Objective Acute kidney injury （AKI） frequently occurs after catheter-based interventional procedures and increases mortality. However, the implications of AKI before thoracic endovascular aneurysm repair （TEVAR） o...Objective Acute kidney injury （AKI） frequently occurs after catheter-based interventional procedures and increases mortality. However, the implications of AKI before thoracic endovascular aneurysm repair （TEVAR） of type B acute aortic dissection （AAD） remain unclear. This study evaluated the incidence, predictors, and in-hospital outcomes of AKI before TEVAR in patients with type B AAD. Methods Between 2009 and 2013, 76 patients were retrospectively evaluated who received TEVAR for type B AAD within 36 h from symptom onset. The patients were classified into no-AKI vs. AKI groups, and the severity of AKI was further staged according to kidney disease： im- proving global outcomes criteria before TEVAR. Results The incidence of preoperative AKI was 36.8%. In-hospital complications was significantly higher in patients with preoperative AKI compared with no-AKI （50.0% vs. 4.2%, respectively; P 〈 0.001）, including acute renal failure （21.4% vs. O, respectively; P 〈 0.001）, and they increased with severity of AKI （P 〈 0.001）. The maximum levels of body tem- perature and white blood cell count were significantly related to maximum serum creatinine level before TEVAR. Multivariate analysis showed that systolic blood pressure on admission （OR： 1.023; 95% CI： 1.003-1.044; P ： 0.0238） and bilateral renal artery involvement （OR： 19.076; 95% CI： 1.914 190.164; P = 0.0120） were strong predictors of preoperative AKI. Conclusions Preoperative AKI frequently occurred in patients with type B AAD, and correlated with higher in-hospital complications and enhanced inflammatory reaction. Systolic blood pressure on admission and bilateral renal artery involvement were major risk factors for AKI before TEVAR.展开更多
Objective:This study was aimed at investigating the effects of the neutrophil-to-lymphocyte ratio(NLR)on the long-term prognosis of patients with acute coronary syndrome(ACS)and obstructive sleep apnea(OSA).Methods:Th...Objective:This study was aimed at investigating the effects of the neutrophil-to-lymphocyte ratio(NLR)on the long-term prognosis of patients with acute coronary syndrome(ACS)and obstructive sleep apnea(OSA).Methods:This prospective study enrolled patients with ACS and OSA at Anzhen Hospital between June 2015 and January 2020.OSA was defined by an apnea-hypopnea index≥15 events·h-1.Baseline NLR was classified as high or low,according to the median.The primary endpoint was major adverse cardiovascular events(MACE),comprising cardiovascular death,recurrent myocardial infarction,stroke,and ischemia-driven revascularization.Results:Atotal of 1011 patients withACS and OSAwere enrolled,506 of whom were in the high NLR(≥2.54)group.No significant differences in sleep monitoring indicators were observed.During a median follow-up of 2.8(1.4,3.6)years,a non-linear correlation between NLR and the incident risk of MACE was observed.After adjustment for clini-cally relevant confounders,a high NLR was independently associated with elevated MACE risk(adjusted HR=1.45,95%CI:1.02–2.06,P=0.040).Conclusions:In patients with ACS and OSA,a high NLR was associated with poorer clinical outcomes during long-term follow-up.Trial registration:ClinicalTrials.gov;Number:NCT03362385;URL:www.clinicaltrials.gov.展开更多
Background Acute kidney injury （AKI） is common after surgery for acute aortic dissection （AAD） and increases in-hospital and long-term mortality. However, few data exist on the clinical and prognostic relevance of...Background Acute kidney injury （AKI） is common after surgery for acute aortic dissection （AAD） and increases in-hospital and long-term mortality. However, few data exist on the clinical and prognostic relevance of early preoperative AKI in patients with type A AAD We aimed to determine the incidence and predictors of preoperative AKI and the impact of AKI on in-hospital outcomes in patients with type A AAD. Methods From May 2009 to June 2014, we retrospectively enrolled 178 patients admitted to our hospital within 48 h from symp- tom onset and receiving open surgery for type A AAD. The patients were divided into no AKI and AKI groups and staged with AKI severity according to the KDIGO criteria before surgery. Results AKI occurred in 41 patients （23.0%）. The incidence of in-hospital complications was significantly higher in patients with preoperative AKI compared to no AKI （41.5% vs. 9.5%, P 〈 0.001）, including renal infarction （7.3% vs. 0, P = 0.012）, and it increased with AKI severity （Ptrend〈 0.001）. Patients with AKI had higher in-hospital mortality compared with pa- tients without AKI, although no significant difference was found （14.6% vs. 5.1%, P = 0.079）. Multivariate analysis indicated that male gender, diastolic blood pressure on admission and bilateral renal artery involvement were independent predictors of preoperative AKI in patients with type A AAD. Conclusions Early AKI before surgery was common in patients with type A AAD, and was associated with increased in-hospital complications. Male gender, diastolic blood pressure on admission and bilateral renal artery involvement were major predictors for preoperative AKI.展开更多
Objective To investigate whether C-reactive protein (CRP) is a biomarker of malignant ventricular arrhythmias (MVA) occurring in non-ST elevation myocardial infarction (NSTEMI) patients with Global Registry of Acute C...Objective To investigate whether C-reactive protein (CRP) is a biomarker of malignant ventricular arrhythmias (MVA) occurring in non-ST elevation myocardial infarction (NSTEMI) patients with Global Registry of Acute Coronary events (GRACE) scores < 140. Methods A total of 1450 NSTEMI patients were included in this study. Hs-CRP blood levels were measured via a turbidimetric immunoassay after confirming the diagnosis of NSTEMI with GRACE scores < 140. Results Consistent with prior studies, the MVA occurrence rate in our cohort was 6.7%, and patients with MVA exhibited a reduced left ventricular ejection fraction (46.1%± 6.9% vs. 61.5%± 8.7%, P = 0.032), a higher incidence of Killip classification > 1 (34.1% vs. 24.2%, P < 0.001), an increased surgical revascularization rate (34.1% vs. 9.7%, P < 0.001), and increased mortality (16.5% vs. 5.8%, P < 0.001). Serum hs-CRP levels were higher (P = 0.003) in NSTEMI patients with MVA, and this increase appeared unrelated to other clinical parameters. The C-statistic to discriminate MVA was 0.82 (95% CI: 0.74–0.89). Using receiver operating characteristics analysis, we optimized a cutoff point of 16 mL/L, and the sensitivity and specificity were 95% and 61%, respectively;the positive predictive value was 20% and the negative predictive value was 99%. Conclusions An hs-CRP assay is a potential MVA biomarker in low-risk NSTEMI patients with GRACE scores < 140. If validated in prospective studies, hs-CRP may offer a low-cost supplementary strategy for risk stratification for NSTEMI patients.展开更多
This paper proposes a new method for estimating the parameter of maneuvering targets based on sparse time-frequency transform in over-the-horizon radar（OTHR）. In this method, the sparse time-frequency distribution o...This paper proposes a new method for estimating the parameter of maneuvering targets based on sparse time-frequency transform in over-the-horizon radar（OTHR）. In this method, the sparse time-frequency distribution of the radar echo is obtained by solving a sparse optimization problem based on the short-time Fourier transform. Then Hough transform is employed to estimate the parameter of the targets. The proposed algorithm has the following advantages： Compared with the Wigner-Hough transform method, the computational complexity of the sparse optimization is low due to the application of fast Fourier transform（FFT）. And the computational cost of Hough transform is also greatly reduced because of the sparsity of the time-frequency distribution. Compared with the high order ambiguity function（HAF） method, the proposed method improves in terms of precision and robustness to noise. Simulation results show that compared with the HAF method, the required SNR and relative mean square error are 8 dB lower and 50 dB lower respectively in the proposed method. While processing the field experiment data, the execution time of Hough transform in the proposed method is only 4% of the Wigner-Hough transform method.展开更多
Colleges and universities are an important position to cultivate high-quality talents.In order to cultivate a group of comprehensive talents with professional skills,post practice skills and high Internet literacy for...Colleges and universities are an important position to cultivate high-quality talents.In order to cultivate a group of comprehensive talents with professional skills,post practice skills and high Internet literacy for the society,it is necessary to fully combine the current“Internet plus”background and actively innovate and reform the talent cultivation mode of entrepreneurship education for college students.展开更多
Due to the strong magneto-elastic coupling in ferromagnetic/ferroelectric heterostructures and the potential applications in lowpower magnetoelectric nanodevices,ferroelastic domains and the corresponding dynamic evol...Due to the strong magneto-elastic coupling in ferromagnetic/ferroelectric heterostructures and the potential applications in lowpower magnetoelectric nanodevices,ferroelastic domains and the corresponding dynamic evolution under external stimuli have attracted intense research interest.Using pulsed laser deposition method,we have successfully grown layered-perovskite Bi_(2)WO_(6)thin films on SrTiO_(3)(001)substrates.Interestingly,for the as-grown thin films with step-flow morphology,the relationship between ferroelastic domain number and size shows a normal distribution,which is similar to the Boltzman distribution for confined gas molecules at equilibrium.In addition,with post-annealing,the thin films with as-grown island-like morphology can be optimized for layered morphology,and the initial small ferroelastic domains can grow into large domains.This study provides an effective strategy for ferroelastic domain engineering,which can be applied for the design of multiferroic heterostructures and low-power nanodevices.展开更多
Ferroelectric materials are widely used in the applications of electronic devices due to their robust spontaneous polarization.The surface roughness of ferroelectric thin films,which is closely related to the morpholo...Ferroelectric materials are widely used in the applications of electronic devices due to their robust spontaneous polarization.The surface roughness of ferroelectric thin films,which is closely related to the morphology,can play an important role in determining the ferroelectric domain structures.In this work,we have investigated the influence of annealing conditions on the surface morphology of epitaxial BiFeO_(3) and SrRuO_(3) thin films prepared by pulsed laser deposition on SrTiO_(3)(001)substrates.It is found that the morphology of the thin films is sensitive to the annealing time and cooling rate,and the corresponding surface roughness decreases with increasing annealing time and decreasing cooling rate.In addition,the ferroelectric domain structures of BiFeO_(3) films have been investigated by piezoelectric force microscopy,which shows a significant improvement in domain size and reverse piezoelectric response in the thin films with decreasing surface roughness.This work provides a simple way to predict and improve the ferroelectric domain structures by in situ annealing.展开更多
In recent years,new media has been booming in our country.College students can learn about everything happening in the world in real time through the Internet,which speeds up their understanding and acceptance of info...In recent years,new media has been booming in our country.College students can learn about everything happening in the world in real time through the Internet,which speeds up their understanding and acceptance of information.However,due to the relatively simple environment the college students grew up in,the incomplete formation of their own values,and the mixture of information on the Internet,learning through the Internet can have adverse effects on the psychology of college students.Based on the in-depth and systematic exploration of the current situation on ideological and political education in colleges and universities,this paper analyzes the existing problems of ideological and political education in colleges and universities under the influence of new media.In view of these problems,an in-depth study on the innovation of ideological and political education in contemporary colleges and universities was conducted,and this paper puts forward relevant improvement methods for the discussion and exchange of the industry.展开更多
Background： Coronary calcification is a major determinant ofstent underexpansion and subsequent adverse events. This study aimed to evaluate the acute- and long-term outcomes of rotational atherectomy （RA） followed...Background： Coronary calcification is a major determinant ofstent underexpansion and subsequent adverse events. This study aimed to evaluate the acute- and long-term outcomes of rotational atherectomy （RA） followed by cutting balloon （CB） versus plain balloon before drug-eluting stent implantation for calcified coronary lesions. Methods： From June April 2013 to March 2016, a total of 127 patients with moderately or severely calcified coronary lesions were treated with RA. Patients were divided into two groups according to the balloon type after RA： RA＋CB group （n = 75） and RA＋plain balloon group （n = 52）. Minimal lumen diameter and acute lumen gain were analyzed by quantitative coronary angiography. In-hospital and long-term （〉1 year） outcomes were recorded. Multivariate Cox regression analysis was performed to determine the independent predictors of in-stent restenosis.Results： The mean age of the patients was 65.5 years, and 76.4% were men. Total lesion length and minimal lumen diameter at baseline were similar in the two groups. After RA and balloon dilation, the lumen diameter was significantly larger in the RA＋CB group than in the RA＋plain balloon group （1.57 ±0.46 mm vs. 1.10 ± 0.40 mm, t = 4.123, P 〈 0.001）. The final lumen diameter was also larger in the RA＋CB group compared to that in the RA group （2.81± 0.41 mm vs. 2.60± 0.25 ram, t = 2.111, P = 0.039）. Moreover, patients receiving RA and CB tended to have larger final lumen gain （2.15 - 0.48 mm vs. 1.95 ± 0.47 mm, t = 1.542, P = 0.132）. Multivariate Cox regression analysis indicated that the strategy of RA＋CB was a significant protective factor against long-term （〉1 year） in-stent restenosis （hazard ratio： 0.136, 95% confidence interval： 0.020-0.936, P = 0.043）. Conclusions： In patients with moderately or severely calcified lesions, a strategy of RA followed by CB before stent implantation can increase lumen diameter and acute lumen gain. This strategy is safe with lower risk of long-term in-stent restenosis.展开更多
Canine health is consistently affected by the circulation of the H3N2 strain of canine influenza virus(CIV).Prior research has indicated that the isolation rate of H3N2 CIVs in dogs has gradually increased in China,an...Canine health is consistently affected by the circulation of the H3N2 strain of canine influenza virus(CIV).Prior research has indicated that the isolation rate of H3N2 CIVs in dogs has gradually increased in China,and these viruses have progressively adapted to humans over the course of their evolution within canine hosts,posing a significant public health threat.However,the key factors influencing the spread of CIVs remain elusive.From January 2020 to December 2022,during the COVID-19 pandemic,strict epidemic prevention policies were implemented in China.Thus,this measure provides an ideal model for studying factors influencing the prevalence of CIVs.In this study,we continuously monitored the prevalence of CIVs in China before and after the COVID-19 pandemic.We found that the pathogen detection rate and seropositivity rate of domestic CIVs significantly declined after the implementa-tion of epidemic control measures.However,after restrictions on human movement were lifted in 2023,the circula-tion of CIVs gradually increased.Our results demonstrate that restricting human activity directly impacts the epi-demic caused by CIVs and provide a theoretical basis for the implementation of control measures during outbreaks of zoonotic diseases in human companion animals.展开更多
Following publication of the original article^([1]),the authors reported that the data for March 2023 was missing in Fig.1,which should be updated from.
To the Editor： Current treatment guidelines for patients with acute coronary syndrome （ACS） undergoing percutaneous coronary intervention （PCI） recommend dual antiplatelet therapy, a combination of aspirin and a ...To the Editor： Current treatment guidelines for patients with acute coronary syndrome （ACS） undergoing percutaneous coronary intervention （PCI） recommend dual antiplatelet therapy, a combination of aspirin and a P2YI2 inhibitor （i.e., clopidogrel, prasugrel, and ticagrelor） for a minimum of 12 months. Ticagrelor, an oral reversibly binding platelet P2Y 12 receptor inhibitor, generates a greater and more consistent inhibitory effect with rapid onset of action as compared to clopidogrel.展开更多
基金This study was supported in part by grants fi＇om the Bei- jing Natural Science Foundation （7141003） and Beijing Municipal Science ＆ Technology Commission （Z14110- 7002514014）.
文摘Objective Acute kidney injury （AKI） frequently occurs after catheter-based interventional procedures and increases mortality. However, the implications of AKI before thoracic endovascular aneurysm repair （TEVAR） of type B acute aortic dissection （AAD） remain unclear. This study evaluated the incidence, predictors, and in-hospital outcomes of AKI before TEVAR in patients with type B AAD. Methods Between 2009 and 2013, 76 patients were retrospectively evaluated who received TEVAR for type B AAD within 36 h from symptom onset. The patients were classified into no-AKI vs. AKI groups, and the severity of AKI was further staged according to kidney disease： im- proving global outcomes criteria before TEVAR. Results The incidence of preoperative AKI was 36.8%. In-hospital complications was significantly higher in patients with preoperative AKI compared with no-AKI （50.0% vs. 4.2%, respectively; P 〈 0.001）, including acute renal failure （21.4% vs. O, respectively; P 〈 0.001）, and they increased with severity of AKI （P 〈 0.001）. The maximum levels of body tem- perature and white blood cell count were significantly related to maximum serum creatinine level before TEVAR. Multivariate analysis showed that systolic blood pressure on admission （OR： 1.023; 95% CI： 1.003-1.044; P ： 0.0238） and bilateral renal artery involvement （OR： 19.076; 95% CI： 1.914 190.164; P = 0.0120） were strong predictors of preoperative AKI. Conclusions Preoperative AKI frequently occurred in patients with type B AAD, and correlated with higher in-hospital complications and enhanced inflammatory reaction. Systolic blood pressure on admission and bilateral renal artery involvement were major risk factors for AKI before TEVAR.
基金funded by the National Natural Science Foundation of China(grant numbers 82370338,81970292,82270258,and 82100260)the National Key Research&Development Program of China(grant number 2020YFC2004800).
文摘Objective:This study was aimed at investigating the effects of the neutrophil-to-lymphocyte ratio(NLR)on the long-term prognosis of patients with acute coronary syndrome(ACS)and obstructive sleep apnea(OSA).Methods:This prospective study enrolled patients with ACS and OSA at Anzhen Hospital between June 2015 and January 2020.OSA was defined by an apnea-hypopnea index≥15 events·h-1.Baseline NLR was classified as high or low,according to the median.The primary endpoint was major adverse cardiovascular events(MACE),comprising cardiovascular death,recurrent myocardial infarction,stroke,and ischemia-driven revascularization.Results:Atotal of 1011 patients withACS and OSAwere enrolled,506 of whom were in the high NLR(≥2.54)group.No significant differences in sleep monitoring indicators were observed.During a median follow-up of 2.8(1.4,3.6)years,a non-linear correlation between NLR and the incident risk of MACE was observed.After adjustment for clini-cally relevant confounders,a high NLR was independently associated with elevated MACE risk(adjusted HR=1.45,95%CI:1.02–2.06,P=0.040).Conclusions:In patients with ACS and OSA,a high NLR was associated with poorer clinical outcomes during long-term follow-up.Trial registration:ClinicalTrials.gov;Number:NCT03362385;URL:www.clinicaltrials.gov.
基金This study was supported in part by grants from the Beijing Natural Science Foundation （7141003）, Beijing Municipal Science ＆ Technology Commission （Z14110700 2514014）, and Beijing Municipal Administration of Hospitals Incubating Program （PX2016048）.
文摘Background Acute kidney injury （AKI） is common after surgery for acute aortic dissection （AAD） and increases in-hospital and long-term mortality. However, few data exist on the clinical and prognostic relevance of early preoperative AKI in patients with type A AAD We aimed to determine the incidence and predictors of preoperative AKI and the impact of AKI on in-hospital outcomes in patients with type A AAD. Methods From May 2009 to June 2014, we retrospectively enrolled 178 patients admitted to our hospital within 48 h from symp- tom onset and receiving open surgery for type A AAD. The patients were divided into no AKI and AKI groups and staged with AKI severity according to the KDIGO criteria before surgery. Results AKI occurred in 41 patients （23.0%）. The incidence of in-hospital complications was significantly higher in patients with preoperative AKI compared to no AKI （41.5% vs. 9.5%, P 〈 0.001）, including renal infarction （7.3% vs. 0, P = 0.012）, and it increased with AKI severity （Ptrend〈 0.001）. Patients with AKI had higher in-hospital mortality compared with pa- tients without AKI, although no significant difference was found （14.6% vs. 5.1%, P = 0.079）. Multivariate analysis indicated that male gender, diastolic blood pressure on admission and bilateral renal artery involvement were independent predictors of preoperative AKI in patients with type A AAD. Conclusions Early AKI before surgery was common in patients with type A AAD, and was associated with increased in-hospital complications. Male gender, diastolic blood pressure on admission and bilateral renal artery involvement were major predictors for preoperative AKI.
基金supported by the Capital Health Research and Development of Special Foundation (2018-1-2061)
文摘Objective To investigate whether C-reactive protein (CRP) is a biomarker of malignant ventricular arrhythmias (MVA) occurring in non-ST elevation myocardial infarction (NSTEMI) patients with Global Registry of Acute Coronary events (GRACE) scores < 140. Methods A total of 1450 NSTEMI patients were included in this study. Hs-CRP blood levels were measured via a turbidimetric immunoassay after confirming the diagnosis of NSTEMI with GRACE scores < 140. Results Consistent with prior studies, the MVA occurrence rate in our cohort was 6.7%, and patients with MVA exhibited a reduced left ventricular ejection fraction (46.1%± 6.9% vs. 61.5%± 8.7%, P = 0.032), a higher incidence of Killip classification > 1 (34.1% vs. 24.2%, P < 0.001), an increased surgical revascularization rate (34.1% vs. 9.7%, P < 0.001), and increased mortality (16.5% vs. 5.8%, P < 0.001). Serum hs-CRP levels were higher (P = 0.003) in NSTEMI patients with MVA, and this increase appeared unrelated to other clinical parameters. The C-statistic to discriminate MVA was 0.82 (95% CI: 0.74–0.89). Using receiver operating characteristics analysis, we optimized a cutoff point of 16 mL/L, and the sensitivity and specificity were 95% and 61%, respectively;the positive predictive value was 20% and the negative predictive value was 99%. Conclusions An hs-CRP assay is a potential MVA biomarker in low-risk NSTEMI patients with GRACE scores < 140. If validated in prospective studies, hs-CRP may offer a low-cost supplementary strategy for risk stratification for NSTEMI patients.
基金supported by the National Natural Science Foundation of China(611011726137118461301262)
文摘This paper proposes a new method for estimating the parameter of maneuvering targets based on sparse time-frequency transform in over-the-horizon radar（OTHR）. In this method, the sparse time-frequency distribution of the radar echo is obtained by solving a sparse optimization problem based on the short-time Fourier transform. Then Hough transform is employed to estimate the parameter of the targets. The proposed algorithm has the following advantages： Compared with the Wigner-Hough transform method, the computational complexity of the sparse optimization is low due to the application of fast Fourier transform（FFT）. And the computational cost of Hough transform is also greatly reduced because of the sparsity of the time-frequency distribution. Compared with the high order ambiguity function（HAF） method, the proposed method improves in terms of precision and robustness to noise. Simulation results show that compared with the HAF method, the required SNR and relative mean square error are 8 dB lower and 50 dB lower respectively in the proposed method. While processing the field experiment data, the execution time of Hough transform in the proposed method is only 4% of the Wigner-Hough transform method.
文摘Colleges and universities are an important position to cultivate high-quality talents.In order to cultivate a group of comprehensive talents with professional skills,post practice skills and high Internet literacy for the society,it is necessary to fully combine the current“Internet plus”background and actively innovate and reform the talent cultivation mode of entrepreneurship education for college students.
基金supported by the NSF of China(Grant No.12004036)State Key Laboratory of New Ceramic and Fine Processing Tsinghua University(No.KFZD202201).
文摘Due to the strong magneto-elastic coupling in ferromagnetic/ferroelectric heterostructures and the potential applications in lowpower magnetoelectric nanodevices,ferroelastic domains and the corresponding dynamic evolution under external stimuli have attracted intense research interest.Using pulsed laser deposition method,we have successfully grown layered-perovskite Bi_(2)WO_(6)thin films on SrTiO_(3)(001)substrates.Interestingly,for the as-grown thin films with step-flow morphology,the relationship between ferroelastic domain number and size shows a normal distribution,which is similar to the Boltzman distribution for confined gas molecules at equilibrium.In addition,with post-annealing,the thin films with as-grown island-like morphology can be optimized for layered morphology,and the initial small ferroelastic domains can grow into large domains.This study provides an effective strategy for ferroelastic domain engineering,which can be applied for the design of multiferroic heterostructures and low-power nanodevices.
基金supported by the NSF of China(Grant No.12004036)State Key Laboratory of New Ceramic and Fine Processing Tsinghua University(No.KFZD202201).
文摘Ferroelectric materials are widely used in the applications of electronic devices due to their robust spontaneous polarization.The surface roughness of ferroelectric thin films,which is closely related to the morphology,can play an important role in determining the ferroelectric domain structures.In this work,we have investigated the influence of annealing conditions on the surface morphology of epitaxial BiFeO_(3) and SrRuO_(3) thin films prepared by pulsed laser deposition on SrTiO_(3)(001)substrates.It is found that the morphology of the thin films is sensitive to the annealing time and cooling rate,and the corresponding surface roughness decreases with increasing annealing time and decreasing cooling rate.In addition,the ferroelectric domain structures of BiFeO_(3) films have been investigated by piezoelectric force microscopy,which shows a significant improvement in domain size and reverse piezoelectric response in the thin films with decreasing surface roughness.This work provides a simple way to predict and improve the ferroelectric domain structures by in situ annealing.
文摘In recent years,new media has been booming in our country.College students can learn about everything happening in the world in real time through the Internet,which speeds up their understanding and acceptance of information.However,due to the relatively simple environment the college students grew up in,the incomplete formation of their own values,and the mixture of information on the Internet,learning through the Internet can have adverse effects on the psychology of college students.Based on the in-depth and systematic exploration of the current situation on ideological and political education in colleges and universities,this paper analyzes the existing problems of ideological and political education in colleges and universities under the influence of new media.In view of these problems,an in-depth study on the innovation of ideological and political education in contemporary colleges and universities was conducted,and this paper puts forward relevant improvement methods for the discussion and exchange of the industry.
基金This study was supported by grants from National Natural Science Foundation of China （No. 81670222 and No. 81600209）, Beijing Municipal Science and Technology Commission （No. Z181100001718060）, Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support （No. ZYEX201710）, Beijing Municipal Administration of Hospitals＇ Youth Program （No. QML20160605）, Beijing Municipal Administration of Hospitals Incubating Program （No. PX2016048）, and Beijing Municipal Organization Department （No. 2016000021469G194）.
文摘Background： Coronary calcification is a major determinant ofstent underexpansion and subsequent adverse events. This study aimed to evaluate the acute- and long-term outcomes of rotational atherectomy （RA） followed by cutting balloon （CB） versus plain balloon before drug-eluting stent implantation for calcified coronary lesions. Methods： From June April 2013 to March 2016, a total of 127 patients with moderately or severely calcified coronary lesions were treated with RA. Patients were divided into two groups according to the balloon type after RA： RA＋CB group （n = 75） and RA＋plain balloon group （n = 52）. Minimal lumen diameter and acute lumen gain were analyzed by quantitative coronary angiography. In-hospital and long-term （〉1 year） outcomes were recorded. Multivariate Cox regression analysis was performed to determine the independent predictors of in-stent restenosis.Results： The mean age of the patients was 65.5 years, and 76.4% were men. Total lesion length and minimal lumen diameter at baseline were similar in the two groups. After RA and balloon dilation, the lumen diameter was significantly larger in the RA＋CB group than in the RA＋plain balloon group （1.57 ±0.46 mm vs. 1.10 ± 0.40 mm, t = 4.123, P 〈 0.001）. The final lumen diameter was also larger in the RA＋CB group compared to that in the RA group （2.81± 0.41 mm vs. 2.60± 0.25 ram, t = 2.111, P = 0.039）. Moreover, patients receiving RA and CB tended to have larger final lumen gain （2.15 - 0.48 mm vs. 1.95 ± 0.47 mm, t = 1.542, P = 0.132）. Multivariate Cox regression analysis indicated that the strategy of RA＋CB was a significant protective factor against long-term （〉1 year） in-stent restenosis （hazard ratio： 0.136, 95% confidence interval： 0.020-0.936, P = 0.043）. Conclusions： In patients with moderately or severely calcified lesions, a strategy of RA followed by CB before stent implantation can increase lumen diameter and acute lumen gain. This strategy is safe with lower risk of long-term in-stent restenosis.
基金supported by the Major Project of Agricultural Biological Breeding(No.2023ZD0405304).
文摘Canine health is consistently affected by the circulation of the H3N2 strain of canine influenza virus(CIV).Prior research has indicated that the isolation rate of H3N2 CIVs in dogs has gradually increased in China,and these viruses have progressively adapted to humans over the course of their evolution within canine hosts,posing a significant public health threat.However,the key factors influencing the spread of CIVs remain elusive.From January 2020 to December 2022,during the COVID-19 pandemic,strict epidemic prevention policies were implemented in China.Thus,this measure provides an ideal model for studying factors influencing the prevalence of CIVs.In this study,we continuously monitored the prevalence of CIVs in China before and after the COVID-19 pandemic.We found that the pathogen detection rate and seropositivity rate of domestic CIVs significantly declined after the implementa-tion of epidemic control measures.However,after restrictions on human movement were lifted in 2023,the circula-tion of CIVs gradually increased.Our results demonstrate that restricting human activity directly impacts the epi-demic caused by CIVs and provide a theoretical basis for the implementation of control measures during outbreaks of zoonotic diseases in human companion animals.
文摘Following publication of the original article^([1]),the authors reported that the data for March 2023 was missing in Fig.1,which should be updated from.
文摘To the Editor： Current treatment guidelines for patients with acute coronary syndrome （ACS） undergoing percutaneous coronary intervention （PCI） recommend dual antiplatelet therapy, a combination of aspirin and a P2YI2 inhibitor （i.e., clopidogrel, prasugrel, and ticagrelor） for a minimum of 12 months. Ticagrelor, an oral reversibly binding platelet P2Y 12 receptor inhibitor, generates a greater and more consistent inhibitory effect with rapid onset of action as compared to clopidogrel.
