Acid-base dissociable antibiotic-metal complexes are known to be emerging contaminants in the aquatic environments.However,little information is available on the photochemical properties and toxicity of these complex ...Acid-base dissociable antibiotic-metal complexes are known to be emerging contaminants in the aquatic environments.However,little information is available on the photochemical properties and toxicity of these complex forms.This study investigated the spectral properties of three fluoroquinolones(FQs)with and without metal ions Fe(III),Cu(II),and Al(III)in solutions under different pH conditions,as well as evaluated the changes in toxicity due to the complex with thesemetal ions using luminescent bacteria(vibrio fischeri).FQs showed a higher tendency to coordinate metal ions under alkaline conditions compared to neutral and acidic conditions,and the formation of complexes weakened the ultravioletabsorbing ability of FQs.At pH=7.0,Cu(II)quenched the fluorescence intensity of FQs.Moreover,their Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy were explored,revealing that the coordination sites of Cu(II)in three FQs were situated in a bidentate manner through the oxygen atom of the deprotonated carboxyl group and cyclic carbonyl oxygen atom.This conclusion was further verified by the theory of molecular surface electrostatic potential.In addition,except for complexes of ciprofloxacin-metals,enhanced toxicity of FQs upon coordination with Fe(III)was observed,while reduced toxicity was found for coordination with Cu(II)and Al(III).These results are important for accurately evaluating the photochemical behavior and risk of these antibiotics in aquatic environments contaminated with metal ions.展开更多
Continuous passive motion(CPM)is an adjunct therapy to the standard postoperative rehabilitation regimen of joint injuries.The capability of real-time monitoring actual bending angle of knee joints is highly desired f...Continuous passive motion(CPM)is an adjunct therapy to the standard postoperative rehabilitation regimen of joint injuries.The capability of real-time monitoring actual bending angle of knee joints is highly desired for treatment strategies of personalized postoperative rehabilitation and telemedicine.Here we report an intelligent CPM system for personalized rehabilitation and telemedicine based on the flexible and versatile ionotronic that possesses impressive mechanical properties(2.56 MPa tensile strength;11.63 MJ m^(−3)toughness),fast self-recovery ability(60 s)and broaden environmental tolerance(−60–45°C).Especially,the ionotronic responds fast and shows stability for cyclic strain sensing,ensuring the detection of actual joint bending angle with high sensitivity and reliability.The intelligent CPM system assembled with this ionotronic and a wireless transmitter was constructed,opening up a horizon for developing digital intelligent medical that can remotely monitor the movement of hospitalized/at-home patients who use CPM for personalized postoperative rehabilitation.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21976045 and 22076112)China Scholarship Council(CSC)Scholarship(Nos.202208610125 and 202308610123)+1 种基金Shaanxi Key Laboratory of Environmental Monitoring and Forewarning of Trace Pollutants(No.SHJKFJJ202318)the Key Research and Development Program of Shaanxi Province(No.2024SF-YBXM-567).
文摘Acid-base dissociable antibiotic-metal complexes are known to be emerging contaminants in the aquatic environments.However,little information is available on the photochemical properties and toxicity of these complex forms.This study investigated the spectral properties of three fluoroquinolones(FQs)with and without metal ions Fe(III),Cu(II),and Al(III)in solutions under different pH conditions,as well as evaluated the changes in toxicity due to the complex with thesemetal ions using luminescent bacteria(vibrio fischeri).FQs showed a higher tendency to coordinate metal ions under alkaline conditions compared to neutral and acidic conditions,and the formation of complexes weakened the ultravioletabsorbing ability of FQs.At pH=7.0,Cu(II)quenched the fluorescence intensity of FQs.Moreover,their Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy were explored,revealing that the coordination sites of Cu(II)in three FQs were situated in a bidentate manner through the oxygen atom of the deprotonated carboxyl group and cyclic carbonyl oxygen atom.This conclusion was further verified by the theory of molecular surface electrostatic potential.In addition,except for complexes of ciprofloxacin-metals,enhanced toxicity of FQs upon coordination with Fe(III)was observed,while reduced toxicity was found for coordination with Cu(II)and Al(III).These results are important for accurately evaluating the photochemical behavior and risk of these antibiotics in aquatic environments contaminated with metal ions.
基金support by funding from National Key R&D Program of China(2022YFE0104200)the International Science&Technology Key Research and Development Program of Shaanxi(2020KWZ-006)+6 种基金Project of Foreign Experts(G20200241017)Chinese and Cee Countries Universities Joint Education Program(202015)National Natural Science Foundation of China(22005103,11674263)the Joint Research Funds of Department of Science and Technology of Shaanxi Province and Northwestern Polytechnical University(2020GXLH-Z-025)Special Foundation of Shaanxi Provincial Department of Education(20JK0543)Natural Science Basic Research Program of Shaanxi(Program No.2023-JC-QN-0134)International Cooperative Training Project from China Scholarship Council(Grant No.202110470006 and No.202110470001).
文摘Continuous passive motion(CPM)is an adjunct therapy to the standard postoperative rehabilitation regimen of joint injuries.The capability of real-time monitoring actual bending angle of knee joints is highly desired for treatment strategies of personalized postoperative rehabilitation and telemedicine.Here we report an intelligent CPM system for personalized rehabilitation and telemedicine based on the flexible and versatile ionotronic that possesses impressive mechanical properties(2.56 MPa tensile strength;11.63 MJ m^(−3)toughness),fast self-recovery ability(60 s)and broaden environmental tolerance(−60–45°C).Especially,the ionotronic responds fast and shows stability for cyclic strain sensing,ensuring the detection of actual joint bending angle with high sensitivity and reliability.The intelligent CPM system assembled with this ionotronic and a wireless transmitter was constructed,opening up a horizon for developing digital intelligent medical that can remotely monitor the movement of hospitalized/at-home patients who use CPM for personalized postoperative rehabilitation.
