Warm dense plasmas are crucial for high-energy-density physics and inertial confinement fusion research.Experiments involving laser-irradiated copper(Cu)foil were performed at the Shenguang-II facility.A highly orient...Warm dense plasmas are crucial for high-energy-density physics and inertial confinement fusion research.Experiments involving laser-irradiated copper(Cu)foil were performed at the Shenguang-II facility.A highly oriented pyrolytic graphite crystal spectrometer measured the time-integrated spectral distribution of Cu under varying laser intensities.Using the two-dimensional radiation-hydrodynamics code FLASH and the spectral analysis code FLYCHK,we simulated the temporal evolution of plasma density and temperature distributions,as well as the emission intensities of spectral lines at different temperatures and densities.The simulation results revealed that the two-electron satellite lines(J)and the resonance line(W)emissions of Cu originate predominantly from the radiation region near the critical density surface,with a density range from approximately 0.5 nc to 1.0 nc,and radiate primarily during the laser irradiation period.By analyzing the J/W intensity ratio of the measured spectral lines,we estimated the electron temperatures near the critical-density surface under different laser intensities.展开更多
We developed a monochromatic crystal backlight imaging system for the double-cone ignition(DCI) scheme, employing a spherically bent quartz crystal. This system was used to measure the spatial distribution and tempora...We developed a monochromatic crystal backlight imaging system for the double-cone ignition(DCI) scheme, employing a spherically bent quartz crystal. This system was used to measure the spatial distribution and temporal evolution of the head-on colliding plasma from the two compressing cones in the DCI experiments. The influence of laser parameters on the x-ray backlighter intensity and spatial resolution of the imaging system was investigated. The imaging system had a spatial resolution of 10 μm when employing a CCD detector. Experiments demonstrated that the system can obtain time-resolved radiographic images with high quality, enabling the precise measurement of the shape, size, and density distribution of the plasma.展开更多
The spherical crystal imaging system,noted for its high energy spectral resolution(monochromaticity)and spatial resolution,is extensively applied in high energy density physics and inertial confinement fusion research...The spherical crystal imaging system,noted for its high energy spectral resolution(monochromaticity)and spatial resolution,is extensively applied in high energy density physics and inertial confinement fusion research.This system supports studies on fast electron transport,hydrodynamic instabilities,and implosion dynamics.The x-ray source,produced through laser-plasma interaction,emits a limited number of photons within short time scales,resulting in predominantly photon-starved images.Through ray-tracing simulations,we investigated the impact of varying crystal dimensions on the performance of a spherical crystal self-emission imager.We observed that increasing the crystal dimension leads to higher imaging efficiency but at the expense of monochromaticity,causing broader spectral acceptance and reduced spatial resolution.Furthermore,we presented a theoretical model to estimate the spatial resolution of the imaging system within a specific energy spectrum range,detailing the expressions for the effective size of the crystal.The spatial resolution derived from the model closely matches the numerical simulations.展开更多
The velocity interferometer system for any reflector(VISAR) coupled with a streaked optical pyrometer(SOP) system is used as a diagnostic tool in inertial confinement fusion(ICF) experiments involving equations of sta...The velocity interferometer system for any reflector(VISAR) coupled with a streaked optical pyrometer(SOP) system is used as a diagnostic tool in inertial confinement fusion(ICF) experiments involving equations of state and shock timing.To validate the process of adiabatically compressing the fuel shell through precise tuning of shocks in experimental campaigns for the double-cone ignition(DCI) scheme of ICF, a compact line-imaging VISAR with an SOP system is designed and implemented at the Shenguang-II upgrade laser facility. The temporal and spatial resolutions of the system are better than 30 ps and 7 μm, respectively. An illumination lens is used to adjust the lighting spot size matching with the target size. A polarization beam splitter and λ/4 waveplate are used to increase the transmission efficiency of our system. The VISAR and SOP work at 660 and 450 nm, respectively, to differentiate the signals from the scattered lights of the drive lasers. The VISAR can measure the shock velocity. At the same time, the SOP system can give the shock timing and relative strength. This system has been used in different DCI campaigns, where the generation and propagation processes of multi-shock are carefully diagnosed.展开更多
Optical diagnostics are essential in monitoring the progression of plasma in high-energy-density physics research.The abrupt transitions in plasma evolution,whether caused by laser irradiation or hydrodynamic instabil...Optical diagnostics are essential in monitoring the progression of plasma in high-energy-density physics research.The abrupt transitions in plasma evolution,whether caused by laser irradiation or hydrodynamic instabilities,cannot be accurately distinguished using only two-dimensional[2D]gated detectors or a streak camera individually.In this paper,we introduce a hybrid diagnostic system that combines a streak camera and gated detectors.This innovative approach enables us to measure both the plasma density evolution and 2D morphology simultaneously.These advanced diagnostics have been utilized in recent laboratory astrophysics experiments,effectively capturing the plasma flow density distribution and flow velocity.展开更多
In the double-cone ignition scheme of inertial confinement fusion,the head-on collision of two compressed fuel jets from the cone-tips forms an isochoric plasma,which is then heated suddenly by a MeV relativistic elec...In the double-cone ignition scheme of inertial confinement fusion,the head-on collision of two compressed fuel jets from the cone-tips forms an isochoric plasma,which is then heated suddenly by a MeV relativistic electron beam produced by ultra-intense picosecond laser pulses.This fast-heating process was studied experimentally at the ShenguangⅡupgrade laser facility.By observing temporal-resolved X-ray emission and the spatial-resolved X-ray spectrum,the colliding process and heating process are carefully studied.The colliding plasma was imaged to have dimensions of approximately86μm in the implosion direction and approximately 120μm in the heating direction.By comparing the simulated plasma X-ray spectrum with experimental data,the electron temperature of the heated plasma was found to rapidly increase to 600±50 eV,almost doubling the temperature achieved before the heating laser incidence.展开更多
Spinal cord injury(SCI)is an overwhelming and incurable disabling event accompanied by complicated inflammation-related pathological processes,such as excessive reactive oxygen species(ROS)produced by the infiltrated ...Spinal cord injury(SCI)is an overwhelming and incurable disabling event accompanied by complicated inflammation-related pathological processes,such as excessive reactive oxygen species(ROS)produced by the infiltrated inflammatory immune cells and released to the extracellular microenvironment,leading to the widespread apoptosis of the neuron cells,glial and oligodendroctyes.In this study,a thioketal-containing and ROS-scavenging hydrogel was prepared for encapsulation of the bone marrow derived mesenchymal stem cells(BMSCs),which promoted the neurogenesis and axon regeneration by scavenging the overproduced ROS and re-building a regenerative microenvironment.The hydrogel could effectively encapsulate BMSCs,and played a remarkable neuroprotective role in vivo by reducing the production of endogenous ROS,attenuating ROS-mediated oxidative damage and downregulating the inflammatory cytokines such as interleukin-1 beta(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-alpha(TNF-α),resulting in a reduced cell apoptosis in the spinal cord tissue.The BMSCs-encapsulated ROS-scavenging hydrogel also reduced the scar formation,and improved the neurogenesis of the spinal cord tissue,and thus distinctly enhanced the motor functional recovery of SCI rats.Our work provides a combinational strategy against ROS-mediated oxidative stress,with potential applications not only in SCI,but also in other central nervous system diseases with similar pathological conditions.展开更多
基金Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA25051000,XDA25010100,XDA25010300,XDA25030100,and XDA25030200)。
文摘Warm dense plasmas are crucial for high-energy-density physics and inertial confinement fusion research.Experiments involving laser-irradiated copper(Cu)foil were performed at the Shenguang-II facility.A highly oriented pyrolytic graphite crystal spectrometer measured the time-integrated spectral distribution of Cu under varying laser intensities.Using the two-dimensional radiation-hydrodynamics code FLASH and the spectral analysis code FLYCHK,we simulated the temporal evolution of plasma density and temperature distributions,as well as the emission intensities of spectral lines at different temperatures and densities.The simulation results revealed that the two-electron satellite lines(J)and the resonance line(W)emissions of Cu originate predominantly from the radiation region near the critical density surface,with a density range from approximately 0.5 nc to 1.0 nc,and radiate primarily during the laser irradiation period.By analyzing the J/W intensity ratio of the measured spectral lines,we estimated the electron temperatures near the critical-density surface under different laser intensities.
基金Project supported by the staff of the Shenguang-Ⅱ upgrade Laser facilityThis study was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA25010100,XDA25010300,XDA25030100,XDA25030200,and XDA25051000)+2 种基金the National Natural Science Foundation of China(Grant Nos.11827807 and 12105359)the Open Foundation of Key Laboratory of High Power Laser and Physics of Chinese Academy of Sciences(Grant No.SGKF202105)the Chinese Academy of Sciences Youth Interdisciplinary Team(Grant No.JCTD-2022-05).
文摘We developed a monochromatic crystal backlight imaging system for the double-cone ignition(DCI) scheme, employing a spherically bent quartz crystal. This system was used to measure the spatial distribution and temporal evolution of the head-on colliding plasma from the two compressing cones in the DCI experiments. The influence of laser parameters on the x-ray backlighter intensity and spatial resolution of the imaging system was investigated. The imaging system had a spatial resolution of 10 μm when employing a CCD detector. Experiments demonstrated that the system can obtain time-resolved radiographic images with high quality, enabling the precise measurement of the shape, size, and density distribution of the plasma.
基金Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA25051000,XDA25010100,XDA25010300,XDA25030100,and XDA25030200)。
文摘The spherical crystal imaging system,noted for its high energy spectral resolution(monochromaticity)and spatial resolution,is extensively applied in high energy density physics and inertial confinement fusion research.This system supports studies on fast electron transport,hydrodynamic instabilities,and implosion dynamics.The x-ray source,produced through laser-plasma interaction,emits a limited number of photons within short time scales,resulting in predominantly photon-starved images.Through ray-tracing simulations,we investigated the impact of varying crystal dimensions on the performance of a spherical crystal self-emission imager.We observed that increasing the crystal dimension leads to higher imaging efficiency but at the expense of monochromaticity,causing broader spectral acceptance and reduced spatial resolution.Furthermore,we presented a theoretical model to estimate the spatial resolution of the imaging system within a specific energy spectrum range,detailing the expressions for the effective size of the crystal.The spatial resolution derived from the model closely matches the numerical simulations.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA25030500 and XDA25010300)the CAS Youth Interdisciplinary Team(Grant No.JCTD-2022-05)+2 种基金the Youth Innovation Promotion Association of the Chinese Academy of Sciencesthe National Natural Science Foundation of China(Grant Nos.11873061 and 12073043)the National Key R&D Program of China(Grant Nos.2022YFA1603200 and 2022YFA1603204)。
文摘The velocity interferometer system for any reflector(VISAR) coupled with a streaked optical pyrometer(SOP) system is used as a diagnostic tool in inertial confinement fusion(ICF) experiments involving equations of state and shock timing.To validate the process of adiabatically compressing the fuel shell through precise tuning of shocks in experimental campaigns for the double-cone ignition(DCI) scheme of ICF, a compact line-imaging VISAR with an SOP system is designed and implemented at the Shenguang-II upgrade laser facility. The temporal and spatial resolutions of the system are better than 30 ps and 7 μm, respectively. An illumination lens is used to adjust the lighting spot size matching with the target size. A polarization beam splitter and λ/4 waveplate are used to increase the transmission efficiency of our system. The VISAR and SOP work at 660 and 450 nm, respectively, to differentiate the signals from the scattered lights of the drive lasers. The VISAR can measure the shock velocity. At the same time, the SOP system can give the shock timing and relative strength. This system has been used in different DCI campaigns, where the generation and propagation processes of multi-shock are carefully diagnosed.
基金supported by the Chinese Academy of Sciences Youth Interdisciplinary Teamthe National Natural Science Foundation of China(Nos.12473099 and 11873061)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Nos.XDA25030500,XDA25030100,XDA25030300,XDA25010100,XDA25010300,and XDA25020101)the National Key R&D Program of China(No.2022YFA1603204)。
文摘Optical diagnostics are essential in monitoring the progression of plasma in high-energy-density physics research.The abrupt transitions in plasma evolution,whether caused by laser irradiation or hydrodynamic instabilities,cannot be accurately distinguished using only two-dimensional[2D]gated detectors or a streak camera individually.In this paper,we introduce a hybrid diagnostic system that combines a streak camera and gated detectors.This innovative approach enables us to measure both the plasma density evolution and 2D morphology simultaneously.These advanced diagnostics have been utilized in recent laboratory astrophysics experiments,effectively capturing the plasma flow density distribution and flow velocity.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA25010100,XDA25010300 and XDA25030100)in part by the National Natural Science Foundation of China(Grants No.11827807)。
文摘In the double-cone ignition scheme of inertial confinement fusion,the head-on collision of two compressed fuel jets from the cone-tips forms an isochoric plasma,which is then heated suddenly by a MeV relativistic electron beam produced by ultra-intense picosecond laser pulses.This fast-heating process was studied experimentally at the ShenguangⅡupgrade laser facility.By observing temporal-resolved X-ray emission and the spatial-resolved X-ray spectrum,the colliding process and heating process are carefully studied.The colliding plasma was imaged to have dimensions of approximately86μm in the implosion direction and approximately 120μm in the heating direction.By comparing the simulated plasma X-ray spectrum with experimental data,the electron temperature of the heated plasma was found to rapidly increase to 600±50 eV,almost doubling the temperature achieved before the heating laser incidence.
基金supported by the Natural Science Foundation of Zhejiang Province(LD21E030001)National Natural Science Foundation of China(51873188).
文摘Spinal cord injury(SCI)is an overwhelming and incurable disabling event accompanied by complicated inflammation-related pathological processes,such as excessive reactive oxygen species(ROS)produced by the infiltrated inflammatory immune cells and released to the extracellular microenvironment,leading to the widespread apoptosis of the neuron cells,glial and oligodendroctyes.In this study,a thioketal-containing and ROS-scavenging hydrogel was prepared for encapsulation of the bone marrow derived mesenchymal stem cells(BMSCs),which promoted the neurogenesis and axon regeneration by scavenging the overproduced ROS and re-building a regenerative microenvironment.The hydrogel could effectively encapsulate BMSCs,and played a remarkable neuroprotective role in vivo by reducing the production of endogenous ROS,attenuating ROS-mediated oxidative damage and downregulating the inflammatory cytokines such as interleukin-1 beta(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-alpha(TNF-α),resulting in a reduced cell apoptosis in the spinal cord tissue.The BMSCs-encapsulated ROS-scavenging hydrogel also reduced the scar formation,and improved the neurogenesis of the spinal cord tissue,and thus distinctly enhanced the motor functional recovery of SCI rats.Our work provides a combinational strategy against ROS-mediated oxidative stress,with potential applications not only in SCI,but also in other central nervous system diseases with similar pathological conditions.
