Patterns of spatial development and protection form a basic category of geoscience,and redesigning them is a popular subject of research in regional sustainable development that is important for ecological civilizatio...Patterns of spatial development and protection form a basic category of geoscience,and redesigning them is a popular subject of research in regional sustainable development that is important for ecological civilization construction.The authors here report a case study of Wuhan city using the circuit theory model and minimum cumulative resistance(MCR)model to rebalance its spatial protection and development.The results show the following:(1)Using the density of the gross domestic product(GDP),density of population,rate of urbanization,and access to transportation as evaluation indicators,seven core areas of development in Wuhan were identified,accounting for 59%of the total number of streets,that exhibited a “circular-satellite”spatial structure.(2)According to the importance of ecosystem services,ecological sensitivity,land use type,and slope of the terrain,the resistance surface of spatial development in Wuhan had a stereoscopic spatial form of an“inverted pyramid,”with high surroundings and a low center.The area of low resistance accounted for 6.64%of the total area of Wuhan.(3)Based on coupling analysis using the MCR and spatial morphological characteristics of current,nine axes of spatial development with a total area of 427.27 km2 and eight key strategic points with a total area of 40.02 km2 were identified.Streets that were prioritized for development accounted for 9.63%of Wuhan's total area.(4)By combining the characterization of the development axis with the structure of the three-level core area,we extracted the structure of spatial development of "one heart,two wings,and three belts" in Wuhan.The research framework and empirical results can provide scientific guidance for the urban spatial layout,the development of regional linkages,and ecological environmental protection in China.展开更多
目的:探讨硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮的美学效果及疗效和安全性。方法:选取2020年12月-2022年12月湖南省中医药研究院附属医院收治的84例玫瑰痤疮患者,按随机数表法分为观察组(硫酸羟氯喹联合甲硝唑凝胶治疗,n=42)和对照组(...目的:探讨硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮的美学效果及疗效和安全性。方法:选取2020年12月-2022年12月湖南省中医药研究院附属医院收治的84例玫瑰痤疮患者,按随机数表法分为观察组(硫酸羟氯喹联合甲硝唑凝胶治疗,n=42)和对照组(甲硝唑凝胶治疗,n=42)。比较两组患者的治疗效果、不良反应,比较两组患者治疗前后的临床症状评分、痤疮特异性生活质量量表(Acne-specific quality of life scale,Acne-QOL)评分及白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumo rnecrosis factor-α,TNF-α)水平。结果:观察组总有效率为95.24%,显著高于对照组的80.95%(P<0.05);治疗后两组各项临床症状评分显著低于治疗前,观察组低于对照组(P<0.05);治疗后两组Acne-QOL各项评分显著高于治疗前,观察组高于对照组(P<0.05);治疗后两组IL-6、CRP、TNF-α显著低于治疗前,观察组低于对照组(P<0.05);观察组和对照组的不良反应总发生率分别为9.52%、7.14%,差异无统计学意义(P>0.05)。结论:硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮安全有效,可有效改善患者的临床症状,提高患者的面部美学效果及生活质量。展开更多
Eu2+ activated pyrosilicate phosphor were prepared under a reducing atmosphere by solid-state reaction.The crystal structure of Ba2 MgSi2 O7: Eu2+ was analyzed by XRD method.The excitation spectrum of Ba2MgSi2 O7; Eu2...Eu2+ activated pyrosilicate phosphor were prepared under a reducing atmosphere by solid-state reaction.The crystal structure of Ba2 MgSi2 O7: Eu2+ was analyzed by XRD method.The excitation spectrum of Ba2MgSi2 O7; Eu2+ is composed of two broad bands centered at about 310 nm and 395 nm respectively.In the emission spectra, the peak wavelength is at about 507 nm under 380 nm UV excitation.It was found that the introduction of Zn2+ into Ba2MgSi2O7: Eu2+ Can effectively increase its emission intensity without changing the position of emission peak.And the Eu2 + and Ce3 + codoped pyrosilicate phosphor is the efficient bluish green phosphor under the excitation of long UV light and its emission intensity is stronger than Eu2+ doped pyrosilicate phosphor.展开更多
文摘目的:观察葛根芩连汤辅助0.1%糠酸莫米松乳膏及盐酸西替利嗪片治疗特应性皮炎(Atopic dermatitis,AD)患者的临床疗效以及血清中神经生长因子(Nerve growth factor,NGF)和神经营养因子4(Neurotrophin-4,NT-4)水平的影响。方法:选取2021年5月-2023年5月收入笔者医院的AD患者60例,根据治疗方案的差异随机分为对照组(西药治疗)、观察组(西药治疗+中药辅助治疗)每组30例。对照组采用外用糠酸莫米松乳膏,口服盐酸西替利嗪进行干预治疗,观察组在对照组基础上采用葛根芩连汤辅助进行治疗。观察两组患者治疗前、后血清中NGF、NT-4水平、瘙痒视觉模拟评分(Visual analogue scale,VAS)、湿疹面积及严重指数(Eczema area and severity index,EASI)评分,治疗后临床疗效及不良反应发生率。结果:治疗前两组患者血清中NGF、NT-4水平、VAS评分、EASI评分相比差异无统计学意义(P>0.05),经治疗后两组患者血清中NGF、NT-4水平、VAS评分、EASI评分均较同组治疗前显著降低(P<0.05),且观察组优于对照组(P<0.05);经治疗后,观察组患者临床疗效总有效率高于对照组,不良反应发生率低于对照组(P<0.05)。结论:葛根芩连汤辅助西药治疗AD可下调患者血清中NGF、NT-4水平,减轻瘙痒症状及皮损程度,改善临床症状,降低不良事件的发生率,值得临床推广应用。
基金National Natural Science Foundation of China,No.71974070,No.41501593Social Sciences Foundation of Ministry of Education of China,No.19YJCZH068Scientific Research Project of Hubei Provincial Natural Resources Department,No.ZRZY2019KY08。
文摘Patterns of spatial development and protection form a basic category of geoscience,and redesigning them is a popular subject of research in regional sustainable development that is important for ecological civilization construction.The authors here report a case study of Wuhan city using the circuit theory model and minimum cumulative resistance(MCR)model to rebalance its spatial protection and development.The results show the following:(1)Using the density of the gross domestic product(GDP),density of population,rate of urbanization,and access to transportation as evaluation indicators,seven core areas of development in Wuhan were identified,accounting for 59%of the total number of streets,that exhibited a “circular-satellite”spatial structure.(2)According to the importance of ecosystem services,ecological sensitivity,land use type,and slope of the terrain,the resistance surface of spatial development in Wuhan had a stereoscopic spatial form of an“inverted pyramid,”with high surroundings and a low center.The area of low resistance accounted for 6.64%of the total area of Wuhan.(3)Based on coupling analysis using the MCR and spatial morphological characteristics of current,nine axes of spatial development with a total area of 427.27 km2 and eight key strategic points with a total area of 40.02 km2 were identified.Streets that were prioritized for development accounted for 9.63%of Wuhan's total area.(4)By combining the characterization of the development axis with the structure of the three-level core area,we extracted the structure of spatial development of "one heart,two wings,and three belts" in Wuhan.The research framework and empirical results can provide scientific guidance for the urban spatial layout,the development of regional linkages,and ecological environmental protection in China.
文摘目的:探讨硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮的美学效果及疗效和安全性。方法:选取2020年12月-2022年12月湖南省中医药研究院附属医院收治的84例玫瑰痤疮患者,按随机数表法分为观察组(硫酸羟氯喹联合甲硝唑凝胶治疗,n=42)和对照组(甲硝唑凝胶治疗,n=42)。比较两组患者的治疗效果、不良反应,比较两组患者治疗前后的临床症状评分、痤疮特异性生活质量量表(Acne-specific quality of life scale,Acne-QOL)评分及白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumo rnecrosis factor-α,TNF-α)水平。结果:观察组总有效率为95.24%,显著高于对照组的80.95%(P<0.05);治疗后两组各项临床症状评分显著低于治疗前,观察组低于对照组(P<0.05);治疗后两组Acne-QOL各项评分显著高于治疗前,观察组高于对照组(P<0.05);治疗后两组IL-6、CRP、TNF-α显著低于治疗前,观察组低于对照组(P<0.05);观察组和对照组的不良反应总发生率分别为9.52%、7.14%,差异无统计学意义(P>0.05)。结论:硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮安全有效,可有效改善患者的临床症状,提高患者的面部美学效果及生活质量。
基金Project supported by the National Natural Foundation of China (59982001)and Natural Science Foundation of Beijing(4012010)
文摘Eu2+ activated pyrosilicate phosphor were prepared under a reducing atmosphere by solid-state reaction.The crystal structure of Ba2 MgSi2 O7: Eu2+ was analyzed by XRD method.The excitation spectrum of Ba2MgSi2 O7; Eu2+ is composed of two broad bands centered at about 310 nm and 395 nm respectively.In the emission spectra, the peak wavelength is at about 507 nm under 380 nm UV excitation.It was found that the introduction of Zn2+ into Ba2MgSi2O7: Eu2+ Can effectively increase its emission intensity without changing the position of emission peak.And the Eu2 + and Ce3 + codoped pyrosilicate phosphor is the efficient bluish green phosphor under the excitation of long UV light and its emission intensity is stronger than Eu2+ doped pyrosilicate phosphor.
