corporation of China under Grant KJGW 2018-014.
文摘To store energy from the grid into spiral torsion spring(STS)smoothly and efficiently via PMSM,a multi-objective control problem of flexible load’s vibration,PMSM’s torque ripple,and electrical loss is raised,where the current studies on vibration and torque ripple are mostly addressed separately,not to mention electrical loss.This research attempts to propose a multi-objective integrative control scenario that can simultaneously solve these problems satisfactorily in a unitary nonlinear control framework.Firstly,a dynamic mathematical model of PMSM is built under stator current vector orientation,and then the model of PMSM is combined with the vibration model of STS to establish the overall system model of STS driven by PMSM with considering motor’s electrical loss.Then,a backstepping control principle-based multi-objective integrative control approach is proposed to realize the suppression of flexible load’s vibration and the reduction of PMSM’s torque ripple and electrical loss concurrently.Meanwhile,this research also designs a wide range speed identification method based on the least square algorithm with a forgetting factor.Simulation and experimental results have verified that the proposed integrative control method enables the state variables to track their respective references quickly and accurately,both torque ripple and load vibration are effectively suppressed,and the operating efficiency of the whole system is improved.
文摘Power transformer is a core equipment of power system, which undertakes the important functions of power transmission and transformation, and its safe and stable operation has great significance to the normal operation of the whole power system. Due to the complex structure of the transformer, the use of single information for condition-based maintenance (CBM) has certain limitations, with the help of advanced sensor monitoring and information fusion technology, multi-source information is applied to the prognostic and health management (PHM) of power transformer, which is an important way to realize the CBM of power transformer. This paper presents a method which combine deep belief network classifier (DBNC) and D-S evidence theory, and it is applied to the PHM of the large power transformer. The experimental results show that the proposed method has a high correct rate of fault diagnosis for the power transformer with a large number of multi-source data.
