Based on the data of the national station in Wengyuan County from 1975 to 2024,the tourism climate comfort of Wengyuan County was analyzed and evaluated by using temperature-humidity index,wind chill index,holiday cli...Based on the data of the national station in Wengyuan County from 1975 to 2024,the tourism climate comfort of Wengyuan County was analyzed and evaluated by using temperature-humidity index,wind chill index,holiday climate index,and linear trend analysis.The results show that in Wengyuan County,people felt most comfortable in April,May,October,and November,and the holiday climate index in each month was over 63,reaching or exceeding the"suitable"level,and there were no"acceptable"or lower levels.Spring and autumn were the best time for people to visit Wengyuan.The temperature-humidity index in Wengyuan County rose significantly at a tendency rate of 0.19/10 a,while wind chill index dropped significantly at a tendency rate of 2.9/10 a.The annual average number of comfortable days in Wengyuan was up to 164 d,accounting for over 44.9%of the total number in the whole year.It tended to decline at a tendency rate of-3.9/10 a.The annual average number of uncomfortable cold days and uncomfortable hot days showed an upward trend at a tendency rate of 1.5/10 a and 1.7/10 a,respectively.HCL and the number of days with unfavorable climate tended to decline slowly at a tendency rate of-0.236/10 a and-0.248/10 a,respectively.The number of days with suitable climate showed an upward trend at a tendency rate of 1.2/10 a,while the number of days with general and acceptable climate showed a slow downward trend at a tendency rate of-1.96/10 a.展开更多
To analyze the additional cost caused by the performance attenuation of a proton exchange membrane electrolyzer(PEMEL)under the fluctuating input of renewable energy,this study proposes an optimization method for powe...To analyze the additional cost caused by the performance attenuation of a proton exchange membrane electrolyzer(PEMEL)under the fluctuating input of renewable energy,this study proposes an optimization method for power scheduling in hydrogen production systems under the scenario of photovoltaic(PV)electrolysis of water.First,voltage and performance attenuation models of the PEMEL are proposed,and the degradation cost of the electrolyzer under a fluctuating input is considered.Then,the calculation of the investment and operating costs of the hydrogen production system for a typical day is based on the life cycle cost.Finally,a layered power scheduling optimization method is proposed to reasonably distribute the power of the electrolyzer and energy storage system in a hydrogen production system.In the up-layer optimization,the PV power absorbed by the hydrogen production system was optimized using MALTAB+Gurobi.In low-layer optimization,the power allocation between the PEMEL and battery energy storage system(BESS)is optimized using a non-dominated sorting genetic algorithm(NSGA-Ⅱ)combined with the firefly algorithm(FA).A better optimization result,characterized by lower degradation and total costs,was obtained using the method proposed in this study.The improved algorithm can search for a better population and obtain optimization results in fewer iterations.As a calculation example,data from a PV power station in northwest China were used for optimization,and the effectiveness and rationality of the proposed optimization method were verified.展开更多
Pathogenic African swine fever virus(ASFV)remains a lethal causative agent in the domestic pig industry,which poses a burden on the swine market and causes substantial socioeconomic losses worldwide.Currently,there ar...Pathogenic African swine fever virus(ASFV)remains a lethal causative agent in the domestic pig industry,which poses a burden on the swine market and causes substantial socioeconomic losses worldwide.Currently,there are no commercially efcacious vaccines or specifc treatments available for ASF prevention and control.Unfortunately,little is known about the swine immune response upon ASFV infection.Here,we investigated the host immune response discrepancy induced by the feld moderately virulent strain ASFV HB-2208 among healthy,diseased and asymptomatic pigs.In the peripheral blood of diseased swine,lymphopenia is caused by the massive loss of bystander lymphocytes,such asγδT cells,B cells and CD4^(+)T cells.Conversely,ASFV has a strong tropism for the mononuclear phagocyte system(MPS)and partial dendritic cells(DCs),whose antigen-presenting ability is impeded by the downregulation of CD80 and MHC I.However,no signifcant diference in the number of CD8α^(high) T cells was detected,whereas the frequencies of NK cells,NKT cells,and regulatory T cells(Tregs)were signifcantly increased.Additionally,an in vitro model was established with a coculture of primary pulmonary alveolar macrophages(PAMs)and peripheral blood mononuclear cells(PBMCs),which signifcantly reducedγδT cells,B cells and CD4^(+)T cells and increased Tregs.The diferentiated immune response might aid in enhancing the understanding of ASFV pathogenesis in suids and provide insights into the mechanism of ASFV-induced lymphopenia for further studies.展开更多
Drought stress and abscisic acid(ABA)have been known to play a critical role in modulating sugar accumulation in fruit,and yet,the underlying molecular mechanisms remain elusive.In this study,we have demonstrated that...Drought stress and abscisic acid(ABA)have been known to play a critical role in modulating sugar accumulation in fruit,and yet,the underlying molecular mechanisms remain elusive.In this study,we have demonstrated that drought-mimicking film mulching increased sucrose levels in Satsuma mandarin(Citrus unshiu)fruit,coinciding with upregulation of CuSPS4,which encodes the sucrose phosphate synthase(SPS),in the transcriptome profiling.CuSPS4 was further shown to be drought-and ABA-inducible and functionally essential for sucrose synthesis.Mechanistically,two transcription factors,CuWRKY41 and CuWRKY23,directly bound to and activated the CuSPS4 promoter via the W-box element,with CuWRKY41 additionally regulating CuWRKY23 expression.Consistently,both Cu WRKY41 and Cu WRKY23 positively regulated sucrose synthesis by upregulating Cu SPS4.Meanwhile,the ubstrateinteracting subunit(Cu Sn RK1β1)and catalytic subunit(Cu Sn RK1α)of SUCROSE NON-FERMENTING RELATED KINASE 1(Sn RK1)interacted with Cu WRKY41,triggering Cu Sn RK1α-mediated phosphorylation and subsequent degradation of Cu WRKY41,thereby suppressing its activation.However,ABA promoted cytoplasmic translocation of Cu Sn RK1αand Cu Sn RK1β1 and reduced nuclear interaction with Cu WRKY41,leading to its phosphorylation alleviation and protein stabilization,concurrent with enhanced transcription activation of Cu WRKY23 and Cu SPS4.Taken together,these findings reveal a sophisticated regulatory mechanism whereby drought promotes sucrose accumulation by suppressing Cu Sn RK1α-mediated phosphorylation and degradation of Cu WRKY41,enabling its transcriptional activation of Cu SPS4 directly or via Cu WRKY23.Our study provides significant insights into the molecular basis of drought-induced sucrose accumulation and presents valuable regulatory components that could be targeted for fruit quality improvement.展开更多
This study explores the potential of the advanced selective state spaces model(SSSM)in modeling complicated process industries system and proposes the process industry state identification model(PISIM)for controlled p...This study explores the potential of the advanced selective state spaces model(SSSM)in modeling complicated process industries system and proposes the process industry state identification model(PISIM)for controlled prediction of flotation cell pulp level.As a neural system identification model,the PISIM inherits two advantages of the SSSM to address the challenges in identifying flotation systems,including modeling the impact of frequent upstream fluctuations on system states,complex nonlinear physicochemical processes,and long-term dependencies.The first advantage is the ability to capture long-range dependencies,thereby boosting its long-term predictive accuracy.The second lies in the model structure adhering to scaling laws,enabling ongoing enhancements in performance as datasets expand.PISIM is evaluated using a real industrial dataset from a flotation plant at a copper mine in Zambia,with the results demonstrating its theoretical advantages.In a 4.5-hour pulp level prediction task,PISIM outperforms the baseline model by more than 31.34%.Furthermore,a flotation process control simulation experimental system based on PISIM is developed and deployed in a flotation plant in Zambia,assisting engineers in evaluating and optimizing setpoint strategies,ensuring stable production and improving production efficiency.展开更多
We reported a wavelength-flexible all-polarization-maintaining self-sweeping fiber laser based on the intracavity loss tuning brought by the bent optical fiber. The bidirectional cavity structure achieved the self-swe...We reported a wavelength-flexible all-polarization-maintaining self-sweeping fiber laser based on the intracavity loss tuning brought by the bent optical fiber. The bidirectional cavity structure achieved the self-sweeping effect due to the appearance of the dynamic grating in the active fiber with the spatial hole burning effect. Under this, a section of fiber was bent into a circle for adjusting the loss of the cavity. With a descending diameter of bent fiber circle, the sweeping range moves to the shorter wavelength and covers a wide range from 1055.6 to 1034.6 nm eventually. Both the initial wavelength of self-sweeping regime and the threshold of the fiber laser show exponential correlation with the diameter of the circular fiber. Our work provides a compact and low-cost way to achieve the broad wavelength-flexible self-sweeping operation.展开更多
We demonstrate a stable narrow linewidth single-frequency erbium-doped fiber laser(EDFL)operating at 1.6μm.A Fabry–Perot fiber Bragg grating and two cascaded subrings are incorporated in the main ring cavity to achi...We demonstrate a stable narrow linewidth single-frequency erbium-doped fiber laser(EDFL)operating at 1.6μm.A Fabry–Perot fiber Bragg grating and two cascaded subrings are incorporated in the main ring cavity to achieve singlefrequency operation.The experimentally measured optical signal-to-noise ratio is greater than 73 dB.Furthermore,the linewidth of the EDFL is measured to be about 480 Hz by the self-built short-delayed self-heterodyne interferometry device.The laser shows superior stability,with no mode-hopping during the 60-min observation period.The proposed EDFL provides a new experimental idea for realizing a single-frequency fiber laser in the L-band.展开更多
Graphite nanoplatelets(GNPs)with their intrinsic two-dimensional structure make an excellent compromise of advantages of both graphite and graphene.Due to their outstanding inherent properties,GNPs have been widely us...Graphite nanoplatelets(GNPs)with their intrinsic two-dimensional structure make an excellent compromise of advantages of both graphite and graphene.Due to their outstanding inherent properties,GNPs have been widely used as the functional fillers to improve certain performances of polymer-based composites.However,the multi-layer stacked construction of GNPs could form aggregations easily,which limits their application in polymer-based dielectric composites.Here,the authors exhibit a polydimethylsilicone(PDMS)-based nanocomposite which loading equivalent carbon nanotubes(CNTs)and GNPs as co-loading fillers,whose dielectric properties are improved significantly.The composites were fabricated through a highly-shearing mechanical mixing process.During the mixing process,both intrinsic CNTs entanglements and GNPs stacked aggregation could be ameliorated due to the interaction between these two types of fillers.Compared with the GNPs solely loaded composites,a small quantity of CNTs addition endows GNPs/CNTs/PDMS ternary composites with a significantly decreased percolation threshold(f_(c)∼1.7 vol.%).Both GNPs and CNTs,these two representative conductive carbon constructions with high aspect ratios are able to effectively enhance the establishing efficiency of internal conductive network inner composites.These results indicate that the development of internal conductive network and dielectric performance of nanocomposites are able to be optimised through the strategy of taking advantage of the synergistic effect of multi-type fillers reasonably.展开更多
The interplay of polarization and magnetisminmaterials with light can create rich nonlinear magnetooptical(NLMO)effects,and the recent discovery of two-dimensional(2D)van der Waals magnets provides remarkable control ...The interplay of polarization and magnetisminmaterials with light can create rich nonlinear magnetooptical(NLMO)effects,and the recent discovery of two-dimensional(2D)van der Waals magnets provides remarkable control over NLMO effects due to their superb tunability.Here,based on firstprinciples calculations,we reported giant NLMO effects in CrI_(3)-based 2D magnets,including a dramatic change of second-harmonics generation(SHG)polarization direction(90°)and intensity(on/off switch)under magnetization reversal and a 100%SHG circular dichroism effect.We further revealed that these effects could not only be used to design ultra-thin multifunctional optical devices but also to detect subtle magnetic orderings.展开更多
We report on the enhancement of phase conjugation degenerate four-wave mixing(DFWM) in hot atomic Rb vapor by using a Bessel beam as the probe beam. The Bessel beam was generated using cross-phase modulation based on ...We report on the enhancement of phase conjugation degenerate four-wave mixing(DFWM) in hot atomic Rb vapor by using a Bessel beam as the probe beam. The Bessel beam was generated using cross-phase modulation based on the thermal nonlinear optical effect. Our results demonstrated that the DFWM signal generated by the Bessel beam is about twice as large as that generated by the Gaussian beam, which can be attributed to the extended depth and tight focusing features of the Bessel beam. We also found that a DFWM signal with reasonable intensity can be detected even when the Bessel beam encounters an obstruction on its way, thanks to the selfhealing property of the Bessel beam. This work not only indicates that DFWM using a Bessel beam would be of great potential in the fields of high-fidelity communication, adaptive optics, and so on, but also suggests that a Bessel beam would be of significance to enhance the nonlinear process, especially in thick and scattering media.展开更多
文摘Based on the data of the national station in Wengyuan County from 1975 to 2024,the tourism climate comfort of Wengyuan County was analyzed and evaluated by using temperature-humidity index,wind chill index,holiday climate index,and linear trend analysis.The results show that in Wengyuan County,people felt most comfortable in April,May,October,and November,and the holiday climate index in each month was over 63,reaching or exceeding the"suitable"level,and there were no"acceptable"or lower levels.Spring and autumn were the best time for people to visit Wengyuan.The temperature-humidity index in Wengyuan County rose significantly at a tendency rate of 0.19/10 a,while wind chill index dropped significantly at a tendency rate of 2.9/10 a.The annual average number of comfortable days in Wengyuan was up to 164 d,accounting for over 44.9%of the total number in the whole year.It tended to decline at a tendency rate of-3.9/10 a.The annual average number of uncomfortable cold days and uncomfortable hot days showed an upward trend at a tendency rate of 1.5/10 a and 1.7/10 a,respectively.HCL and the number of days with unfavorable climate tended to decline slowly at a tendency rate of-0.236/10 a and-0.248/10 a,respectively.The number of days with suitable climate showed an upward trend at a tendency rate of 1.2/10 a,while the number of days with general and acceptable climate showed a slow downward trend at a tendency rate of-1.96/10 a.
基金supported by the National Key Research and Development Program of China(Materials and Process Basis of Electrolytic Hydrogen Production from Fluctuating Power Sources such as Photovoltaic/Wind Power,No.2021YFB4000100)。
文摘To analyze the additional cost caused by the performance attenuation of a proton exchange membrane electrolyzer(PEMEL)under the fluctuating input of renewable energy,this study proposes an optimization method for power scheduling in hydrogen production systems under the scenario of photovoltaic(PV)electrolysis of water.First,voltage and performance attenuation models of the PEMEL are proposed,and the degradation cost of the electrolyzer under a fluctuating input is considered.Then,the calculation of the investment and operating costs of the hydrogen production system for a typical day is based on the life cycle cost.Finally,a layered power scheduling optimization method is proposed to reasonably distribute the power of the electrolyzer and energy storage system in a hydrogen production system.In the up-layer optimization,the PV power absorbed by the hydrogen production system was optimized using MALTAB+Gurobi.In low-layer optimization,the power allocation between the PEMEL and battery energy storage system(BESS)is optimized using a non-dominated sorting genetic algorithm(NSGA-Ⅱ)combined with the firefly algorithm(FA).A better optimization result,characterized by lower degradation and total costs,was obtained using the method proposed in this study.The improved algorithm can search for a better population and obtain optimization results in fewer iterations.As a calculation example,data from a PV power station in northwest China were used for optimization,and the effectiveness and rationality of the proposed optimization method were verified.
基金support provided by the National Natural Sciences Foundation of China(Grant Nos.32172873 and 31941005)the National Programme on Key Research Project of China(2021YFD1800105-2)National Natural Sciences Foundation of China,32172873,Min Cui,31941005,Min Cui,National Programme on Key Research Project of China,2021YFD1800105-2,Min Cui。
文摘Pathogenic African swine fever virus(ASFV)remains a lethal causative agent in the domestic pig industry,which poses a burden on the swine market and causes substantial socioeconomic losses worldwide.Currently,there are no commercially efcacious vaccines or specifc treatments available for ASF prevention and control.Unfortunately,little is known about the swine immune response upon ASFV infection.Here,we investigated the host immune response discrepancy induced by the feld moderately virulent strain ASFV HB-2208 among healthy,diseased and asymptomatic pigs.In the peripheral blood of diseased swine,lymphopenia is caused by the massive loss of bystander lymphocytes,such asγδT cells,B cells and CD4^(+)T cells.Conversely,ASFV has a strong tropism for the mononuclear phagocyte system(MPS)and partial dendritic cells(DCs),whose antigen-presenting ability is impeded by the downregulation of CD80 and MHC I.However,no signifcant diference in the number of CD8α^(high) T cells was detected,whereas the frequencies of NK cells,NKT cells,and regulatory T cells(Tregs)were signifcantly increased.Additionally,an in vitro model was established with a coculture of primary pulmonary alveolar macrophages(PAMs)and peripheral blood mononuclear cells(PBMCs),which signifcantly reducedγδT cells,B cells and CD4^(+)T cells and increased Tregs.The diferentiated immune response might aid in enhancing the understanding of ASFV pathogenesis in suids and provide insights into the mechanism of ASFV-induced lymphopenia for further studies.
基金supported by the National Natural Science Foundation of China(32330095)the Hubei Hongshan Laboratory project(2021hszd009)。
文摘Drought stress and abscisic acid(ABA)have been known to play a critical role in modulating sugar accumulation in fruit,and yet,the underlying molecular mechanisms remain elusive.In this study,we have demonstrated that drought-mimicking film mulching increased sucrose levels in Satsuma mandarin(Citrus unshiu)fruit,coinciding with upregulation of CuSPS4,which encodes the sucrose phosphate synthase(SPS),in the transcriptome profiling.CuSPS4 was further shown to be drought-and ABA-inducible and functionally essential for sucrose synthesis.Mechanistically,two transcription factors,CuWRKY41 and CuWRKY23,directly bound to and activated the CuSPS4 promoter via the W-box element,with CuWRKY41 additionally regulating CuWRKY23 expression.Consistently,both Cu WRKY41 and Cu WRKY23 positively regulated sucrose synthesis by upregulating Cu SPS4.Meanwhile,the ubstrateinteracting subunit(Cu Sn RK1β1)and catalytic subunit(Cu Sn RK1α)of SUCROSE NON-FERMENTING RELATED KINASE 1(Sn RK1)interacted with Cu WRKY41,triggering Cu Sn RK1α-mediated phosphorylation and subsequent degradation of Cu WRKY41,thereby suppressing its activation.However,ABA promoted cytoplasmic translocation of Cu Sn RK1αand Cu Sn RK1β1 and reduced nuclear interaction with Cu WRKY41,leading to its phosphorylation alleviation and protein stabilization,concurrent with enhanced transcription activation of Cu WRKY23 and Cu SPS4.Taken together,these findings reveal a sophisticated regulatory mechanism whereby drought promotes sucrose accumulation by suppressing Cu Sn RK1α-mediated phosphorylation and degradation of Cu WRKY41,enabling its transcriptional activation of Cu SPS4 directly or via Cu WRKY23.Our study provides significant insights into the molecular basis of drought-induced sucrose accumulation and presents valuable regulatory components that could be targeted for fruit quality improvement.
基金supported by the National Natural Science Foundation of China(62506031,62332017,U22A2022)National Science and Technology Major Project of the Ministry of Science and Technology of China(2024ZD0608100).
文摘This study explores the potential of the advanced selective state spaces model(SSSM)in modeling complicated process industries system and proposes the process industry state identification model(PISIM)for controlled prediction of flotation cell pulp level.As a neural system identification model,the PISIM inherits two advantages of the SSSM to address the challenges in identifying flotation systems,including modeling the impact of frequent upstream fluctuations on system states,complex nonlinear physicochemical processes,and long-term dependencies.The first advantage is the ability to capture long-range dependencies,thereby boosting its long-term predictive accuracy.The second lies in the model structure adhering to scaling laws,enabling ongoing enhancements in performance as datasets expand.PISIM is evaluated using a real industrial dataset from a flotation plant at a copper mine in Zambia,with the results demonstrating its theoretical advantages.In a 4.5-hour pulp level prediction task,PISIM outperforms the baseline model by more than 31.34%.Furthermore,a flotation process control simulation experimental system based on PISIM is developed and deployed in a flotation plant in Zambia,assisting engineers in evaluating and optimizing setpoint strategies,ensuring stable production and improving production efficiency.
基金supported by the National Natural Science Foundation of China (No. 61905193)the National Key R&D Program of China (No. 2017YFB0405102)the Key R&D Project of Shaanxi Province–International Science and Technology Cooperation Project (No. 2020KW-018)。
文摘We reported a wavelength-flexible all-polarization-maintaining self-sweeping fiber laser based on the intracavity loss tuning brought by the bent optical fiber. The bidirectional cavity structure achieved the self-sweeping effect due to the appearance of the dynamic grating in the active fiber with the spatial hole burning effect. Under this, a section of fiber was bent into a circle for adjusting the loss of the cavity. With a descending diameter of bent fiber circle, the sweeping range moves to the shorter wavelength and covers a wide range from 1055.6 to 1034.6 nm eventually. Both the initial wavelength of self-sweeping regime and the threshold of the fiber laser show exponential correlation with the diameter of the circular fiber. Our work provides a compact and low-cost way to achieve the broad wavelength-flexible self-sweeping operation.
基金supported by the Shaanxi Key Science and Technology Innovation Team Project(No.2023-CX-TD-06)。
文摘We demonstrate a stable narrow linewidth single-frequency erbium-doped fiber laser(EDFL)operating at 1.6μm.A Fabry–Perot fiber Bragg grating and two cascaded subrings are incorporated in the main ring cavity to achieve singlefrequency operation.The experimentally measured optical signal-to-noise ratio is greater than 73 dB.Furthermore,the linewidth of the EDFL is measured to be about 480 Hz by the self-built short-delayed self-heterodyne interferometry device.The laser shows superior stability,with no mode-hopping during the 60-min observation period.The proposed EDFL provides a new experimental idea for realizing a single-frequency fiber laser in the L-band.
文摘Graphite nanoplatelets(GNPs)with their intrinsic two-dimensional structure make an excellent compromise of advantages of both graphite and graphene.Due to their outstanding inherent properties,GNPs have been widely used as the functional fillers to improve certain performances of polymer-based composites.However,the multi-layer stacked construction of GNPs could form aggregations easily,which limits their application in polymer-based dielectric composites.Here,the authors exhibit a polydimethylsilicone(PDMS)-based nanocomposite which loading equivalent carbon nanotubes(CNTs)and GNPs as co-loading fillers,whose dielectric properties are improved significantly.The composites were fabricated through a highly-shearing mechanical mixing process.During the mixing process,both intrinsic CNTs entanglements and GNPs stacked aggregation could be ameliorated due to the interaction between these two types of fillers.Compared with the GNPs solely loaded composites,a small quantity of CNTs addition endows GNPs/CNTs/PDMS ternary composites with a significantly decreased percolation threshold(f_(c)∼1.7 vol.%).Both GNPs and CNTs,these two representative conductive carbon constructions with high aspect ratios are able to effectively enhance the establishing efficiency of internal conductive network inner composites.These results indicate that the development of internal conductive network and dielectric performance of nanocomposites are able to be optimised through the strategy of taking advantage of the synergistic effect of multi-type fillers reasonably.
基金supported by the Basic Science Center Project of NSFC(Grant No.52388201)the National Science Fund for Distinguished Young Scholars(Grant No.12025405)+1 种基金the Beijing Advanced Innovation Center for Future Chip(ICFC)the Beijing Advanced Innovation Center for Materials Genome Engineering,and NSAF(Grant No.U2330401).
文摘The interplay of polarization and magnetisminmaterials with light can create rich nonlinear magnetooptical(NLMO)effects,and the recent discovery of two-dimensional(2D)van der Waals magnets provides remarkable control over NLMO effects due to their superb tunability.Here,based on firstprinciples calculations,we reported giant NLMO effects in CrI_(3)-based 2D magnets,including a dramatic change of second-harmonics generation(SHG)polarization direction(90°)and intensity(on/off switch)under magnetization reversal and a 100%SHG circular dichroism effect.We further revealed that these effects could not only be used to design ultra-thin multifunctional optical devices but also to detect subtle magnetic orderings.
基金National Natural Science Foundation of China(NSFC)(61475125)Natural Science Foundation of Shaanxi Province(2017JQ6066)+1 种基金Education Department of Shaanxi Province(16JK1776)Northwest University Doctorate Dissertation of Excellence Funds(YYB17006)
文摘We report on the enhancement of phase conjugation degenerate four-wave mixing(DFWM) in hot atomic Rb vapor by using a Bessel beam as the probe beam. The Bessel beam was generated using cross-phase modulation based on the thermal nonlinear optical effect. Our results demonstrated that the DFWM signal generated by the Bessel beam is about twice as large as that generated by the Gaussian beam, which can be attributed to the extended depth and tight focusing features of the Bessel beam. We also found that a DFWM signal with reasonable intensity can be detected even when the Bessel beam encounters an obstruction on its way, thanks to the selfhealing property of the Bessel beam. This work not only indicates that DFWM using a Bessel beam would be of great potential in the fields of high-fidelity communication, adaptive optics, and so on, but also suggests that a Bessel beam would be of significance to enhance the nonlinear process, especially in thick and scattering media.