The oxidation characteristics of sulfite and thiosulfate were examined by using thermodynamic calculations and simulated desulfurization solution experiments to investigate their difference.Subsequently,a new multista...The oxidation characteristics of sulfite and thiosulfate were examined by using thermodynamic calculations and simulated desulfurization solution experiments to investigate their difference.Subsequently,a new multistage oxidation method using oxygen−ammonium persulfate was presented and applied to the oxidation of a real desulfurization solution.The results show that the concentrations of thiosulfate and sulfite in the real desulfurization solution decrease from 48.76 and 61.76 g/L to 2.24 and 0.02 g/L,respectively,and the ammonium sulfate products obtained are white with uniform particles.In addition,compared with ammonium persulfate alone,the multistage oxidation method can reduce the ammonium persulfate addition by 37.56%and treatment cost by 28.13%.展开更多
The Yanchang Formation Chang 7 oil-bearing layer of the Ordos Basin is important in China for producing shale oil.The present-day in situ stress state is of practical implications for the exploration and development o...The Yanchang Formation Chang 7 oil-bearing layer of the Ordos Basin is important in China for producing shale oil.The present-day in situ stress state is of practical implications for the exploration and development of shale oil;however,few studies are focused on stress distributions within the Chang 7 reservoir.In this study,the present-day in situ stress distribution within the Chang 7 reservoir was predicted using the combined spring model based on well logs and measured stress data.The results indicate that stress magnitudes increase with burial depth within the Chang 7 reservoir.Overall,the horizontal maximum principal stress(SHmax),horizontal minimum principal stress(Shmin) and vertical stress(Sv) follow the relationship of Sv≥SHmax>Shmin,indicating a dominant normal faulting stress regime within the Chang 7 reservoir of Ordos Basin.Laterally,high stress values are mainly distributed in the northwestern parts of the studied region,while low stress values are found in the southeastern parts.Factors influencing stress distributions are also analyzed.Stress magnitudes within the Chang 7 reservoir show a positive linear relationship with burial depth.A larger value of Young's modulus results in higher stress magnitudes,and the differential horizontal stress becomes higher when the rock Young's modulus grows larger.展开更多
We described a serious of zinc complexes that exhibit characteristic fluorescence responses toward pyrophosphate （PPi） and adenosine triphosphate （ATP） in aqueous media. These novel probes exploited tetraphenyleth...We described a serious of zinc complexes that exhibit characteristic fluorescence responses toward pyrophosphate （PPi） and adenosine triphosphate （ATP） in aqueous media. These novel probes exploited tetraphenylethene （TPE） as fluorophore and macrocycle-polyamine （including 1,4,7,10-tetraazacyclo- dodecane and 1,4,7-triazacyclononane） Zn（ll） complexes as binding group. These ＂OFF-ON＂ type probes exhibited promising selectivity and sensitivity to PPi and ATP via a restriction ofintramolecular rotation （RIR） mechanism. The detection limit for PPi was found within nmol/L range.展开更多
Chromatin remodeling and transcriptional reprogramming play critical roles during mammalian meiotic prophase I;however,the precise mechanisms regulating these processes remain poorly understood.Our previous work demon...Chromatin remodeling and transcriptional reprogramming play critical roles during mammalian meiotic prophase I;however,the precise mechanisms regulating these processes remain poorly understood.Our previous work demonstrated that deletion of heat shock factor 5(HSF5),a member of the heat shock factor family,induces meiotic arrest and male infertility.However,the molecular pathways through which HSF5 governs meiotic progression have not yet been fully elucidated.In this study,a comprehensive multi-omics approach was applied to investigate the role of HSF5 in modulating chromatin dynamics and transcriptional reprogramming during pachynema progression.Analysis of ATAC-seq and single-cell RNA sequencing data revealed significant alterations in chromatin accessibility and disruption of the transcriptional regulatory network(TRN)in Hsf5−/−spermatocytes.Additionally,HSF5 deficiency resulted in defective XY body formation and altered histone modifications.Notably,Hsf5−/−spermatocytes also exhibited abnormal spermatoproteasome activity specifically on sex chromosomes,with evidence indicating that HSF5 may form a complex with USP7 in vivo to suppress H2AK119ub on meiotic sex chromosomes.These findings provide new insights into the complex,multifunctional role of HSF5 in regulating key meiotic events and advancing our understanding of its function during pachynema progression.展开更多
基金financial support of the Yunnan Major Scientific and Technological Project,China(No.202302AG050008)Yunnan Fundamental Research Project,China(No.202101BE070001-023)“Yunnan Revitalization Talents Support Plan”High-End Foreign Talents Program,China。
文摘The oxidation characteristics of sulfite and thiosulfate were examined by using thermodynamic calculations and simulated desulfurization solution experiments to investigate their difference.Subsequently,a new multistage oxidation method using oxygen−ammonium persulfate was presented and applied to the oxidation of a real desulfurization solution.The results show that the concentrations of thiosulfate and sulfite in the real desulfurization solution decrease from 48.76 and 61.76 g/L to 2.24 and 0.02 g/L,respectively,and the ammonium sulfate products obtained are white with uniform particles.In addition,compared with ammonium persulfate alone,the multistage oxidation method can reduce the ammonium persulfate addition by 37.56%and treatment cost by 28.13%.
基金financial supports are from the National Natural Science Foundation of China (41702130 and 41971335)China Postdoctoral Science Foundation (2017T100419 and 2019M660269)Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)。
文摘The Yanchang Formation Chang 7 oil-bearing layer of the Ordos Basin is important in China for producing shale oil.The present-day in situ stress state is of practical implications for the exploration and development of shale oil;however,few studies are focused on stress distributions within the Chang 7 reservoir.In this study,the present-day in situ stress distribution within the Chang 7 reservoir was predicted using the combined spring model based on well logs and measured stress data.The results indicate that stress magnitudes increase with burial depth within the Chang 7 reservoir.Overall,the horizontal maximum principal stress(SHmax),horizontal minimum principal stress(Shmin) and vertical stress(Sv) follow the relationship of Sv≥SHmax>Shmin,indicating a dominant normal faulting stress regime within the Chang 7 reservoir of Ordos Basin.Laterally,high stress values are mainly distributed in the northwestern parts of the studied region,while low stress values are found in the southeastern parts.Factors influencing stress distributions are also analyzed.Stress magnitudes within the Chang 7 reservoir show a positive linear relationship with burial depth.A larger value of Young's modulus results in higher stress magnitudes,and the differential horizontal stress becomes higher when the rock Young's modulus grows larger.
基金financially supported by the National Program on Key Basic Research Project of China (973 Program, Nos. 2012CB720603, 2013CB328900)the National Science Foundation of China (Nos. 21232005, 21321061, J1310008and J1103315)the Specialized Research Fund for the Doctoral Program of Higher Education in China (No. 20120181130006)
文摘We described a serious of zinc complexes that exhibit characteristic fluorescence responses toward pyrophosphate （PPi） and adenosine triphosphate （ATP） in aqueous media. These novel probes exploited tetraphenylethene （TPE） as fluorophore and macrocycle-polyamine （including 1,4,7,10-tetraazacyclo- dodecane and 1,4,7-triazacyclononane） Zn（ll） complexes as binding group. These ＂OFF-ON＂ type probes exhibited promising selectivity and sensitivity to PPi and ATP via a restriction ofintramolecular rotation （RIR） mechanism. The detection limit for PPi was found within nmol/L range.
基金supported by the National Natural Science Foundation of China(U24A20657,82371613 to F.S.82301798)+2 种基金Key Research and Development Program of Zhejiang Province(2023C03035 to F.S.)China Post-doctoral Science Foundation(2022M722767)Fellowship of China National Postdoctoral Program for Innovative Talents(BX20230314)。
文摘Chromatin remodeling and transcriptional reprogramming play critical roles during mammalian meiotic prophase I;however,the precise mechanisms regulating these processes remain poorly understood.Our previous work demonstrated that deletion of heat shock factor 5(HSF5),a member of the heat shock factor family,induces meiotic arrest and male infertility.However,the molecular pathways through which HSF5 governs meiotic progression have not yet been fully elucidated.In this study,a comprehensive multi-omics approach was applied to investigate the role of HSF5 in modulating chromatin dynamics and transcriptional reprogramming during pachynema progression.Analysis of ATAC-seq and single-cell RNA sequencing data revealed significant alterations in chromatin accessibility and disruption of the transcriptional regulatory network(TRN)in Hsf5−/−spermatocytes.Additionally,HSF5 deficiency resulted in defective XY body formation and altered histone modifications.Notably,Hsf5−/−spermatocytes also exhibited abnormal spermatoproteasome activity specifically on sex chromosomes,with evidence indicating that HSF5 may form a complex with USP7 in vivo to suppress H2AK119ub on meiotic sex chromosomes.These findings provide new insights into the complex,multifunctional role of HSF5 in regulating key meiotic events and advancing our understanding of its function during pachynema progression.
