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微矩阵电极在人类多功能干细胞分化的心肌细胞上的应用
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作者 卢珺 heming wei 张广钦 《中国现代药物应用》 2012年第5期11-13,共3页
目的应用微矩阵电极系统MEA(Multielectrode Array,MEA)鉴别人类多功能干细胞分化的心肌细胞的电生理特性并建立体外药物检测平台。方法将人类多功能干细胞分化的心肌细胞团贴于经0.1%明胶处理过的MEA芯片,培养3d后,心肌细胞团保持节律... 目的应用微矩阵电极系统MEA(Multielectrode Array,MEA)鉴别人类多功能干细胞分化的心肌细胞的电生理特性并建立体外药物检测平台。方法将人类多功能干细胞分化的心肌细胞团贴于经0.1%明胶处理过的MEA芯片,培养3d后,心肌细胞团保持节律性收缩,应用McRack采集分析软件记录给予10M河豚毒素(TTX)前后心肌细胞场电位(field potential duration,FPD)和心率(heart rate)的变化。结果该方法可用于记录心肌细胞胞外电生理特性;10M的TTX可降低心率,缩短FP min的幅度。结论该技术操作简单,高效,可成功记录人类多功能干细胞分化的心肌细胞的电生理特性,并可用于临床药物筛选。 展开更多
关键词 诱导性多功能干细胞 心肌细胞 药物检测
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Simultaneous temperature and strain sensing based on a supermode interferometer
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作者 Zhifeng Wang Jing Wen +3 位作者 Mengshi Zhu heming wei Liang Zhang Fufei Pang 《Chinese Optics Letters》 2025年第1期48-54,共7页
A novel Mach–Zehnder interferometer(MZI)sensor based on multiple supermode interferences that can be used for dualparameter measurements of temperature and strain is proposed and demonstrated.The MZI is made by splic... A novel Mach–Zehnder interferometer(MZI)sensor based on multiple supermode interferences that can be used for dualparameter measurements of temperature and strain is proposed and demonstrated.The MZI is made by splicing a coupled four-core sapphire-derived fiber(FSDF)between two single-mode fibers,utilizing the differences in temperature response and strain response of different supermodes in the FSDF to realize the simultaneous measurement of the two parameters.Experimental results demonstrate that the proposed MZI can achieve up to 1600μεand 1000℃ measurements with a temperature-strain cross-sensitivity of approximately 0.075℃/με. 展开更多
关键词 SUPERMODE dual-parameter measurement fiber optic sensor Mach-Zehnder interferometer
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Two-photon 3D printed spring-based Fabry-Pérot cavity resonator for acoustic wave detection and imaging 被引量:5
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作者 heming wei ZHANGLI WU +8 位作者 KEXUAN SUN HAIYAN ZHANG CHEN WANG KEMIN WANG TIAN YANG FUFEI PANG XIAOBEI ZHANG TINGYUN WANG SRIDHAR KRISHNASWAMY 《Photonics Research》 SCIE EI CAS CSCD 2023年第5期780-786,共7页
Optical fiber microresonators have attracted considerable interest for acoustic detection because of their compact size and high optical quality.Here,we have proposed,designed,and fabricated a spring-based Fabry-P... Optical fiber microresonators have attracted considerable interest for acoustic detection because of their compact size and high optical quality.Here,we have proposed,designed,and fabricated a spring-based Fabry-Pérot cavity microresonator for highly sensitive acoustic detection.We observed two resonator vibration modes:one relating to the spring vibration state and the other determined by the point-clamped circular plate vibration mode.We found that the vibration modes can be coupled and optimized by changing the structure size.The proposed resonator is directly 3D printed on an optical fiber tip through two-photon polymerization and is used for acoustic detection and imaging.The experiments show that the device exhibits a high sensitivity and low noise equivalent acoustic signal level of 2.39 mPa∕Hz^(1∕2)at 75 kHz that can detect weak acoustic waves,which can be used for underwater object imaging.The results demonstrate that the proposed work has great potential in acoustic detection and biomedical imaging applications. 展开更多
关键词 RESONATOR FIBER CAVITY
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Direct laser writing spiral Sagnac waveguide for ultrahigh magnetic field sensing 被引量:1
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作者 Dengwei Zhang Zhihang Zhang +2 位作者 heming wei Jianrong Qiu Sridhar Krishnaswamy 《Photonics Research》 SCIE EI CAS CSCD 2021年第10期1984-1991,共8页
A high-birefringence spiral Sagnac waveguide(SSW)device fabricated via direct laser writing(DLW)using a two-photon polymerization(2PP)technique is proposed,designed,and experimentally demonstrated as an ultrahigh magn... A high-birefringence spiral Sagnac waveguide(SSW)device fabricated via direct laser writing(DLW)using a two-photon polymerization(2PP)technique is proposed,designed,and experimentally demonstrated as an ultrahigh magnetic field sensor.The sensor comprises a Y-style tapered waveguide and an SSW containing two microfluidic channels.The SSW has a total length of∼2.4 mm and a spiral radius of∼200μm.Due to the asymmetric structure,the SSW has a high birefringence of 0.016,which can be designed as a magnetic field sensor,as a magnetic fluid can be filled into the microfluidic channel changing the guiding mode and the birefringence and consequently leading to a change in phase of the interferometer when the applied magnetic field changes.The experimental results show that the proposed photonic device has a sensitivity to magnetic fields as high as 0.48 nm/Oe within a range from 10 to 100 Oe.The proposed device is very stable and easy to fabricate,and it can therefore be used for weak magnetic field detection. 展开更多
关键词 WAVEGUIDE LASER INTERFEROMETER
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Two-photon 3D printed fiber-optic Fabry–Perot probe for triaxial contact force detection of guidewire tips 被引量:1
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作者 RUIXUE YIN YUHANG YANG +3 位作者 LINSONG HOU heming wei HONGBO ZHANG WENJUN ZHANG 《Photonics Research》 CSCD 2024年第11期2474-2487,共14页
The demand for real-time feedback and miniaturization of sensing elements is a crucial issue in the treating vascular diseases with minimally invasive interventions.Here,Fabry–Perot microcavities fabricated via direc... The demand for real-time feedback and miniaturization of sensing elements is a crucial issue in the treating vascular diseases with minimally invasive interventions.Here,Fabry–Perot microcavities fabricated via direct laser writing using a two-photon polymerization technique on fiber tips are proposed,designed,simulated,and experimentally demonstrated as a miniature triaxial force sensor for monitoring real-time interactions between the tip of a guidewire and human blood vessels and tissues during minimally invasive surgeries.The sensor contains four fiber tip-based Fabry–Perot cavities,which can be seamlessly integrated into medical guidewires and achieves three-axis force decoupling through symmetrically arranged flexible structures.The results showed that the proposed sensor achieved a cross-sectional diameter of 890μm and a high sensitivity of about 85.16 nm/N within a range of 0 to 0.5 N with a resolution of hundreds of micro-Newtons.The proposed triaxial force sensor exhibits high resolution,good biocompatibility,and electromagnetic compatibility,which can be utilized as an efficient monitoring tool integrated into minimally invasive surgical intervention devices for biomedical applications. 展开更多
关键词 sectional utilized compatibility
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