目的参照瑞典Ahlqvist团队的聚类分型方式对新诊断T2DM患者进行分型,以探讨聚类分型下各亚型患者甲状腺功能和胰岛功能指标的特点。方法回顾性收集我院2019年1月—2022年6月365例新诊断T2DM患者的性别、年龄等一般资料及甲状腺功能、胰...目的参照瑞典Ahlqvist团队的聚类分型方式对新诊断T2DM患者进行分型,以探讨聚类分型下各亚型患者甲状腺功能和胰岛功能指标的特点。方法回顾性收集我院2019年1月—2022年6月365例新诊断T2DM患者的性别、年龄等一般资料及甲状腺功能、胰岛功能等临床资料。使用诊断年龄、BMI、糖化血红蛋白(HbA1c)、胰岛β细胞功能指数(HOMA2-β)和胰岛素抵抗指数(HOMA2-IR)这5个变量,对新诊断T2DM患者进行K均值聚类分析,分型成功后比较各亚型间甲状腺功能及胰岛功能的差异。结果聚类分型前:女性患者的诊断年龄、HOMA2-β、TSH值、甲状腺抗体阳性率、亚临床甲减患病率均高于男性,BMI、HbA1c、FPG、FT3值均低于男性,差异有统计学意义(P<0.05);INS、CP值在不同性别间比较差异无统计学意义(P>0.05)。聚类分型后各亚型甲状腺功能:SIDD亚型患者的T3、FT3水平均最低,MARD亚型患者的T4、FT4水平均最低,上述差异有统计学意义(P<0.05);而各亚型患者之间甲状腺抗体阳性率和甲状腺疾病患病率比较差异无统计学意义(P>0.05)。聚类分型后各亚型胰岛功能:SIDD亚型患者的胰岛功能和血糖控制情况较差,SIRD亚型患者的IR程度较重;MARD亚型患者的2 h CP最高,2 h INS在SIDD亚型患者中较高、MOD亚型患者中较低,上述差异有统计学意义(P<0.05)。结论聚类分型后各亚型特征稳定,可将新诊断2型糖尿病患者进行一个较为清晰的归类;各亚型间甲状腺功能指标无明显差异,胰岛功能指标特征差异显著。展开更多
The UN-led peacekeeping operation is a lodestar within the field of current international security.As an important example of her peaceful diplomacy,China has consistently and continuously supported the UN-led peaceke...The UN-led peacekeeping operation is a lodestar within the field of current international security.As an important example of her peaceful diplomacy,China has consistently and continuously supported the UN-led peacekeeping operations since 1998 when China joined the UN peacekeeping Operation Special Committee.The Chinese peacekeepers accomplished their UN-authorized missions successfully.With their impressive professionalism,high spirits,combat capabilities,and outstanding achievements,the Chinese peacekeepers have been highly acknowledged by the UN organizations,the host nations and the international media.展开更多
It is generally believed that regarding nuclear arms control the stronger sides in the strategic nuclear relations need to shoulder more responsibilities and take more substantive steps in developing CBMs.1 China,as a...It is generally believed that regarding nuclear arms control the stronger sides in the strategic nuclear relations need to shoulder more responsibilities and take more substantive steps in developing CBMs.1 China,as an asymmetrical participant in the international nuclear relations though,still plays a constructive role in stabilizing global security strategic structure.It should be pointed out展开更多
This essay intends to offer a comment on concepts, trends and attitudes concerning arms control and strategic stability with reference to the current international security situation. It also offers observations from ...This essay intends to offer a comment on concepts, trends and attitudes concerning arms control and strategic stability with reference to the current international security situation. It also offers observations from two different perspectives about strategic stability: one proceeds from the concept of universal security and aims to prevent conflicts and instability from disrupting regional and international security environment on which nation states depend so much for their peaceful development; the other starts from maintaining the global leadership by a super power and aiming to contain any challenge that sways or is likely to sway its dominating status. If China and the United States commit themselves to the undertaking of a new type of major powers relationship that stresses win-win cooperation, they will be able to contribute greatly to a stable international security architecture that is good for world peaceful development.展开更多
文摘目的参照瑞典Ahlqvist团队的聚类分型方式对新诊断T2DM患者进行分型,以探讨聚类分型下各亚型患者甲状腺功能和胰岛功能指标的特点。方法回顾性收集我院2019年1月—2022年6月365例新诊断T2DM患者的性别、年龄等一般资料及甲状腺功能、胰岛功能等临床资料。使用诊断年龄、BMI、糖化血红蛋白(HbA1c)、胰岛β细胞功能指数(HOMA2-β)和胰岛素抵抗指数(HOMA2-IR)这5个变量,对新诊断T2DM患者进行K均值聚类分析,分型成功后比较各亚型间甲状腺功能及胰岛功能的差异。结果聚类分型前:女性患者的诊断年龄、HOMA2-β、TSH值、甲状腺抗体阳性率、亚临床甲减患病率均高于男性,BMI、HbA1c、FPG、FT3值均低于男性,差异有统计学意义(P<0.05);INS、CP值在不同性别间比较差异无统计学意义(P>0.05)。聚类分型后各亚型甲状腺功能:SIDD亚型患者的T3、FT3水平均最低,MARD亚型患者的T4、FT4水平均最低,上述差异有统计学意义(P<0.05);而各亚型患者之间甲状腺抗体阳性率和甲状腺疾病患病率比较差异无统计学意义(P>0.05)。聚类分型后各亚型胰岛功能:SIDD亚型患者的胰岛功能和血糖控制情况较差,SIRD亚型患者的IR程度较重;MARD亚型患者的2 h CP最高,2 h INS在SIDD亚型患者中较高、MOD亚型患者中较低,上述差异有统计学意义(P<0.05)。结论聚类分型后各亚型特征稳定,可将新诊断2型糖尿病患者进行一个较为清晰的归类;各亚型间甲状腺功能指标无明显差异,胰岛功能指标特征差异显著。
文摘The UN-led peacekeeping operation is a lodestar within the field of current international security.As an important example of her peaceful diplomacy,China has consistently and continuously supported the UN-led peacekeeping operations since 1998 when China joined the UN peacekeeping Operation Special Committee.The Chinese peacekeepers accomplished their UN-authorized missions successfully.With their impressive professionalism,high spirits,combat capabilities,and outstanding achievements,the Chinese peacekeepers have been highly acknowledged by the UN organizations,the host nations and the international media.
文摘It is generally believed that regarding nuclear arms control the stronger sides in the strategic nuclear relations need to shoulder more responsibilities and take more substantive steps in developing CBMs.1 China,as an asymmetrical participant in the international nuclear relations though,still plays a constructive role in stabilizing global security strategic structure.It should be pointed out
文摘This essay intends to offer a comment on concepts, trends and attitudes concerning arms control and strategic stability with reference to the current international security situation. It also offers observations from two different perspectives about strategic stability: one proceeds from the concept of universal security and aims to prevent conflicts and instability from disrupting regional and international security environment on which nation states depend so much for their peaceful development; the other starts from maintaining the global leadership by a super power and aiming to contain any challenge that sways or is likely to sway its dominating status. If China and the United States commit themselves to the undertaking of a new type of major powers relationship that stresses win-win cooperation, they will be able to contribute greatly to a stable international security architecture that is good for world peaceful development.
