Objective:To investigate the impact of precise nursing care based on dynamic nursing quality feedback model on the postoperative recovery of elderly patients undergoing radical resection for colon cancer,with a partic...Objective:To investigate the impact of precise nursing care based on dynamic nursing quality feedback model on the postoperative recovery of elderly patients undergoing radical resection for colon cancer,with a particular focus on its effects on psychological flexibility.Methods:Medical records of 124 elderly patients undergoing radical resection for colon cancer at The First Affiliated Hospital of Baotou Medical College between January 2021 and May 2024 were retrospectively analyzed in this study.Based on the received nursing interventions,the patients were divided into a control group(standard nursing care)and an observation group(precise nursing care based on a dynamic nursing quality feedback model).Results:The observation group exhibited significantly higher levels of hemoglobin,prealbumin,and albumin compared to the control group.Additionally,the observation group had lower scores in somatization,interpersonal sensitivity,depression,anxiety,obsessions-compulsions,hostility,phobic anxiety,psychoticism,and paranoid ideation.The observation group also demonstrated higher scores in active coping,self-efficacy,and the management of emotions,life,and symptoms.Improvements were also observed in nursing quality,perioperative intervention,satisfaction with rehabilitation guidance,and awareness of regular reexaminations,diet intervention,and complication prevention(all with P<0.05).Conclusion:Precise nursing based on a dynamic nursing quality feedback model can improve nutritional status and medical coping style,reduce psychological issues,and enhance self-management abilities in elderly patients following radical resection of colon cancer.Additionally,it increases nursing satisfaction and raises awareness regarding the importance of regular reexaminations and complication prevention.展开更多
Sjögren’s syndrome(SS)is a challenging condition within the realm of rheumatologic immune disorders.Recent studies have indicated that the imbalance in the immune microenvironment,exacerbated by mitochondrial dy...Sjögren’s syndrome(SS)is a challenging condition within the realm of rheumatologic immune disorders.Recent studies have indicated that the imbalance in the immune microenvironment,exacerbated by mitochondrial dysfunction(MDF),plays a critical role in the pathogenesis of SS.The efficacy of traditional Chinese medicine(TCM)in treating SS has been noteworthy.In the present study,we compiled medical cases of SS treated by Lu Zhizheng,a renowned master of Chinese medicine,and identified bidentate achyranthes and American ginseng as high-frequency medicinal pairs utilized in the treatment of desiccation syndrome through data mining.Network pharmacology analysis revealed that key genes associated with these medicinal pairs were linked to both upstream and downstream components of the cGAS-STING signaling pathway.Our findings suggested that bidentate achyranthes and American ginseng might correct MDF through the mtDNA-cGAS-STING signaling axis,thereby restoring the balance of the immune microenvironment in the submandibular gland.This mechanism potentially led to the treatment and alleviation of symptoms associated with SS.展开更多
Although tremendous efforts have been devoted to the structural and functional tailoring of natural polyphenol-functionalized nan oparticles,preparing ultrasmall sized(<6 nm)particles with precisely-defined structu...Although tremendous efforts have been devoted to the structural and functional tailoring of natural polyphenol-functionalized nan oparticles,preparing ultrasmall sized(<6 nm)particles with precisely-defined structures has remained a grand challenge.In this work,we reported the preparation of ultra-small and precisely structured polyhedral oligomeric silsesquioxanes(POSS)-based polyphenol nanopartides(T8^-,T10^-,and T12^-GAPOSS)by accurately functionalizing the POSS surface with plant polyphenol gallic acid units via thiol-Michael"click"reactions.Those polyphenol nanoparticles exhibited strong free radical scavenging capacity,good biocompatibility and ability to resist cell oxidative damage,which dem on strated great potentials in inhibiting oxidative stress in duced pathologies.展开更多
Seamount is a unique deep-sea ecosystem widely distributed in the world.Its biodiversity is vibrant due to its specific geographical and hydrological conditions.However,the diversity and features of foraminifera in su...Seamount is a unique deep-sea ecosystem widely distributed in the world.Its biodiversity is vibrant due to its specific geographical and hydrological conditions.However,the diversity and features of foraminifera in such an environment have rarely been studied.We extracted environmental DNA(eDNA)in sedime nts and amplified the partial small subunit ribo somal DNA(SSU rDNA)of fo raminife ra to understand the foraminiferal diversity from four sites in Magellan Seamount(Western Pacific Ocean).Partial S SU rDNA sequencing was conducted and 912979 foraminiferal reads were obtained and gathered into 266 operational taxonomic units(OTUs).In the available dataset,a high proportion of rare OTUs and low identity OTUs in each studied sample showed that the Magellan Seamount foraminiferal community might have a high genetic novelty.The relative abundance of foraminifera varied between replicates probably due to the existence of bias in amplification process and patchiness of the deep-sea floor.It showed that the Magellan Seamount has a relatively high benthic foraminiferal diversity characterized mainly by monothalamiids(76.37%of total reads)in association with rotaliids(19.03%of total reads),including planktic foraminiferal sequences(38.58%of rotaliids;7.36%of total reads).The remaining reads were assigned to miliolids(0.83%of total reads)and textulariids(0.66%of total reads),and 3.11%of total reads are unassigned to a specific family.The co mparative analysis with foraminiferal assemblage s from coastal and deep-sea environme nts indicated that seamounts could aggregate species from a nearby deep-sea.展开更多
The torque and bending moment acting on a flexible overhung shaft in a gas–liquid stirred vessel agitated by a Rushton turbine and three different curved-blade disk turbines(half circular blades disk turbine, half el...The torque and bending moment acting on a flexible overhung shaft in a gas–liquid stirred vessel agitated by a Rushton turbine and three different curved-blade disk turbines(half circular blades disk turbine, half elliptical blades disk turbine, and parabolic blades disk turbine) were experimentally measured by a customized moment sensor. The results show that the amplitude distribution of torque can be fitted by a symmetric bimodal distribution for disk turbines, and generally the distribution is more dispersive as the blade curvature or the gas flow rate increases. The amplitude distribution of shaft bending moment can be fitted by an asymmetric Weibull distribution for disk turbines. The relative shaft bending moment manifests a "rising-falling-rising" trend over the gas flow number, which is a corporate contribution of the unstable gas–liquid flow around the impeller, the gas cavities behind the blades, and the direct impact of gas on the impeller. And the "falling" stage is greater and lasts wider over the gas flow number for Rushton turbine than for the curved-blade disk turbines.展开更多
We study inserting Co layer thickness-dependent spin transport and spin-orbit torques(SOTs)in the Pt/Co/Py trilayers by spin-torque ferromagnetic resonance.The interfacial perpendicular magnetic anisotropy(IPMA)energy...We study inserting Co layer thickness-dependent spin transport and spin-orbit torques(SOTs)in the Pt/Co/Py trilayers by spin-torque ferromagnetic resonance.The interfacial perpendicular magnetic anisotropy(IPMA)energy density(Ks=2.7 erg/cm^(2),1 erg=10^(-7) J),which is dominated by interfacial spin-orbit coupling(ISOC)in the Pt/Co interface,total effective spin-mixing conductance(G↑↓eff,tot=0.42×10^(15) Ω^(-1)·m^(-2))and two-magnon scattering(βTMS=0.46 nm2)are first characterized,and the damping-like torque(ξDL=0.103)and field-like torque(ξFL=-0.017)efficiencies are also calculated quantitatively by varying the thickness of the inserting Co layer.The significant enhancement of ξDL and ξFL in Pt/Co/Py than Pt/Py bilayer system originates from the interfacial Rashba-Edelstein effect due to the strong ISOC between Co-3d and Pt-5d orbitals at the Pt/Co interface.Additionally,we find a considerable out-of-plane spin polarization SOT,which is ascribed to the spin anomalous Hall effect and possible spin precession effect due to IPMA-induced perpendicular magnetization at the Pt/Co interface.Our results demonstrate that the ISOC of the Pt/Co interface plays a vital role in spin transport and SOTs-generation.Our finds offer an alternative approach to improve the conventional SOTs efficiencies and generate unconventional SOTs with out-of-plane spin polarization to develop low power Pt-based spintronic via tailoring the Pt/FM interface.展开更多
Wind energy has been widely applied in power generation to alleviate climate problems.The wind turbine layout of a wind farm is a primary factor of impacting power conversion efficiency due to the wake effect that red...Wind energy has been widely applied in power generation to alleviate climate problems.The wind turbine layout of a wind farm is a primary factor of impacting power conversion efficiency due to the wake effect that reduces the power outputs of wind turbines located in downstream.Wind farm layout optimization(WFLO)aims to reduce the wake effect for maximizing the power outputs of the wind farm.Nevertheless,the wake effect among wind turbines increases significantly as the number of wind turbines increases in the wind farm,which severely affect power conversion efficiency.Conventional heuristic algorithms suffer from issues of low solution quality and local optimum for large-scale WFLO under complex wind scenarios.Thus,a chaotic local search-based genetic learning particle swarm optimizer(CGPSO)is proposed to optimize large-scale WFLO problems.CGPSO is tested on four larger-scale wind farms under four complex wind scenarios and compares with eight state-of-the-art algorithms.The experiment results indicate that CGPSO significantly outperforms its competitors in terms of performance,stability,and robustness.To be specific,a success and failure memories-based selection is proposed to choose a chaotic map for chaotic search local.It improves the solution quality.The parameter and search pattern of chaotic local search are also analyzed for WFLO problems.展开更多
We investigate properties of perpendicular anisotropy magnetic tunnel junctions(pMTJs) with a stack structure MgO/CoFeB/Ta/CoFeB/MgO as the free layer(or recording layer),and obtain the necessary device parameters fro...We investigate properties of perpendicular anisotropy magnetic tunnel junctions(pMTJs) with a stack structure MgO/CoFeB/Ta/CoFeB/MgO as the free layer(or recording layer),and obtain the necessary device parameters from the tunneling magnetoresistance(TMR) vs.field loops and current-driven magnetization switching experiments.Based on the experimental results and device parameters,we further estimate current-driven switching performance of pMTJ including switching time and power,and their dependence on perpendicular magnetic anisotropy and damping constant of the free layer by SPICE-based circuit simulations.Our results show that the pMTJ cells exhibit a less than 1 ns switching time and write energies <1.4 pJ;meanwhile the lower perpendicular magnetic anisotropy(PMA) and damping constant can further reduce the switching time at the studied range of damping constant α <0.1.Additionally,our results demonstrate that the pMTJs with the thermal stability factor■73 can be easily transformed into spin-torque nano-oscillators from magnetic memory as microwave sources or detectors for telecommunication devices.展开更多
Energy issues have always been one of the most significant concerns for scientists worldwide.With the ongoing over exploitation and continued outbreaks of wars,traditional energy sources face the threat of depletion.W...Energy issues have always been one of the most significant concerns for scientists worldwide.With the ongoing over exploitation and continued outbreaks of wars,traditional energy sources face the threat of depletion.Wind energy is a readily available and sustainable energy source.Wind farm layout optimization problem,through scientifically arranging wind turbines,significantly enhances the efficiency of harnessing wind energy.Meta-heuristic algorithms have been widely employed in wind farm layout optimization.This paper introduces an Adaptive strategy-incorporated Integer Genetic Algorithm,referred to as AIGA,for optimizing wind farm layout problems.The adaptive strategy dynamically adjusts the placement of wind turbines,leading to a substantial improvement in energy utilization efficiency within the wind farm.In this study,AIGA is tested in four different wind conditions,alongside four other classical algorithms,to assess their energy conversion efficiency within the wind farm.Experimental results demonstrate a notable advantage of AIGA.展开更多
Artificial spin ice(ASI) structures have significant technological potential as reconfigurable metamaterials and magnetic storage media.We investigate the field/frequency-dependent magnetic dynamics of a kagome ASI ma...Artificial spin ice(ASI) structures have significant technological potential as reconfigurable metamaterials and magnetic storage media.We investigate the field/frequency-dependent magnetic dynamics of a kagome ASI made of 25-nm-thick permalloy nanomagnet elements,combining magnetoresistance(MR) and microscale ferromagnetic resonance(FMR) techniques.Our FMR spectra show a broadband absorption spectrum from 0.2 GHz to 3 GHz at H below 0.3 kOe,where the magnetic configuration of the kagome ASI is in the multidomain state,because the external magnetic field is below the obtained coercive field Hc~0.3 kOe,based on both the low-field range MR loops and simulations,suggesting that the low-field magnetization dynamics of kagome ASI is dominated by a multimode resonance regime.However,the FMR spectra exhibit five distinctive resonance modes at the highfield quasi-uniform magnetization state.Furthermore,our micromagnetic simulations provide additional spatial resolution of these resonance modes,identifying the presence of two high-frequency primary modes,localized in the horizontal and vertical bars of the ASI,respectively;three other low-frequency modes are mutually exclusive and separately pinned at the corners of the kagome ASI by an edge-induced dipolar field.Our results suggest that an ASI structural design can be adopted as an efficient approach for the development of low-power filters and magnonic devices.展开更多
Magnonic devices based on spin waves are considered as a new generation of energy-efficient and high-speed devices for storage and processing of information.Here we experimentally demonstrate that three distinct domin...Magnonic devices based on spin waves are considered as a new generation of energy-efficient and high-speed devices for storage and processing of information.Here we experimentally demonstrate that three distinct dominated magneto-dynamic modes are excited simultaneously and coexist in a transversely magnetized ferromagnetic wire by the ferromagnetic resonance(FMR)technique.Besides the uniform FMR mode,the spin-wave well mode,the backward volume magnetostatic spin-wave mode,and the perpendicular standing spin-wave mode are experimentally observed and further confirmed with more detailed spatial profiles by micromagnetic simulation.Furthermore,our experimental approach can also access and reveal damping coefficients of these spin-wave modes,which provides essential information for development of magnonic devices in the future.展开更多
Animals’ immunity is an important factor to determine their survival and fitness. Unpredictable food shortage is common to small mammals due to fluctuation of food resources throughout a year. In general, acute food ...Animals’ immunity is an important factor to determine their survival and fitness. Unpredictable food shortage is common to small mammals due to fluctuation of food resources throughout a year. In general, acute food deprivation (FD) inhibited immune function in rodents. In the present study we tested the hypothesis that stochastic FD would also suppress T cell-mediated immunity in mice. Fifteen adult male Kunming mice were randomly assigned into the Fed (n = 7) and FD (n = 8) groups, in which the latter were subjected to stochastic FD regime. Unexpectedly, T cell-mediated immunity assessed by PHA response was increased in the FD mice compared with the fed controls. However, body fat mass, wet thymus and spleen mass, white blood cells, serum leptin and corticosterone concentrations did not differ between the Fed and FD groups. Taken together, stochastic food deprivation can enhance cellular immunity in Kunming mice.展开更多
Memristors,with their compactness,nonvolatile storage,and dynamic resistance modulation,are poised to revolutionize next-generation memory and neuromorphic computing paradigms.III-nitride materials,such as boron nitri...Memristors,with their compactness,nonvolatile storage,and dynamic resistance modulation,are poised to revolutionize next-generation memory and neuromorphic computing paradigms.III-nitride materials,such as boron nitride(BN),gallium nitride(GaN),and aluminum nitride(AlN),exhibit exceptional properties for advancing memristive technologies,including wide bandgaps(3.4-6.2 eV),high electron mobility(10^(2)-10^(3)cm^(2)(V·s)^(-1)),high thermal conductivity(up to 400 W(m·K)^(-1)),and robust resistance to harsh environments(e.g.extreme temperatures,radiation).Coupled with inherent complementary metal-oxide-semiconductor(CMOS)compatibility,these attributes position nitride-based memristors as a transformative platform for scalable,energy-efficient,and reliable electronics.In this review,we systematically examine recent advancements in III-nitride memristors,with a focus on materials engineering,device structures,and emerging applications.We begin by outlining the unique advantages of III-nitride materials for memristor design,followed by a critical analysis of progress in BN,GaN,AlN,and AlScN-based devices.We then explore their hardware-level implementations,demonstrating their role in next-generation chip architectures.Finally,we discuss the challenges and future directions to advance nitride-based memristive technologies.Notably,III-nitride memristors unlock unprecedented opportunities for high-performance electronics in extreme environments while bridging the gap between bio-inspired computing paradigms and hardware scalability,enabling adaptive,high-speed,and energy-efficient intelligent systems.展开更多
Breast cancer remains the most prevalent malignancy among women worldwide,with triple-negative breast cancer(TNBC) representing its most aggressive and lethal subtype.TNBC is characterized by high rates of recurrence ...Breast cancer remains the most prevalent malignancy among women worldwide,with triple-negative breast cancer(TNBC) representing its most aggressive and lethal subtype.TNBC is characterized by high rates of recurrence and lung metastasis after surgery,severely impacting patient quality of life.Recent studies highlight the critical role of metabolic reprogramming in driving cancer recurrence,migration,and invasion.While the underlying mechanisms remain complex and not fully elucidated,transcriptomic analyses comparing primary and metastatic breast cancer tissues from TNBC and Luminal patients have identified lysophosphatidylcholine acyltransferase 1(LPCAT1) as a key enzyme upregulated in lung metastases and TNBC.LPCAT1 is strongly associated with poor prognosis due to its activation of the TGFβ signaling pathway.This activation is driven by LPCAT1's ability to increase cellular ATP levels,fostering a high-energy state that stimulates ATPase activity.Consequently,ATP-dependent chromatin remodeling via the BAF complex,which includes double PHD finger 2(DPF2) as a critical subunit,regulates gene transcription essential for tumor progression.Through the LPCAT1-DPF2-TGFBR2 axis,TNBC cells enhance TGFβ signaling,promoting malignant behavior and metastasis.Addressing this,we developed a reduction-responsive nanoparticle platform for the systemic delivery of LPCAT1-targeted si RNA(si LPCAT1),which has shown significant efficacy in suppressing TNBC tumor growth and metastasis.These findings suggest that nanoparticle-mediated si LPCAT1 delivery represents a promising therapeutic strategy for advanced TNBC treatment.展开更多
Background:Primary Sjogren syndrome(pSS)is an autoimmune disease for which traditional Chinese medicine has shown significant therapeutic effects based on different syndrome types of Sjögren syndrome.However,the ...Background:Primary Sjogren syndrome(pSS)is an autoimmune disease for which traditional Chinese medicine has shown significant therapeutic effects based on different syndrome types of Sjögren syndrome.However,the research findings between it and related plant extracts are limited.Objective:To explore the symptoms of patients with Yin deficiency syndrome and non-Yin deficiency syndrome of Sjogren syndrome and their relationship with plant extracts under the background of traditional Chinese medicine.Methods:Whole blood samples were collected from SS patients with Yin deficiency syndrome(5),SS patients without Yin deficiency syndrome(5),and healthy volunteers(5)for proteomic testing.Using healthy volunteers as the control group,the differential protein expression of SS with Yin deficiency syndrome was screened for enrichment analysis and functional annotation;combining previous effective clinical cases and prescription drugs for data mining and network pharmacological analysis,potential effective plant extracts were screened and enriched.Finally,molecular docking was used to validate the results of network analysis,providing a highly probable new idea for the correlation between potential drug targets for SS patients with Yin deficiency syndrome and potential effective plant extracts.Results:(1)By analyzing the proteomic data of clinical samples,the differential genes of healthy individuals versus Sjogren syndrome with Yin deficiency versus Sjogren syndrome without Yin deficiency were discovered.By overlapping the above data,it was found that the key target genes for treating Sjogren syndrome are HBA1,MST1,PCSK9,and HBB.(2)Enrichment analysis of plant extracts(PE)through clinical data mining of effective cases revealed the tremendous potential of four Chinese botanical drugs—β-sitosterol,quercetin,berberine,and kaempferol in treating Sjogren syndrome patients with Yin deficiency syndrome.(3)The pathogenesis and regulation of Sjogren syndrome with Yin deficiency syndrome may be related to interleukin-related pathways,DNA synthesis,and oxidative stress.(4)Molecular docking suggests that berberine has good binding activity with MST1.Conclusions:We believe that berberine and MST1 may have significant research value in the treatment of Sjogren syndrome in female patients.This study provides valuable reference points for future research on Sjogren syndrome with Yin deficiency syndrome.展开更多
We propose a new mechanism to achieve nonreciprocal quantum entanglement in a cavity magnomechanical system by exploiting the chiral cavity-magnon coupling.The system consists of a magnon mode,a mechanical vibration m...We propose a new mechanism to achieve nonreciprocal quantum entanglement in a cavity magnomechanical system by exploiting the chiral cavity-magnon coupling.The system consists of a magnon mode,a mechanical vibration mode,and two degenerate counter-propagating microwave cavity modes in a torus-shaped cavity.We show that nonreciprocal stationary microwave-magnon and-phonon bipartite entanglements and photon-magnon-phonon tripartite entanglement can be achieved by respectively driving different circulating cavity modes that hold a chiral coupling to the magnon mode.The nonreciprocal entanglements are shown to be robust against various experimental imperfections.We specifically show how such nonreciprocal entanglement can realize the channel multiplexing quantum teleportation from a microwave field to a solidstate magnon mode.The work may find promising applications of the cavity magnomechanical systems in noise-tolerant quantum processing,channel multiplexing quantum teleportation,and chiral magnonic quantum networks.展开更多
Inspired by the multimodal perception of human skin,flexible sensors are advancing intelligent sensing systems in healthcare and robotics.Pressure-temperature bimodal sensing is crucial for enhanced environmental perc...Inspired by the multimodal perception of human skin,flexible sensors are advancing intelligent sensing systems in healthcare and robotics.Pressure-temperature bimodal sensing is crucial for enhanced environmental perception and cross-domain applications.However,critical challenges remain in interference suppression and effective integration for augmented tactile and thermal perception.Here,we propose an interference-free flexible intelligent sensing patch that is composed of a laser-patterned pressure sensor and a thermistor.The patch demonstrates a large pressure detection range of 8 Pa to 220 kPa with a rapid response time of 50 ms,and a high temperature-sensing resolution of 0.01℃at the range of 10–50℃.Additionally,it can maintain highly stable performance under 150°bending deformation and 10%tensile strain.Furthermore,we built an integrated real-time processing platform to demonstrate its versatility through continuous,non-invasive monitoring for wrist pulse and epidermis temperature.Impressively,the patch can enhance real-time tactile feedback for soft robotic grippers during object manipulation,achieving tactile recognition with an accuracy of 94.09%for ten distinct objects.Intelligent sensing patches for augmented tactile and thermal perception hold promises for delivering precise and natural experiences while driving innovation and advancement in artificial prosthetics,intelligent robotics,wearable devices,and health monitoring.展开更多
Antioxidants play a crucial role in alleviating oxidative stress,essential for preventing aging and a wide range of diseases,including cancer,cardiovascular diseases,and neurodegenerative disorders.However,the efficac...Antioxidants play a crucial role in alleviating oxidative stress,essential for preventing aging and a wide range of diseases,including cancer,cardiovascular diseases,and neurodegenerative disorders.However,the efficacy of exogenous antioxidants employed in clinical settings is often compromised due to the oxidative depletion of their reducing functional groups.A majority of strategies reported to date predominantly focus on tuning the initial concentration and scavenging capacity of the antioxidants,which inevitably results in heightened biological toxicity and elevated treatment expenses.To address this critical issue,we synthesized a series of self-reinforced polyphenolic nanoparticle(PNP)antioxidants by incorporating multiple dynamic bonds such as utilizing borate ester linkages and nitrogenboron(B←N)coordination bonds in this work.The resulting nanoantioxidants exhibited high stability under physiological conditions and could progressively release antioxidative moieties in response to elevated free radical concentrations,thus achieving self-reinforced and superior antioxidative capability.This work presents a new strategy for overcoming the functional decay of polyphenolic antioxidants via the preparation of robust self-reinforced nanoantioxidants.展开更多
Leopoldamys edwardsi is a species with wide distribution ranges in southern China but is not discussed in studies on geographic variation and species differentiation.We used 2 mitochondrial(Cytb,CO1)and 3 nuclear(GHR,...Leopoldamys edwardsi is a species with wide distribution ranges in southern China but is not discussed in studies on geographic variation and species differentiation.We used 2 mitochondrial(Cytb,CO1)and 3 nuclear(GHR,IRBP and RAG1)genes to clarify species phylogeography and geographical differentiation.Maximum likelihood(ML)and Bayesian phylogenetic inference(BI)trees consistently indicated that L.edwardsi is a species complex containing 3 main lineages with high Kimura-2-parameter(K2P)divergences(i.e.lineages LN,LS and LHN)found in the northern and southern China and Hainan Island,respectively.The 3 species delimitation methods,automated barcoding gap discovery,Bayesian poisson tree process analysis and Bayesian phylogenetics and phylogeography,consistently supported the existence of cryptic species.Divergence times among the main lineages were inferred to be during the Pleistocene,with LHN/LS split at 1.33 Ma and LN/(LHN+LS)at 2.61 Ma;the diversifications of L.edwardsi complex might be caused by the rapid uplifts of Tibetan Plateau,paleoclimate change and complex topography.The divergence between LHN and LS was probably related to the separation of Hainan Island from the mainland via the formation of the Qiongzhou Strait.Lineages LN and(LS+LHN)likely diverged due to the Wuyi-Nanling mountain range forming a dispersal barrier.Our results suggested that L.edwardsi complex contains at least 3 distinct species:LHN represents L.hainanensis,endemic to Hainan Island and previously considered as a subspecies L.e.hainanensis;LS represents a cryptic species distributed throughout the southern Chinese continent;and LN represents the nominotypical species L.edwardsi.展开更多
文摘Objective:To investigate the impact of precise nursing care based on dynamic nursing quality feedback model on the postoperative recovery of elderly patients undergoing radical resection for colon cancer,with a particular focus on its effects on psychological flexibility.Methods:Medical records of 124 elderly patients undergoing radical resection for colon cancer at The First Affiliated Hospital of Baotou Medical College between January 2021 and May 2024 were retrospectively analyzed in this study.Based on the received nursing interventions,the patients were divided into a control group(standard nursing care)and an observation group(precise nursing care based on a dynamic nursing quality feedback model).Results:The observation group exhibited significantly higher levels of hemoglobin,prealbumin,and albumin compared to the control group.Additionally,the observation group had lower scores in somatization,interpersonal sensitivity,depression,anxiety,obsessions-compulsions,hostility,phobic anxiety,psychoticism,and paranoid ideation.The observation group also demonstrated higher scores in active coping,self-efficacy,and the management of emotions,life,and symptoms.Improvements were also observed in nursing quality,perioperative intervention,satisfaction with rehabilitation guidance,and awareness of regular reexaminations,diet intervention,and complication prevention(all with P<0.05).Conclusion:Precise nursing based on a dynamic nursing quality feedback model can improve nutritional status and medical coping style,reduce psychological issues,and enhance self-management abilities in elderly patients following radical resection of colon cancer.Additionally,it increases nursing satisfaction and raises awareness regarding the importance of regular reexaminations and complication prevention.
基金Research on the Knowledge Graph System of “Disease Syndrome Formula (Medicine)” for Rheumatology,Science and Technology Innovation Project of the Chinese Academy of Traditional Chinese Medicine (Grant No. C12021A01507)the Basic Research Business Fee of the Institute of Traditional Chinese Medicine Basic Theory,Chinese Academy of Traditional Chinese Medicine,is based on knowledge graphs and deep learning to trace the academic ideas of Lu Zhizheng in the treatment of rheumatism during three periods (Grant No. YZX-202317)+1 种基金Central High-level Chinese Medicine Hospital Clinical Research and Results Translation Capacity Enhancement Program (Grant No. HLCMHPP20230120)High Level Chinese Medical Hospital Promotion Project (Grant No. HLCMHPP2023087)。
文摘Sjögren’s syndrome(SS)is a challenging condition within the realm of rheumatologic immune disorders.Recent studies have indicated that the imbalance in the immune microenvironment,exacerbated by mitochondrial dysfunction(MDF),plays a critical role in the pathogenesis of SS.The efficacy of traditional Chinese medicine(TCM)in treating SS has been noteworthy.In the present study,we compiled medical cases of SS treated by Lu Zhizheng,a renowned master of Chinese medicine,and identified bidentate achyranthes and American ginseng as high-frequency medicinal pairs utilized in the treatment of desiccation syndrome through data mining.Network pharmacology analysis revealed that key genes associated with these medicinal pairs were linked to both upstream and downstream components of the cGAS-STING signaling pathway.Our findings suggested that bidentate achyranthes and American ginseng might correct MDF through the mtDNA-cGAS-STING signaling axis,thereby restoring the balance of the immune microenvironment in the submandibular gland.This mechanism potentially led to the treatment and alleviation of symptoms associated with SS.
基金the National Natural Science Foundation of China(Nos.51603133 and 21774079)National Key R&D Program of China(No.2019YFA0904500)+1 种基金the Program of the Science,Technology Department of Guangzhou,China(No.201803020039)the Fundamental Research Funds for Central Universities.
文摘Although tremendous efforts have been devoted to the structural and functional tailoring of natural polyphenol-functionalized nan oparticles,preparing ultrasmall sized(<6 nm)particles with precisely-defined structures has remained a grand challenge.In this work,we reported the preparation of ultra-small and precisely structured polyhedral oligomeric silsesquioxanes(POSS)-based polyphenol nanopartides(T8^-,T10^-,and T12^-GAPOSS)by accurately functionalizing the POSS surface with plant polyphenol gallic acid units via thiol-Michael"click"reactions.Those polyphenol nanoparticles exhibited strong free radical scavenging capacity,good biocompatibility and ability to resist cell oxidative damage,which dem on strated great potentials in inhibiting oxidative stress in duced pathologies.
基金the Science&Technology Basic Resources Investigation Program of China(No.2017FY100804)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB42000000)+5 种基金the National Program on Global Change and Air-Sea Interaction(No.GASIGEOGE-04)the Key Program of National Natural Science Foundation of China(No.41930533)the Taishan Scholars Project Funding(No.TS20190963)the Senior User Project of R/V KexueCenter for Ocean Mega-Science,Chinese Academy of Sciences。
文摘Seamount is a unique deep-sea ecosystem widely distributed in the world.Its biodiversity is vibrant due to its specific geographical and hydrological conditions.However,the diversity and features of foraminifera in such an environment have rarely been studied.We extracted environmental DNA(eDNA)in sedime nts and amplified the partial small subunit ribo somal DNA(SSU rDNA)of fo raminife ra to understand the foraminiferal diversity from four sites in Magellan Seamount(Western Pacific Ocean).Partial S SU rDNA sequencing was conducted and 912979 foraminiferal reads were obtained and gathered into 266 operational taxonomic units(OTUs).In the available dataset,a high proportion of rare OTUs and low identity OTUs in each studied sample showed that the Magellan Seamount foraminiferal community might have a high genetic novelty.The relative abundance of foraminifera varied between replicates probably due to the existence of bias in amplification process and patchiness of the deep-sea floor.It showed that the Magellan Seamount has a relatively high benthic foraminiferal diversity characterized mainly by monothalamiids(76.37%of total reads)in association with rotaliids(19.03%of total reads),including planktic foraminiferal sequences(38.58%of rotaliids;7.36%of total reads).The remaining reads were assigned to miliolids(0.83%of total reads)and textulariids(0.66%of total reads),and 3.11%of total reads are unassigned to a specific family.The co mparative analysis with foraminiferal assemblage s from coastal and deep-sea environme nts indicated that seamounts could aggregate species from a nearby deep-sea.
基金Supported by the National Key R&D Program of China(2017YFB0306704)the National Natural Science Foundation of China(21676007)
文摘The torque and bending moment acting on a flexible overhung shaft in a gas–liquid stirred vessel agitated by a Rushton turbine and three different curved-blade disk turbines(half circular blades disk turbine, half elliptical blades disk turbine, and parabolic blades disk turbine) were experimentally measured by a customized moment sensor. The results show that the amplitude distribution of torque can be fitted by a symmetric bimodal distribution for disk turbines, and generally the distribution is more dispersive as the blade curvature or the gas flow rate increases. The amplitude distribution of shaft bending moment can be fitted by an asymmetric Weibull distribution for disk turbines. The relative shaft bending moment manifests a "rising-falling-rising" trend over the gas flow number, which is a corporate contribution of the unstable gas–liquid flow around the impeller, the gas cavities behind the blades, and the direct impact of gas on the impeller. And the "falling" stage is greater and lasts wider over the gas flow number for Rushton turbine than for the curved-blade disk turbines.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11774150,12074178,11874135,and 12004171)the Applied Basic Research Programs of the Science and Technology Commission Foundation of Jiangsu Province,China(Grant No.BK20200309)+1 种基金the Open Research Fund of Jiangsu Provincial Key Laboratory for Nanotechnology,Key Research and Development Program of Zhejiang Province,China(Grant No.2021C01039)the Scientific Foundation of Nanjing University of Posts and Telecommunications(Grant No.NY220164).
文摘We study inserting Co layer thickness-dependent spin transport and spin-orbit torques(SOTs)in the Pt/Co/Py trilayers by spin-torque ferromagnetic resonance.The interfacial perpendicular magnetic anisotropy(IPMA)energy density(Ks=2.7 erg/cm^(2),1 erg=10^(-7) J),which is dominated by interfacial spin-orbit coupling(ISOC)in the Pt/Co interface,total effective spin-mixing conductance(G↑↓eff,tot=0.42×10^(15) Ω^(-1)·m^(-2))and two-magnon scattering(βTMS=0.46 nm2)are first characterized,and the damping-like torque(ξDL=0.103)and field-like torque(ξFL=-0.017)efficiencies are also calculated quantitatively by varying the thickness of the inserting Co layer.The significant enhancement of ξDL and ξFL in Pt/Co/Py than Pt/Py bilayer system originates from the interfacial Rashba-Edelstein effect due to the strong ISOC between Co-3d and Pt-5d orbitals at the Pt/Co interface.Additionally,we find a considerable out-of-plane spin polarization SOT,which is ascribed to the spin anomalous Hall effect and possible spin precession effect due to IPMA-induced perpendicular magnetization at the Pt/Co interface.Our results demonstrate that the ISOC of the Pt/Co interface plays a vital role in spin transport and SOTs-generation.Our finds offer an alternative approach to improve the conventional SOTs efficiencies and generate unconventional SOTs with out-of-plane spin polarization to develop low power Pt-based spintronic via tailoring the Pt/FM interface.
基金partially supported by the Japan Society for the Promotion of Science(JSPS)KAKENHI(JP22H03643)Japan Science and Technology Agency(JST)Support for Pioneering Research Initiated by the Next Generation(SPRING)(JPMJSP2145)JST through the Establishment of University Fellowships towards the Creation of Science Technology Innovation(JPMJFS2115)。
文摘Wind energy has been widely applied in power generation to alleviate climate problems.The wind turbine layout of a wind farm is a primary factor of impacting power conversion efficiency due to the wake effect that reduces the power outputs of wind turbines located in downstream.Wind farm layout optimization(WFLO)aims to reduce the wake effect for maximizing the power outputs of the wind farm.Nevertheless,the wake effect among wind turbines increases significantly as the number of wind turbines increases in the wind farm,which severely affect power conversion efficiency.Conventional heuristic algorithms suffer from issues of low solution quality and local optimum for large-scale WFLO under complex wind scenarios.Thus,a chaotic local search-based genetic learning particle swarm optimizer(CGPSO)is proposed to optimize large-scale WFLO problems.CGPSO is tested on four larger-scale wind farms under four complex wind scenarios and compares with eight state-of-the-art algorithms.The experiment results indicate that CGPSO significantly outperforms its competitors in terms of performance,stability,and robustness.To be specific,a success and failure memories-based selection is proposed to choose a chaotic map for chaotic search local.It improves the solution quality.The parameter and search pattern of chaotic local search are also analyzed for WFLO problems.
基金Project supported by State Grid Corporation of China under the 2018 Science and Technology Project of State Grid Corporation:Research on electromagnetic measurement technology based on EIT and TMR(Grant No.JL71-18-007)。
文摘We investigate properties of perpendicular anisotropy magnetic tunnel junctions(pMTJs) with a stack structure MgO/CoFeB/Ta/CoFeB/MgO as the free layer(or recording layer),and obtain the necessary device parameters from the tunneling magnetoresistance(TMR) vs.field loops and current-driven magnetization switching experiments.Based on the experimental results and device parameters,we further estimate current-driven switching performance of pMTJ including switching time and power,and their dependence on perpendicular magnetic anisotropy and damping constant of the free layer by SPICE-based circuit simulations.Our results show that the pMTJ cells exhibit a less than 1 ns switching time and write energies <1.4 pJ;meanwhile the lower perpendicular magnetic anisotropy(PMA) and damping constant can further reduce the switching time at the studied range of damping constant α <0.1.Additionally,our results demonstrate that the pMTJs with the thermal stability factor■73 can be easily transformed into spin-torque nano-oscillators from magnetic memory as microwave sources or detectors for telecommunication devices.
基金supported by the Japan Society for the Promotion of Science(JSPS)KAKENHI under Grant JP22H03643,Japan Science and Technology Agency(JST)Support for Pioneering Research Initiated by the Next Generation(SPRING)under Grant JPMJSP2145JST through the Establishment of University Fellowships towards the Creation of Science Technology Innovation under Grant JPMJFS2115.
文摘Energy issues have always been one of the most significant concerns for scientists worldwide.With the ongoing over exploitation and continued outbreaks of wars,traditional energy sources face the threat of depletion.Wind energy is a readily available and sustainable energy source.Wind farm layout optimization problem,through scientifically arranging wind turbines,significantly enhances the efficiency of harnessing wind energy.Meta-heuristic algorithms have been widely employed in wind farm layout optimization.This paper introduces an Adaptive strategy-incorporated Integer Genetic Algorithm,referred to as AIGA,for optimizing wind farm layout problems.The adaptive strategy dynamically adjusts the placement of wind turbines,leading to a substantial improvement in energy utilization efficiency within the wind farm.In this study,AIGA is tested in four different wind conditions,alongside four other classical algorithms,to assess their energy conversion efficiency within the wind farm.Experimental results demonstrate a notable advantage of AIGA.
基金the State Grid Corporation of China via the Science and Technology Project:Research on Electromagnetic Measurement Technology Based on EIT and TMR(Grant No.JL71-18-007)。
文摘Artificial spin ice(ASI) structures have significant technological potential as reconfigurable metamaterials and magnetic storage media.We investigate the field/frequency-dependent magnetic dynamics of a kagome ASI made of 25-nm-thick permalloy nanomagnet elements,combining magnetoresistance(MR) and microscale ferromagnetic resonance(FMR) techniques.Our FMR spectra show a broadband absorption spectrum from 0.2 GHz to 3 GHz at H below 0.3 kOe,where the magnetic configuration of the kagome ASI is in the multidomain state,because the external magnetic field is below the obtained coercive field Hc~0.3 kOe,based on both the low-field range MR loops and simulations,suggesting that the low-field magnetization dynamics of kagome ASI is dominated by a multimode resonance regime.However,the FMR spectra exhibit five distinctive resonance modes at the highfield quasi-uniform magnetization state.Furthermore,our micromagnetic simulations provide additional spatial resolution of these resonance modes,identifying the presence of two high-frequency primary modes,localized in the horizontal and vertical bars of the ASI,respectively;three other low-frequency modes are mutually exclusive and separately pinned at the corners of the kagome ASI by an edge-induced dipolar field.Our results suggest that an ASI structural design can be adopted as an efficient approach for the development of low-power filters and magnonic devices.
基金Supported by the National Key Research and Development Program of China(Grant No.2016YFA0300803)the Open Research Fund of Jiangsu Provincial Key Laboratory for Nanotechnology,the National Natural Science Foundation of China(Grant Nos.11774150 and 11704191)the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20171026 and BK20170627).
文摘Magnonic devices based on spin waves are considered as a new generation of energy-efficient and high-speed devices for storage and processing of information.Here we experimentally demonstrate that three distinct dominated magneto-dynamic modes are excited simultaneously and coexist in a transversely magnetized ferromagnetic wire by the ferromagnetic resonance(FMR)technique.Besides the uniform FMR mode,the spin-wave well mode,the backward volume magnetostatic spin-wave mode,and the perpendicular standing spin-wave mode are experimentally observed and further confirmed with more detailed spatial profiles by micromagnetic simulation.Furthermore,our experimental approach can also access and reveal damping coefficients of these spin-wave modes,which provides essential information for development of magnonic devices in the future.
文摘Animals’ immunity is an important factor to determine their survival and fitness. Unpredictable food shortage is common to small mammals due to fluctuation of food resources throughout a year. In general, acute food deprivation (FD) inhibited immune function in rodents. In the present study we tested the hypothesis that stochastic FD would also suppress T cell-mediated immunity in mice. Fifteen adult male Kunming mice were randomly assigned into the Fed (n = 7) and FD (n = 8) groups, in which the latter were subjected to stochastic FD regime. Unexpectedly, T cell-mediated immunity assessed by PHA response was increased in the FD mice compared with the fed controls. However, body fat mass, wet thymus and spleen mass, white blood cells, serum leptin and corticosterone concentrations did not differ between the Fed and FD groups. Taken together, stochastic food deprivation can enhance cellular immunity in Kunming mice.
基金support from the National Natural Science Foundation of China(62374018)the National Key Research and Development Program of China(2023YFC3603501)。
文摘Memristors,with their compactness,nonvolatile storage,and dynamic resistance modulation,are poised to revolutionize next-generation memory and neuromorphic computing paradigms.III-nitride materials,such as boron nitride(BN),gallium nitride(GaN),and aluminum nitride(AlN),exhibit exceptional properties for advancing memristive technologies,including wide bandgaps(3.4-6.2 eV),high electron mobility(10^(2)-10^(3)cm^(2)(V·s)^(-1)),high thermal conductivity(up to 400 W(m·K)^(-1)),and robust resistance to harsh environments(e.g.extreme temperatures,radiation).Coupled with inherent complementary metal-oxide-semiconductor(CMOS)compatibility,these attributes position nitride-based memristors as a transformative platform for scalable,energy-efficient,and reliable electronics.In this review,we systematically examine recent advancements in III-nitride memristors,with a focus on materials engineering,device structures,and emerging applications.We begin by outlining the unique advantages of III-nitride materials for memristor design,followed by a critical analysis of progress in BN,GaN,AlN,and AlScN-based devices.We then explore their hardware-level implementations,demonstrating their role in next-generation chip architectures.Finally,we discuss the challenges and future directions to advance nitride-based memristive technologies.Notably,III-nitride memristors unlock unprecedented opportunities for high-performance electronics in extreme environments while bridging the gap between bio-inspired computing paradigms and hardware scalability,enabling adaptive,high-speed,and energy-efficient intelligent systems.
基金supported by the National Natural Science Foundation of China (82173392,81874226,82072930 and 81802700)the grants from Guangdong Science and Technology Department (2024B1515040006,2021A1515111106,2020A1515011298,and 2019A1515011932)+6 种基金Guangdong Province Outstanding Youth Fund Project (2021B1515020066)Guangzhou Province Basic Research Fund (202201020576)Guangzhou Science and Technology Bureau (2024A03J0846,20210303004,and 202103000093)the Natural Science Foundation of Hunan Province (2023JJ50149)111 Project (B20056)the “Three million for Three Years” Project of the High-level Talent Special Funding Scheme of Sun Yat-Sen Memorial HospitalYouth Doctor Program Fund of the Second Affiliated Hospital,Army Medical University (2023YQB003)。
文摘Breast cancer remains the most prevalent malignancy among women worldwide,with triple-negative breast cancer(TNBC) representing its most aggressive and lethal subtype.TNBC is characterized by high rates of recurrence and lung metastasis after surgery,severely impacting patient quality of life.Recent studies highlight the critical role of metabolic reprogramming in driving cancer recurrence,migration,and invasion.While the underlying mechanisms remain complex and not fully elucidated,transcriptomic analyses comparing primary and metastatic breast cancer tissues from TNBC and Luminal patients have identified lysophosphatidylcholine acyltransferase 1(LPCAT1) as a key enzyme upregulated in lung metastases and TNBC.LPCAT1 is strongly associated with poor prognosis due to its activation of the TGFβ signaling pathway.This activation is driven by LPCAT1's ability to increase cellular ATP levels,fostering a high-energy state that stimulates ATPase activity.Consequently,ATP-dependent chromatin remodeling via the BAF complex,which includes double PHD finger 2(DPF2) as a critical subunit,regulates gene transcription essential for tumor progression.Through the LPCAT1-DPF2-TGFBR2 axis,TNBC cells enhance TGFβ signaling,promoting malignant behavior and metastasis.Addressing this,we developed a reduction-responsive nanoparticle platform for the systemic delivery of LPCAT1-targeted si RNA(si LPCAT1),which has shown significant efficacy in suppressing TNBC tumor growth and metastasis.These findings suggest that nanoparticle-mediated si LPCAT1 delivery represents a promising therapeutic strategy for advanced TNBC treatment.
基金Science and Technology Innovation Project of Chinese Academy of Traditional Chinese Medicine:Study on Syndrome Regularity of Sjogren syndrome and Biomarkers of Core Syndrome(No.CI2021A01502)The project of improving the ability of clinical research and achievement transformation in the Central Highlevel Hospital of Traditional Chinese Medicine:the project of integrating clinical research talents(innovative team cultivation project)(No.HLCMHPP2023002)+2 种基金Central Public Welfare Research Institute Basic Research Service Fee Project:Development of Shao Teng Granules for the Application of Medical Institution Preparations(No.ZZ15-XY-PT-11)Science and Technology Innovation Project of Chinese Academy of Traditional Chinese Medicine:Research on the Knowledge Graph System of“Disease Syndrome Formula(Medicine)”for Rheumatology(C12021A01507)The self-selected project of the Basic Research Business Fee of the Institute of Traditional Chinese Medicine Basic Theory,Chinese Academy of Traditional Chinese Medicine:Based on knowledge graphs and deep learning to trace the academic ideas of Lu Zhizheng in the treatment of rheumatism during 3 periods(YZX-202317).
文摘Background:Primary Sjogren syndrome(pSS)is an autoimmune disease for which traditional Chinese medicine has shown significant therapeutic effects based on different syndrome types of Sjögren syndrome.However,the research findings between it and related plant extracts are limited.Objective:To explore the symptoms of patients with Yin deficiency syndrome and non-Yin deficiency syndrome of Sjogren syndrome and their relationship with plant extracts under the background of traditional Chinese medicine.Methods:Whole blood samples were collected from SS patients with Yin deficiency syndrome(5),SS patients without Yin deficiency syndrome(5),and healthy volunteers(5)for proteomic testing.Using healthy volunteers as the control group,the differential protein expression of SS with Yin deficiency syndrome was screened for enrichment analysis and functional annotation;combining previous effective clinical cases and prescription drugs for data mining and network pharmacological analysis,potential effective plant extracts were screened and enriched.Finally,molecular docking was used to validate the results of network analysis,providing a highly probable new idea for the correlation between potential drug targets for SS patients with Yin deficiency syndrome and potential effective plant extracts.Results:(1)By analyzing the proteomic data of clinical samples,the differential genes of healthy individuals versus Sjogren syndrome with Yin deficiency versus Sjogren syndrome without Yin deficiency were discovered.By overlapping the above data,it was found that the key target genes for treating Sjogren syndrome are HBA1,MST1,PCSK9,and HBB.(2)Enrichment analysis of plant extracts(PE)through clinical data mining of effective cases revealed the tremendous potential of four Chinese botanical drugs—β-sitosterol,quercetin,berberine,and kaempferol in treating Sjogren syndrome patients with Yin deficiency syndrome.(3)The pathogenesis and regulation of Sjogren syndrome with Yin deficiency syndrome may be related to interleukin-related pathways,DNA synthesis,and oxidative stress.(4)Molecular docking suggests that berberine has good binding activity with MST1.Conclusions:We believe that berberine and MST1 may have significant research value in the treatment of Sjogren syndrome in female patients.This study provides valuable reference points for future research on Sjogren syndrome with Yin deficiency syndrome.
基金supported by National Key Research and Development Program of China(2022YFA1405200,2024YFA1408900)National Natural Science Foun-dation of China(12474365,92265202)Zhejiang Provincial Natural Science Foundation of China(LR25A050001).
文摘We propose a new mechanism to achieve nonreciprocal quantum entanglement in a cavity magnomechanical system by exploiting the chiral cavity-magnon coupling.The system consists of a magnon mode,a mechanical vibration mode,and two degenerate counter-propagating microwave cavity modes in a torus-shaped cavity.We show that nonreciprocal stationary microwave-magnon and-phonon bipartite entanglements and photon-magnon-phonon tripartite entanglement can be achieved by respectively driving different circulating cavity modes that hold a chiral coupling to the magnon mode.The nonreciprocal entanglements are shown to be robust against various experimental imperfections.We specifically show how such nonreciprocal entanglement can realize the channel multiplexing quantum teleportation from a microwave field to a solidstate magnon mode.The work may find promising applications of the cavity magnomechanical systems in noise-tolerant quantum processing,channel multiplexing quantum teleportation,and chiral magnonic quantum networks.
基金the Beijing Natural Science Foundation(L223006)the National Key Research and Development Program of China(2023YFC3603501)the Beijing Institute of Technology Research Fund Program for Young Scholars。
文摘Inspired by the multimodal perception of human skin,flexible sensors are advancing intelligent sensing systems in healthcare and robotics.Pressure-temperature bimodal sensing is crucial for enhanced environmental perception and cross-domain applications.However,critical challenges remain in interference suppression and effective integration for augmented tactile and thermal perception.Here,we propose an interference-free flexible intelligent sensing patch that is composed of a laser-patterned pressure sensor and a thermistor.The patch demonstrates a large pressure detection range of 8 Pa to 220 kPa with a rapid response time of 50 ms,and a high temperature-sensing resolution of 0.01℃at the range of 10–50℃.Additionally,it can maintain highly stable performance under 150°bending deformation and 10%tensile strain.Furthermore,we built an integrated real-time processing platform to demonstrate its versatility through continuous,non-invasive monitoring for wrist pulse and epidermis temperature.Impressively,the patch can enhance real-time tactile feedback for soft robotic grippers during object manipulation,achieving tactile recognition with an accuracy of 94.09%for ten distinct objects.Intelligent sensing patches for augmented tactile and thermal perception hold promises for delivering precise and natural experiences while driving innovation and advancement in artificial prosthetics,intelligent robotics,wearable devices,and health monitoring.
基金supported by the National Natural Science Foundation of China(grant nos.52225311 and 52403182)the Sichuan Science and Technology Program,China(grant no.2025NSFTD0011)the Fundamental Research Funds for Central Universities.
文摘Antioxidants play a crucial role in alleviating oxidative stress,essential for preventing aging and a wide range of diseases,including cancer,cardiovascular diseases,and neurodegenerative disorders.However,the efficacy of exogenous antioxidants employed in clinical settings is often compromised due to the oxidative depletion of their reducing functional groups.A majority of strategies reported to date predominantly focus on tuning the initial concentration and scavenging capacity of the antioxidants,which inevitably results in heightened biological toxicity and elevated treatment expenses.To address this critical issue,we synthesized a series of self-reinforced polyphenolic nanoparticle(PNP)antioxidants by incorporating multiple dynamic bonds such as utilizing borate ester linkages and nitrogenboron(B←N)coordination bonds in this work.The resulting nanoantioxidants exhibited high stability under physiological conditions and could progressively release antioxidative moieties in response to elevated free radical concentrations,thus achieving self-reinforced and superior antioxidative capability.This work presents a new strategy for overcoming the functional decay of polyphenolic antioxidants via the preparation of robust self-reinforced nanoantioxidants.
基金the Major International(Regional)Joint Research Project of NSFC(Grant No.31110103910)the Japan Society for the Promotion of Science(JSPS)Core-to-Core Program B Asia-Africa Scientific Platforms,and the JSPS Grants-in-Aid for Scientific Research(26304009).
文摘Leopoldamys edwardsi is a species with wide distribution ranges in southern China but is not discussed in studies on geographic variation and species differentiation.We used 2 mitochondrial(Cytb,CO1)and 3 nuclear(GHR,IRBP and RAG1)genes to clarify species phylogeography and geographical differentiation.Maximum likelihood(ML)and Bayesian phylogenetic inference(BI)trees consistently indicated that L.edwardsi is a species complex containing 3 main lineages with high Kimura-2-parameter(K2P)divergences(i.e.lineages LN,LS and LHN)found in the northern and southern China and Hainan Island,respectively.The 3 species delimitation methods,automated barcoding gap discovery,Bayesian poisson tree process analysis and Bayesian phylogenetics and phylogeography,consistently supported the existence of cryptic species.Divergence times among the main lineages were inferred to be during the Pleistocene,with LHN/LS split at 1.33 Ma and LN/(LHN+LS)at 2.61 Ma;the diversifications of L.edwardsi complex might be caused by the rapid uplifts of Tibetan Plateau,paleoclimate change and complex topography.The divergence between LHN and LS was probably related to the separation of Hainan Island from the mainland via the formation of the Qiongzhou Strait.Lineages LN and(LS+LHN)likely diverged due to the Wuyi-Nanling mountain range forming a dispersal barrier.Our results suggested that L.edwardsi complex contains at least 3 distinct species:LHN represents L.hainanensis,endemic to Hainan Island and previously considered as a subspecies L.e.hainanensis;LS represents a cryptic species distributed throughout the southern Chinese continent;and LN represents the nominotypical species L.edwardsi.
