Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China a...Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China and investigated their association with obesity.MeP,BPP,PrP,BPA,EtP,BPE,and BPC were frequently detected in more than 50%of the adipose tissues.A positive correlation between bisphenol A and body mass index(BMI)was observed in both multivariate linear regression model(β=0.87,95%confidence interval:0.21-1.53,p=0.011)and multivariate logistic regression analysis(odds ratio=1.28,95%confidence interval:1.01-1.62,0.044).Restricted cubic spline regression analysis revealed a significant nonlinear association between bisphenol P and BMI.Weighted quantile sum regression and quantile-based g-computation revealed a slight positive trend between EDCs mixed exposure and BMI,with bisphenol A as the primary contributor to the positive correlation with BMI.Our findings suggest the extensive existence of environmental EDCs in the adipose tissue of the adult Chinese population and indicate that exposure to BPA in adipose tissue may be associated with the occurrence of obesity.展开更多
Nano-Fe3O4 particles were prepared by a two-step microemulsion method, the influence of molar ratio of water to NP-5 (R), alkali concentration and temperature on dispersibility and shape of the nanoparticles were disc...Nano-Fe3O4 particles were prepared by a two-step microemulsion method, the influence of molar ratio of water to NP-5 (R), alkali concentration and temperature on dispersibility and shape of the nanoparticles were discussed. Magnetic studies were also carried out using VSM in this paper. It was found that the optimum preparation parameters are R = 6.0, alkali concentration = 2.5 mol.L–1, initial total iron concentration as 0.88 mol.L–1, and the temperature being 30°C, the prepared nano magnetite particles have uniform size and good dispersibility with a crystal structure belonging to cubicFe3O4 and lattice parameters of a = 8.273 ?. The results of magnetic studies show, magnetic properties of particles are influenced by dispersibility of nanoparticles which depends on size of clusters. The better dispersibility of nanoparticles leads to more ordered inner magnetic vector, and so the stronger magnetic behavior of nano-Fe3O4 particles.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22125606 and 22241604)the Chinese Academy of Sciences Project of Young Scientists in Basic Research(No.YSBR-086).
文摘Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China and investigated their association with obesity.MeP,BPP,PrP,BPA,EtP,BPE,and BPC were frequently detected in more than 50%of the adipose tissues.A positive correlation between bisphenol A and body mass index(BMI)was observed in both multivariate linear regression model(β=0.87,95%confidence interval:0.21-1.53,p=0.011)and multivariate logistic regression analysis(odds ratio=1.28,95%confidence interval:1.01-1.62,0.044).Restricted cubic spline regression analysis revealed a significant nonlinear association between bisphenol P and BMI.Weighted quantile sum regression and quantile-based g-computation revealed a slight positive trend between EDCs mixed exposure and BMI,with bisphenol A as the primary contributor to the positive correlation with BMI.Our findings suggest the extensive existence of environmental EDCs in the adipose tissue of the adult Chinese population and indicate that exposure to BPA in adipose tissue may be associated with the occurrence of obesity.
文摘Nano-Fe3O4 particles were prepared by a two-step microemulsion method, the influence of molar ratio of water to NP-5 (R), alkali concentration and temperature on dispersibility and shape of the nanoparticles were discussed. Magnetic studies were also carried out using VSM in this paper. It was found that the optimum preparation parameters are R = 6.0, alkali concentration = 2.5 mol.L–1, initial total iron concentration as 0.88 mol.L–1, and the temperature being 30°C, the prepared nano magnetite particles have uniform size and good dispersibility with a crystal structure belonging to cubicFe3O4 and lattice parameters of a = 8.273 ?. The results of magnetic studies show, magnetic properties of particles are influenced by dispersibility of nanoparticles which depends on size of clusters. The better dispersibility of nanoparticles leads to more ordered inner magnetic vector, and so the stronger magnetic behavior of nano-Fe3O4 particles.
