This article introduces a novel 20 V radiation-hardened high-voltage metal-oxide-semiconductor field-effect transistor(MOSFET)driver with an optimized input circuit and a drain-surrounding-source(DSS)structure.The inp...This article introduces a novel 20 V radiation-hardened high-voltage metal-oxide-semiconductor field-effect transistor(MOSFET)driver with an optimized input circuit and a drain-surrounding-source(DSS)structure.The input circuit of a conventional inverter consists of a thick-gate-oxide n-type MOSFET(NMOS).These conventional drivers can tolerate a total ionizing dose(TID)of up to 100 krad(Si).In contrast,the proposed comparator input circuit uses both a thick-gate-oxide p-type MOSFET(PMOS)and thin-gate-oxide NMOS to offer a high input voltage and higher TID tolerance.Because the thick-gate-oxide PMOS and thin-gate-oxide NMOS collectively provide better TID tolerance than the thick-gate-oxide NMOS,the circuit exhibits enhanced TID tolerance of>300 krad(Si).Simulations and experimental date indicate that the DSS structure reduces the probability of unwanted parasitic bipolar junction transistor activation,yielding a better single-event effect tolerance of over 81.8 MeVcm^(2)mg^(-1).The innovative strategy proposed in this study involves circuit and layout design optimization,and does not require any specialized process flow.Hence,the proposed circuit can be manufactured using common commercial 0.35μm BCD processes.展开更多
This work researched the impact of total dose irradiation on the threshold voltage of N-type metal oxide semiconductor field effect transistors(nMOSFETs) in silicon-on-insulator(SOI) technology.Using the subthreshold ...This work researched the impact of total dose irradiation on the threshold voltage of N-type metal oxide semiconductor field effect transistors(nMOSFETs) in silicon-on-insulator(SOI) technology.Using the subthreshold separation technology,the factor causing the threshold voltage shift was divided into two parts:trapped oxide charges and interface states,the effects of which are presented under irradiation.Furthermore,by analyzing the data,the threshold voltage shows a negative shift at first and then turns to positive shift when irradiation dose is lower.Additionally,the influence of the dose rate effects on threshold voltage is discussed.The research results show that the threshold voltage shift is more significant in low dose rate conditions,even for a low dose of100 krad(Si).The degeneration value of threshold voltage is 23.4%and 58.0%for the front-gate and the back-gate at the low dose rate,respectively.展开更多
The(GeTe)_(x)(AgSbTe_(2))_(100-x)alloys(TAGS-x)have been demonstrated as a promising p-type candidate for thermoelectric applications,attracting numerous atten-tions on the advancements of thermoelectric performance.M...The(GeTe)_(x)(AgSbTe_(2))_(100-x)alloys(TAGS-x)have been demonstrated as a promising p-type candidate for thermoelectric applications,attracting numerous atten-tions on the advancements of thermoelectric performance.Manipulation of carrier concentration for optimizing ther-moelectric performance in TAGS can be achieved by varying the ratio of Ag to Sb,and the Ag/Sb ratio of~2/3 has been proven as the optimal composition.Therefore,this work focuses on the systematic investigation on ther-moelectric properties of(GeTe)_(1-x)[(Ag_(2)Te)_(0.4)(Sb_(2)Te_(3))_(0.6)]_(x) alloys.The crystal structure for the alloys transfers from rhombohedral to cubic at room temperature as x≥0.2.The evolution of band parameter is estimated using a single parabolic band(SPB)model with acoustic phonon scat-tering.The density of states effective mass increases with x increasing,which leads to an enhancement of Seebeck coefficient along with a reduction in Hall mobility due to the additional carrier scattering by point defects.Mean-while,the lattice thermal conductivity of lower than~0.7 W·m^(-1)·K^(-1) in the entire temperature range and the lowest one of only 0.45 W·m^(-1)·K^(-1) is achieved due to additional phonon scattering by point defects.As a result,a peak thermoelectric figure of merit(zT)of~1.80 and an average one of~1.37 in 300–800 K are realized in non-stoichiometric TAGS alloys here.展开更多
The total dose effect of ^(60)Co γ-rays on 0.8μm H-gate partially depleted-silicon-on-insulator NMOS devices was investigated at different irradiation doses. The results show that the shift in saturation current at ...The total dose effect of ^(60)Co γ-rays on 0.8μm H-gate partially depleted-silicon-on-insulator NMOS devices was investigated at different irradiation doses. The results show that the shift in saturation current at high dose rate is greater than that at low dose rate, due to increase in interface-state density with decreasing dose rate; the scattering effect of interface state on electrons in the channel causes degradation in carrier mobility; and the body current and transconductance of the back gate enhance low-doserate sensitivity when the irradiation is under OFF-bias. A double transconductance peak is observed at 3 kGy(Si)under high dose rates.展开更多
The separation of aromatic/aliphatic hydrocarbon mixtures is a significant process in chemical industry, but challenged in some cases. Compared with conventional separation technologies, pervaporation is quite promisi...The separation of aromatic/aliphatic hydrocarbon mixtures is a significant process in chemical industry, but challenged in some cases. Compared with conventional separation technologies, pervaporation is quite promising in terms of its economical, energy-saving, and eco-friendly advantages. However, this technique has not been used in industry for separating aromatic/aliphatic mixtures yet. One of the main reasons is that the separation performance of existed pervaporation membranes is unsatisfactory. Membrane material is an important factor that affects the separation performance. This review provides an overview on the advances in studying membrane materials for the pervaporation separation of aromatic/aliphatic mixtures over the past decade. Explored pristine polymers and their hybrid materials(as hybrid membranes) are summarized to highlight their nature and separation performance. We anticipate that this review could provide some guidance in the development of new materials for the aromatic/aliphatic pervaporation separation.展开更多
The genus Ptyobathra Turner is newly reported from China. Ptyobathra recta sp. nov. is described as new; P. hypolepidota Turner, 1905 is newly recorded for China. Images of adults and genitalia are provided.
The genus Etiella Zeller, 1839 is reviewed in China. Etiella brevis sp. nov. is described as new; E. grisea Hampson, 1903 and E. walsinghamella Ragonot, 1888 are newly recorded for China. Images of adults and genitali...The genus Etiella Zeller, 1839 is reviewed in China. Etiella brevis sp. nov. is described as new; E. grisea Hampson, 1903 and E. walsinghamella Ragonot, 1888 are newly recorded for China. Images of adults and genitalia are provided, along with a key to all the known Chinese species of this genus.展开更多
Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of cancers.Discovery of new multi-target scaffolds are important for developing such agents. A series ...Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of cancers.Discovery of new multi-target scaffolds are important for developing such agents. A series of five novel acridine analogues,LXL 1-5,were synthesized and their antiproliferative activity against HepC-2 cell lines were evaluated,among which the 9-benzyloxyacridine analogue,LXL-5, showed inhibitory activity against tyrosine kinases,VEGFR-2 and Src.The results of UV-visible absorption spectra and fluorescence emission spectra,as well as DNA topoisomerase I inhibition assay, indicated topoisomerase I inhibitory activity.Our study suggested that acridine scaffold,previously shown to have no multi-target kinase and topoisomerase inhibitory activity,might be potentially developed as a multi-target inhibitor of tyrosine kinases and topoisomerase I.展开更多
Objective: This study used a bibliometric analysis to explore the research development of schizo-phrenia nursing in China from 2010 to 2014. Methods: The CNKI, VIP, and CBM databases were used to retrieve articles in ...Objective: This study used a bibliometric analysis to explore the research development of schizo-phrenia nursing in China from 2010 to 2014. Methods: The CNKI, VIP, and CBM databases were used to retrieve articles in China descri-bing schizophrenia nursing that met the predefined criteria from 2010 to 2014. Altogether, 1486 articles were included and analyzed by bibliometric methods. Results: The area of schizophrenia nursing had an annual average publication of 351 papers. The most productive institutions in schizophrenia nursing were located in Guangdong, Jiangsu, and Shandong, followed by Henan and Zhejiang. The papers were mainly published in the Medical Journal of Chinese People’ s Health and then in the International Journal of Nursing and the Chi-nese Journal of Modern Nursing. The study subjects mainly were on schizophrenics and then care-givers of schizophrenics ( including families, nursing assistant, nurse) . The most often used study designs in schizophrenia nursing research were a quasi-experimental study followed by experience reports and an investigational study. The research topics mainly focused on nursing intervention and rehabilitation training, followed by psychological, quality of life and social function. Conclusions: The schizophrenia nursing research has rapidly developed, with extensive content and abundant study topics, over the past 5 years.展开更多
Novel DNA binding agents against topoisomerases are needed for effective treatment of cancers. A series of new acridine-based derivatives 7a-7d were synthesized and their antiproliferative activity against K562 and He...Novel DNA binding agents against topoisomerases are needed for effective treatment of cancers. A series of new acridine-based derivatives 7a-7d were synthesized and their antiproliferative activity against K562 and HepG-2 cell lines were evaluated. Compound 7c with pyridin-2-yl-methanamino group substituted at the C9 position of acridine showed good antitumor activity against both cell lines. The DNA-binding affinity of compound 7c was evaluated by UV-vis absorption spectra and fluorescence emission spectra. DNA topoisomerase I mediated relaxation of plasmid pBR322 DNA was also tested. Our results suggested that compound 7c with good antitumor activity and topoisomerase I inhibition activity can be developed as a prime candidate for further chemical optimization.展开更多
Objective： This study aimed to explore adherence to and beliefs about immunosuppressive medication using the Necessity-Concerns Framework（NCF） in liver transplant recipients.Methods： A cross-sectional study perfor...Objective： This study aimed to explore adherence to and beliefs about immunosuppressive medication using the Necessity-Concerns Framework（NCF） in liver transplant recipients.Methods： A cross-sectional study performed in recipients who were at least 3 months post liver transplantation. A convenience sample of 243 recipients was recruited. Self-reported medication adherence was measured by the Basel Assessment of Adherence with Immunosuppressive Medication Scale（BAASIS）. The NCF was operationalized using the Beliefs about Medication Questionnaire（BMQ） to assess the beliefs about necessity and concerns with taking immunosuppressive medication.Results： One-hundred-forty-five liver transplant recipients were non-adherent（59.67%）. Compared to adherers, non-adherers had lower beliefs regarding the necessity of taking immunosuppressive medication and lower scores on the necessity-concerns different from adherers.Conclusions： Non-adherence is common in liver transplant recipients. Non-adherers hold beliefs that are different from adherers. Efforts to increase adherence should be made by targeting medication beliefs.展开更多
Single-crystalline samples of Eu/Ba-filled Sn-based type-Ⅷ clathrate are prepared by the Ga flux method with different stoichiometric ratios. The electrical transport properties of the samples are optimized by Eu dop...Single-crystalline samples of Eu/Ba-filled Sn-based type-Ⅷ clathrate are prepared by the Ga flux method with different stoichiometric ratios. The electrical transport properties of the samples are optimized by Eu doping. Results indicate that Eu atoms tend to replace Ba atoms. With the increase of the Eu initial content, the carrier density increases and the carrier mobility decreases, which leads to an increase of the Seebeck coefficient. By contrast, the electrical conductivity decreases. Finally, the sample with Eu initial content of x = 0.75 behaves with excellent electrical properties, which shows a maximal power factor of 1.51 mW·m^-1K^-2 at 480K, and the highest ZT achieved is 0.87 near the temperature of 483K.展开更多
Effects of initial surface termination on electrical characteristics of La2O3/Al2O3 nanolaminates deposited by atomic layer deposition are studied by conductive atomic force microscopy working in contact mode and stan...Effects of initial surface termination on electrical characteristics of La2O3/Al2O3 nanolaminates deposited by atomic layer deposition are studied by conductive atomic force microscopy working in contact mode and standard electrical characterization methods.It is found that,compared with La2O3/Al2O3 nanolaminates with LaOx as termination,lower interface trap density,less current leakage spots,and higher breakdown voltage are obtained in the La2O3/Al2O3 nanolaminates with AlOx as termination after annealing.A clear promotion of interface silicate layer is observed for La2O3/Al2O3 nanolaminates with AlOx as termination compared with LaOx as termination under the same annealing condition.In addition,the current conduction mechanism in La2O3/Al2O3 nanolaminates is considered as the Poole-Frenkel conduction.All results indicate that the AlOx is a more appropriate termination to deposit La2O3/Al2O3 nanolaminates on Si substrate,which is useful for the high-κ process development.展开更多
Protoplast isolation is relevant for many different applications and has been principally used in proceduresnvolving genetic manipulation. In this study, the age of mycelium, osmotic stabilizers, enzyme, incubation te...Protoplast isolation is relevant for many different applications and has been principally used in proceduresnvolving genetic manipulation. In this study, the age of mycelium, osmotic stabilizers, enzyme, incubation temperature and incubation time were evaluated in terms of their effects on protoplast yield. The young mycelia （3 d） of Tulasnella calospora were digested for 6 h at 30℃ in a mixture of 1.2 mol·L-1 MgSO_4 ＋ 10 mmoI·L-1 K2HPO4 as the osmotic stabilizer, with a 1.0% lysing enzyme and 1.5% driselase： more than 106 protoplasts mL-1 were obtained. When collected 3y density gradient centrifugation, the concentration of protoplasts can reach 107-108 protoplasts mL-1, an amount suitable enough for experiments of transformation in fungi. For every 10_5 protoplasts, about 15-25 protoplasts can egenerate after 24-36 h cultivation in a liquid medium and after 8-10 d in an agar medium. This study produced an efficient method for protoplast production, reverting them into a typical mycelia morphology using a Tulasnella calospora solate.展开更多
HoBi single crystal and polycrystalline compounds with Na Cl-type structure are successfully obtained,and their magnetic and magnetocaloric properties are studied in detail.With temperature increasing,Ho Bi compound u...HoBi single crystal and polycrystalline compounds with Na Cl-type structure are successfully obtained,and their magnetic and magnetocaloric properties are studied in detail.With temperature increasing,Ho Bi compound undergoes two magnetic transitions at 3.7 K and 6 K,respectively.The transition temperature at 6 K is recognized as an antiferromagneticto-paramagnetic(AFM–PM)transition,which belongs to the first-order magnetic phase transition(FOMT).It is interesting that the Ho Bi compound with FOMT exhibits good thermal and magnetic reversibility.Furthermore,a large inverse and normal magnetocaloric effect(MCE)is found in Ho Bi single crystal in the H||[100]direction,and the positive?SMpeak reaches 13.1 J/kg·K under a low field change of 2 T and the negative?S_(M)peak arrives at-18 J/kg·K under a field change of5 T.These excellent properties are expected to be applied to some magnetic refrigerators with special designs and functions.展开更多
Objective: To investigate the correlation of abnormal Toll-like receptor 4 (TLR4) /Myeloid differentiation factor 88 (MyD88) expression with ectopic cell proliferation and invasion in endometriosis lesions. Methods: P...Objective: To investigate the correlation of abnormal Toll-like receptor 4 (TLR4) /Myeloid differentiation factor 88 (MyD88) expression with ectopic cell proliferation and invasion in endometriosis lesions. Methods: Patients undergoing surgical treatment for ovarian endometriosis in Shenmu Hospital between April 2013 and July 2017 were selected as endometriosis (EMs) group, and patients undergoing surgical treatment due to uterine fibroids in Shenmu Hospital during the same period were selected as control group. The ectopic endometrium tissue was collected from EMs group and the eutopic normal endometrium tissue was collected from control group to determine the mRNA expression of TLR4/MyD88 as well as cell proliferation and invasion regulation genes. Results: TLR4, MyD88, cFLIP, Nanog, Oct4, eIF4E, Twist1, Twist2 and MMP1 mRNA expression in ectopic endometrium tissue of EMs group were significantly higher than those in eutopic normal endometrium tissue of control group whereas LC3, Smac, Bak, E-cadherin, TIMP1 and TIMP2 mRNA expression were significantly lower than those in eutopic normal endometrium tissue of control group;TLR4 and MyD88 mRNA expression in ectopic endometrium tissue of EMs group were negatively correlated with LC3, Smac, Bak, E-cadherin, TIMP1 and TIMP2 mRNA expression, and positively correlated with cFLIP, Nanog, Oct4, eIF4E, Twist1, Twist2 and MMP1 mRNA expression. Conclusion: The abnormal high expression of TLR4/MyD88 in the endometriosis lesion can promote the proliferation and invasion of ectopic cells.展开更多
This study prepares a group of single crystalline β-Zn_4Sb_3 with Ge and Sn codoped by the Sn-flux method according to the nominal stoichiometric ratios of Zn_（4.4）Sb_3 Ge_xSn_3（x = 0–0.15）. The prepared samples...This study prepares a group of single crystalline β-Zn_4Sb_3 with Ge and Sn codoped by the Sn-flux method according to the nominal stoichiometric ratios of Zn_（4.4）Sb_3 Ge_xSn_3（x = 0–0.15）. The prepared samples possess a metallic luster surface with perfect appearance and large crystal sizes. The microscopic cracks or defects are invisible in the samples from the back-scattered electron image. Except for the heavily Ge-doped sample of x = 0.15, all the samples are single phase with space group R3c. The thermal analysis results show that the samples doped with Ge exhibit an excellent thermal stability.Compared with the polycrystalline Ge-substituted β-Zn_4Sb_3, the present single crystals have higher carrier mobility, and hence the electrical conductivity is improved, which reaches 7.48×10~4S·m^（-1） at room temperature for the x = 0.1 sample.The change of Ge and Sn contents does not improve the Seebeck coefficient significantly. Benefiting from the increased electrical conductivity, the sample with x = 0.075 gets the highest power factor of 1.45×10^（-3）W·m^（-1）·K^（-2） at 543 K.展开更多
Objective:To investigate the influence of TRPV1 and LGR5 on downstream proliferation and invasion-related gene expression in endocardial cancer lesions.Methods:A total of 40 patients with endometrial cancer undergoing...Objective:To investigate the influence of TRPV1 and LGR5 on downstream proliferation and invasion-related gene expression in endocardial cancer lesions.Methods:A total of 40 patients with endometrial cancer undergoing surgical treatment in our hospital between June 2013 and June 2017 were selected, TRPV1 and LGR5 gene expression in endometrial cancer tissue and adjacent normal tissue were detected, and their median was referred to divide the patients into high TRPV1 group and low TRPV1 group as well as high LGR5 group and low LGR5 group, 20 cases in each group. The differences in proliferation and invasion gene expression in endometrial cancer tissues with different TRPV1 and LGR5 expression were compared. Results:TRPV1 and LGR5 gene expression in endometrial cancer tissues were significantly higher than those in adjacent tissues. Proliferation genes HMGB1, SRPX2 and Wip-1 mRNA expression in lesion tissues of high TRPV1 group and high LGR5 group were higher than those of low TRPV1 group and low LGR5 group respectively whereas ITLN-1 mRNA expression were lower than those of low TRPV1 group and low LGR5 group respectively;invasion genes MTA1, hnRNP H and Snail mRNA expression in lesion tissues of high TRPV1 group and high LGR5 group were higher than those of low TRPV1 group and low LGR5 group respectively whereas Dickkopf and DKK1 mRNA expression were lower than those of low TRPV1 group and low LGR5 group respectively.Conclusions:TRPV1 and LGR5 expression abnormally increase in endometrial cancer, which are directly correlated with the expression of downstream proliferation and invasion genes, and can affect the progress of the disease together.展开更多
Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque psoriasis.We conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in...Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque psoriasis.We conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque psoriasis.Methods:We randomly assigned 686 patients(2:1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12 weeks.The primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week 12.Results:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,P<0.05)and placebo(13.9%,P<0.05)groups.The proportion of patients achieving an sPGA score 0 or 1 was 66.3%in the benvitimod group and 63.9%in the calcipotriol group,which were both significantly higher than that in the placebo group(34%,P<0.05).In the long-term follow-up study,50.8%of patients experienced recurrence.After retreatment with 1%benvitimod,73.3%of patients achieved an sPGA score of 0 or 1 again at week 52.Adverse events included application site irritation,follicular papules,and contact dermatitis.No systemic adverse reactions were reported.Conclusion:During this 12-week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis.展开更多
Objectives To develop a high-performance liquid chromatography （HPLC） tandem mass spectrometry method for screening and identifying the multiple constituents in the complex Chinese materia medica （CMM） formulation...Objectives To develop a high-performance liquid chromatography （HPLC） tandem mass spectrometry method for screening and identifying the multiple constituents in the complex Chinese materia medica （CMM） formulation Sini Decoction. Methods The chemical constituents in Sini prescription as an entirety were isolated and analyzed by HPLC coupled with electrospray ionization ion-trap mass spectrometry （ESI-IT-MS） in order to clarify the chemical components of Sini Decoction and explore the chemical methods of studying CMM prescriptions. Results Twenty-five compounds were isolated from the water extract of this decoction. Through chemical and spectral analyses, the structures of 20 compounds were elucidated, including 15 flavonoids, one triterpene, two coumarins, and two other types of compounds. By using HPLC-DAD-MSn technique, the MSn cleavage behaviors of the flavonoids have been summarized as well as the origin of the isolated compounds was assigned. Conclusion The phytochemical compositon of Sini prescription is tentatively characterized by HPLC-DAD-ESI-IT-MS.. The results of the experiments demonstrate that the combination of HPLC and ESI-MSn is a sensitive and effective tool for rapidly investigating the complex CMM formulations.展开更多
基金supported by the National Natural Science Foundation of China(U2241221).
文摘This article introduces a novel 20 V radiation-hardened high-voltage metal-oxide-semiconductor field-effect transistor(MOSFET)driver with an optimized input circuit and a drain-surrounding-source(DSS)structure.The input circuit of a conventional inverter consists of a thick-gate-oxide n-type MOSFET(NMOS).These conventional drivers can tolerate a total ionizing dose(TID)of up to 100 krad(Si).In contrast,the proposed comparator input circuit uses both a thick-gate-oxide p-type MOSFET(PMOS)and thin-gate-oxide NMOS to offer a high input voltage and higher TID tolerance.Because the thick-gate-oxide PMOS and thin-gate-oxide NMOS collectively provide better TID tolerance than the thick-gate-oxide NMOS,the circuit exhibits enhanced TID tolerance of>300 krad(Si).Simulations and experimental date indicate that the DSS structure reduces the probability of unwanted parasitic bipolar junction transistor activation,yielding a better single-event effect tolerance of over 81.8 MeVcm^(2)mg^(-1).The innovative strategy proposed in this study involves circuit and layout design optimization,and does not require any specialized process flow.Hence,the proposed circuit can be manufactured using common commercial 0.35μm BCD processes.
基金supported by the Project of National Natural Science Foundation of China(Grant Nos.61376099,11235008,61434007)the Specialized Research Fund for the Doctoral Program of High Education(Grant No.20130203130002)
文摘This work researched the impact of total dose irradiation on the threshold voltage of N-type metal oxide semiconductor field effect transistors(nMOSFETs) in silicon-on-insulator(SOI) technology.Using the subthreshold separation technology,the factor causing the threshold voltage shift was divided into two parts:trapped oxide charges and interface states,the effects of which are presented under irradiation.Furthermore,by analyzing the data,the threshold voltage shows a negative shift at first and then turns to positive shift when irradiation dose is lower.Additionally,the influence of the dose rate effects on threshold voltage is discussed.The research results show that the threshold voltage shift is more significant in low dose rate conditions,even for a low dose of100 krad(Si).The degeneration value of threshold voltage is 23.4%and 58.0%for the front-gate and the back-gate at the low dose rate,respectively.
基金financially supported by the National Natural Science Foundation of China (Nos. 51861145305 and 52022068)the Fundamental Research Funds for Science and Technology Innovation Plan of Shanghai (No. 18JC1414600)+1 种基金Hefei National Laboratory for Physical Sciences at the Microscale (No. KF2020007)Shanghai Natural Science Foundation (No. 19ZR1459900)。
文摘The(GeTe)_(x)(AgSbTe_(2))_(100-x)alloys(TAGS-x)have been demonstrated as a promising p-type candidate for thermoelectric applications,attracting numerous atten-tions on the advancements of thermoelectric performance.Manipulation of carrier concentration for optimizing ther-moelectric performance in TAGS can be achieved by varying the ratio of Ag to Sb,and the Ag/Sb ratio of~2/3 has been proven as the optimal composition.Therefore,this work focuses on the systematic investigation on ther-moelectric properties of(GeTe)_(1-x)[(Ag_(2)Te)_(0.4)(Sb_(2)Te_(3))_(0.6)]_(x) alloys.The crystal structure for the alloys transfers from rhombohedral to cubic at room temperature as x≥0.2.The evolution of band parameter is estimated using a single parabolic band(SPB)model with acoustic phonon scat-tering.The density of states effective mass increases with x increasing,which leads to an enhancement of Seebeck coefficient along with a reduction in Hall mobility due to the additional carrier scattering by point defects.Mean-while,the lattice thermal conductivity of lower than~0.7 W·m^(-1)·K^(-1) in the entire temperature range and the lowest one of only 0.45 W·m^(-1)·K^(-1) is achieved due to additional phonon scattering by point defects.As a result,a peak thermoelectric figure of merit(zT)of~1.80 and an average one of~1.37 in 300–800 K are realized in non-stoichiometric TAGS alloys here.
基金supported by the National Natural Science Foundation of China(No.61376099)the Foundation for Fundamental Research of China(No.JSZL2016110B003)the Major Fundamental Research Program of Shaanxi(No.2017ZDJC-26)
文摘The total dose effect of ^(60)Co γ-rays on 0.8μm H-gate partially depleted-silicon-on-insulator NMOS devices was investigated at different irradiation doses. The results show that the shift in saturation current at high dose rate is greater than that at low dose rate, due to increase in interface-state density with decreasing dose rate; the scattering effect of interface state on electrons in the channel causes degradation in carrier mobility; and the body current and transconductance of the back gate enhance low-doserate sensitivity when the irradiation is under OFF-bias. A double transconductance peak is observed at 3 kGy(Si)under high dose rates.
基金Supported by the National Natural Science Foundation of China(21406006,21576003)the Science and Technology Program of Beijing Municipal Education Commission(KM201510005010)+1 种基金the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions(CIT&TCD20150309)the China Postdoctoral Science Foundation funded project(2015M580954)
文摘The separation of aromatic/aliphatic hydrocarbon mixtures is a significant process in chemical industry, but challenged in some cases. Compared with conventional separation technologies, pervaporation is quite promising in terms of its economical, energy-saving, and eco-friendly advantages. However, this technique has not been used in industry for separating aromatic/aliphatic mixtures yet. One of the main reasons is that the separation performance of existed pervaporation membranes is unsatisfactory. Membrane material is an important factor that affects the separation performance. This review provides an overview on the advances in studying membrane materials for the pervaporation separation of aromatic/aliphatic mixtures over the past decade. Explored pristine polymers and their hybrid materials(as hybrid membranes) are summarized to highlight their nature and separation performance. We anticipate that this review could provide some guidance in the development of new materials for the aromatic/aliphatic pervaporation separation.
基金supported by the National Natural Science Foundation of China(31093430 and 31172141)
文摘The genus Ptyobathra Turner is newly reported from China. Ptyobathra recta sp. nov. is described as new; P. hypolepidota Turner, 1905 is newly recorded for China. Images of adults and genitalia are provided.
基金supported by the National Natural Science Foundation of China(31093430 and 31172141)
文摘The genus Etiella Zeller, 1839 is reviewed in China. Etiella brevis sp. nov. is described as new; E. grisea Hampson, 1903 and E. walsinghamella Ragonot, 1888 are newly recorded for China. Images of adults and genitalia are provided, along with a key to all the known Chinese species of this genus.
基金supports from the Ministry of Science and Technology of China(Nos. 2012ZX09506001-010,2012AA020305 and 2011DFA30620)the National Natural Science Foundation of China(Nos.21272134 and 20902053)Shenzhen Sci & Tech Bureau(No. JCYJ20120831165730905)
文摘Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of cancers.Discovery of new multi-target scaffolds are important for developing such agents. A series of five novel acridine analogues,LXL 1-5,were synthesized and their antiproliferative activity against HepC-2 cell lines were evaluated,among which the 9-benzyloxyacridine analogue,LXL-5, showed inhibitory activity against tyrosine kinases,VEGFR-2 and Src.The results of UV-visible absorption spectra and fluorescence emission spectra,as well as DNA topoisomerase I inhibition assay, indicated topoisomerase I inhibitory activity.Our study suggested that acridine scaffold,previously shown to have no multi-target kinase and topoisomerase inhibitory activity,might be potentially developed as a multi-target inhibitor of tyrosine kinases and topoisomerase I.
基金supported by research fund of Beijing University of Chinese Medicine(No.2013-X-060)
文摘Objective: This study used a bibliometric analysis to explore the research development of schizo-phrenia nursing in China from 2010 to 2014. Methods: The CNKI, VIP, and CBM databases were used to retrieve articles in China descri-bing schizophrenia nursing that met the predefined criteria from 2010 to 2014. Altogether, 1486 articles were included and analyzed by bibliometric methods. Results: The area of schizophrenia nursing had an annual average publication of 351 papers. The most productive institutions in schizophrenia nursing were located in Guangdong, Jiangsu, and Shandong, followed by Henan and Zhejiang. The papers were mainly published in the Medical Journal of Chinese People’ s Health and then in the International Journal of Nursing and the Chi-nese Journal of Modern Nursing. The study subjects mainly were on schizophrenics and then care-givers of schizophrenics ( including families, nursing assistant, nurse) . The most often used study designs in schizophrenia nursing research were a quasi-experimental study followed by experience reports and an investigational study. The research topics mainly focused on nursing intervention and rehabilitation training, followed by psychological, quality of life and social function. Conclusions: The schizophrenia nursing research has rapidly developed, with extensive content and abundant study topics, over the past 5 years.
基金the Ministry of Science and Technology of the People’s Republic of China(Nos.2012AA020305and 2011DFA30620)the National Natural Science Foundation of China(Nos.21272134 and 21372141)Shenzhen Sci.&Tech.Bureau(No.JCYJ20120831165730905)for the financial supports
文摘Novel DNA binding agents against topoisomerases are needed for effective treatment of cancers. A series of new acridine-based derivatives 7a-7d were synthesized and their antiproliferative activity against K562 and HepG-2 cell lines were evaluated. Compound 7c with pyridin-2-yl-methanamino group substituted at the C9 position of acridine showed good antitumor activity against both cell lines. The DNA-binding affinity of compound 7c was evaluated by UV-vis absorption spectra and fluorescence emission spectra. DNA topoisomerase I mediated relaxation of plasmid pBR322 DNA was also tested. Our results suggested that compound 7c with good antitumor activity and topoisomerase I inhibition activity can be developed as a prime candidate for further chemical optimization.
基金supported by State Scholarship Fund(No.201506555004)China Scholarship CouncilBeijing Natural Science Foundation of China(No.7144223)
文摘Objective： This study aimed to explore adherence to and beliefs about immunosuppressive medication using the Necessity-Concerns Framework（NCF） in liver transplant recipients.Methods： A cross-sectional study performed in recipients who were at least 3 months post liver transplantation. A convenience sample of 243 recipients was recruited. Self-reported medication adherence was measured by the Basel Assessment of Adherence with Immunosuppressive Medication Scale（BAASIS）. The NCF was operationalized using the Beliefs about Medication Questionnaire（BMQ） to assess the beliefs about necessity and concerns with taking immunosuppressive medication.Results： One-hundred-forty-five liver transplant recipients were non-adherent（59.67%）. Compared to adherers, non-adherers had lower beliefs regarding the necessity of taking immunosuppressive medication and lower scores on the necessity-concerns different from adherers.Conclusions： Non-adherence is common in liver transplant recipients. Non-adherers hold beliefs that are different from adherers. Efforts to increase adherence should be made by targeting medication beliefs.
基金Supported by the National Natural Science Foundation of China under Grant No 51262032
文摘Single-crystalline samples of Eu/Ba-filled Sn-based type-Ⅷ clathrate are prepared by the Ga flux method with different stoichiometric ratios. The electrical transport properties of the samples are optimized by Eu doping. Results indicate that Eu atoms tend to replace Ba atoms. With the increase of the Eu initial content, the carrier density increases and the carrier mobility decreases, which leads to an increase of the Seebeck coefficient. By contrast, the electrical conductivity decreases. Finally, the sample with Eu initial content of x = 0.75 behaves with excellent electrical properties, which shows a maximal power factor of 1.51 mW·m^-1K^-2 at 480K, and the highest ZT achieved is 0.87 near the temperature of 483K.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61604016 and 51802025)China Postdoctoral Science Foundation(Grant No.2017M613028)+1 种基金the Fundamental Research Funds for the Central Universities,China(Grant Nos.300102319209 and 300102310501)the Innovation,and Entrepreneurship Training Program for Undergraduates(Grant Nos.202010710231 and 201910710564).
文摘Effects of initial surface termination on electrical characteristics of La2O3/Al2O3 nanolaminates deposited by atomic layer deposition are studied by conductive atomic force microscopy working in contact mode and standard electrical characterization methods.It is found that,compared with La2O3/Al2O3 nanolaminates with LaOx as termination,lower interface trap density,less current leakage spots,and higher breakdown voltage are obtained in the La2O3/Al2O3 nanolaminates with AlOx as termination after annealing.A clear promotion of interface silicate layer is observed for La2O3/Al2O3 nanolaminates with AlOx as termination compared with LaOx as termination under the same annealing condition.In addition,the current conduction mechanism in La2O3/Al2O3 nanolaminates is considered as the Poole-Frenkel conduction.All results indicate that the AlOx is a more appropriate termination to deposit La2O3/Al2O3 nanolaminates on Si substrate,which is useful for the high-κ process development.
基金supported by the National Key Project of Scientific and Technical Supporting Programs funded by the Ministry of Science & Technology, China (No. 2012BAC01B05-3)
文摘Protoplast isolation is relevant for many different applications and has been principally used in proceduresnvolving genetic manipulation. In this study, the age of mycelium, osmotic stabilizers, enzyme, incubation temperature and incubation time were evaluated in terms of their effects on protoplast yield. The young mycelia （3 d） of Tulasnella calospora were digested for 6 h at 30℃ in a mixture of 1.2 mol·L-1 MgSO_4 ＋ 10 mmoI·L-1 K2HPO4 as the osmotic stabilizer, with a 1.0% lysing enzyme and 1.5% driselase： more than 106 protoplasts mL-1 were obtained. When collected 3y density gradient centrifugation, the concentration of protoplasts can reach 107-108 protoplasts mL-1, an amount suitable enough for experiments of transformation in fungi. For every 10_5 protoplasts, about 15-25 protoplasts can egenerate after 24-36 h cultivation in a liquid medium and after 8-10 d in an agar medium. This study produced an efficient method for protoplast production, reverting them into a typical mycelia morphology using a Tulasnella calospora solate.
基金the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province,China(Grant No.2021L304)the Taiyuan University of Science and Technology Scientific Research Initial Funding,China(Grant Nos.20202022 and 20222002)+2 种基金the Funding for Outstanding Doctoral Research in Jin,China(Grant No.20212002)the Fund from the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology,China(Grant No.2022-KF-32)the National Natural Science Foundation of China(Grant No.51901150)。
文摘HoBi single crystal and polycrystalline compounds with Na Cl-type structure are successfully obtained,and their magnetic and magnetocaloric properties are studied in detail.With temperature increasing,Ho Bi compound undergoes two magnetic transitions at 3.7 K and 6 K,respectively.The transition temperature at 6 K is recognized as an antiferromagneticto-paramagnetic(AFM–PM)transition,which belongs to the first-order magnetic phase transition(FOMT).It is interesting that the Ho Bi compound with FOMT exhibits good thermal and magnetic reversibility.Furthermore,a large inverse and normal magnetocaloric effect(MCE)is found in Ho Bi single crystal in the H||[100]direction,and the positive?SMpeak reaches 13.1 J/kg·K under a low field change of 2 T and the negative?S_(M)peak arrives at-18 J/kg·K under a field change of5 T.These excellent properties are expected to be applied to some magnetic refrigerators with special designs and functions.
文摘Objective: To investigate the correlation of abnormal Toll-like receptor 4 (TLR4) /Myeloid differentiation factor 88 (MyD88) expression with ectopic cell proliferation and invasion in endometriosis lesions. Methods: Patients undergoing surgical treatment for ovarian endometriosis in Shenmu Hospital between April 2013 and July 2017 were selected as endometriosis (EMs) group, and patients undergoing surgical treatment due to uterine fibroids in Shenmu Hospital during the same period were selected as control group. The ectopic endometrium tissue was collected from EMs group and the eutopic normal endometrium tissue was collected from control group to determine the mRNA expression of TLR4/MyD88 as well as cell proliferation and invasion regulation genes. Results: TLR4, MyD88, cFLIP, Nanog, Oct4, eIF4E, Twist1, Twist2 and MMP1 mRNA expression in ectopic endometrium tissue of EMs group were significantly higher than those in eutopic normal endometrium tissue of control group whereas LC3, Smac, Bak, E-cadherin, TIMP1 and TIMP2 mRNA expression were significantly lower than those in eutopic normal endometrium tissue of control group;TLR4 and MyD88 mRNA expression in ectopic endometrium tissue of EMs group were negatively correlated with LC3, Smac, Bak, E-cadherin, TIMP1 and TIMP2 mRNA expression, and positively correlated with cFLIP, Nanog, Oct4, eIF4E, Twist1, Twist2 and MMP1 mRNA expression. Conclusion: The abnormal high expression of TLR4/MyD88 in the endometriosis lesion can promote the proliferation and invasion of ectopic cells.
基金Project supported by the National Natural Science Foundation of China(Grant No.51262032)
文摘This study prepares a group of single crystalline β-Zn_4Sb_3 with Ge and Sn codoped by the Sn-flux method according to the nominal stoichiometric ratios of Zn_（4.4）Sb_3 Ge_xSn_3（x = 0–0.15）. The prepared samples possess a metallic luster surface with perfect appearance and large crystal sizes. The microscopic cracks or defects are invisible in the samples from the back-scattered electron image. Except for the heavily Ge-doped sample of x = 0.15, all the samples are single phase with space group R3c. The thermal analysis results show that the samples doped with Ge exhibit an excellent thermal stability.Compared with the polycrystalline Ge-substituted β-Zn_4Sb_3, the present single crystals have higher carrier mobility, and hence the electrical conductivity is improved, which reaches 7.48×10~4S·m^（-1） at room temperature for the x = 0.1 sample.The change of Ge and Sn contents does not improve the Seebeck coefficient significantly. Benefiting from the increased electrical conductivity, the sample with x = 0.075 gets the highest power factor of 1.45×10^（-3）W·m^（-1）·K^（-2） at 543 K.
文摘Objective:To investigate the influence of TRPV1 and LGR5 on downstream proliferation and invasion-related gene expression in endocardial cancer lesions.Methods:A total of 40 patients with endometrial cancer undergoing surgical treatment in our hospital between June 2013 and June 2017 were selected, TRPV1 and LGR5 gene expression in endometrial cancer tissue and adjacent normal tissue were detected, and their median was referred to divide the patients into high TRPV1 group and low TRPV1 group as well as high LGR5 group and low LGR5 group, 20 cases in each group. The differences in proliferation and invasion gene expression in endometrial cancer tissues with different TRPV1 and LGR5 expression were compared. Results:TRPV1 and LGR5 gene expression in endometrial cancer tissues were significantly higher than those in adjacent tissues. Proliferation genes HMGB1, SRPX2 and Wip-1 mRNA expression in lesion tissues of high TRPV1 group and high LGR5 group were higher than those of low TRPV1 group and low LGR5 group respectively whereas ITLN-1 mRNA expression were lower than those of low TRPV1 group and low LGR5 group respectively;invasion genes MTA1, hnRNP H and Snail mRNA expression in lesion tissues of high TRPV1 group and high LGR5 group were higher than those of low TRPV1 group and low LGR5 group respectively whereas Dickkopf and DKK1 mRNA expression were lower than those of low TRPV1 group and low LGR5 group respectively.Conclusions:TRPV1 and LGR5 expression abnormally increase in endometrial cancer, which are directly correlated with the expression of downstream proliferation and invasion genes, and can affect the progress of the disease together.
基金Beijing Wenfeng Tianji Pharma Ltd.and the grant from National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2011ZX09101-006-02)。
文摘Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque psoriasis.We conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque psoriasis.Methods:We randomly assigned 686 patients(2:1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12 weeks.The primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week 12.Results:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,P<0.05)and placebo(13.9%,P<0.05)groups.The proportion of patients achieving an sPGA score 0 or 1 was 66.3%in the benvitimod group and 63.9%in the calcipotriol group,which were both significantly higher than that in the placebo group(34%,P<0.05).In the long-term follow-up study,50.8%of patients experienced recurrence.After retreatment with 1%benvitimod,73.3%of patients achieved an sPGA score of 0 or 1 again at week 52.Adverse events included application site irritation,follicular papules,and contact dermatitis.No systemic adverse reactions were reported.Conclusion:During this 12-week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis.
文摘Objectives To develop a high-performance liquid chromatography （HPLC） tandem mass spectrometry method for screening and identifying the multiple constituents in the complex Chinese materia medica （CMM） formulation Sini Decoction. Methods The chemical constituents in Sini prescription as an entirety were isolated and analyzed by HPLC coupled with electrospray ionization ion-trap mass spectrometry （ESI-IT-MS） in order to clarify the chemical components of Sini Decoction and explore the chemical methods of studying CMM prescriptions. Results Twenty-five compounds were isolated from the water extract of this decoction. Through chemical and spectral analyses, the structures of 20 compounds were elucidated, including 15 flavonoids, one triterpene, two coumarins, and two other types of compounds. By using HPLC-DAD-MSn technique, the MSn cleavage behaviors of the flavonoids have been summarized as well as the origin of the isolated compounds was assigned. Conclusion The phytochemical compositon of Sini prescription is tentatively characterized by HPLC-DAD-ESI-IT-MS.. The results of the experiments demonstrate that the combination of HPLC and ESI-MSn is a sensitive and effective tool for rapidly investigating the complex CMM formulations.
