Studies to enhance the management of electrical energy have gained considerable momentum in recent years. The question of how much energy will be needed in households is a pressing issue as it allows the management pl...Studies to enhance the management of electrical energy have gained considerable momentum in recent years. The question of how much energy will be needed in households is a pressing issue as it allows the management plan of the available resources at the power grids and consumer levels. A non-intrusive inference process can be adopted to predict the amount of energy required by appliances. In this study, an inference process of appliance consumption based on temporal and environmental factors used as a soft sensor is proposed. First, a study of the correlation between the electrical and environmental variables is presented. Then, a resampling process is applied to the initial data set to generate three other subsets of data. All the subsets were evaluated to deduce the adequate granularity for the prediction of the energy demand. Then, a cloud-assisted deep neural network model is designed to forecast short-term energy consumption in a residential area while preserving user privacy. The solution is applied to the consumption data of four appliances elected from a set of real household power data. The experiment results show that the proposed framework is effective for estimating consumption with convincing accuracy.展开更多
A series of Eu^(2+)/Eu^(3+)doped 20La_(2)O_(3)-20Al_(2)O_(3)-60SiO_(2)glasses(LAS:Eu)were fabricated via melting quenching method in air atmosphere.By introducing the reducing agent Si_(3)N_(4),the ratio of Eu^(2+)/Eu...A series of Eu^(2+)/Eu^(3+)doped 20La_(2)O_(3)-20Al_(2)O_(3)-60SiO_(2)glasses(LAS:Eu)were fabricated via melting quenching method in air atmosphere.By introducing the reducing agent Si_(3)N_(4),the ratio of Eu^(2+)/Eu^(3+)in glasses can be controlled under atmospheric conditions at 1520℃for 5 h.As the tunable Eu^(2+)/Eu^(3+)component in LAS:Eu glasses,the wavelength conversion of photoluminescence is achieved upon the395 nm excitation,where LAS:0.7Eu exhibits a color coordinate of(0.334,0.314).According to calculation,the energy transfer mechanism between Eu^(2+)and Eu^(3+)in glasses is dipole-dipole interactions dominate.Meanwhile,relative X-ray excited luminescence(XEL)intensity of the single Eu^(2+)doped glass can reach 38.6%of that of Bi_(4)Ge_(3)O_(12)(BGO)crystal.The temperature-dependent emission spectra of the LAS:Eu glasses were tested under photoluminescence and X-ray excitation,and the thermal activation energy was calculated.These results demonstrate the potential of LAS:Eu glass for applications as lightemitting diode(LED)materials and scintillators in nuclear radiation detection.展开更多
Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side effects.In the...Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side effects.In the present study,we combined metabolomics and network pharmacology to further explore the active ingredients in’Chuju’,as well as the target and pharmacological mechanisms of the active ingredients.A visualized network analysis model based on chemistry,pharmacokinetics,and pharmacology was constructed to predict the potential pharmacological mechanism of’Chuju’.A total of 424 metabolites of’Chuju’were identified,of which 21 ingredients had positive pharmacological effects after ADME screening.The network pharmacology revealed that acacetin and beta-sitosterol in’Chuju’could act on GSK3B,MAPK14,ADRA1R,and NOS2 to regulate diabetes mellitus,Alzheimer’s disease,breast cancer,and inflammatory diseases.These results indicated the potential pharmacological effects of the active components in’Chuju’.展开更多
The pollution caused by agricultural production poses a threat to the ecological integrity of river ecosystems,altering the structure and function of river ecosystems.Differences in microbial community structure provi...The pollution caused by agricultural production poses a threat to the ecological integrity of river ecosystems,altering the structure and function of river ecosystems.Differences in microbial community structure provide useful information about the impact of agricultural pollution on the biological integrity of ecosystems,but generally convey little information regarding ecosystem functions.In this study,using Illumina MiSeq sequencing technology based on the 16 S rRNA gene,river sediment samples associated with four different types of agricultural pollution were comprehensively analyzed.The results show that the total organic carbon(TOC)content was highest at the YZS site(animal husbandry sewage)among the assayed sites,but the species richness and uniformity were lowest at this site,which may have been caused by the high nutrient source of the sewage.Furthermore,in the three YZS samples affected by the long-term discharge of aquaculture tail-water,the unique genus Dechloromonas and the genus Candidatus-Competitor were observed,which are strongly correlated with phosphorus conversion.The formation of network modules may correspond to the coexistence of functional bacteria accustomed to multiple niche combinations under different agricultural pollution conditions in river sediments.According to the PICRUSt functional prediction,the bacterial community in the agricultural polluted river sediment primarily harbored 46 subfunctions,exhibiting richness of functions.Overall,our results provide a more comprehensive understanding of the structure and ecological processes associated with the aggregation of bacterial communities,which is beneficial for the management of river environments.展开更多
<正>A novel neurochip based on light addressable potentiometric sensor (LAPS) is designed.Using its light addressable characteristic.The problems of the limitations of restricted discrete active sites of current...<正>A novel neurochip based on light addressable potentiometric sensor (LAPS) is designed.Using its light addressable characteristic.The problems of the limitations of restricted discrete active sites of current neurochips,such as microelectrode array and field effect transistor array can be settled easily.Based on the theoretical analysis of the interface between cells and LAPS,spontaneously discharges of hippocampal neurons induced by Mg~ 2+)-free media treatment were recorded by LAPS.The results demonstrate that this kind of neurochip has potential to monitor electrophysiology of cultured cells in a non-invasive way.展开更多
Cellular metabolism arouses the changes of substance in extracellular physiological microenvironment,and the metabolic level reflects the physiological state of cells.This paper developed a novel microphysiometer auto...Cellular metabolism arouses the changes of substance in extracellular physiological microenvironment,and the metabolic level reflects the physiological state of cells.This paper developed a novel microphysiometer automatic analysis instrument based on multiparameter cell-based biosensors for quick drug analysis.This study included the multiparameter cell-based biosensors,cell culture chamber,drug auto-injection detection and analysis.The analysis instrument was capable of real-time detection for the acidic product and other chemical parameters generated by the cellular metabolism in the micro-volume.Finally,the paper employs human breast cancer cell line MCF-7 and drug experiments to verify the performance of microphysiometer,and study effects of different drugs on cell metabolism.Further,the research explores drug analysis method of the multiparameter microphysiometer.The results showed that the cell-based microphysiometer system provides a utility platform for rapid,long-term and automatic cell physiological environment detection and drug analysis.展开更多
The light-addressable potentiometric sensor (LAPS) is a semiconductor-based cellular biosensor with an electrolyte-insulator-semiconductor (EIS) structure.By depositing biocompatible layers on the sensing surface fo...The light-addressable potentiometric sensor (LAPS) is a semiconductor-based cellular biosensor with an electrolyte-insulator-semiconductor (EIS) structure.By depositing biocompatible layers on the sensing surface for cell culture, it can be used to detect bioelectrical parameters of cells.The characteristic curve for photocurrent versus applied bias voltage to the system shows a current-voltage curve (Ⅰ-Ⅴcurve).This technique can be used to detect the action potential changes towards different drugs based on the bias voltage dependence of an optical current,and provides a dynamic system by scanning light beam at the very cell on the sensor device.The LAPS overcomes the limitation of recording sites,but high spatial resolution and sensitivity are also paramount.This paper discussed a novel structure of LAPS array for extracellular monitoring to decrease potential noise level.Both characteristics of active recording array areas and cell culture conditions are measured.展开更多
Immune evasion behavior and immunosuppressive characteristics of tumor extensively impedethe immune initiation effect of therapy triggered immunogeniccell death (ICD). In this work, a carrier-adjuvantedimmunostimulato...Immune evasion behavior and immunosuppressive characteristics of tumor extensively impedethe immune initiation effect of therapy triggered immunogeniccell death (ICD). In this work, a carrier-adjuvantedimmunostimulator (designated as CoCeC) is developed toboost photodynamic immunotherapy by downregulatingprogrammed death ligand 1 (PD-L1) and impairing adenosinetriphosphate (ATP) hydrolysis. Among these, the crosslinkedchitosan oligosaccharide is applied as the drug carrier fordelivery of Ce6 and Ceritinib, which also serves as an immuneadjuvant to downregulate PD-L1. Meanwhile, the robustphotodynamic therapy (PDT) of CoCeC exhibits lethal toxicityagainst tumor cells to induce ICD and release damage-associated molecular patterns (DAMPs), which can also impairATP hydrolysis by blocking CD39. In vitro and in vivo resultsdemonstrate the robust therapeutic efficacy of CoCeC tosuppress primary tumor growth and activate a superior immune elimination against lung metastasis by amplifying theimmune initiation of ICD with the assistance of immune adjuvants.This work provides a self-adjuvanted strategy to enhance the immune response of therapy induced ICD, which ispromising to activate systemic antitumor immunity in consideration of the complicated immunosuppressive factors.展开更多
Brucellosis is a highly infectious anthropozoonotic disease caused by the genus Brucella,which is the pathogenic bacteria in public health risk and occupation exposure.Therefore,rapid detection and identification of B...Brucellosis is a highly infectious anthropozoonotic disease caused by the genus Brucella,which is the pathogenic bacteria in public health risk and occupation exposure.Therefore,rapid detection and identification of Brucella is crucial for controlling and managing the prevalence of brucellosis.In this work,matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS)combined with machine learning(ML)algorithms was developed to identify Brucella isolates at the species level rapidly.A total of 1440 MALDI spectral data from 59 strains of B.melitensis(23 strains of B.melitensis bv.1 and 36 strains of B.melitensis bv.3)were obtained.Four ML algorithms including support vector machine(SVM),random forest(RF),extreme gradient boosting(XGBoost),and logistic regression(LR)were compared for typing Brucella species.The area under receiver operating characteristic(ROC)curve,precision-recall ratio(PR),accuracy,specificity,and sensitivity were used to evaluate the performances of diff erent ML algorithms.These results showed that MALDI-TOF MS combined with the XGBoost algorithm is the best method for typing Brucella species with good performances,demonstrating the significant potential applications in the diagnosis,control,and epidemiology of brucellosis.展开更多
With the significant progress of high-energy physics,nuclear science,and technology,the demand for high-performance scintillators is growing rapidly.Among solid-state scintillators,glass scintillators would play a vit...With the significant progress of high-energy physics,nuclear science,and technology,the demand for high-performance scintillators is growing rapidly.Among solid-state scintillators,glass scintillators would play a vital role in the field of high-energy radiation detections because of their merits including low cost,batch production,and arbitrariness in shape.In this review article,the research and development of glass scintillators is introduced with respect to the following key parameters including:density,light yield,scintillation decay time,and radiation hardness.The scintillation mechanisms,preparation methods particularly for Ce^(3+)-activated glasses,standard testing methods,scintillation performance,and applications of glass scintillators are comprehensively reviewed and critically discussed.Finally,the problems existing in the research field are presented and the future development directions of glass scintillators for performance improvement are suggested.展开更多
Correction to:Radiation Detection Technology and Methods(2024)8:1-1105.https://doi.org/10.1007/s41605-024-00463-y.In this article all authors name was missing in the springer link.It has been corrected.The original ar...Correction to:Radiation Detection Technology and Methods(2024)8:1-1105.https://doi.org/10.1007/s41605-024-00463-y.In this article all authors name was missing in the springer link.It has been corrected.The original article has been corrected.展开更多
The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 3...The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.展开更多
A graph is 1-planar if it can be drawn on the plane so that each edge is crossed by at most one other edge. In this paper, we verify the total coloring conjecture for every 1-planar graph G if either △（G） ≥9 and g...A graph is 1-planar if it can be drawn on the plane so that each edge is crossed by at most one other edge. In this paper, we verify the total coloring conjecture for every 1-planar graph G if either △（G） ≥9 and g（G）≥ 4, or △（G） ≥ 7 and g（G）≥5, where △（G） is the maximum degree of G and g（G） is the girth of G.展开更多
A graph is 1-planar if it can be drawn on the plane so that each edge is crossed by at most one other edge. In this paper, we prove that every 1-planar graph G with maximum degree △（G） 〉 12 and girth at least five...A graph is 1-planar if it can be drawn on the plane so that each edge is crossed by at most one other edge. In this paper, we prove that every 1-planar graph G with maximum degree △（G） 〉 12 and girth at least five is totally （△（G）＋1）-colorable.展开更多
The growing scale and complexity of component interactions in cloud computing systems post great challenges for operators to understand the characteristics of system performance. Profiling has long been proved to be a...The growing scale and complexity of component interactions in cloud computing systems post great challenges for operators to understand the characteristics of system performance. Profiling has long been proved to be an effective approach to performance analysis; however, existing approaches confront new challenges that emerge in cloud computing systems. First, the efficiency of the profiling becomes of critical concern; second, service-oriented profiling should be considered to support separation-of-concerns performance analysis. To address the above issues, in this paper, we present P-Tracer, an online performance profiling tool specifically tailored for cloud computing systems. P-Tracer constructs a specific search engine that proactively processes performance logs and generates a particular index for fast queries; second, for each service, P-Tracer retrieves a statistical insight of performance characteristics from multi-dimensions and provides operators with a suite of web-based interfaces to query the critical information. We evaluate P- Tracer in the aspects of tracing overheads, data preprocessing scalability and querying efficiency. Three real-world case studies that happened in Alibaba cloud computing platform demonstrate that P-Tracer can help operators understand soft-ware behaviors and localize the primary causes of performance anomalies effectively and efficiently.展开更多
A k-total-coloring of a graph G is a coloring of vertices and edges of G using k colors such that no two adjacent or incident elements receive the same color.In this paper,it is proved that if G is a planar graph with...A k-total-coloring of a graph G is a coloring of vertices and edges of G using k colors such that no two adjacent or incident elements receive the same color.In this paper,it is proved that if G is a planar graph with Δ（G） ≥ 7 and without chordal 7-cycles,then G has a（Δ（G） ＋ 1）-total-coloring.展开更多
Purpose Glass is a potential choice for the scintillator in Hadronic calorimetry(HCAL)of the CEPC.It requires sophisticated instruments and suitable methods to obtain scintillation properties of the glasses in the fir...Purpose Glass is a potential choice for the scintillator in Hadronic calorimetry(HCAL)of the CEPC.It requires sophisticated instruments and suitable methods to obtain scintillation properties of the glasses in the first time.It is necessary to establish an evaluation method for nuclear radiation detection performance of glass scintillator.Methods The spectroscopy research of the glass includes transmission/absorption spectrum and emission spectrum.The time characteristics include rise time,scintillation decay time and afterglow.The scintillation properties include light yield,energy resolution and minimum ionizing particle(MIP)response.And a new method for measuring the low light yield of glass scintillators is proposed.Results We have built a complete performance test system and evaluation method,which can evaluate the nuclear radiation detection performance of different glass scintillators.Conclusion By continuously improving the composition and preparation process of the glass,it can provide potential possibilities for the application in the high-energy physics experiment and nuclear radiation detection fields.展开更多
基金funded by NARI Group’s Independent Project of China(Grant No.524609230125)the Foundation of NARI-TECH Nanjing Control System Ltd.of China(Grant No.0914202403120020).
文摘Studies to enhance the management of electrical energy have gained considerable momentum in recent years. The question of how much energy will be needed in households is a pressing issue as it allows the management plan of the available resources at the power grids and consumer levels. A non-intrusive inference process can be adopted to predict the amount of energy required by appliances. In this study, an inference process of appliance consumption based on temporal and environmental factors used as a soft sensor is proposed. First, a study of the correlation between the electrical and environmental variables is presented. Then, a resampling process is applied to the initial data set to generate three other subsets of data. All the subsets were evaluated to deduce the adequate granularity for the prediction of the energy demand. Then, a cloud-assisted deep neural network model is designed to forecast short-term energy consumption in a residential area while preserving user privacy. The solution is applied to the consumption data of four appliances elected from a set of real household power data. The experiment results show that the proposed framework is effective for estimating consumption with convincing accuracy.
基金Project supported by"Pioneer"and"Leading Goose"R&D Program of Zhejiang(2022C01046)the National Natural Science Foundation of China(12375183,61505193,12275262,11975220,51972291)Natural Science Foundation of Zhejiang(LGG22E020001)。
文摘A series of Eu^(2+)/Eu^(3+)doped 20La_(2)O_(3)-20Al_(2)O_(3)-60SiO_(2)glasses(LAS:Eu)were fabricated via melting quenching method in air atmosphere.By introducing the reducing agent Si_(3)N_(4),the ratio of Eu^(2+)/Eu^(3+)in glasses can be controlled under atmospheric conditions at 1520℃for 5 h.As the tunable Eu^(2+)/Eu^(3+)component in LAS:Eu glasses,the wavelength conversion of photoluminescence is achieved upon the395 nm excitation,where LAS:0.7Eu exhibits a color coordinate of(0.334,0.314).According to calculation,the energy transfer mechanism between Eu^(2+)and Eu^(3+)in glasses is dipole-dipole interactions dominate.Meanwhile,relative X-ray excited luminescence(XEL)intensity of the single Eu^(2+)doped glass can reach 38.6%of that of Bi_(4)Ge_(3)O_(12)(BGO)crystal.The temperature-dependent emission spectra of the LAS:Eu glasses were tested under photoluminescence and X-ray excitation,and the thermal activation energy was calculated.These results demonstrate the potential of LAS:Eu glass for applications as lightemitting diode(LED)materials and scintillators in nuclear radiation detection.
基金Key Project of Natural Science Research in Colleges and Universities in Anhui Province(Grant No.KJ2019A0639,KJ2020A0715)Open Foundation of the Key Laboratory of Crop Gene Resources and Germplasm Creation in East China,Ministry of Agriculture(Grant No.ECG2018001)+1 种基金the Key Project of Excellent Young Talents Support Program in Universities of Anhui Province(Grant No.gxyq ZD2021133)Chuzhou Science and Technology Plan Project(Grant No.2020ZN013)。
文摘Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side effects.In the present study,we combined metabolomics and network pharmacology to further explore the active ingredients in’Chuju’,as well as the target and pharmacological mechanisms of the active ingredients.A visualized network analysis model based on chemistry,pharmacokinetics,and pharmacology was constructed to predict the potential pharmacological mechanism of’Chuju’.A total of 424 metabolites of’Chuju’were identified,of which 21 ingredients had positive pharmacological effects after ADME screening.The network pharmacology revealed that acacetin and beta-sitosterol in’Chuju’could act on GSK3B,MAPK14,ADRA1R,and NOS2 to regulate diabetes mellitus,Alzheimer’s disease,breast cancer,and inflammatory diseases.These results indicated the potential pharmacological effects of the active components in’Chuju’.
基金the Key University Science Research Project of Anhui Province(No.KJ2019A0641)the Key Research and development program of Anhui Province(No.202004i07020010)+1 种基金the Resistance in Winter Wheat Region in the Middle and Lower Reaches of the Yangtze River(No.2017YFD0100800)the Anhui Academy of Agricultural Sciences Research and Application Innovation Team Project of Aquaculture Water Environment(No.2020YL043)。
文摘The pollution caused by agricultural production poses a threat to the ecological integrity of river ecosystems,altering the structure and function of river ecosystems.Differences in microbial community structure provide useful information about the impact of agricultural pollution on the biological integrity of ecosystems,but generally convey little information regarding ecosystem functions.In this study,using Illumina MiSeq sequencing technology based on the 16 S rRNA gene,river sediment samples associated with four different types of agricultural pollution were comprehensively analyzed.The results show that the total organic carbon(TOC)content was highest at the YZS site(animal husbandry sewage)among the assayed sites,but the species richness and uniformity were lowest at this site,which may have been caused by the high nutrient source of the sewage.Furthermore,in the three YZS samples affected by the long-term discharge of aquaculture tail-water,the unique genus Dechloromonas and the genus Candidatus-Competitor were observed,which are strongly correlated with phosphorus conversion.The formation of network modules may correspond to the coexistence of functional bacteria accustomed to multiple niche combinations under different agricultural pollution conditions in river sediments.According to the PICRUSt functional prediction,the bacterial community in the agricultural polluted river sediment primarily harbored 46 subfunctions,exhibiting richness of functions.Overall,our results provide a more comprehensive understanding of the structure and ecological processes associated with the aggregation of bacterial communities,which is beneficial for the management of river environments.
基金supported by the National Natural Science Foundation of China(Grant Nos.30270387,No.30570492)the Project of State Key Laboratory of Transducer Technology of China(Grant No.SKT0403)the Foundation for the Bureau of Zhejiang Province of China(Grant No.20040197).
文摘<正>A novel neurochip based on light addressable potentiometric sensor (LAPS) is designed.Using its light addressable characteristic.The problems of the limitations of restricted discrete active sites of current neurochips,such as microelectrode array and field effect transistor array can be settled easily.Based on the theoretical analysis of the interface between cells and LAPS,spontaneously discharges of hippocampal neurons induced by Mg~ 2+)-free media treatment were recorded by LAPS.The results demonstrate that this kind of neurochip has potential to monitor electrophysiology of cultured cells in a non-invasive way.
基金This work was supported by the National Natural Science Foundation of China(Grant No.81027003)the Zhejiang Provincial Science and Technology Major Special Program(No.2010C14006).
文摘Cellular metabolism arouses the changes of substance in extracellular physiological microenvironment,and the metabolic level reflects the physiological state of cells.This paper developed a novel microphysiometer automatic analysis instrument based on multiparameter cell-based biosensors for quick drug analysis.This study included the multiparameter cell-based biosensors,cell culture chamber,drug auto-injection detection and analysis.The analysis instrument was capable of real-time detection for the acidic product and other chemical parameters generated by the cellular metabolism in the micro-volume.Finally,the paper employs human breast cancer cell line MCF-7 and drug experiments to verify the performance of microphysiometer,and study effects of different drugs on cell metabolism.Further,the research explores drug analysis method of the multiparameter microphysiometer.The results showed that the cell-based microphysiometer system provides a utility platform for rapid,long-term and automatic cell physiological environment detection and drug analysis.
基金This work was supported by the National Natural Science Foundation of China （Grant Nos. 30270387, No. 30570492）；the Project of State Key Laboratory of Transducer Technology of China （Grant No. SKT0403）；the Foundation for the Bureau of Zhejiang Province of China （Grant No. 20040197）.
文摘The light-addressable potentiometric sensor (LAPS) is a semiconductor-based cellular biosensor with an electrolyte-insulator-semiconductor (EIS) structure.By depositing biocompatible layers on the sensing surface for cell culture, it can be used to detect bioelectrical parameters of cells.The characteristic curve for photocurrent versus applied bias voltage to the system shows a current-voltage curve (Ⅰ-Ⅴcurve).This technique can be used to detect the action potential changes towards different drugs based on the bias voltage dependence of an optical current,and provides a dynamic system by scanning light beam at the very cell on the sensor device.The LAPS overcomes the limitation of recording sites,but high spatial resolution and sensitivity are also paramount.This paper discussed a novel structure of LAPS array for extracellular monitoring to decrease potential noise level.Both characteristics of active recording array areas and cell culture conditions are measured.
基金financially supported by the National Key R&D Program of China (2021YFD1800600)the National Natural Science Foundation of China (32371394)the Open Research Foundation of State Key Laboratory of Respiratory Diseases (SKLRD-OP-202204)。
文摘Immune evasion behavior and immunosuppressive characteristics of tumor extensively impedethe immune initiation effect of therapy triggered immunogeniccell death (ICD). In this work, a carrier-adjuvantedimmunostimulator (designated as CoCeC) is developed toboost photodynamic immunotherapy by downregulatingprogrammed death ligand 1 (PD-L1) and impairing adenosinetriphosphate (ATP) hydrolysis. Among these, the crosslinkedchitosan oligosaccharide is applied as the drug carrier fordelivery of Ce6 and Ceritinib, which also serves as an immuneadjuvant to downregulate PD-L1. Meanwhile, the robustphotodynamic therapy (PDT) of CoCeC exhibits lethal toxicityagainst tumor cells to induce ICD and release damage-associated molecular patterns (DAMPs), which can also impairATP hydrolysis by blocking CD39. In vitro and in vivo resultsdemonstrate the robust therapeutic efficacy of CoCeC tosuppress primary tumor growth and activate a superior immune elimination against lung metastasis by amplifying theimmune initiation of ICD with the assistance of immune adjuvants.This work provides a self-adjuvanted strategy to enhance the immune response of therapy induced ICD, which ispromising to activate systemic antitumor immunity in consideration of the complicated immunosuppressive factors.
基金supported by the Science and Technology Service Network Initiative(KFJ-STS-QYZD-188)National Natural Science Foundation of China(22476064)Fundamental Research Funds for the Central Universities(21624203)。
文摘Brucellosis is a highly infectious anthropozoonotic disease caused by the genus Brucella,which is the pathogenic bacteria in public health risk and occupation exposure.Therefore,rapid detection and identification of Brucella is crucial for controlling and managing the prevalence of brucellosis.In this work,matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS)combined with machine learning(ML)algorithms was developed to identify Brucella isolates at the species level rapidly.A total of 1440 MALDI spectral data from 59 strains of B.melitensis(23 strains of B.melitensis bv.1 and 36 strains of B.melitensis bv.3)were obtained.Four ML algorithms including support vector machine(SVM),random forest(RF),extreme gradient boosting(XGBoost),and logistic regression(LR)were compared for typing Brucella species.The area under receiver operating characteristic(ROC)curve,precision-recall ratio(PR),accuracy,specificity,and sensitivity were used to evaluate the performances of diff erent ML algorithms.These results showed that MALDI-TOF MS combined with the XGBoost algorithm is the best method for typing Brucella species with good performances,demonstrating the significant potential applications in the diagnosis,control,and epidemiology of brucellosis.
基金support fromthe National Key Research and Development Program of China(2023YFF0721700)the National Natural Science Foundation of China(52372003)+2 种基金the Natural Science Foundation of Heilongjiang Province of China(ZD2023E004)the Science and Technology Plan Project of Ji’an City(20233-117685)Fundamental Research Funds for the Central Universities,and the State Key Laboratory of Particle Detection and Electronics(SKLPDE-KF-202414).
文摘With the significant progress of high-energy physics,nuclear science,and technology,the demand for high-performance scintillators is growing rapidly.Among solid-state scintillators,glass scintillators would play a vital role in the field of high-energy radiation detections because of their merits including low cost,batch production,and arbitrariness in shape.In this review article,the research and development of glass scintillators is introduced with respect to the following key parameters including:density,light yield,scintillation decay time,and radiation hardness.The scintillation mechanisms,preparation methods particularly for Ce^(3+)-activated glasses,standard testing methods,scintillation performance,and applications of glass scintillators are comprehensively reviewed and critically discussed.Finally,the problems existing in the research field are presented and the future development directions of glass scintillators for performance improvement are suggested.
文摘Correction to:Radiation Detection Technology and Methods(2024)8:1-1105.https://doi.org/10.1007/s41605-024-00463-y.In this article all authors name was missing in the springer link.It has been corrected.The original article has been corrected.
基金support from diverse funding sources,including the National Key Program for S&T Research and Development of the Ministry of Science and Technology(MOST),Yifang Wang's Science Studio of the Ten Thousand Talents Project,the CAS Key Foreign Cooperation Grant,the National Natural Science Foundation of China(NSFC)Beijing Municipal Science&Technology Commission,the CAS Focused Science Grant,the IHEP Innovation Grant,the CAS Lead Special Training Programthe CAS Center for Excellence in Particle Physics,the CAS International Partnership Program,and the CAS/SAFEA International Partnership Program for Creative Research Teams.
文摘The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.
基金Supported by the scientific research program of Xinjiang Uygur Autonomous Region grant 2016D01C012 the Scientific Research Program(XJEDU2016I046)of the Higher Education Institution of Xinjiang
文摘A graph is 1-planar if it can be drawn on the plane so that each edge is crossed by at most one other edge. In this paper, we verify the total coloring conjecture for every 1-planar graph G if either △（G） ≥9 and g（G）≥ 4, or △（G） ≥ 7 and g（G）≥5, where △（G） is the maximum degree of G and g（G） is the girth of G.
基金supported by National Natural Science Foundation of China(Grant No.11271006)
文摘A graph is 1-planar if it can be drawn on the plane so that each edge is crossed by at most one other edge. In this paper, we prove that every 1-planar graph G with maximum degree △（G） 〉 12 and girth at least five is totally （△（G）＋1）-colorable.
基金This research was supported by the National Basic Research Program of China （2011CB302600）, the National High Technology Research and Development Program of China （2012AA011201）, the National Natural Science Foundation of China （Grant Nos. 61161160565, 90818028, 91118008, 60903043）, and an NSFC/RGC Joint Research Scheme sponsored by the Research Grants Council of Hong Kong, China and National Natural Science Foundation of China Project （JC201104220300A）.
文摘The growing scale and complexity of component interactions in cloud computing systems post great challenges for operators to understand the characteristics of system performance. Profiling has long been proved to be an effective approach to performance analysis; however, existing approaches confront new challenges that emerge in cloud computing systems. First, the efficiency of the profiling becomes of critical concern; second, service-oriented profiling should be considered to support separation-of-concerns performance analysis. To address the above issues, in this paper, we present P-Tracer, an online performance profiling tool specifically tailored for cloud computing systems. P-Tracer constructs a specific search engine that proactively processes performance logs and generates a particular index for fast queries; second, for each service, P-Tracer retrieves a statistical insight of performance characteristics from multi-dimensions and provides operators with a suite of web-based interfaces to query the critical information. We evaluate P- Tracer in the aspects of tracing overheads, data preprocessing scalability and querying efficiency. Three real-world case studies that happened in Alibaba cloud computing platform demonstrate that P-Tracer can help operators understand soft-ware behaviors and localize the primary causes of performance anomalies effectively and efficiently.
基金Supported by National Natural Science Foundation of China(Grant No.11271006)
文摘A k-total-coloring of a graph G is a coloring of vertices and edges of G using k colors such that no two adjacent or incident elements receive the same color.In this paper,it is proved that if G is a planar graph with Δ（G） ≥ 7 and without chordal 7-cycles,then G has a（Δ（G） ＋ 1）-total-coloring.
基金supported by National Natural Science Foundation of China(No.12175253,12335012)the Program of Science Technology Service Network of Chinese Academy of Science,Youth Innovation Promotion Association CAS.
文摘Purpose Glass is a potential choice for the scintillator in Hadronic calorimetry(HCAL)of the CEPC.It requires sophisticated instruments and suitable methods to obtain scintillation properties of the glasses in the first time.It is necessary to establish an evaluation method for nuclear radiation detection performance of glass scintillator.Methods The spectroscopy research of the glass includes transmission/absorption spectrum and emission spectrum.The time characteristics include rise time,scintillation decay time and afterglow.The scintillation properties include light yield,energy resolution and minimum ionizing particle(MIP)response.And a new method for measuring the low light yield of glass scintillators is proposed.Results We have built a complete performance test system and evaluation method,which can evaluate the nuclear radiation detection performance of different glass scintillators.Conclusion By continuously improving the composition and preparation process of the glass,it can provide potential possibilities for the application in the high-energy physics experiment and nuclear radiation detection fields.
