Background: We investigated the diagnostic importance of segmental high-intensity (SHI) areas not corresponding to mass lesions on T1-weighted magnetic resonance (MR) images. Methods: We conducted a retrospective inve...Background: We investigated the diagnostic importance of segmental high-intensity (SHI) areas not corresponding to mass lesions on T1-weighted magnetic resonance (MR) images. Methods: We conducted a retrospective investigation of hepatic MR images obtained from 634 patients during a 4-year period at our institution. Images were compared with findings reported in the patients’medical records. There were 16 patients (2.5%) with SHI areas not corresponding to a mass lesion. We compared MR images with plain computed tomographic (CT) scans (n = 16), angiograms (n = 12), and histologic findings (n = 10). Results: The segments with intrahepatic bile duct dilatation showed hyperintensity on T1-weighted images. In six of 16 patients, the biliary duct was more dilated in the area of hyperintensity than in areas without hyperintensity. The SHI areas appeared as areas of low attenuation (n = 13), high attenuation (n = 1), or isoattenuation (n = 2) on plain CT scans. Histologically, these areas showed ductular proliferation and deposition of bile pigment within the hepatocytes. Conclusion: Segmental areas of increased signal intensity on T1-weighted images were probably due to intrahepatic cholestasis.展开更多
Purpose: To review 244 cases of orbital tumors to determine the distribution of patient age, pathology, and tumor origin and location. Methods: We reviewed cases of histopathologically or radiologically verified orbit...Purpose: To review 244 cases of orbital tumors to determine the distribution of patient age, pathology, and tumor origin and location. Methods: We reviewed cases of histopathologically or radiologically verified orbital tumors at our institution from 1981 through 2002, and studied the distribution of patient age, pathology, origin of tumors, and tumor location in the orbit in 244 consecutive patients (aged from 0 to 90 years, mean, 48.7 years; 114 men, 130 women). Results: Among the 244 cases, 213 (89% ) were primary orbital tumors, 23 (9% ) were secondary tumors originating in contiguous spaces, and 8 ( 2% )weremetastatic tumors. Regarding the location in the orbit, 122 tumors (50% ) were extraconal, 36 (15% ) were intraconal, and 86 (35% ) were in the lacrimal gland area. The common tumors were reactive lymphoid hyperplasia (22% ) and malignant lymphoma (20% ) in the extraconal area; cavernous hemangioma (25% ), optic nerve glioma (14% ), and optic nerve sheath meningioma (14% ) in the intraconal area; and malignant lym-phoma (40% ) and pleomorphic adenoma (24% ) in the lacrimal gland area. The age distribution of the 244 patients exhibited two peaks, at 0 to 9 years and 60 to 69 years. In the 0- to 9- year-old patients, the most common tumors were dermoid cyst (26% ), optic nerve glioma (11% ), capillary hemangioma (11% ), and hemorrhagic lymphangioma (11% ). On the other hand, in patients over 40 years of age, the common tumors were malignant lymphoma (31% ), orbital pseudotumor (24% )- , pleomorphic adenoma (10% ), and cavernous hemangioma (9% ). Conclusions: The pathologic profiles of orbital tumors were characterized according to patient age and the location of the tumor in the orbit. The age of onset, tumor location, and radiological findings provide us with important information for the diagnosis of a tumor prior to biopsy or tumor resection and for the determination of the treatment strategy.展开更多
To review 244 cases of orbital tumors to determine pathologic findings in Japa nese patients. Observational case series. We studied the pathology and origin of tumors in the orbit in 244 consecutive Japanese patients ...To review 244 cases of orbital tumors to determine pathologic findings in Japa nese patients. Observational case series. We studied the pathology and origin of tumors in the orbit in 244 consecutive Japanese patients with orbital tumors at our institution from 1981 through 2002 (age 0 to 90 years, mean, 48.7 years; 11 4 men, 130 women). The most common tumors were lymphoproliferative diseases (n=1 14, 42.5%), including malignant lymphoma (n=59, 24.1%) and reactive lymphoid h yperplasia (n=45, 18.4%), pleomorphic adenoma (n=21, 8.6%), and cavernous hema ngioma (n=18, 7.4%). The incidence of lymphoproliferative diseases, especially malignant lymphoma, was very high in Japanese patients.展开更多
Objective: presenilin- 2 is one of the causative genes for familial Alzheimer’s disease, and the apolipoprotein E∈ 4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer’s disease...Objective: presenilin- 2 is one of the causative genes for familial Alzheimer’s disease, and the apolipoprotein E∈ 4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer’s disease. Polymorphism of the regulatory region of presenilin- 2 has recently been reported to be associated with sporadic Alzheimer’s disease in a Russian population. The purpose of this study was to determine whether Alzheimer’s disease is associated with the presenilin- 2 gene polymorphism and the apolipoprotein E genotype in an extended case-control study. Methods: We examined 230 patients with Alzheimer s disease, along with an equal number of age-and sex-matched controls from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis. Results: The presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer’s disease patients (0.17) and younger controls (0.15), and in late-onset Alzheimer’s disease (0.20) and elderly controls (0.20). We found no evidence for an association between the presenilin-2 polymorphism and the apolipoprotein E∈ 4 allele. Conclusions: Our results fail to support an association of presenilin- 2 gene polymorphism with Alzheimer’s disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences.展开更多
文摘Background: We investigated the diagnostic importance of segmental high-intensity (SHI) areas not corresponding to mass lesions on T1-weighted magnetic resonance (MR) images. Methods: We conducted a retrospective investigation of hepatic MR images obtained from 634 patients during a 4-year period at our institution. Images were compared with findings reported in the patients’medical records. There were 16 patients (2.5%) with SHI areas not corresponding to a mass lesion. We compared MR images with plain computed tomographic (CT) scans (n = 16), angiograms (n = 12), and histologic findings (n = 10). Results: The segments with intrahepatic bile duct dilatation showed hyperintensity on T1-weighted images. In six of 16 patients, the biliary duct was more dilated in the area of hyperintensity than in areas without hyperintensity. The SHI areas appeared as areas of low attenuation (n = 13), high attenuation (n = 1), or isoattenuation (n = 2) on plain CT scans. Histologically, these areas showed ductular proliferation and deposition of bile pigment within the hepatocytes. Conclusion: Segmental areas of increased signal intensity on T1-weighted images were probably due to intrahepatic cholestasis.
文摘Purpose: To review 244 cases of orbital tumors to determine the distribution of patient age, pathology, and tumor origin and location. Methods: We reviewed cases of histopathologically or radiologically verified orbital tumors at our institution from 1981 through 2002, and studied the distribution of patient age, pathology, origin of tumors, and tumor location in the orbit in 244 consecutive patients (aged from 0 to 90 years, mean, 48.7 years; 114 men, 130 women). Results: Among the 244 cases, 213 (89% ) were primary orbital tumors, 23 (9% ) were secondary tumors originating in contiguous spaces, and 8 ( 2% )weremetastatic tumors. Regarding the location in the orbit, 122 tumors (50% ) were extraconal, 36 (15% ) were intraconal, and 86 (35% ) were in the lacrimal gland area. The common tumors were reactive lymphoid hyperplasia (22% ) and malignant lymphoma (20% ) in the extraconal area; cavernous hemangioma (25% ), optic nerve glioma (14% ), and optic nerve sheath meningioma (14% ) in the intraconal area; and malignant lym-phoma (40% ) and pleomorphic adenoma (24% ) in the lacrimal gland area. The age distribution of the 244 patients exhibited two peaks, at 0 to 9 years and 60 to 69 years. In the 0- to 9- year-old patients, the most common tumors were dermoid cyst (26% ), optic nerve glioma (11% ), capillary hemangioma (11% ), and hemorrhagic lymphangioma (11% ). On the other hand, in patients over 40 years of age, the common tumors were malignant lymphoma (31% ), orbital pseudotumor (24% )- , pleomorphic adenoma (10% ), and cavernous hemangioma (9% ). Conclusions: The pathologic profiles of orbital tumors were characterized according to patient age and the location of the tumor in the orbit. The age of onset, tumor location, and radiological findings provide us with important information for the diagnosis of a tumor prior to biopsy or tumor resection and for the determination of the treatment strategy.
文摘To review 244 cases of orbital tumors to determine pathologic findings in Japa nese patients. Observational case series. We studied the pathology and origin of tumors in the orbit in 244 consecutive Japanese patients with orbital tumors at our institution from 1981 through 2002 (age 0 to 90 years, mean, 48.7 years; 11 4 men, 130 women). The most common tumors were lymphoproliferative diseases (n=1 14, 42.5%), including malignant lymphoma (n=59, 24.1%) and reactive lymphoid h yperplasia (n=45, 18.4%), pleomorphic adenoma (n=21, 8.6%), and cavernous hema ngioma (n=18, 7.4%). The incidence of lymphoproliferative diseases, especially malignant lymphoma, was very high in Japanese patients.
文摘Objective: presenilin- 2 is one of the causative genes for familial Alzheimer’s disease, and the apolipoprotein E∈ 4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer’s disease. Polymorphism of the regulatory region of presenilin- 2 has recently been reported to be associated with sporadic Alzheimer’s disease in a Russian population. The purpose of this study was to determine whether Alzheimer’s disease is associated with the presenilin- 2 gene polymorphism and the apolipoprotein E genotype in an extended case-control study. Methods: We examined 230 patients with Alzheimer s disease, along with an equal number of age-and sex-matched controls from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis. Results: The presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer’s disease patients (0.17) and younger controls (0.15), and in late-onset Alzheimer’s disease (0.20) and elderly controls (0.20). We found no evidence for an association between the presenilin-2 polymorphism and the apolipoprotein E∈ 4 allele. Conclusions: Our results fail to support an association of presenilin- 2 gene polymorphism with Alzheimer’s disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences.
