Natural plant or functional food-derived biologically active ingredients have recently raised considerable interest in their antiobesity effect.However,the antiobesity role of polyphenols of white radish roots remains...Natural plant or functional food-derived biologically active ingredients have recently raised considerable interest in their antiobesity effect.However,the antiobesity role of polyphenols of white radish roots remains unknown.This study examined the therapeutic efficacy and underlying mechanisms of polyphenols extract from white radish roots(RPE)on obese mice.RPE administration significantly decreased the weight gain in high-fat diet(HFD)fed mouse models.RPE intervention also increased serum glutathione transferase and superoxide dismutase levels,and decreased malondialdehyde,tumor necrosis factor-a and lipopolysaccharide levels in the HFD-fed mice.The intervention led to an escalation in the proportion of beneficial bacteria(Akkermansia,Clostridia),and a corresponding decline in the fraction of harmful bacteria(Proteobacteria).According to liquid chromatography-mass spectrometry-based gut metabolomics,the RPE intervention notably influenced several metabolic pathways,including those involved in protein digestion and absorption,centralcarbon metabolism related to cancer,and the biosynthesis of steroid hormones.Additionally,RPE treatment led to a reduction in the intestinal microbes possessing bile-salt hydrolase activity,whereas increased the expression levels of the bile acid(BA)synthesis enzyme cholesterol 7a-hydroxylase(Cyp7a1).This led to increase hepatic production and fecal excretion of BAs,reduce hepatic cholesterol,and decrease lipogenesis.Treated HDF-fed mice showed mitigation of hepatic steatosis and inflammation through gut-liver axis modulation by RPE interference.These findings together offer a significant understanding of the potential of RPE as an anti-obesity treatment and could assist in developing strategies for weight loss.展开更多
Urban fine management needs scientific traffic management methods and efficient signal control programs.Green wave control is usually used to facilitate the unban traffic.However,maximum bandwidth optimization on arte...Urban fine management needs scientific traffic management methods and efficient signal control programs.Green wave control is usually used to facilitate the unban traffic.However,maximum bandwidth optimization on arterial traffic signal timing is usually yielded from the sacrifice of the branch road.The green wave on branch roads and pedestrian crossing time at intersections are often neglected.In this paper,an extended integrated green wave control method is presented to solve the coordinated control issue,which considers green time constraints to ensure necessary time for vehicles on branch roads and pedestrian crossing time at intersections.Non-coordinated phase saturation is first introduced to describe the green time on branch roads.Next,the arterial roads are partitioned to enlarge the green wave bandwidth and an extended green wave optimization model with green time constraints is proposed.Combined with the green wave searching method,an improved genetic algorithm is applied.Finally,a real-world case study in Shenzhen,China,is employed to assess the model.Results show the proposed model can(1)reach the same public green time as in the traditional method and(2)increase the average sub-green wave bandwidth to improve the signal control.展开更多
基金supported by the Open Fund of Institute of Ocean Research,Bohai University(BDHYYJY2025006).
文摘Natural plant or functional food-derived biologically active ingredients have recently raised considerable interest in their antiobesity effect.However,the antiobesity role of polyphenols of white radish roots remains unknown.This study examined the therapeutic efficacy and underlying mechanisms of polyphenols extract from white radish roots(RPE)on obese mice.RPE administration significantly decreased the weight gain in high-fat diet(HFD)fed mouse models.RPE intervention also increased serum glutathione transferase and superoxide dismutase levels,and decreased malondialdehyde,tumor necrosis factor-a and lipopolysaccharide levels in the HFD-fed mice.The intervention led to an escalation in the proportion of beneficial bacteria(Akkermansia,Clostridia),and a corresponding decline in the fraction of harmful bacteria(Proteobacteria).According to liquid chromatography-mass spectrometry-based gut metabolomics,the RPE intervention notably influenced several metabolic pathways,including those involved in protein digestion and absorption,centralcarbon metabolism related to cancer,and the biosynthesis of steroid hormones.Additionally,RPE treatment led to a reduction in the intestinal microbes possessing bile-salt hydrolase activity,whereas increased the expression levels of the bile acid(BA)synthesis enzyme cholesterol 7a-hydroxylase(Cyp7a1).This led to increase hepatic production and fecal excretion of BAs,reduce hepatic cholesterol,and decrease lipogenesis.Treated HDF-fed mice showed mitigation of hepatic steatosis and inflammation through gut-liver axis modulation by RPE interference.These findings together offer a significant understanding of the potential of RPE as an anti-obesity treatment and could assist in developing strategies for weight loss.
基金jointly supported by the grants from the National Natural Science Foundation of China(71971144)the Beijing Natural Science Foundation(8192006)the Beijing Municipal Education Commission Foundation(SZ201910038021)
文摘Urban fine management needs scientific traffic management methods and efficient signal control programs.Green wave control is usually used to facilitate the unban traffic.However,maximum bandwidth optimization on arterial traffic signal timing is usually yielded from the sacrifice of the branch road.The green wave on branch roads and pedestrian crossing time at intersections are often neglected.In this paper,an extended integrated green wave control method is presented to solve the coordinated control issue,which considers green time constraints to ensure necessary time for vehicles on branch roads and pedestrian crossing time at intersections.Non-coordinated phase saturation is first introduced to describe the green time on branch roads.Next,the arterial roads are partitioned to enlarge the green wave bandwidth and an extended green wave optimization model with green time constraints is proposed.Combined with the green wave searching method,an improved genetic algorithm is applied.Finally,a real-world case study in Shenzhen,China,is employed to assess the model.Results show the proposed model can(1)reach the same public green time as in the traditional method and(2)increase the average sub-green wave bandwidth to improve the signal control.
