Background and Objectives:Growing evidence has explored the effects of water-soluble vitamins supplementa tion on glycemic control and insulin resistance in diabetic patients;however,the results of previous meta-analy...Background and Objectives:Growing evidence has explored the effects of water-soluble vitamins supplementa tion on glycemic control and insulin resistance in diabetic patients;however,the results of previous meta-analyses are inconsistent.To address this,we conducted an umbrella review to synthesize the evidence on these effects.Methods and Study Design:A systematic literature search in Web of science,PubMed,and Cochrane Database of Systematic Reviews was performed from 2012 to November 2022.he quality of the meta-analyses was assessed using AMSTAR-2 and GRADE.Results:Fourteen systematic reviews and meta-analyses met the inclusion criteria,examining the effects of five water-soluble vitamins(B-1,B-3,biotin,B-9,and C)on glycemic control and insulin resistance.The findings suggest that vitamin C supplementation can improve glycemic control in type 2 diabetes,as indicated by reduced FBG and HbA1c,with more significant effects observed for durations longer than 30 days.Conclusions:Insulin resistance is improved by folic acid supplementations.More well-designed individual ran domized controlled trials are needed in the future,as well as meta-analysis of higher quality.展开更多
文摘Background and Objectives:Growing evidence has explored the effects of water-soluble vitamins supplementa tion on glycemic control and insulin resistance in diabetic patients;however,the results of previous meta-analyses are inconsistent.To address this,we conducted an umbrella review to synthesize the evidence on these effects.Methods and Study Design:A systematic literature search in Web of science,PubMed,and Cochrane Database of Systematic Reviews was performed from 2012 to November 2022.he quality of the meta-analyses was assessed using AMSTAR-2 and GRADE.Results:Fourteen systematic reviews and meta-analyses met the inclusion criteria,examining the effects of five water-soluble vitamins(B-1,B-3,biotin,B-9,and C)on glycemic control and insulin resistance.The findings suggest that vitamin C supplementation can improve glycemic control in type 2 diabetes,as indicated by reduced FBG and HbA1c,with more significant effects observed for durations longer than 30 days.Conclusions:Insulin resistance is improved by folic acid supplementations.More well-designed individual ran domized controlled trials are needed in the future,as well as meta-analysis of higher quality.
