An aging population is a double-edged sword.On one hand,advancements in biotechnology and healthcare allow more people to enjoy longer lives.On the other hand,increases in the aging population accompany a surge in age...An aging population is a double-edged sword.On one hand,advancements in biotechnology and healthcare allow more people to enjoy longer lives.On the other hand,increases in the aging population accompany a surge in age-associated diseases,particularly neurodegenerative disorders.Since aging is the primary risk factor for many neurodegenerative disorders,living longer does not necessarily equate to maintaining a reasonable quality of life(Feigin et al.,2020).展开更多
A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor symptoms.Included in this group are Parkinson’s disease(PD),dementia with Lew...A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor symptoms.Included in this group are Parkinson’s disease(PD),dementia with Lewy bodies(DLB),multiple system atrophy(MSA),corticobasal syndrome(CBS),and progressive supranuclear palsy(PSP).These disorders are differentiated neuropathologically by their dominant protein pathologies involvingα-synuclein(α-syn)and/or tau,the types of brain cells affected,such as neurons,oligodendroglia,and astrocytes,and the specific brain regions involved(Tolosa et al.,2021).展开更多
Synucleinopathies are neurodegenerative diseases char-acterized by accumulation of misfoldedα-synuclein(α-syn)inclusions in neuronal and/or glial cells.Despite differences in the underlying pathophysiology,synucle-i...Synucleinopathies are neurodegenerative diseases char-acterized by accumulation of misfoldedα-synuclein(α-syn)inclusions in neuronal and/or glial cells.Despite differences in the underlying pathophysiology,synucle-inopathies often are misdiagnosed,especially in early stages,due to the overlapping clinical symptoms[1].展开更多
文摘An aging population is a double-edged sword.On one hand,advancements in biotechnology and healthcare allow more people to enjoy longer lives.On the other hand,increases in the aging population accompany a surge in age-associated diseases,particularly neurodegenerative disorders.Since aging is the primary risk factor for many neurodegenerative disorders,living longer does not necessarily equate to maintaining a reasonable quality of life(Feigin et al.,2020).
文摘A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor symptoms.Included in this group are Parkinson’s disease(PD),dementia with Lewy bodies(DLB),multiple system atrophy(MSA),corticobasal syndrome(CBS),and progressive supranuclear palsy(PSP).These disorders are differentiated neuropathologically by their dominant protein pathologies involvingα-synuclein(α-syn)and/or tau,the types of brain cells affected,such as neurons,oligodendroglia,and astrocytes,and the specific brain regions involved(Tolosa et al.,2021).
基金supported by grants from the MSA Coalition 2017-10-007(GB)California Department of Public Health 18-10926(GB)+5 种基金The Alzheimer’s Association,The Michael J.Fox Foundation,Weston Brain Institute,and Alzheimer’s Research UK Biomarkers Across Neurodegenerative Diseases(BAND 3)17990(GB)CurePSP 665-2019-07(GB)The Michael J.Fox Foundation 18303(GB)The National Ataxia Foundation 20201551(GB and BLF),Cure Sanfilippo Foundation 20215318(GB)NIH/NIEHS ES10544(BR)generous gifts from the Karen Toffler Charitable Trust and the Binder Foundation。
文摘Synucleinopathies are neurodegenerative diseases char-acterized by accumulation of misfoldedα-synuclein(α-syn)inclusions in neuronal and/or glial cells.Despite differences in the underlying pathophysiology,synucle-inopathies often are misdiagnosed,especially in early stages,due to the overlapping clinical symptoms[1].
