Bud dormancy represents a critical adaptation mechanism in perennial fruit plants,enabling survival during unfavorable environmental conditions.While this adaptive strategy is essential for plant survival and reproduc...Bud dormancy represents a critical adaptation mechanism in perennial fruit plants,enabling survival during unfavorable environmental conditions.While this adaptive strategy is essential for plant survival and reproduction,its molecular mechanisms remain incompletely understood.This study investigated two grape transcription factors:EARLY BUD BREAK(VvEBB)and SHORT VEGETATIVE PHASE 4(VvSVP4).Through heterologous transformation in poplar,the research demonstrated that VvSVP4 functions as a negative regulator of bud break,while VvEBB serves as a positive regulator.Transcriptome analysis revealed significant enrichment of plant hormone signaling pathways particularly ABA,IAA,and CK in plants overexpressing VvSVP4(VvSVP4-OE)and VvEBB(VvEBB-OE)compared to controls.Endogenous hormone level changes correlated positively with transcriptome data.During endodormancy,VvSVP4 directly and positively regulated the ABA receptor gene Vv PYL9 expression,maintaining bud dormancy.Conversely,during ecodormancy,rapid upregulation of VvEBB negatively regulated the expression of sucrose nonfermenting 1-related protein kinase 2 gene(Vv SAPK2),facilitating dormancy release.This study provides comprehensive insights into how VvSVP4 and VvEBB genes regulate dormancy and bud break through cell cycle regulation and multiple hormone signaling pathways.展开更多
Retrieving high-fidelity images from optical speckles remains challenging,especially when the information in speckles is severely insufficient.To address classification through scattering media under such constraints,...Retrieving high-fidelity images from optical speckles remains challenging,especially when the information in speckles is severely insufficient.To address classification through scattering media under such constraints,we propose Speckle Transformer,a vision-transformer-based model that directly classifies objects using raw speckle patterns without intermediate image retrieval.By leveraging inherent features within speckles to extract discriminative features,our approach achieves nearly 90%accuracy for classifying speckles encoded with different images,outperforming traditional retrieval-classification pipelines by up to five times,even with extreme information sparsity(i.e.,1/1024 speckle regions of interest).In addition,we quantify speckle information capacity via information entropy analysis,demonstrating that classification accuracy correlates strongly with the information entropy of speckle autocorrelation.We not only overcome limitations of conventional methods but also establish a paradigm for real-time classification in scattering environments with constrained data.展开更多
Numerous arthropods evolve and optimize sensory systems, enabling them to effectively adapt complex and competitive habitats. Typically, scorpions can precisely perceive the prey location with the lowest metabolic rat...Numerous arthropods evolve and optimize sensory systems, enabling them to effectively adapt complex and competitive habitats. Typically, scorpions can precisely perceive the prey location with the lowest metabolic rate among invertebrates. This biological phenomenon contrasts sharply with engineered systems, which generally associates high accuracy with substantial energy consumption. Inspired by the Scorpion Compound Slit Sensilla (SCSS) with a stress field modulation strategy, a bionic positioning sensor with superior precision and minimal power consumption is developed for the first time, which utilizes the particular Minimum Positioning Units (MPUs) to efficiently locate vibration signals. The single MPU of the SCSS can recognize the direction of collinear loads by regulating the stress field distribution and further, the coupling action of three MPUs can realize all-angle vibration monitoring in plane. Experiments demonstrate that the bionic positioning sensor achieves 1.43 degrees of angle-error-free accuracy without additional energy supply. As a proof of concept, two bionic positioning sensors and machine learning algorithm are integrated to provide centimeter (cm)-accuracy target localization, ideally suited for the man-machine interaction. The novel design offers a new mechanism for the design of traditional positioning devices, improving precision and efficiency in both the meta-universe and real-world Internet-connected systems.展开更多
Neutral oxygen evolution reaction(OER)is a crucial half-reaction for electrocatalytic chemical production under mild condition,but with limited development due to low activity and poor stability.Herein,a tungsten-dope...Neutral oxygen evolution reaction(OER)is a crucial half-reaction for electrocatalytic chemical production under mild condition,but with limited development due to low activity and poor stability.Herein,a tungsten-doped cobalt molybdate(WDCMO)catalyst was synthesized for efficient and durable OER under neutral electrolyte.It is demonstrated that catalyst reconstruction is suppressed by W doping,which stabilizes the Co-O-Mo point-to-point connection in CoMoO_(4) architecture and stimulates to a lower valence state of active sites over the surface phase.Thereby,the surface structure maintains to avoid compound dissolution caused by over-oxidation during OER.Meanwhile,the WDCMO catalyst promotes charge transfer and optimizes*OH intermediate adsorption,which improves reaction kinetics and intrinsic activity.Consequently,the WDCMO electrode exhibits an overpotential of 302 mV at 10 mA cm^(-2) in neutral electrolyte with an improvement of 182 mV compared with CoMoO4 electrode.Furthermore,W doping significantly improves the electrode stability from 50 h to more than 320 h,with a suppressive potential attenuation from 2.82 to 0.29 mV h^(-1).This work will shed new light on designing rational electrocatalysts for neutral OER.展开更多
This paper presents an ultralow-frequency cyclic loading creep test system for rock salt.The system comprises five subsystems:a cyclic load generation system,a triaxial pressure chamber,a pressure and deformation moni...This paper presents an ultralow-frequency cyclic loading creep test system for rock salt.The system comprises five subsystems:a cyclic load generation system,a triaxial pressure chamber,a pressure and deformation monitoring system,a signal acquisition and load control integrated system,and an automatic oil replenishment and discharge system.This test system overcomes the limitations of traditional electrohydraulic servo creep testing machines and gravity loading creep testing machines when conducting low-frequency cyclic load creep tests.This allows for long-term(1-2 years)creep tests under extremely-low-frequency cyclic loading conditions,which simulate the actual operating conditions of salt cavern gas storage.The cyclic load generation system converted constant-weight loads into a continuously variable hydraulic oil pressure and amplified the oil pressure using a pressure intensifier,which provided a stable load source for the test system.Using this test system,creep tests were performed under low-frequency cyclic loading with periods of 1 d and 7 d.The results showed that the test system performed well,as evidenced by the validation of the loading capacity,loading stability,and temperature control stability.Comparing the creep deformation of rock salt samples with the cyclic periods of 1 d and 7 d,it was observed that,within this cyclic period range,the creep deformation of the sample increased with higher loading frequencies,provided that the cyclic loading waveform and stress remained constant.展开更多
Previous studies have suggested that abnormal hepatobiliary system function may contribute to poor prognosis in patientswith acute coronary syndrome(ACS)and that abnormal hepatobiliary system function may be associate...Previous studies have suggested that abnormal hepatobiliary system function may contribute to poor prognosis in patientswith acute coronary syndrome(ACS)and that abnormal hepatobiliary system function may be associated with per-and polyfluoroalkyl substances(PFAS)exposure.However,there is limited evidence for this association in cardiovascular subpopulations,particularly in the ACS patients.Therefore,we performed this study to evaluate the association between plasma PFAS exposure and hepatobiliary system function biomarkers in patients with ACS.This study included 546 newly diagnosed ACS patients at the Second Hospital of Hebei Medical University,and data on 15 hepatobiliary system function biomarkers were obtained from medical records.Associations between single PFAS and hepatobiliary system function biomarkers were assessed using multiple linear regression models and restricted cubic spline model(RCS),and mixture effects were assessed using the Quantile g-computation model.The results showed that total bile acids(TBA)was negative associated with perfluorohexane sulfonic acid(PFHxS)(-7.69%,95%CI:-12.15%,-3.01%).According to the RCS model,linear associations were found between TBA and PFHxS(P for overall=0.003,P for non-linear=0.234).We also have observed the association between between PFAS congeners and liver enzyme such as aspartate aminotransferase(AST)and α-l-Fucosidase(AFU),but it was not statistically significant after correction.In addition,Our results also revealed an association between prealbumin(PA)and PFAS congeners as well as mixtures.Our findings have provided a piece of epidemiological evidence on associations between PFAS congeners or mixture,and serum hepatobiliary system function biomarkers in ACS patients,which could be a basis for subsequent mechanism studies.展开更多
Associations of per-and polyfluoroalkyl substances(PFAS)on lipid metabolism have been documented but research remains scarce regarding effect of PFAS on lipid variability.To deeply understand their relationship,a step...Associations of per-and polyfluoroalkyl substances(PFAS)on lipid metabolism have been documented but research remains scarce regarding effect of PFAS on lipid variability.To deeply understand their relationship,a step-forward in causal inference is expected.To address these,we conducted a longitudinal study with three repeated measurements involving 201 participants in Beijing,among which 100 eligible participants were included for the present study.Twenty-three PFAS and four lipid indicators were assessed at each visit.We used linear mixed models and quantile g-computation models to investigate associations between PFAS and blood lipid levels.A latent class growth model described PFAS serum exposure patterns,and a generalized linear model demonstrated associations between these patterns and lipid variability.Our study found that PFDA was associated with increased TC(β=0.083,95%CI:0.011,0.155)and HDL-C(β=0.106,95%CI:0.034,0.178).The PFAS mixture also showed a positive relationship with TC(β=0.06,95%CI:0.02,0.10),with PFDA contributing most positively.Compared to the low trajectory group,the middle trajectory group for PFDA was associated with VIM of TC(β=0.756,95%CI:0.153,1.359).Furthermore,PFDA showed biological gradientswith lipid metabolism.This is the first repeated-measures study to identify the impact of PFAS serum exposure pattern on the lipid metabolism and the first to estimate the association between PFAS and blood lipid levels in middle-aged and elderly Chinese and reinforce the evidence of their causal relationship through epidemiological studies.展开更多
The thermal stability of lithium-ion battery separators is a critical determinant of battery safety and performance,especially in the context of rapidly expanding applications in electric vehicles and energy storage s...The thermal stability of lithium-ion battery separators is a critical determinant of battery safety and performance,especially in the context of rapidly expanding applications in electric vehicles and energy storage systems.While traditional polyolefin separators(PP/PE)dominate the market due to their cost-effectiveness and mechanical robustness,their inherent poor thermal stability poses significant safety risks under high-temperature conditions.This review provides a comprehensive analysis of recent advancements in enhancing separator thermal stability through coating materials(metal,ceramic,inorganic)and novel high-temperature-resistant polymers(e.g.,PVDF copolymers,PI,PAN).Notably,we critically evaluate the trade-offs between thermal resilience and electrochemical performance,such as the unintended increase in electronic conductivity from metal coatings(e.g.,Cu,MOFs)and reduced electrolyte wettability in ceramic coatings(e.g.,Al_(2)O_(3)).Innovations in hybrid coatings(e.g.,BN/PAN composites,gradient-structured MOFs)and scalable manufacturing techniques(e.g.,roll-to-roll electrospinning)are highlighted as promising strategies to balance these competing demands.Furthermore,a comparative analysis of next-generation high-temperature-resistant separators underscores their ionic conductivity,mechanical strength,and scalability,offering actionable insights for material selection.The review concludes with forward-looking perspectives on integrating machine learning for material discovery,optimizing interfacial adhesion in ceramic coatings,and advancing semi-/all-solid-state batteries to address both thermal and electrochemical challenges.This work aims to bridge the gap between laboratory innovations and industrial applications,fostering safer and more efficient lithium battery technologies.展开更多
Although per-and polyfluoroalkyl substances(PFAS)have been frequently linked to cardiovascular and renal disease separately,evidence remains scarce regarding their systematic effect.Therefore,we recruited 546 newly di...Although per-and polyfluoroalkyl substances(PFAS)have been frequently linked to cardiovascular and renal disease separately,evidence remains scarce regarding their systematic effect.Therefore,we recruited 546 newly diagnosed acute coronary syndrome(ACS)patients and detected seven myocardial enzymes and six kidney function biomarkers.Twelve PFASwere also assessedwith ultra-high-performance liquid chromatography-tandem mass spectrometry.Generalized linear model and restricted cubic spline model were applied to single pollutant analysis.Quantile g-computation was used for mixture analysis.Network model was utilized to identify central and bridge nodes of pollutants and phenotypes.In the present study,perfluorohexane sulfonic acid was positively associated with uric acid(UA)(β=0.04,95%confidence interval(CI):0.01,0.07),and perfluorobutanoic acid was negatively associated with estimated glomerular filtration rate(β=-0.04,95%CI:-0.07,-0.01)but positively associated with UA(β=0.03,95%CI:0.01,0.06).In mixture analysis,each quantile increase in the PFAS mixture was significantly associated with UA(β=0.08,95%CI:0.04,0.11).Network analysis revealed that perfluorooctanoate,UA,and myoglobin were denoted as bridge nodes,and the first principal component of lactate dehydrogenase and creatine kinase-myocardial band was identified as the node with the highest strength and expected influence.This study investigates the systematic impact of PFAS exposure through cardiorenal interaction network,which highlights that PFAS may serve as an upstream approach in UA-modulated cardiorenal network to affect cardiorenal system comprehensively.展开更多
A series of measures to implement national volume‐based procurement(NVBP)and follow‐on NVBP in China have significantly reduced insulin prices and increased patient affordability.However,NVBP may lead to a higher bu...A series of measures to implement national volume‐based procurement(NVBP)and follow‐on NVBP in China have significantly reduced insulin prices and increased patient affordability.However,NVBP may lead to a higher burden of insulin‐related consumables(such as injection pens and needles),which might discourage patients from using insulin in the pooled list and increase the risk of needle reuse.This article emphasizes that it is essential NVBP be implemented for both drugs and consumables,which will contribute to the achievement of universal insulin access.展开更多
This paper presents zircon U-Pb-Hf isotopic compositions and whole-rock geochemical data for monzogranites and mafic-ultramafic complexes of the Maxingdawannan area in the western end of the east Kunlun orogenic belt,...This paper presents zircon U-Pb-Hf isotopic compositions and whole-rock geochemical data for monzogranites and mafic-ultramafic complexes of the Maxingdawannan area in the western end of the east Kunlun orogenic belt, western China. The data are used to determine the ages, petrogenesis, magma sources, and geodynamic setting of the studied rocks. U-Pb zircon dating indicates that monzogranites and gabbros of the complexes were emplaced at 399 and 397 Ma, respectively. The monzogranites are shoshonitic, with high SiO2, Al2 O3 and total-alkali contents, and low TFeO, MgO, TiO2 and P2 O5 contents. The mafic-ultramafic complexes are characterized by low Si O2 contents. The monzogranites display enrichment in light rare-earth elements(LREE) and large-ion lithophile elements(LILE), depletion in heavy REEs(HREE) and high-field-strength elements(HFSE), and negative Eu anomalies(Eu/Eu*=0.36–0.48). The mafic-ultramafic complexes are also enriched in LREEs and LILEs, and depleted in HREEs and HFSEs, with weak Eu anomalies(Eu/Eu*=0.84–1.16). Zircon εHf(t) values for the monzogranites and mafic-ultramafic complexes range from-6.68 to 1.11 and-1.81 to 6.29, with zircon model ages of 1 812–1 319 Ma(TDM2) and 1 087–769 Ma(TDM1), respectively. Hf isotopic data indicate that primary magmas of the monzogranites are originated from partial melting of ancient lower crust during the Paleo-Mesoproterozoic, with a juvenile-crust component. Primitive magmas of the mafic-ultramafic complexes are likely originated from a depleted-mantle source modified by slab-derived fluids and contaminated by crustal components. Geochemical data and the geological setting indicate that Devonian intrusions in the Maxingdawannan area are related to northward subduction of the ProtoTethys oceanic lithosphere.展开更多
An efficient method for prediction in the capture of SO_(2)from flue gas by imidazolium ionic liquids was reported,where the concentration of SO_(2)is 2000 ppm.On the basis of quantitative calculations through a combi...An efficient method for prediction in the capture of SO_(2)from flue gas by imidazolium ionic liquids was reported,where the concentration of SO_(2)is 2000 ppm.On the basis of quantitative calculations through a combination of Langmuir simulation,theoretical calculation and quantum chemical method,SO_(2)absorption and desorption performance from flue gas by twelve kinds of imidazolium ionic liquids with different anions were designed and predicted.Then,among them,five kinds of imidazolium ionic liquids were chosen and prepared to investigate their behavior of SO_(2)absorption capacity,desorption residue,and available absorption capacity.The results indicated that the experimental values were in good agreement with the predicted values.Thus,an ideal ionic liquid[Emim][Tetz]was obtained through the predictive method for the capture of SO_(2)of 2000 ppm,which showed high available absorption capacity of 0.24 g SO_(2)per g ionic liquid and excellent reversibility.展开更多
The interest in ionic liquids(IL) is motivated by its unique properties, such as negligible vapor pressure, thermal stability, wide electrochemical stability window, and tunability of properties. ILs have been highlig...The interest in ionic liquids(IL) is motivated by its unique properties, such as negligible vapor pressure, thermal stability, wide electrochemical stability window, and tunability of properties. ILs have been highlighted as solvents for liquid-liquid extraction and liquid membrane separation. To further expand its application in separation field, the ionic liquid membranes(ILMs) and its separation technology have been proposed and developed rapidly. This paper is to give a comprehensive overview on the recent applications of ILMs for the separation of various compounds, including organic compounds, mixed gases, and metal ions. Firstly, ILMs was classified into supported ionic liquid membranes(SILMs) and quasi-solidified ionic liquid membranes(QSILMs) according to the immobilization method of ILs. Then, preparation methods of ILMs, membrane stability as well as applications of ILMs in the separation of various mixtures were reviewed. Followed this, transport mechanisms of gaseous mixtures and organic compounds were elucidated in order to better understand the separation process of ILMs. This tutorial review intends to not only offer an overview on the development of ILMs but also provide a guide for ILMs preparations and applications.展开更多
The electron paramagnetic resonance spectra of the chelate-based ionic liquid[C_(10)mim][Cu(F_6-acac)_3]in different solvents have been obtained at 120 K.It was found that the values of the^(63)Cu hyperfine coupling c...The electron paramagnetic resonance spectra of the chelate-based ionic liquid[C_(10)mim][Cu(F_6-acac)_3]in different solvents have been obtained at 120 K.It was found that the values of the^(63)Cu hyperfine coupling constants(A_(IL))of[C_(10)mim][Cu(F_6-acac)_3]in molecular solvents were from 116 to 180 Gauss.Moreover,the A_(IL)values in general ionic liquids are more complicated,and two sets of peaks can often be observed in their electron paramagnetic resonance spectra.Based on the Kamlet-Taft parameters,relative permittivity,the experimental results were discussed in terms of solvation effect and coordination of the solvents.展开更多
Uranium-reducing bacteria were immobilized with sodium alginate, anthraquinone-2,6-disulfonate（AQDS）, and carbon nanotubes（CNTs）. The effects of different AQDS-CNTs contents, U（Ⅳ） concentrations, and metal ions...Uranium-reducing bacteria were immobilized with sodium alginate, anthraquinone-2,6-disulfonate（AQDS）, and carbon nanotubes（CNTs）. The effects of different AQDS-CNTs contents, U（Ⅳ） concentrations, and metal ions on U（Ⅳ） reduction by immobilized beads were examined. Over 97.5% U（Ⅵ）（20 mg/L） was removed in 8 hr when the beads were added to 0.7% AQDS-CNTs, which was higher than that without AQDS-CNTs. This result may be attributed to the enhanced electron transfer by AQDS and CNTs. The reduction of U（Ⅵ） occurred at initial U（Ⅵ） concentrations of 10 to 100 mg/L and increased with increasing AQDS-CNT content from 0.1% to 1%. The presence of Fe（Ⅲ）, Cu（Ⅱ） and Mn（Ⅱ）slightly increased U（Ⅵ） reduction, whereas Cr（Ⅵ）, Ni（Ⅱ）, Pb（Ⅱ）, and Zn（Ⅱ） significantly inhibited U（Ⅵ） reduction. After eight successive incubation-washing cycles or 8 hr of retention time（HRT） for 48 hr of continuous operation, the removal efficiency of uranium was above 90% and 92%, respectively. The results indicate that the AQDS-CNT/AL/cell beads are suitable for the treatment of uranium-containing wastewaters.展开更多
Applications of process systems engineering(PSE)in plants and enterprises are boosting industrial reform from automation to digitization and intelligence.For ethylene thermal cracking,knowledge expression,numerical mo...Applications of process systems engineering(PSE)in plants and enterprises are boosting industrial reform from automation to digitization and intelligence.For ethylene thermal cracking,knowledge expression,numerical modeling and intelligent optimization are key steps for intelligent manufacturing.This paper provides an overview of progress and contributions to the PSE-aided production of thermal cracking;introduces the frameworks,methods and algorithms that have been proposed over the past10 years and discusses the advantages,limitations and applications in industrial practice.An entire set of molecular-level modeling approaches from feedstocks to products,including feedstock molecular reconstruction,reaction-network auto-generation and cracking unit simulation are described.Multilevel control and optimization methods are exhibited,including at the operational,cycle,plant and enterprise level.Relevant software packages are introduced.Finally,an outlook in terms of future directions is presented.展开更多
This investigation aimed to unveil new prospective diagnosis-related biomarkers together with treatment targets against glioblastoma.Methods:The expression levels of long non-coding RNA(lncRNA)DPP10-AS1 were assessed ...This investigation aimed to unveil new prospective diagnosis-related biomarkers together with treatment targets against glioblastoma.Methods:The expression levels of long non-coding RNA(lncRNA)DPP10-AS1 were assessed using real-time quantitative polymerase chain reaction(RT-qPCR)within both the patient tissue specimens and glioblastoma cell lines.The relationship between lncRNA DPP10-AS1 expression in glioblastoma and patient prognosis was investigated.Cell Counting Kit-8(CCK-8),transwell,and clonogenic experiments were utilized to assess tumor cells’proliferation,invasiveness,and migratory potentials after lncRNA DPP10-AS1 expression was up or down-regulated.Using an online bioinformatics prediction tool,the intracellular localization of lncRNA DPP10-AS1 and its target miRNA were predicted,and RNA-FISH verified results.A dual-luciferase reporter experiment validated the relationship across miR-24-3p together with lncRNA DPP10-AS1.MiR-24-3p expression within glioblastoma was identified through RT-qPCR,and potential link across miR-24-3p and lncRNA DPP10-AS1 was assessed using Pearson correlation analysis.Moreover,influence from lncRNA DPP10-AS1/miR-24-3p axis upon glioblastoma cell progression was assessed in vivo via a subcutaneous xenograft tumor model.Results:The expression of lncRNA DPP10-AS1 was notably reduced in both surgical specimens of glioblastoma and the equivalent cell lines.Low level of lncRNA DPP10-AS1 in glioblastoma is following poor prognosis.The downregulation of lncRNA DPP10-AS1 in glioblastoma cells resulted in enhanced cellular proliferation,migration,and invasion capabilities,accompanied by downregulated E-cadherin and upregulated vimentin and N-cadherin.Additionally,the observed upregulation of lncRNA DPP10-AS1 demonstrated a substantial inhibitory function upon proliferation,invasion,and migratory capabilities of LN229 cells.Subcellular localization disclosed that lncRNA DPP10-AS1 had a binding site that interacted with miR-24-3p.Upregulated miR-24-3p was detected in glioblastomas,displaying an inverse correlation with lncRNA DPP10-AS1 expression.MiR-24-3p downstream target has been determined as chromodomain helicase DNA binding protein 5(CHD5).LncRNA DPP10-AS1 affected the invasion and proliferation of glioblastoma by controlling the miR-24-3p/CHD5 axis.Conclusion:The present study demonstrated that lncRNA DPP10-AS1 can inhibit the invasive,migratory,and proliferative properties of glioblastoma by regulating the miR-24-3p/CHD5 signaling pathway.Consequently,lncRNA DPP10-AS1 has potential as a tumor suppressor and might be utilized for accurate diagnosis and targeted treatments of glioblastomas.展开更多
In this paper,we co-design the transmission power and the offloading strategy for job offloading to a mobile edge computing(MEC)server at Terahertz(THz)frequencies.The goal is to minimize the communication energy cons...In this paper,we co-design the transmission power and the offloading strategy for job offloading to a mobile edge computing(MEC)server at Terahertz(THz)frequencies.The goal is to minimize the communication energy consumption while providing ultra-reliable low end-to-end latency(URLLC)services.To that end,we first establish a novel reliability framework,where the end-to-end(E2E)delay equals a weighted sum of the local computing delay,the communication delay and the edge computing delay,and the reliability is defined as the probability that the E2E delay remains below a certain pre-defined threshold.This reliability gives a full view of the statistics of the E2E delay,thus constituting advancement over prior works that have considered only average delays.Based on this framework,we establish the communication energy consumption minimization problem under URLLC constraints.This optimization problem is non-convex.To handle that issue,we first consider the special single-user case,where we derive the optimal solution by analyzing the structure of the optimization problem.Further,based on the analytical result for the single-user case,we decouple the optimization problem for multi-user scenarios into several sub-optimization problems and propose a sub-optimal algorithm to solve it.Numerical results verify the performance of the proposed algorithm.展开更多
There has been a continuous need for high active, excellently durable and low-cost electrocatalysts for rechargeable zinc-air batteries. Among many low-cost metal based candidates, transition metal oxides with the CNT...There has been a continuous need for high active, excellently durable and low-cost electrocatalysts for rechargeable zinc-air batteries. Among many low-cost metal based candidates, transition metal oxides with the CNTs composite have gained increasing attention. In this paper, the 3-D hollow sphere MnO_2 nanotube-supported Co_3O_4 nanoparticles and its carbon nanotubes hybrid material(Co_3 O_4/MnO_2-CNTs) have been synthesized via a simple co-precipitation method combined with post-heat treatment. The morphology and composition of the catalysts are thoroughly analyzed through SEM, TEM, TEM-mapping, XRD, EDX and XPS. In comparison with the commercial 20% Pt/C, Co_3O_4/MnO_2,bare MnO_2 nanotubes and CNTs, the hybrid Co_3O_4/MnO_2-CNTs-350 exhibits perfect bi-functional catalytic activity toward oxygen reduction reaction and oxygen evolution reaction under alkaline condition(0.1 M KOH). Therefore, high cell performances are achieved which result in an appropriate open circuit voltage(～1.47 V),a high discharge peak power density(340 mW cm^(-2)) and a large specific capacity(775 mAh g^(-1) at 10 mA cm^(-2)) for the primary Zn-air battery, a small charge-discharge voltage gap and a high cycle-life(504 cycles at 10 mA cm^(-2) with 10 min per cycle) for the rechargeable Zn-air battery. In particular, the simple synthesis method is suitable for a large-scale production of this bifunctional material due to a green, cost effective and readily available process.展开更多
基金supported by the China Agriculture Research System of MOF and MARA(CARS-29)the Xinjiang Uygur Autonomous Region Tianchi Talent Introduction Program,Chinathe Key R&D Technology Commissioner Projects in Hainan Province,China(ZDYF2024KJTPY008)。
文摘Bud dormancy represents a critical adaptation mechanism in perennial fruit plants,enabling survival during unfavorable environmental conditions.While this adaptive strategy is essential for plant survival and reproduction,its molecular mechanisms remain incompletely understood.This study investigated two grape transcription factors:EARLY BUD BREAK(VvEBB)and SHORT VEGETATIVE PHASE 4(VvSVP4).Through heterologous transformation in poplar,the research demonstrated that VvSVP4 functions as a negative regulator of bud break,while VvEBB serves as a positive regulator.Transcriptome analysis revealed significant enrichment of plant hormone signaling pathways particularly ABA,IAA,and CK in plants overexpressing VvSVP4(VvSVP4-OE)and VvEBB(VvEBB-OE)compared to controls.Endogenous hormone level changes correlated positively with transcriptome data.During endodormancy,VvSVP4 directly and positively regulated the ABA receptor gene Vv PYL9 expression,maintaining bud dormancy.Conversely,during ecodormancy,rapid upregulation of VvEBB negatively regulated the expression of sucrose nonfermenting 1-related protein kinase 2 gene(Vv SAPK2),facilitating dormancy release.This study provides comprehensive insights into how VvSVP4 and VvEBB genes regulate dormancy and bud break through cell cycle regulation and multiple hormone signaling pathways.
基金supported by the National Natural Science Foundation of China(Grant Nos.81930048 and 82330061)the Hong Kong Research Grant Council(Grant Nos.15217721,C7074-21GF,and 15125724)+4 种基金the Hong Kong Innovation and Technology Commission(Grant Nos.GHP/043/19SZ and GHP/044/19GD)the Guangdong Science and Technology Commission(Grant No.2019BT02X105)the Shenzhen Science and Technology Innovation Commission(Grant No.JCYJ20220818100202005)the Hong Kong Polytechnic University(Grant Nos.P0038180,P0039517,P0043485,and P0045762)the Fundamental Research Funds for the Central Universities(Grant No.QTZX25121).
文摘Retrieving high-fidelity images from optical speckles remains challenging,especially when the information in speckles is severely insufficient.To address classification through scattering media under such constraints,we propose Speckle Transformer,a vision-transformer-based model that directly classifies objects using raw speckle patterns without intermediate image retrieval.By leveraging inherent features within speckles to extract discriminative features,our approach achieves nearly 90%accuracy for classifying speckles encoded with different images,outperforming traditional retrieval-classification pipelines by up to five times,even with extreme information sparsity(i.e.,1/1024 speckle regions of interest).In addition,we quantify speckle information capacity via information entropy analysis,demonstrating that classification accuracy correlates strongly with the information entropy of speckle autocorrelation.We not only overcome limitations of conventional methods but also establish a paradigm for real-time classification in scattering environments with constrained data.
基金supported by the National Natural Science Foundation of China(No.52175269)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.52021003)+2 种基金Science and Technology Research Project of Education Department of Jilin Province(JJKH20231146KJ,JJKH20241262KJ)Project ZR2024ME104 supported by Shandong Provincial Natural Science FoundationChina Postdoctoral Science Foundation(No.2024M751086).
文摘Numerous arthropods evolve and optimize sensory systems, enabling them to effectively adapt complex and competitive habitats. Typically, scorpions can precisely perceive the prey location with the lowest metabolic rate among invertebrates. This biological phenomenon contrasts sharply with engineered systems, which generally associates high accuracy with substantial energy consumption. Inspired by the Scorpion Compound Slit Sensilla (SCSS) with a stress field modulation strategy, a bionic positioning sensor with superior precision and minimal power consumption is developed for the first time, which utilizes the particular Minimum Positioning Units (MPUs) to efficiently locate vibration signals. The single MPU of the SCSS can recognize the direction of collinear loads by regulating the stress field distribution and further, the coupling action of three MPUs can realize all-angle vibration monitoring in plane. Experiments demonstrate that the bionic positioning sensor achieves 1.43 degrees of angle-error-free accuracy without additional energy supply. As a proof of concept, two bionic positioning sensors and machine learning algorithm are integrated to provide centimeter (cm)-accuracy target localization, ideally suited for the man-machine interaction. The novel design offers a new mechanism for the design of traditional positioning devices, improving precision and efficiency in both the meta-universe and real-world Internet-connected systems.
文摘Neutral oxygen evolution reaction(OER)is a crucial half-reaction for electrocatalytic chemical production under mild condition,but with limited development due to low activity and poor stability.Herein,a tungsten-doped cobalt molybdate(WDCMO)catalyst was synthesized for efficient and durable OER under neutral electrolyte.It is demonstrated that catalyst reconstruction is suppressed by W doping,which stabilizes the Co-O-Mo point-to-point connection in CoMoO_(4) architecture and stimulates to a lower valence state of active sites over the surface phase.Thereby,the surface structure maintains to avoid compound dissolution caused by over-oxidation during OER.Meanwhile,the WDCMO catalyst promotes charge transfer and optimizes*OH intermediate adsorption,which improves reaction kinetics and intrinsic activity.Consequently,the WDCMO electrode exhibits an overpotential of 302 mV at 10 mA cm^(-2) in neutral electrolyte with an improvement of 182 mV compared with CoMoO4 electrode.Furthermore,W doping significantly improves the electrode stability from 50 h to more than 320 h,with a suppressive potential attenuation from 2.82 to 0.29 mV h^(-1).This work will shed new light on designing rational electrocatalysts for neutral OER.
基金funding support from the General Program of the National Natural Science Foundation of China(Grant No.52374069)the Excellent Young Scientists Fund Program of the National Natural Science Foundation of China(Grant No.52122403)the Youth Innovation Promotion Association CAS(Grant No.Y2023089).
文摘This paper presents an ultralow-frequency cyclic loading creep test system for rock salt.The system comprises five subsystems:a cyclic load generation system,a triaxial pressure chamber,a pressure and deformation monitoring system,a signal acquisition and load control integrated system,and an automatic oil replenishment and discharge system.This test system overcomes the limitations of traditional electrohydraulic servo creep testing machines and gravity loading creep testing machines when conducting low-frequency cyclic load creep tests.This allows for long-term(1-2 years)creep tests under extremely-low-frequency cyclic loading conditions,which simulate the actual operating conditions of salt cavern gas storage.The cyclic load generation system converted constant-weight loads into a continuously variable hydraulic oil pressure and amplified the oil pressure using a pressure intensifier,which provided a stable load source for the test system.Using this test system,creep tests were performed under low-frequency cyclic loading with periods of 1 d and 7 d.The results showed that the test system performed well,as evidenced by the validation of the loading capacity,loading stability,and temperature control stability.Comparing the creep deformation of rock salt samples with the cyclic periods of 1 d and 7 d,it was observed that,within this cyclic period range,the creep deformation of the sample increased with higher loading frequencies,provided that the cyclic loading waveform and stress remained constant.
基金supported by the National Natural Science Foundation of China(No.21976050)the Science and Technology Program of Hebei Province(No.21377779D)+3 种基金the Natural Science Foundation of Hebei Province(No.B2020206008)China Postdoctoral Science Foundation(Nos.2023M730317 and 2023T160066)the Fundamental Research Funds for the Central Universities(No.3332023042)the Open Project of Hebei Key Laboratory of Environment and Human Health(No.202301).
文摘Previous studies have suggested that abnormal hepatobiliary system function may contribute to poor prognosis in patientswith acute coronary syndrome(ACS)and that abnormal hepatobiliary system function may be associated with per-and polyfluoroalkyl substances(PFAS)exposure.However,there is limited evidence for this association in cardiovascular subpopulations,particularly in the ACS patients.Therefore,we performed this study to evaluate the association between plasma PFAS exposure and hepatobiliary system function biomarkers in patients with ACS.This study included 546 newly diagnosed ACS patients at the Second Hospital of Hebei Medical University,and data on 15 hepatobiliary system function biomarkers were obtained from medical records.Associations between single PFAS and hepatobiliary system function biomarkers were assessed using multiple linear regression models and restricted cubic spline model(RCS),and mixture effects were assessed using the Quantile g-computation model.The results showed that total bile acids(TBA)was negative associated with perfluorohexane sulfonic acid(PFHxS)(-7.69%,95%CI:-12.15%,-3.01%).According to the RCS model,linear associations were found between TBA and PFHxS(P for overall=0.003,P for non-linear=0.234).We also have observed the association between between PFAS congeners and liver enzyme such as aspartate aminotransferase(AST)and α-l-Fucosidase(AFU),but it was not statistically significant after correction.In addition,Our results also revealed an association between prealbumin(PA)and PFAS congeners as well as mixtures.Our findings have provided a piece of epidemiological evidence on associations between PFAS congeners or mixture,and serum hepatobiliary system function biomarkers in ACS patients,which could be a basis for subsequent mechanism studies.
基金supported by the National Natural Science Foundation of China(No.82404365)the Noncommunicable Chronic Diseases-National Science and Technology Major Project(No.2023ZD0513200)+7 种基金China Medical Board(No.15-230)China Postdoctoral Science Foundation(Nos.2023M730317and 2023T160066)the Fundamental Research Funds for the Central Universities(No.3332023042)the Open Project of Hebei Key Laboratory of Environment and Human Health(No.202301)the National Key Research and Development Program of China(No.2022YFC3703000)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2022-JKCS-11)the CAMS Innovation Fund for Medical Sciences(No.2022-I2M-JB-003)the Programs of the National Natural Science Foundation of China(No.21976050).
文摘Associations of per-and polyfluoroalkyl substances(PFAS)on lipid metabolism have been documented but research remains scarce regarding effect of PFAS on lipid variability.To deeply understand their relationship,a step-forward in causal inference is expected.To address these,we conducted a longitudinal study with three repeated measurements involving 201 participants in Beijing,among which 100 eligible participants were included for the present study.Twenty-three PFAS and four lipid indicators were assessed at each visit.We used linear mixed models and quantile g-computation models to investigate associations between PFAS and blood lipid levels.A latent class growth model described PFAS serum exposure patterns,and a generalized linear model demonstrated associations between these patterns and lipid variability.Our study found that PFDA was associated with increased TC(β=0.083,95%CI:0.011,0.155)and HDL-C(β=0.106,95%CI:0.034,0.178).The PFAS mixture also showed a positive relationship with TC(β=0.06,95%CI:0.02,0.10),with PFDA contributing most positively.Compared to the low trajectory group,the middle trajectory group for PFDA was associated with VIM of TC(β=0.756,95%CI:0.153,1.359).Furthermore,PFDA showed biological gradientswith lipid metabolism.This is the first repeated-measures study to identify the impact of PFAS serum exposure pattern on the lipid metabolism and the first to estimate the association between PFAS and blood lipid levels in middle-aged and elderly Chinese and reinforce the evidence of their causal relationship through epidemiological studies.
基金supported by Beijing Institute of Technology Student Innovation Training Program(BIT2024LH013).
文摘The thermal stability of lithium-ion battery separators is a critical determinant of battery safety and performance,especially in the context of rapidly expanding applications in electric vehicles and energy storage systems.While traditional polyolefin separators(PP/PE)dominate the market due to their cost-effectiveness and mechanical robustness,their inherent poor thermal stability poses significant safety risks under high-temperature conditions.This review provides a comprehensive analysis of recent advancements in enhancing separator thermal stability through coating materials(metal,ceramic,inorganic)and novel high-temperature-resistant polymers(e.g.,PVDF copolymers,PI,PAN).Notably,we critically evaluate the trade-offs between thermal resilience and electrochemical performance,such as the unintended increase in electronic conductivity from metal coatings(e.g.,Cu,MOFs)and reduced electrolyte wettability in ceramic coatings(e.g.,Al_(2)O_(3)).Innovations in hybrid coatings(e.g.,BN/PAN composites,gradient-structured MOFs)and scalable manufacturing techniques(e.g.,roll-to-roll electrospinning)are highlighted as promising strategies to balance these competing demands.Furthermore,a comparative analysis of next-generation high-temperature-resistant separators underscores their ionic conductivity,mechanical strength,and scalability,offering actionable insights for material selection.The review concludes with forward-looking perspectives on integrating machine learning for material discovery,optimizing interfacial adhesion in ceramic coatings,and advancing semi-/all-solid-state batteries to address both thermal and electrochemical challenges.This work aims to bridge the gap between laboratory innovations and industrial applications,fostering safer and more efficient lithium battery technologies.
基金supported by the China Postdoctoral Science Foundation(Nos.2023M730317 and 2023T160066)the Fundamental Research Funds for the Central Universities(No.3332023042)+3 种基金the Open Project of Hebei Key Laboratory of Environment and Human Health(No.202301)the Programs of the National Natural Science Foundation of China(No.21976050)the Science and Technology Program of Hebei Province(No.21377779D)the Natural Science Foundation of Hebei Province,China(No.B2020206008).
文摘Although per-and polyfluoroalkyl substances(PFAS)have been frequently linked to cardiovascular and renal disease separately,evidence remains scarce regarding their systematic effect.Therefore,we recruited 546 newly diagnosed acute coronary syndrome(ACS)patients and detected seven myocardial enzymes and six kidney function biomarkers.Twelve PFASwere also assessedwith ultra-high-performance liquid chromatography-tandem mass spectrometry.Generalized linear model and restricted cubic spline model were applied to single pollutant analysis.Quantile g-computation was used for mixture analysis.Network model was utilized to identify central and bridge nodes of pollutants and phenotypes.In the present study,perfluorohexane sulfonic acid was positively associated with uric acid(UA)(β=0.04,95%confidence interval(CI):0.01,0.07),and perfluorobutanoic acid was negatively associated with estimated glomerular filtration rate(β=-0.04,95%CI:-0.07,-0.01)but positively associated with UA(β=0.03,95%CI:0.01,0.06).In mixture analysis,each quantile increase in the PFAS mixture was significantly associated with UA(β=0.08,95%CI:0.04,0.11).Network analysis revealed that perfluorooctanoate,UA,and myoglobin were denoted as bridge nodes,and the first principal component of lactate dehydrogenase and creatine kinase-myocardial band was identified as the node with the highest strength and expected influence.This study investigates the systematic impact of PFAS exposure through cardiorenal interaction network,which highlights that PFAS may serve as an upstream approach in UA-modulated cardiorenal network to affect cardiorenal system comprehensively.
基金SUSTech Medical Research Innovation Project,Grant/Award Number:G030410001National Natural Science Foundation of China,Grant/Award Number:72342016+1 种基金Shenzhen Science and Technology Program,Grant/Award Number:JCYJ20250604144558076China Scholarship Council Scholarship,Grant/Award Number:202506280122。
文摘A series of measures to implement national volume‐based procurement(NVBP)and follow‐on NVBP in China have significantly reduced insulin prices and increased patient affordability.However,NVBP may lead to a higher burden of insulin‐related consumables(such as injection pens and needles),which might discourage patients from using insulin in the pooled list and increase the risk of needle reuse.This article emphasizes that it is essential NVBP be implemented for both drugs and consumables,which will contribute to the achievement of universal insulin access.
基金supported by the National Natural Science Foundation of China (No. 41272093)China Geological Survey (No. 12120114080901)
文摘This paper presents zircon U-Pb-Hf isotopic compositions and whole-rock geochemical data for monzogranites and mafic-ultramafic complexes of the Maxingdawannan area in the western end of the east Kunlun orogenic belt, western China. The data are used to determine the ages, petrogenesis, magma sources, and geodynamic setting of the studied rocks. U-Pb zircon dating indicates that monzogranites and gabbros of the complexes were emplaced at 399 and 397 Ma, respectively. The monzogranites are shoshonitic, with high SiO2, Al2 O3 and total-alkali contents, and low TFeO, MgO, TiO2 and P2 O5 contents. The mafic-ultramafic complexes are characterized by low Si O2 contents. The monzogranites display enrichment in light rare-earth elements(LREE) and large-ion lithophile elements(LILE), depletion in heavy REEs(HREE) and high-field-strength elements(HFSE), and negative Eu anomalies(Eu/Eu*=0.36–0.48). The mafic-ultramafic complexes are also enriched in LREEs and LILEs, and depleted in HREEs and HFSEs, with weak Eu anomalies(Eu/Eu*=0.84–1.16). Zircon εHf(t) values for the monzogranites and mafic-ultramafic complexes range from-6.68 to 1.11 and-1.81 to 6.29, with zircon model ages of 1 812–1 319 Ma(TDM2) and 1 087–769 Ma(TDM1), respectively. Hf isotopic data indicate that primary magmas of the monzogranites are originated from partial melting of ancient lower crust during the Paleo-Mesoproterozoic, with a juvenile-crust component. Primitive magmas of the mafic-ultramafic complexes are likely originated from a depleted-mantle source modified by slab-derived fluids and contaminated by crustal components. Geochemical data and the geological setting indicate that Devonian intrusions in the Maxingdawannan area are related to northward subduction of the ProtoTethys oceanic lithosphere.
基金supported by the National Key Basic Research Program of China(2015CB251401)the National Natural Science Foundation of China(21776235)+1 种基金the Zhejiang Provincial Natural Science Foundation of China(LZ17B060001)the Fundamental Research Funds for the Central Universities
文摘An efficient method for prediction in the capture of SO_(2)from flue gas by imidazolium ionic liquids was reported,where the concentration of SO_(2)is 2000 ppm.On the basis of quantitative calculations through a combination of Langmuir simulation,theoretical calculation and quantum chemical method,SO_(2)absorption and desorption performance from flue gas by twelve kinds of imidazolium ionic liquids with different anions were designed and predicted.Then,among them,five kinds of imidazolium ionic liquids were chosen and prepared to investigate their behavior of SO_(2)absorption capacity,desorption residue,and available absorption capacity.The results indicated that the experimental values were in good agreement with the predicted values.Thus,an ideal ionic liquid[Emim][Tetz]was obtained through the predictive method for the capture of SO_(2)of 2000 ppm,which showed high available absorption capacity of 0.24 g SO_(2)per g ionic liquid and excellent reversibility.
基金supported by the National Natural Science Foundation of China(21406235 and U1407111)the National High Technology Research and Development Program of China(863 Program,2014AA021006)
文摘The interest in ionic liquids(IL) is motivated by its unique properties, such as negligible vapor pressure, thermal stability, wide electrochemical stability window, and tunability of properties. ILs have been highlighted as solvents for liquid-liquid extraction and liquid membrane separation. To further expand its application in separation field, the ionic liquid membranes(ILMs) and its separation technology have been proposed and developed rapidly. This paper is to give a comprehensive overview on the recent applications of ILMs for the separation of various compounds, including organic compounds, mixed gases, and metal ions. Firstly, ILMs was classified into supported ionic liquid membranes(SILMs) and quasi-solidified ionic liquid membranes(QSILMs) according to the immobilization method of ILs. Then, preparation methods of ILMs, membrane stability as well as applications of ILMs in the separation of various mixtures were reviewed. Followed this, transport mechanisms of gaseous mixtures and organic compounds were elucidated in order to better understand the separation process of ILMs. This tutorial review intends to not only offer an overview on the development of ILMs but also provide a guide for ILMs preparations and applications.
基金supported by the National Natural Science Foundation,China(No.21573196)the Fundamental Research Funds for the Central Universities,Chinathe National High Technology Research and the National Natural Science Foundation,China(No.22073081)。
文摘The electron paramagnetic resonance spectra of the chelate-based ionic liquid[C_(10)mim][Cu(F_6-acac)_3]in different solvents have been obtained at 120 K.It was found that the values of the^(63)Cu hyperfine coupling constants(A_(IL))of[C_(10)mim][Cu(F_6-acac)_3]in molecular solvents were from 116 to 180 Gauss.Moreover,the A_(IL)values in general ionic liquids are more complicated,and two sets of peaks can often be observed in their electron paramagnetic resonance spectra.Based on the Kamlet-Taft parameters,relative permittivity,the experimental results were discussed in terms of solvation effect and coordination of the solvents.
基金supported by the China Ocean Mineral Resources Research Program (No. DY125-15-T-08)the National Natural Sciences Foundation of China (Nos. 21176026 21176242)
文摘Uranium-reducing bacteria were immobilized with sodium alginate, anthraquinone-2,6-disulfonate（AQDS）, and carbon nanotubes（CNTs）. The effects of different AQDS-CNTs contents, U（Ⅳ） concentrations, and metal ions on U（Ⅳ） reduction by immobilized beads were examined. Over 97.5% U（Ⅵ）（20 mg/L） was removed in 8 hr when the beads were added to 0.7% AQDS-CNTs, which was higher than that without AQDS-CNTs. This result may be attributed to the enhanced electron transfer by AQDS and CNTs. The reduction of U（Ⅵ） occurred at initial U（Ⅵ） concentrations of 10 to 100 mg/L and increased with increasing AQDS-CNT content from 0.1% to 1%. The presence of Fe（Ⅲ）, Cu（Ⅱ） and Mn（Ⅱ）slightly increased U（Ⅵ） reduction, whereas Cr（Ⅵ）, Ni（Ⅱ）, Pb（Ⅱ）, and Zn（Ⅱ） significantly inhibited U（Ⅵ） reduction. After eight successive incubation-washing cycles or 8 hr of retention time（HRT） for 48 hr of continuous operation, the removal efficiency of uranium was above 90% and 92%, respectively. The results indicate that the AQDS-CNT/AL/cell beads are suitable for the treatment of uranium-containing wastewaters.
基金The authors gratefully acknowledge the National Natural Science Foundation of China for its financial support(U1462206).
文摘Applications of process systems engineering(PSE)in plants and enterprises are boosting industrial reform from automation to digitization and intelligence.For ethylene thermal cracking,knowledge expression,numerical modeling and intelligent optimization are key steps for intelligent manufacturing.This paper provides an overview of progress and contributions to the PSE-aided production of thermal cracking;introduces the frameworks,methods and algorithms that have been proposed over the past10 years and discusses the advantages,limitations and applications in industrial practice.An entire set of molecular-level modeling approaches from feedstocks to products,including feedstock molecular reconstruction,reaction-network auto-generation and cracking unit simulation are described.Multilevel control and optimization methods are exhibited,including at the operational,cycle,plant and enterprise level.Relevant software packages are introduced.Finally,an outlook in terms of future directions is presented.
基金supported through the Natural Science Foundation of Jiangsu Province(No.BK20201172)the Key Project of the Jiangsu Health Commission(No.ZDB2020016)the Jiangsu Province Key Research and Development Program:Social Development Project(No.BE2021653).
文摘This investigation aimed to unveil new prospective diagnosis-related biomarkers together with treatment targets against glioblastoma.Methods:The expression levels of long non-coding RNA(lncRNA)DPP10-AS1 were assessed using real-time quantitative polymerase chain reaction(RT-qPCR)within both the patient tissue specimens and glioblastoma cell lines.The relationship between lncRNA DPP10-AS1 expression in glioblastoma and patient prognosis was investigated.Cell Counting Kit-8(CCK-8),transwell,and clonogenic experiments were utilized to assess tumor cells’proliferation,invasiveness,and migratory potentials after lncRNA DPP10-AS1 expression was up or down-regulated.Using an online bioinformatics prediction tool,the intracellular localization of lncRNA DPP10-AS1 and its target miRNA were predicted,and RNA-FISH verified results.A dual-luciferase reporter experiment validated the relationship across miR-24-3p together with lncRNA DPP10-AS1.MiR-24-3p expression within glioblastoma was identified through RT-qPCR,and potential link across miR-24-3p and lncRNA DPP10-AS1 was assessed using Pearson correlation analysis.Moreover,influence from lncRNA DPP10-AS1/miR-24-3p axis upon glioblastoma cell progression was assessed in vivo via a subcutaneous xenograft tumor model.Results:The expression of lncRNA DPP10-AS1 was notably reduced in both surgical specimens of glioblastoma and the equivalent cell lines.Low level of lncRNA DPP10-AS1 in glioblastoma is following poor prognosis.The downregulation of lncRNA DPP10-AS1 in glioblastoma cells resulted in enhanced cellular proliferation,migration,and invasion capabilities,accompanied by downregulated E-cadherin and upregulated vimentin and N-cadherin.Additionally,the observed upregulation of lncRNA DPP10-AS1 demonstrated a substantial inhibitory function upon proliferation,invasion,and migratory capabilities of LN229 cells.Subcellular localization disclosed that lncRNA DPP10-AS1 had a binding site that interacted with miR-24-3p.Upregulated miR-24-3p was detected in glioblastomas,displaying an inverse correlation with lncRNA DPP10-AS1 expression.MiR-24-3p downstream target has been determined as chromodomain helicase DNA binding protein 5(CHD5).LncRNA DPP10-AS1 affected the invasion and proliferation of glioblastoma by controlling the miR-24-3p/CHD5 axis.Conclusion:The present study demonstrated that lncRNA DPP10-AS1 can inhibit the invasive,migratory,and proliferative properties of glioblastoma by regulating the miR-24-3p/CHD5 signaling pathway.Consequently,lncRNA DPP10-AS1 has potential as a tumor suppressor and might be utilized for accurate diagnosis and targeted treatments of glioblastomas.
文摘In this paper,we co-design the transmission power and the offloading strategy for job offloading to a mobile edge computing(MEC)server at Terahertz(THz)frequencies.The goal is to minimize the communication energy consumption while providing ultra-reliable low end-to-end latency(URLLC)services.To that end,we first establish a novel reliability framework,where the end-to-end(E2E)delay equals a weighted sum of the local computing delay,the communication delay and the edge computing delay,and the reliability is defined as the probability that the E2E delay remains below a certain pre-defined threshold.This reliability gives a full view of the statistics of the E2E delay,thus constituting advancement over prior works that have considered only average delays.Based on this framework,we establish the communication energy consumption minimization problem under URLLC constraints.This optimization problem is non-convex.To handle that issue,we first consider the special single-user case,where we derive the optimal solution by analyzing the structure of the optimization problem.Further,based on the analytical result for the single-user case,we decouple the optimization problem for multi-user scenarios into several sub-optimization problems and propose a sub-optimal algorithm to solve it.Numerical results verify the performance of the proposed algorithm.
基金financial support from the National Natural Science Foundation of China (U1510120, 91645110)the Project of Introducing Overseas Intelligence High Education of China (2017-2018)+1 种基金the Graduate Thesis Innovation Foundation of Donghua University (EG2016034)the College of Environmental Science and Engineering, State Environmental Protection Engineering Center for Pollution Treatment and Control in Textile Industry, Donghua University
文摘There has been a continuous need for high active, excellently durable and low-cost electrocatalysts for rechargeable zinc-air batteries. Among many low-cost metal based candidates, transition metal oxides with the CNTs composite have gained increasing attention. In this paper, the 3-D hollow sphere MnO_2 nanotube-supported Co_3O_4 nanoparticles and its carbon nanotubes hybrid material(Co_3 O_4/MnO_2-CNTs) have been synthesized via a simple co-precipitation method combined with post-heat treatment. The morphology and composition of the catalysts are thoroughly analyzed through SEM, TEM, TEM-mapping, XRD, EDX and XPS. In comparison with the commercial 20% Pt/C, Co_3O_4/MnO_2,bare MnO_2 nanotubes and CNTs, the hybrid Co_3O_4/MnO_2-CNTs-350 exhibits perfect bi-functional catalytic activity toward oxygen reduction reaction and oxygen evolution reaction under alkaline condition(0.1 M KOH). Therefore, high cell performances are achieved which result in an appropriate open circuit voltage(～1.47 V),a high discharge peak power density(340 mW cm^(-2)) and a large specific capacity(775 mAh g^(-1) at 10 mA cm^(-2)) for the primary Zn-air battery, a small charge-discharge voltage gap and a high cycle-life(504 cycles at 10 mA cm^(-2) with 10 min per cycle) for the rechargeable Zn-air battery. In particular, the simple synthesis method is suitable for a large-scale production of this bifunctional material due to a green, cost effective and readily available process.
