Acrylamide(AA)is a typical by-product of the Maillard reaction in food processing.AA can destroy the antioxidant balance,induce neurotoxicity,and affect the occurrence and development of neurodegenerative diseases.Dis...Acrylamide(AA)is a typical by-product of the Maillard reaction in food processing.AA can destroy the antioxidant balance,induce neurotoxicity,and affect the occurrence and development of neurodegenerative diseases.Disturbances in the gut microbiota can lead to neurological diseases.Flavonoids have multiple biological activities,such as antioxidant,anti-inflammatory,and regulation of intestinal flora structure,and have a certain intervention effect on the neurotoxicity of AA.the gut microbiota has a variety of mechanisms affecting brain homeostasis and neurodevelopment,and regulating the gut microbiota can effectively improve the severity of neurodegenerative diseases.this article calls for attention to the role of flavonoids in the AA-mediated neurogenic disease prevention and control pathway and proposes a positive effect between plantbased diet and brain health.展开更多
基金sponsored by the National Natural Science Foundation of China(32072333)the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(2020QNRC001)+1 种基金the Key Lishui Natural Science Foundation(2023zdyf23)the Key Ningbo Natural Science Foundation(2022J073).
文摘Acrylamide(AA)is a typical by-product of the Maillard reaction in food processing.AA can destroy the antioxidant balance,induce neurotoxicity,and affect the occurrence and development of neurodegenerative diseases.Disturbances in the gut microbiota can lead to neurological diseases.Flavonoids have multiple biological activities,such as antioxidant,anti-inflammatory,and regulation of intestinal flora structure,and have a certain intervention effect on the neurotoxicity of AA.the gut microbiota has a variety of mechanisms affecting brain homeostasis and neurodevelopment,and regulating the gut microbiota can effectively improve the severity of neurodegenerative diseases.this article calls for attention to the role of flavonoids in the AA-mediated neurogenic disease prevention and control pathway and proposes a positive effect between plantbased diet and brain health.
