Cell membranes have recently emerged as a new source of materials for molecular delivery systems.Cell membranes have been extruded or sonicated to make nanoscale vesicles.Unlike synthetic lipid or polymeric nanopartic...Cell membranes have recently emerged as a new source of materials for molecular delivery systems.Cell membranes have been extruded or sonicated to make nanoscale vesicles.Unlike synthetic lipid or polymeric nanoparticles,cell membrane-derived vesicles have a unique multicomponent feature,comprising lipids,proteins,and carbohydrates.Because cell membrane-derived vesicles contain the intrinsic functionalities and signaling networks of their parent cells,they can overcome various obstacles encountered in vivo.Moreover,the different natural combinations of membranes from various cell sources expand the range of cell membrane-derived vesicles,creating an entirely new category of drug-delivery systems.Cell membrane-derived vesicles can carry therapeutic agents within their interior or can coat the surfaces of drug-loaded core nanoparticles.Cell membranes typically come from single cell sources,including red blood cells,platelets,immune cells,stem cells,and cancer cells.However,recent studies have reported hybrid sources from two different types of cells.This review will summarize approaches for manufacturing cell membrane-derived vesicles and treatment applications of various types of cell membrane-derived drug-delivery systems,and discuss challenges and future directions.展开更多
基金supported by grants from the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(NRF-2021R1A2B5B03002123,NRF-2018R1A5A2024425,Republic of Korea)the Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health&Welfare,the Ministry of Food and Drug Safety+1 种基金NTIS Number:9991007273,Republic of Korea)the Korean Health Technology R&D Project(No.HI18C2177,HI19C0664,Republic of Korea),Ministry of Health&Welfare
文摘Cell membranes have recently emerged as a new source of materials for molecular delivery systems.Cell membranes have been extruded or sonicated to make nanoscale vesicles.Unlike synthetic lipid or polymeric nanoparticles,cell membrane-derived vesicles have a unique multicomponent feature,comprising lipids,proteins,and carbohydrates.Because cell membrane-derived vesicles contain the intrinsic functionalities and signaling networks of their parent cells,they can overcome various obstacles encountered in vivo.Moreover,the different natural combinations of membranes from various cell sources expand the range of cell membrane-derived vesicles,creating an entirely new category of drug-delivery systems.Cell membrane-derived vesicles can carry therapeutic agents within their interior or can coat the surfaces of drug-loaded core nanoparticles.Cell membranes typically come from single cell sources,including red blood cells,platelets,immune cells,stem cells,and cancer cells.However,recent studies have reported hybrid sources from two different types of cells.This review will summarize approaches for manufacturing cell membrane-derived vesicles and treatment applications of various types of cell membrane-derived drug-delivery systems,and discuss challenges and future directions.
