Background: Scar contractions caused by hand burns seriously impact both the function and appearance of the hand.Consequently,post-burn hand reconstruction is a primary focus of secondary reconstructive surgery perfor...Background: Scar contractions caused by hand burns seriously impact both the function and appearance of the hand.Consequently,post-burn hand reconstruction is a primary focus of secondary reconstructive surgery performed within the first 10 years after a burn injury.This study aimed to identify developmental trends and research hotspots in post-burn hand reconstruction,providing insights and recommendations for researchers.Methods: Bibliometric and visualization analyses were conducted using Cite Space v6.4.R1(64-bit) and VOS viewer.The Web of Science Core Collection served as the data source.A total of 136 articles between 1997 and2025 were included based on the following keywords: “postburn hand reconstruction” or “postburn hand” or“scar contraction hand deformity.”Results: The field of post-burn hand reconstruction is advancing,as indicated by the overall and annual increase in publications.The United States leads in number of published papers.However,major institutions show low centrality,indicating weak collaboration between countries and regions,with research still dominated by singlecenter studies.The top three most prolific authors were Paul P M van Zuijlen,Fatih Uyghur,and Ersin Uyghur.The keywords “double Z-plasty” and the cluster “flap” not only have high emergence intensity but also appear frequently in recent studies,marking them as current research hotspots.Conclusion: The lack of long-term research and consensus limits further advancements in post-burn hand reconstruction.To address this,multi-center and multi-disciplinary collaborations should be encouraged.Additionally,integrating basic medical research with biomedical engineering could enhance the management and outcomes of post-burn hand reconstruction.展开更多
In this report,we present the case of a 55-year-old woman with a 30-year history of multiple familial trichoe-pithelioma(MFT),with facial surface tumors that progressively worsened,causing ventilation disorders.In ord...In this report,we present the case of a 55-year-old woman with a 30-year history of multiple familial trichoe-pithelioma(MFT),with facial surface tumors that progressively worsened,causing ventilation disorders.In order to improve the patient’s appearance and functional impairment,we performed a two-step surgical excision and skin grafting procedure post diagnosis through genetic testing.The 18-month follow-up confirmed that the effect was satisfactory without obvious recurrence.Based on this outcome,we have developed a diagnosis and treat-ment process for patients with MFT,aiming to provide a reference for standardized treatment of this rare disease.展开更多
Background:Keloids are a common skin fibroproliferative disease that can result in severe aesthetic and functional concerns.Pruritus and pain are the most prevalent clinical manifestations of keloids.Schwann cells(SCs...Background:Keloids are a common skin fibroproliferative disease that can result in severe aesthetic and functional concerns.Pruritus and pain are the most prevalent clinical manifestations of keloids.Schwann cells(SCs)variation and neuropathy within keloids contribute to these uncomfortable sensations;however the underlying mechanisms remain unclear.This study aims to explore the potential role of fibroblasts(FBs)and SCs in pruritic and pain keloids.Methods:The activity of FBs and SCs was investigated using single-cell RNA sequencing(scRNA-seq)data of keloids.These bioinformatics analysis results were validated through in vitro cell culture,clinical samples,and in vivo experiments.The selected molecule was confirmed to be correlated with pain and itch and was subsequently used to treat cells in order to investigate its role in keloids.The in vivo inhibition assay was performed to evaluate its therapeutic potential.Results:Our scRNA-seq analysis identified specific types of FBs and SCs were present in higher proportions in keloids and exhibited neurogenesis-related functions.Upon conducting an interaction analysis of these two cell types,we identified a critical molecule,Midkine(MDK),which is positively correlated with the patients'pain and itching levels.Besides,MDK treatment facilitated the proliferation of SCs and their transition to a repairing phenotype,resulting in neuronal axonogenesis.This activation of repairing SCs promoted the release of substance P from nerve fibers,leading to clinical symptoms of pain and pruritus in keloid patients.Targeting MDK effectively reduces abnormal Schwann cell proliferation and subsequently inhibits the secretion of neuropeptides that trigger pain and pruritus.Conclusions:Our study uncovered the interaction between FBs and SCs in the development of keloidal pain and pruritus,offering a novel therapeutic strategy to alleviate the distressing symptoms of keloids.展开更多
文摘Background: Scar contractions caused by hand burns seriously impact both the function and appearance of the hand.Consequently,post-burn hand reconstruction is a primary focus of secondary reconstructive surgery performed within the first 10 years after a burn injury.This study aimed to identify developmental trends and research hotspots in post-burn hand reconstruction,providing insights and recommendations for researchers.Methods: Bibliometric and visualization analyses were conducted using Cite Space v6.4.R1(64-bit) and VOS viewer.The Web of Science Core Collection served as the data source.A total of 136 articles between 1997 and2025 were included based on the following keywords: “postburn hand reconstruction” or “postburn hand” or“scar contraction hand deformity.”Results: The field of post-burn hand reconstruction is advancing,as indicated by the overall and annual increase in publications.The United States leads in number of published papers.However,major institutions show low centrality,indicating weak collaboration between countries and regions,with research still dominated by singlecenter studies.The top three most prolific authors were Paul P M van Zuijlen,Fatih Uyghur,and Ersin Uyghur.The keywords “double Z-plasty” and the cluster “flap” not only have high emergence intensity but also appear frequently in recent studies,marking them as current research hotspots.Conclusion: The lack of long-term research and consensus limits further advancements in post-burn hand reconstruction.To address this,multi-center and multi-disciplinary collaborations should be encouraged.Additionally,integrating basic medical research with biomedical engineering could enhance the management and outcomes of post-burn hand reconstruction.
基金supported by the National Natural Science Foundation of China(grant nos.82272264 and 82072177).
文摘In this report,we present the case of a 55-year-old woman with a 30-year history of multiple familial trichoe-pithelioma(MFT),with facial surface tumors that progressively worsened,causing ventilation disorders.In order to improve the patient’s appearance and functional impairment,we performed a two-step surgical excision and skin grafting procedure post diagnosis through genetic testing.The 18-month follow-up confirmed that the effect was satisfactory without obvious recurrence.Based on this outcome,we have developed a diagnosis and treat-ment process for patients with MFT,aiming to provide a reference for standardized treatment of this rare disease.
基金supported by grants from National Natural Science Foundation of China(82072177,82272264,82472557)the China Postdoctoral Science Foundation(2024 M752023)Shanghai Plastic Surgery Research Center of Shanghai Priority Research Center(2023ZZ02023).
文摘Background:Keloids are a common skin fibroproliferative disease that can result in severe aesthetic and functional concerns.Pruritus and pain are the most prevalent clinical manifestations of keloids.Schwann cells(SCs)variation and neuropathy within keloids contribute to these uncomfortable sensations;however the underlying mechanisms remain unclear.This study aims to explore the potential role of fibroblasts(FBs)and SCs in pruritic and pain keloids.Methods:The activity of FBs and SCs was investigated using single-cell RNA sequencing(scRNA-seq)data of keloids.These bioinformatics analysis results were validated through in vitro cell culture,clinical samples,and in vivo experiments.The selected molecule was confirmed to be correlated with pain and itch and was subsequently used to treat cells in order to investigate its role in keloids.The in vivo inhibition assay was performed to evaluate its therapeutic potential.Results:Our scRNA-seq analysis identified specific types of FBs and SCs were present in higher proportions in keloids and exhibited neurogenesis-related functions.Upon conducting an interaction analysis of these two cell types,we identified a critical molecule,Midkine(MDK),which is positively correlated with the patients'pain and itching levels.Besides,MDK treatment facilitated the proliferation of SCs and their transition to a repairing phenotype,resulting in neuronal axonogenesis.This activation of repairing SCs promoted the release of substance P from nerve fibers,leading to clinical symptoms of pain and pruritus in keloid patients.Targeting MDK effectively reduces abnormal Schwann cell proliferation and subsequently inhibits the secretion of neuropeptides that trigger pain and pruritus.Conclusions:Our study uncovered the interaction between FBs and SCs in the development of keloidal pain and pruritus,offering a novel therapeutic strategy to alleviate the distressing symptoms of keloids.
