Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude ionosphere.Metallic sodium detected by l...Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude ionosphere.Metallic sodium detected by lidar can yield clues to dynamic and chemical processes in these spatial layers above the Earth’s atmosphere.This paper is based on sodium layer data collected at two low-latitude stations,one in the northern hemisphere and one in the southern.The low-latitude sodium layer exhibits conspicuous seasonal variations in shape,density,and altitude;these variations are similar between Earth’s hemispheres:sodium layer density at both stations reaches its seasonal maximum in autumn and minimum in summer.However,maximal Na density over Brazil is greater than that over Hainan.Nocturnal variations of Na density above the two low-latitude stations are also similar;at both,maxima are observed before sunrise.Some variations of the Na layer over Brazil that differ from those observed in the northern hemisphere may be related to the South Atlantic Magnetic Anomaly(SAMA)or fountain effect.We suggest that low-latitude Na layer data may provide useful additional evidence that could significantly improve the low-latitude part of the WACCM-Na model.展开更多
Undesirable self-excited chatter has always been a typical issue restricting the improvement of robotic milling quality and efficiency.Sensitive chatter identification based on processing signals can prompt operators ...Undesirable self-excited chatter has always been a typical issue restricting the improvement of robotic milling quality and efficiency.Sensitive chatter identification based on processing signals can prompt operators to adjust the machining process and prevent chatter damage.Compared with the traditional machine tool,the uncertain multiple chatter frequency bands and the band-moving of the chatter frequency in robotic milling process make it more challenging to extract chatter information.This paper proposes a novel method of chatter identification using optimized variational mode decomposition(OVMD)with multi-band information fusion and compression technology(MT).During the robotic milling process,the number of decomposed modes k and the penalty coefficient a are optimized based on the dominant component of frequency scope partition and fitness of the mode center frequency.Moreover,the mayfly optimization algorithm(MA)is employed to obtain the global optimal parameter selection.In order to conquer information collection about the uncertain multiple chatter frequency bands and the band-moving of the chatter frequency in robotic milling process,MT is presented to reduce computation and extract signal characteristics.Finally,the cross entropy of the image(CEI)is proposed as the final chatter indicator to identify the chatter occurrence.The robotic milling experiments are carried out to verify the proposed method,and the results show that it can distinguish the robotic milling condition by extracting the uncertain multiple chatter frequency bands and overcome the band-moving of the chatter frequency in robotic milling process.展开更多
From April 2020 to June 2022,a Ca+lidar with dual-wavelength and narrow-band emitting lasers utilizing all-solid-state technology was employed to conduct observations in Beijing(40.41°N,116.01°E)for a total ...From April 2020 to June 2022,a Ca+lidar with dual-wavelength and narrow-band emitting lasers utilizing all-solid-state technology was employed to conduct observations in Beijing(40.41°N,116.01°E)for a total duration of 1797.79 hours over 280 nights.A total of 286 sporadic Ca+layers were observed,with heights ranging from 88 to 120 km and densities varying from 5.33 to 2200 cm^(-3).We simultaneously observed the ionosonde,located 28 km from the lidar,and found a correlation of 61.89%between the sporadic Ca+layer and the sporadic E layer.When the sporadic Ca+layer has a downward phase trend,there is a correlation of 76.84%.By excluding the influence of ionosonde sensitivity,we focus only on calcium ions that have a density exceeding 140 cm^(-3),which exhibit a correlation of82.25%.Above 100 km,the correlation significantly increases,reaching approximately 90%.Furthermore,the correlation between the sporadic Ca+layer and the sporadic E layer is particularly noticeable during the summer season,reaching around 90%.This phenomenon can be attributed to the variations in metal ions that occur during different seasons.展开更多
China consumes significant amount of natural gas in winter.The integrated community energy utilization system(ICEUS)cannot stabilize the output of electricity and heat if there is a shortage of natural gas.The operati...China consumes significant amount of natural gas in winter.The integrated community energy utilization system(ICEUS)cannot stabilize the output of electricity and heat if there is a shortage of natural gas.The operation cost of the system still needs improvement.An energy supply structure using garbage power as the core of ICEUS was established in the study.The optimal dispatchingmodel of ICEUS was established using the regulating characteristic of the community load.The sine-cosine algorithm(SCA)based on nonlinear factors and segmented weight was presented to solve the optimal dispatching model of ICEUS.From the simulation results,compared with particle swarm optimization algorithm(PSO),SCA,exponential sinecosine algorithm(ESCA),and parabolic sine-cosine algorithm(PSCA),the daily operation cost of ICEUS was reduced by the improved SCA by 4.4%,2.9%,2.6%and 4.1%,respectively,in winter.The same was true in summer.The daily system operating cost was effectively reduced by the algorithm proposed in the study.The cost benefits of the optimized ICEUS operation was realized.展开更多
The nitrogen-vacancy(NV)center in diamond is a point defect formed by a substitutional nitrogen atom adjacent to a carbon vacancy.Owing to its exceptional fluorescence properties and long quantum coherence,the NV cent...The nitrogen-vacancy(NV)center in diamond is a point defect formed by a substitutional nitrogen atom adjacent to a carbon vacancy.Owing to its exceptional fluorescence properties and long quantum coherence,the NV center has broad applications in quantum computing,quantum sensing,and magnetic field imaging.This study focuses on the magnetic field sensing capabilities of NV centers,with performance critically dependent on the NV concentrations and coherence time.High-performance NV center diamond samples were synthesized using microwave plasma chemical vapor deposition(MPCVD)with controlled nitrogen doping,followed by electron irradiation and high-temperature annealing.We obtained diamond samples with high NV concentrations and a coherence time of T_(2)*=0.48µs.These diamonds were processed into micrometer-sized crystals via laser cutting and polishing,then integrated into an optical fiber-based probe for magnetic field detection.The sensor’s performance was first characterized independently,with a magnetic sensitivity of 5.77{\rm nT}/{\sqrt{\rm Hz}}and a magnetic resolution of 0.1 G@4715 G.Subsequently,two-dimensional magnetic field imaging experiments were performed on chip surfaces,demonstrating the probe’s capability for precise mapping of local magnetic fields.展开更多
Multiple metal ions are traditionally detected using inductively coupled plasma massspectrometry (ICP-MS) and atomic fluorescence spectrometry. Although thesemethodsare sensitive and accurate, they depend on complex i...Multiple metal ions are traditionally detected using inductively coupled plasma massspectrometry (ICP-MS) and atomic fluorescence spectrometry. Although thesemethodsare sensitive and accurate, they depend on complex instruments and requirehighly trained operators, making low costly rapid detection challenging. It is urgentto develop a convenient, rapid and sensitive method to detect multiple metal ions.Herein, we designed a bispyrene derivative (BP) with aggregation-induced enhancedemission (AIEE) property to construct a high fluorescent sensor array to realize theeffective identification of four metal ions (Fe^(3+), Cu^(2+), Co^(2+) and Cd^(2+)). The differentialcoordination capability between metal ions and BP with the aid of acetateions resulted the possibility of array-based sensing. The four heavy metal ions couldbe immediately classified in the concentration of 100 nM. The limit of detection(LOD) of Fe^(3+), Cu^(2+), Co^(2+), and Cd^(2+) were as low as 16.2, 21.8, 51.4, and 25.9 nM,respectively. Furthermore, the sensor array was applied for identification multipleheavy metal ions in environmental samples and iron ion in rat serums with identifiedof 100%. The sample consumption as low as 2 μL for each detection andthe results could be extracted by smartphones under ultraviolet lamps. It provideda rapid, sensitive, low-cost, and on-site multiple metal ions detection method.展开更多
In order to fully understand the research progress of human factors and traffic safety in curve driving,from the perspective of driver-vehicle-road-environment dynamic traffic system,this paper explored the current re...In order to fully understand the research progress of human factors and traffic safety in curve driving,from the perspective of driver-vehicle-road-environment dynamic traffic system,this paper explored the current research status and development trend of human factors of curve driving,and displayed the development process and structural relationship of human factors research of curve driving by using scientific knowledge map.Through the core collection database of Web of Science,1408 English literatures related to human factors research of curve driving published from 2012 to 2022(as of October 1,2022)were obtained,and the literatures in this field were sorted and analyzed based on the VOSviewer visualization software.The results show that China,Tongji University and Accident Analysis and Prevention are the country,institution and journal with the largest contribution rate in the field of human factors research on curve driving.Co-citation analysis shows that the research contents in this field are divided into 5 clusters:driver’s visual characteristics,risk of collision,vehicle dynamics characteristics,the influence of traffic engineering facilities on driving behavior,selection of driving speed.The co-occurrence analysis of keywords shows that the topics of curve geometry design and vehicle dynamics,driving behavior and risk,driving speed and safety,behavior prediction and intervention measures are the current research hotspots in the research field.It is found that the development trend of traffic safety improvement in curves is to construct a continuous,consistent,multi-level visual reference frame conforming to driving expectation through visual guiding technology,and summarizes the technical concept of linear visual guidance.This study can provide a reference for the study of human factors of curve driving.展开更多
Background Healthy plasma therapy reverses cognitive deficits and promotes neuroplasticity in ageing brain disease.However,whether healthy plasma therapy improve blood-brain barrier integrity after stroke remains unkn...Background Healthy plasma therapy reverses cognitive deficits and promotes neuroplasticity in ageing brain disease.However,whether healthy plasma therapy improve blood-brain barrier integrity after stroke remains unknown.Methods Here,we intravenously injected healthy female mouse plasma into adult female ischaemic stroke C57BL/6 mouse induced by 90 min transient middle cerebral artery occlusion for eight consecutive days.Infarct volume,brain atrophy and neurobehavioural tests were examined to assess the outcomes of plasma treatment.Cell apoptosis,blood-brain barrier integrity and fibroblast growth factor 21 knockout mice were used to explore the underlying mechanism.Results Plasma injection improved neurobehavioural recovery and decreased infarct volume,brain oedema and atrophy after stroke.Immunostaining showed that the number of transferase dUTP nick end labelling+/NeuN+cells decreased in the plasma-injected group.Meanwhile,plasma injection reduced ZO-1,occluding and claudin-5 tight junction gap formation and IgG extravasation at 3 days after ischaemic stroke.Western blot results showed that the FGF21 expression increased in the plasma-injected mice.However,using FGF21 knockout mouse plasma injecting to the ischaemic wild-type mice diminished the neuroprotective effects.Conclusions Our study demonstrated that healthy adult plasma treatment protected the structural and functional integrity of blood-brain barrier,reduced neuronal apoptosis and improved functional recovery via FGF21,opening a new avenue for ischaemic stroke therapy.展开更多
Atomically precise gold nanoclusters(Au NCs) are an emerging class of quantum-sized nanomaterials with discrete electronic energy levels, which has led to a range of attractive electronic and optical applications. Nev...Atomically precise gold nanoclusters(Au NCs) are an emerging class of quantum-sized nanomaterials with discrete electronic energy levels, which has led to a range of attractive electronic and optical applications. Nevertheless, the lack of general methods to transfer Au NCs protected with hydrophobic ligands to an aqueous solution hampers their use in physiological settings. Here,we developed a single-stranded DNA-based approach that could transfer ~90% hydrophobic Au NCs into an aqueous solution.We experimentally and theoretically established that multivalent electrostatic and hydrophobic interactions between DNA strands and the hydrophobic ligand layer on Au NCs resulted in monodispersed DNA-coated Au NCs with high physical integrity in an aqueous solution. The fluorescence quantum yield of Au NCs was increased by ~13 fold, and surface-constrained DNA retained the specific recognition ability for biosensing. We further demonstrated the versatility of this phase-transfer approach, which thus holds great potential to advance biological and medical applications of Au NCs.展开更多
The approval of Epidiolex,an anti-epileptic drug containing cannabidiol(CBD)as its active component,has brought hope to patients with refractory epilepsy.However,the anti-seizure effect of full-spectrum hemp extract(H...The approval of Epidiolex,an anti-epileptic drug containing cannabidiol(CBD)as its active component,has brought hope to patients with refractory epilepsy.However,the anti-seizure effect of full-spectrum hemp extract(HE),a CBD-enriched hemp oil,remains unclear.In this study,we investigated the anti-seizure effect of HE using drug-induced seizure models.Our findings revealed that HE significantly reduced seizure susceptibility comparable to CBD at the same doses.Moreover,we explored the pharmacokinetic properties of CBD in HE and observed improved characteristics such as faster oral absorption,enhanced brain distribution,and slower elimination.We further assessed the anti-seizure effects of the other five main non-addictive components in HE.Among these components,cannabichromene(CBC)and cannabinol(CBN)showed significant anti-seizure effects.To gain insights into the mechanisms of CBC and CBN,we investigated their allosteric modulation on the GABA_(A) receptor.Our results revealed that CBC enhanced GABA-induced currents in both Xenopus laevis oocytes and mouse primary cortical neurons.Additionally,we identified V436 in the𝛽2 subunit of the GABA_(A) receptor as a critical binding site for CBC.These findings provide compelling evidence for the anti-seizure activities of HE and shed light on its underlying mechanisms.Our study provides insights into the broader therapeutic potential of hemp extracts and suggests their possible development as anti-seizure treatments.展开更多
In this article the authors’names were given in the order Surname Name,it should have been Name,Surname,i.e.instead of Zhang Xianling,Sheng Yinan,and Zheng Haoran,it should have been Xianling Zhang,Yinan Sheng,and Ha...In this article the authors’names were given in the order Surname Name,it should have been Name,Surname,i.e.instead of Zhang Xianling,Sheng Yinan,and Zheng Haoran,it should have been Xianling Zhang,Yinan Sheng,and Haoran Zheng.展开更多
In this paper,we investigate a one-dimensional Euler-Poisson sys-tem with varying background charges,which are two different constants when the flow speed is less than and greater than the sound speed.Using the shock ...In this paper,we investigate a one-dimensional Euler-Poisson sys-tem with varying background charges,which are two different constants when the flow speed is less than and greater than the sound speed.Using the shock matching method,we derive the properties of the solution trajectories and es-tablish a monotonic relationship between the density at the nozzle exit and the shock position.This relationship demonstrates the existence and uniqueness of a transonic shock solution under suitable boundary conditions.展开更多
α-RuCl_(3)is a tantalizing playground to search for the quantum spin liquid states with leading Kitaev term due to the conformation of Jackeli-Khaliullin mechanism.Suppressing the non-Kitaev interaction to approach t...α-RuCl_(3)is a tantalizing playground to search for the quantum spin liquid states with leading Kitaev term due to the conformation of Jackeli-Khaliullin mechanism.Suppressing the non-Kitaev interaction to approach the Kitaev limit is the major objective in the experimental design of Kitaev-Jackeli-Khaliullin materials,for which the practical feasibility rests on the manipulation of the exact crystalline structure.A tensile strain,leading to the further compressive trigonal field splitting which would alter the spin-orbital entangled character and tune the intrinsic hopping exchanges,has been widely proposed as the promising strategy to enhance the comparative Kitaev interaction.In this work,we preform in-depth Scan Tunneling Microscope study on the electronic patterns of strainedα-RuCl_(3)monolayer on graphite substrate.Based on Chen’s derivative rule,a further trigonal field splitting is identified by analyzing the lateral-gradient imaging effect caused by an anisotropic tip.A spatial variation of the magnitude of trigonal crystal field due to the slight inhomogeneity of strain accords with the orbital polarization near the Mott gap.All evidences point to the facts that the compressive trigonal crystal field in the stretchedα-RuCl_(3)monolayer lifts the degeneracy of t2g states with higher eg and lower a1g orbitals,and the Coulomb interactions of the eg orbitals take the main responsibility for the Mott effect.展开更多
基金supported by the NSFC (42374204, 42004143,42364012)the Project of Stable Support for Youth Team in Basic Research Field,Chinese Academy of Sciences (Grant No.YSBR-018)+3 种基金the Scientific Projects of Hainan Province(KJRC2023C05, ZDYF2021GXJS040)the Innovational Fund for Scientific and Technological Personnel of Hainan Provincethe Chinese Meridian ProjectPandeng Program of National Space Science Center,Chinese Academy of Sciences
文摘Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude ionosphere.Metallic sodium detected by lidar can yield clues to dynamic and chemical processes in these spatial layers above the Earth’s atmosphere.This paper is based on sodium layer data collected at two low-latitude stations,one in the northern hemisphere and one in the southern.The low-latitude sodium layer exhibits conspicuous seasonal variations in shape,density,and altitude;these variations are similar between Earth’s hemispheres:sodium layer density at both stations reaches its seasonal maximum in autumn and minimum in summer.However,maximal Na density over Brazil is greater than that over Hainan.Nocturnal variations of Na density above the two low-latitude stations are also similar;at both,maxima are observed before sunrise.Some variations of the Na layer over Brazil that differ from those observed in the northern hemisphere may be related to the South Atlantic Magnetic Anomaly(SAMA)or fountain effect.We suggest that low-latitude Na layer data may provide useful additional evidence that could significantly improve the low-latitude part of the WACCM-Na model.
基金supported by the Civil Aircraft Project(No.MJZ4-1N22),National Natural Science Foundation of China(No.51975053)Inversion and Application Project of Outcome(Nos.D44F9A65 and 2B0188E1)+1 种基金Key R&D Program of Inner Mongolia(No.2022YFHH0121)the Basic Research Fund of Beijing Institute of Technology(No.2021CX01023).
文摘Undesirable self-excited chatter has always been a typical issue restricting the improvement of robotic milling quality and efficiency.Sensitive chatter identification based on processing signals can prompt operators to adjust the machining process and prevent chatter damage.Compared with the traditional machine tool,the uncertain multiple chatter frequency bands and the band-moving of the chatter frequency in robotic milling process make it more challenging to extract chatter information.This paper proposes a novel method of chatter identification using optimized variational mode decomposition(OVMD)with multi-band information fusion and compression technology(MT).During the robotic milling process,the number of decomposed modes k and the penalty coefficient a are optimized based on the dominant component of frequency scope partition and fitness of the mode center frequency.Moreover,the mayfly optimization algorithm(MA)is employed to obtain the global optimal parameter selection.In order to conquer information collection about the uncertain multiple chatter frequency bands and the band-moving of the chatter frequency in robotic milling process,MT is presented to reduce computation and extract signal characteristics.Finally,the cross entropy of the image(CEI)is proposed as the final chatter indicator to identify the chatter occurrence.The robotic milling experiments are carried out to verify the proposed method,and the results show that it can distinguish the robotic milling condition by extracting the uncertain multiple chatter frequency bands and overcome the band-moving of the chatter frequency in robotic milling process.
基金supported by the National Natural Science Foundation of China(42004134,42374204,41627804)Fundamental Research Program of Shanxi Province(202303021221051)+2 种基金State Key Laboratory of Space Weather,Scientific Projects of Hainan Province(ZDYF2021GXJS040)the Innovational Fund for Scientific and Technological Personnel of Hainan Province(KJRC2023C05)Chinese Academy of Sciences(YSBR-018)。
文摘From April 2020 to June 2022,a Ca+lidar with dual-wavelength and narrow-band emitting lasers utilizing all-solid-state technology was employed to conduct observations in Beijing(40.41°N,116.01°E)for a total duration of 1797.79 hours over 280 nights.A total of 286 sporadic Ca+layers were observed,with heights ranging from 88 to 120 km and densities varying from 5.33 to 2200 cm^(-3).We simultaneously observed the ionosonde,located 28 km from the lidar,and found a correlation of 61.89%between the sporadic Ca+layer and the sporadic E layer.When the sporadic Ca+layer has a downward phase trend,there is a correlation of 76.84%.By excluding the influence of ionosonde sensitivity,we focus only on calcium ions that have a density exceeding 140 cm^(-3),which exhibit a correlation of82.25%.Above 100 km,the correlation significantly increases,reaching approximately 90%.Furthermore,the correlation between the sporadic Ca+layer and the sporadic E layer is particularly noticeable during the summer season,reaching around 90%.This phenomenon can be attributed to the variations in metal ions that occur during different seasons.
基金The work is funded partly by the Natural Science Foundation of Inner Mongolia(2019MS05047)Key Technology Projects of Inner Mongolia Autonomous Region(2019GG319)Research on Key Technologies of MW advanced flywheel energy storage(2020ZD0017).
文摘China consumes significant amount of natural gas in winter.The integrated community energy utilization system(ICEUS)cannot stabilize the output of electricity and heat if there is a shortage of natural gas.The operation cost of the system still needs improvement.An energy supply structure using garbage power as the core of ICEUS was established in the study.The optimal dispatchingmodel of ICEUS was established using the regulating characteristic of the community load.The sine-cosine algorithm(SCA)based on nonlinear factors and segmented weight was presented to solve the optimal dispatching model of ICEUS.From the simulation results,compared with particle swarm optimization algorithm(PSO),SCA,exponential sinecosine algorithm(ESCA),and parabolic sine-cosine algorithm(PSCA),the daily operation cost of ICEUS was reduced by the improved SCA by 4.4%,2.9%,2.6%and 4.1%,respectively,in winter.The same was true in summer.The daily system operating cost was effectively reduced by the algorithm proposed in the study.The cost benefits of the optimized ICEUS operation was realized.
基金support by the National Key Research and Development Program of China(Grant No.2021YFB2012600)the Fund of National Key laboratory of Plasma Physics(Grant No.6142A04240204)+4 种基金the National Natural Science Foundation of China(Grant No.62474165)the Science and Technology Major Project of Henan Province(Grant No.231100230300)the Henan Association for Science and Technology Youth Talent Support Program(Grant No.2024HYTP024)the Key Research and Development Project of Henan Province(Grant No.231111232100)the Natural Science Foundation of Henan Province(Grant No.252300421228),and Zhongyuan Science and Technology Innovation Youth Top Talent Program.
文摘The nitrogen-vacancy(NV)center in diamond is a point defect formed by a substitutional nitrogen atom adjacent to a carbon vacancy.Owing to its exceptional fluorescence properties and long quantum coherence,the NV center has broad applications in quantum computing,quantum sensing,and magnetic field imaging.This study focuses on the magnetic field sensing capabilities of NV centers,with performance critically dependent on the NV concentrations and coherence time.High-performance NV center diamond samples were synthesized using microwave plasma chemical vapor deposition(MPCVD)with controlled nitrogen doping,followed by electron irradiation and high-temperature annealing.We obtained diamond samples with high NV concentrations and a coherence time of T_(2)*=0.48µs.These diamonds were processed into micrometer-sized crystals via laser cutting and polishing,then integrated into an optical fiber-based probe for magnetic field detection.The sensor’s performance was first characterized independently,with a magnetic sensitivity of 5.77{\rm nT}/{\sqrt{\rm Hz}}and a magnetic resolution of 0.1 G@4715 G.Subsequently,two-dimensional magnetic field imaging experiments were performed on chip surfaces,demonstrating the probe’s capability for precise mapping of local magnetic fields.
基金NSFC,Grant/Award Numbers:82073602,82473685,52325311Natural Science Foundation of Jilin Province,Grant/Award Number:20200201081JC。
文摘Multiple metal ions are traditionally detected using inductively coupled plasma massspectrometry (ICP-MS) and atomic fluorescence spectrometry. Although thesemethodsare sensitive and accurate, they depend on complex instruments and requirehighly trained operators, making low costly rapid detection challenging. It is urgentto develop a convenient, rapid and sensitive method to detect multiple metal ions.Herein, we designed a bispyrene derivative (BP) with aggregation-induced enhancedemission (AIEE) property to construct a high fluorescent sensor array to realize theeffective identification of four metal ions (Fe^(3+), Cu^(2+), Co^(2+) and Cd^(2+)). The differentialcoordination capability between metal ions and BP with the aid of acetateions resulted the possibility of array-based sensing. The four heavy metal ions couldbe immediately classified in the concentration of 100 nM. The limit of detection(LOD) of Fe^(3+), Cu^(2+), Co^(2+), and Cd^(2+) were as low as 16.2, 21.8, 51.4, and 25.9 nM,respectively. Furthermore, the sensor array was applied for identification multipleheavy metal ions in environmental samples and iron ion in rat serums with identifiedof 100%. The sample consumption as low as 2 μL for each detection andthe results could be extracted by smartphones under ultraviolet lamps. It provideda rapid, sensitive, low-cost, and on-site multiple metal ions detection method.
基金supported by the National Natural Science Foundation of China(Grant No.52072291)。
文摘In order to fully understand the research progress of human factors and traffic safety in curve driving,from the perspective of driver-vehicle-road-environment dynamic traffic system,this paper explored the current research status and development trend of human factors of curve driving,and displayed the development process and structural relationship of human factors research of curve driving by using scientific knowledge map.Through the core collection database of Web of Science,1408 English literatures related to human factors research of curve driving published from 2012 to 2022(as of October 1,2022)were obtained,and the literatures in this field were sorted and analyzed based on the VOSviewer visualization software.The results show that China,Tongji University and Accident Analysis and Prevention are the country,institution and journal with the largest contribution rate in the field of human factors research on curve driving.Co-citation analysis shows that the research contents in this field are divided into 5 clusters:driver’s visual characteristics,risk of collision,vehicle dynamics characteristics,the influence of traffic engineering facilities on driving behavior,selection of driving speed.The co-occurrence analysis of keywords shows that the topics of curve geometry design and vehicle dynamics,driving behavior and risk,driving speed and safety,behavior prediction and intervention measures are the current research hotspots in the research field.It is found that the development trend of traffic safety improvement in curves is to construct a continuous,consistent,multi-level visual reference frame conforming to driving expectation through visual guiding technology,and summarizes the technical concept of linear visual guidance.This study can provide a reference for the study of human factors of curve driving.
基金This study was supported by grants from the Scientific Research and Innovation Program of Shanghai Education Commission 2019-01-07-00-02-E00064(G-YY)National Key R&D,Program of China#2016YFC1300602(G-YY),#2019YFA0112000(YT)+1 种基金the National Natural Science Foundation of China(NSFC)projects 81771251(G-YY),81801170(YT),82071284(YT),81771244(ZZ),81974179(ZZ),81870921(YW)K.C.Wong Education Foundation(G-YY,no award/grant number).
文摘Background Healthy plasma therapy reverses cognitive deficits and promotes neuroplasticity in ageing brain disease.However,whether healthy plasma therapy improve blood-brain barrier integrity after stroke remains unknown.Methods Here,we intravenously injected healthy female mouse plasma into adult female ischaemic stroke C57BL/6 mouse induced by 90 min transient middle cerebral artery occlusion for eight consecutive days.Infarct volume,brain atrophy and neurobehavioural tests were examined to assess the outcomes of plasma treatment.Cell apoptosis,blood-brain barrier integrity and fibroblast growth factor 21 knockout mice were used to explore the underlying mechanism.Results Plasma injection improved neurobehavioural recovery and decreased infarct volume,brain oedema and atrophy after stroke.Immunostaining showed that the number of transferase dUTP nick end labelling+/NeuN+cells decreased in the plasma-injected group.Meanwhile,plasma injection reduced ZO-1,occluding and claudin-5 tight junction gap formation and IgG extravasation at 3 days after ischaemic stroke.Western blot results showed that the FGF21 expression increased in the plasma-injected mice.However,using FGF21 knockout mouse plasma injecting to the ischaemic wild-type mice diminished the neuroprotective effects.Conclusions Our study demonstrated that healthy adult plasma treatment protected the structural and functional integrity of blood-brain barrier,reduced neuronal apoptosis and improved functional recovery via FGF21,opening a new avenue for ischaemic stroke therapy.
基金supported by the National Key R&D Program of China (2020YFA0908104)the National Natural Science Foundation of China (91953106, 92056117, 21904087, 21705159)+1 种基金the Shanghai Municipal Science and Technology Commission (19JC1410300,19ZR1474600, 20dz1101000, 21QA1404800)the Fundamental Research Funds for the Central Universities and Shanghai Jiao Tong University。
文摘Atomically precise gold nanoclusters(Au NCs) are an emerging class of quantum-sized nanomaterials with discrete electronic energy levels, which has led to a range of attractive electronic and optical applications. Nevertheless, the lack of general methods to transfer Au NCs protected with hydrophobic ligands to an aqueous solution hampers their use in physiological settings. Here,we developed a single-stranded DNA-based approach that could transfer ~90% hydrophobic Au NCs into an aqueous solution.We experimentally and theoretically established that multivalent electrostatic and hydrophobic interactions between DNA strands and the hydrophobic ligand layer on Au NCs resulted in monodispersed DNA-coated Au NCs with high physical integrity in an aqueous solution. The fluorescence quantum yield of Au NCs was increased by ~13 fold, and surface-constrained DNA retained the specific recognition ability for biosensing. We further demonstrated the versatility of this phase-transfer approach, which thus holds great potential to advance biological and medical applications of Au NCs.
基金supported by Chinese National Programs for Brain Science and Brain-like intelligence technology(2021ZD0202102)the National Natural Science Foundation of China(31871083,81371432,82271498 and 32000674)the Ningxia Hui Autonomous Region Key Research and Development Project(2022BEG02042).
文摘The approval of Epidiolex,an anti-epileptic drug containing cannabidiol(CBD)as its active component,has brought hope to patients with refractory epilepsy.However,the anti-seizure effect of full-spectrum hemp extract(HE),a CBD-enriched hemp oil,remains unclear.In this study,we investigated the anti-seizure effect of HE using drug-induced seizure models.Our findings revealed that HE significantly reduced seizure susceptibility comparable to CBD at the same doses.Moreover,we explored the pharmacokinetic properties of CBD in HE and observed improved characteristics such as faster oral absorption,enhanced brain distribution,and slower elimination.We further assessed the anti-seizure effects of the other five main non-addictive components in HE.Among these components,cannabichromene(CBC)and cannabinol(CBN)showed significant anti-seizure effects.To gain insights into the mechanisms of CBC and CBN,we investigated their allosteric modulation on the GABA_(A) receptor.Our results revealed that CBC enhanced GABA-induced currents in both Xenopus laevis oocytes and mouse primary cortical neurons.Additionally,we identified V436 in the𝛽2 subunit of the GABA_(A) receptor as a critical binding site for CBC.These findings provide compelling evidence for the anti-seizure activities of HE and shed light on its underlying mechanisms.Our study provides insights into the broader therapeutic potential of hemp extracts and suggests their possible development as anti-seizure treatments.
文摘In this article the authors’names were given in the order Surname Name,it should have been Name,Surname,i.e.instead of Zhang Xianling,Sheng Yinan,and Zheng Haoran,it should have been Xianling Zhang,Yinan Sheng,and Haoran Zheng.
文摘In this paper,we investigate a one-dimensional Euler-Poisson sys-tem with varying background charges,which are two different constants when the flow speed is less than and greater than the sound speed.Using the shock matching method,we derive the properties of the solution trajectories and es-tablish a monotonic relationship between the density at the nozzle exit and the shock position.This relationship demonstrates the existence and uniqueness of a transonic shock solution under suitable boundary conditions.
基金the National Key Research and Development Program of China(Grant No.2019YFA0308404)Science and Technology Commission of Shanghai Municipality(Grant No.20JC1415900)+3 种基金Shanghai Municipal Science and Technology Major Project(Grant No.2019SHZDZX01)support from the National Natural Science Foundation of China(Grants No.12174062)sponsored by Shanghai Pujiang Program No.19PJ1401000National Natural Science Foundation of China(Grant No.12004076).
文摘α-RuCl_(3)is a tantalizing playground to search for the quantum spin liquid states with leading Kitaev term due to the conformation of Jackeli-Khaliullin mechanism.Suppressing the non-Kitaev interaction to approach the Kitaev limit is the major objective in the experimental design of Kitaev-Jackeli-Khaliullin materials,for which the practical feasibility rests on the manipulation of the exact crystalline structure.A tensile strain,leading to the further compressive trigonal field splitting which would alter the spin-orbital entangled character and tune the intrinsic hopping exchanges,has been widely proposed as the promising strategy to enhance the comparative Kitaev interaction.In this work,we preform in-depth Scan Tunneling Microscope study on the electronic patterns of strainedα-RuCl_(3)monolayer on graphite substrate.Based on Chen’s derivative rule,a further trigonal field splitting is identified by analyzing the lateral-gradient imaging effect caused by an anisotropic tip.A spatial variation of the magnitude of trigonal crystal field due to the slight inhomogeneity of strain accords with the orbital polarization near the Mott gap.All evidences point to the facts that the compressive trigonal crystal field in the stretchedα-RuCl_(3)monolayer lifts the degeneracy of t2g states with higher eg and lower a1g orbitals,and the Coulomb interactions of the eg orbitals take the main responsibility for the Mott effect.
