In recent years,the research on superconductivity in one-dimensional(1D)materials has been attracting increasing attention due to its potential applications in low-dimensional nanodevices.However,the critical temperat...In recent years,the research on superconductivity in one-dimensional(1D)materials has been attracting increasing attention due to its potential applications in low-dimensional nanodevices.However,the critical temperature(T_(c))of 1D superconductors is low.In this work,we theoretically investigate the possible high T_(c) superconductivity of(5,5)carbon nanotube(CNT).The pristine(5,5)CNT is a Dirac semimetal and can be modulated into a semiconductor by full hydrogenation.Interestingly,by further hole doping,it can be regulated into a metallic state with the sp3-hybridized𝜎electrons metalized,and a giant Kohn anomaly appears in the optical phonons.The two factors together enhance the electron–phonon coupling,and lead to high-T_(c) superconductivity.When the hole doping concentration of hydrogenated-(5,5)CNT is 2.5 hole/cell,the calculated T_(c) is 82.3 K,exceeding the boiling point of liquid nitrogen.Therefore,the predicted hole-doped hydrogenated-(5,5)CNT provides a new platform for 1D high-T_(c) superconductivity and may have potential applications in 1D nanodevices.展开更多
Emission characteristics of biogenic volatile organic compounds(BVOCs)from dominant tree species in the subtropical pristine forests of China are extremely limited.Here we conducted in situ field measurements of BVOCs...Emission characteristics of biogenic volatile organic compounds(BVOCs)from dominant tree species in the subtropical pristine forests of China are extremely limited.Here we conducted in situ field measurements of BVOCs emissions from representative mature evergreen trees by using dynamic branch enclosures at four altitude gradients(600-1690ma.s.l.)in the Nanling Mountains of southern China.Composition characteristics as well as seasonal and altitudinal variations were analyzed.Standardized emission rates and canopyscale emission factors were then calculated.Results showed that BVOCs emission intensities in the wet season were generally higher than those in the dry season.Monoterpenes were the dominant BVOCs emitted from most broad-leaved trees,accounting for over 70%of the total.Schima superba,Yushania basihirsuta and Altingia chinensis had relatively high emission intensities and secondary pollutant formation potentials.The localized emission factors of isoprene were comparable to the defaults in the Model of Emissions of Gases and Aerosols fromNature(MEGAN),while emission factors of monoterpenes and sesquiterpenes were 2 to 58 times of those in the model.Our results can be used to update the current BVOCs emission inventory in MEGAN,thereby reducing the uncertainties of BVOCs emission estimations in forested regions of southern China.展开更多
Background Caffeic acid(CA)and its derivative,chlorogenic acid(CGA),have shown promise in preventing and alleviating fatty liver disease.CA,compared to CGA,has much lower production costs and higher bioavailability,ma...Background Caffeic acid(CA)and its derivative,chlorogenic acid(CGA),have shown promise in preventing and alleviating fatty liver disease.CA,compared to CGA,has much lower production costs and higher bioavailability,making it a potentially superior feed additive.However,the efficacy,mechanistic differences,and comparative impacts of CA and CGA on fatty liver disease in laying hens remain unclear.This study aimed to evaluate and compare the effects of CA and CGA on production performance,egg quality,and fatty liver disease in laying hens.Results A total of 1,44061-week-old Hyline Brown laying hens were randomly divided into 8 groups and fed diets supplemented with basal diet,25,50,100 and 200 mg/kg of CA,and 100,200 and 400 mg/kg of CGA(CON,CA25,CA50,CA100,CA200,CGA100,CGA200 and CGA400,respectively)for 12 weeks.Both CA and CGA improved production performance and egg quality,while reducing markers of hepatic damage and lipid accumulation.CA and CGA significantly decreased TG,TC,and LDL-C levels and increased T-SOD activity.Transcriptomic and proteomic analyses revealed that CA and CGA reduced hepatic lipid accumulation through downregulation of lipid biosynthesis-related genes(ACLY,ACACA,FASN,and SCD1)and enhanced lipid transport and oxidation genes(FABPs,CD36,CPT1A,ACOX1,and SCP2).Of note,low-dose CA25 exhibited equivalent efficacy to the higher dose CGA100 group in alleviating fatty liver conditions.Mechanistically,CA and CGA alleviated lipid accumulation via activation of the ADPN-AMPK-PPARαsignaling pathway.Conclusions This study demonstrates that dietary CA and CGA effectively improve laying performance,egg quality,and hepatic lipid metabolism in laying hens,with CA potentially being more economical and efficient.Transcriptomic and proteomic evidence highlight shared mechanisms between CA25 and CGA100.These findings provide a foundation for CA and CGA as therapeutic agents for fatty liver disease and related metabolic diseases in hens,and also offer insights into the targeted modification of CGA(including the isomer of CGA)into CA,thereby providing novel strategies for the efficient utilization of CGA.Highlights(1)Dietary CA and CGA improve fatty liver,laying performance and egg quality.(2)Lower dose of CA25 achieves the equivalent improvement as CGA100 or CGA200.(3)CA and CGA mediate the ADPN-AMPK-PPARαpathway to alleviate fatty liver.展开更多
Titanium(Ti)and its alloys are frequently utilized as critical components in a variety of engineering ap-plications because of their high specific strength and excellent corrosion resistance.Compared to conven-tional ...Titanium(Ti)and its alloys are frequently utilized as critical components in a variety of engineering ap-plications because of their high specific strength and excellent corrosion resistance.Compared to conven-tional surface strengthening technologies,laser shock peening(LSP)has increasingly attracted attention from researchers and industries,since it significantly improves the surface strength,biocompatibility,fa-tigue resistance,and anti-corrosion ability of Ti and its alloys.Despite numerous studies that have been carried out to elucidate the effects of LSP on microstructural evolution and mechanical properties of Ti and its alloys in recent years,a comprehensive review of recent advancements in the field of Ti and its alloys subjected to LSP is still lacking.In this review,the standard LSP and the novel process designs of LSP assisted by thermal,cryogenic,electropulsing and magnetic fields are discussed and compared.Microstructural evolution,with focuses on the dislocation dynamics,deformation twinning,grain refine-ment and surface amorphization,during LSP processing of Ti alloys is reviewed.Furthermore,the en-hanced engineering performance of the L SP-processed(L SPed)Ti alloys,including surface hardness,wear resistance,fatigue life and corrosion resistance are summarized.Finally,this review concludes by present-ing an overview of the current challenges encountered in this field and offering insights into anticipated future trends.展开更多
With the increasing severity of arsenic(As)pollution,quantifying the environmental behavior of pollutant based on numerical model has become an important approach to determine the potential impacts and finalize the pr...With the increasing severity of arsenic(As)pollution,quantifying the environmental behavior of pollutant based on numerical model has become an important approach to determine the potential impacts and finalize the precise control strategies.Taking the industrialintensive Jinsha River Basin as typical area,a two-dimensional hydrodynamic water quality model coupled with Soil andWater Assessment Tool(SWAT)model was developed to accurately simulate the watershed-scale distribution and transport of As in the terrestrial and aquatic environment at high spatial and temporal resolution.The effects of hydro-climate change,hydropower station construction and non-point source emissions on Aswere quantified based on the coupled model.The result indicated that higher As concentration areas mainly centralized in urban districts and concentration slowly decreased from upstream to downstream.Due to the enhanced rainfall,the As concentration was significantly higher during the rainy season than the dry season.Hydro-climate change and the construction of hydropower station not only affected the dissolved As concentration,but also affected the adsorption and desorption of As in sediment.Furthermore,As concentration increased with the input of non-point source pollution,with the maximum increase about 30%,resulting that non-point sources contributed important pollutant impacts to waterways.The coupled model used in pollutant behavior analysis is generalwith high potential application to predict and mitigate water pollution.展开更多
Objective Acupuncture therapies are known for their effectiveness in treating a variety of gastric diseases,although the mechanisms underlying these effects are not fully understood.This study tested the effectiveness...Objective Acupuncture therapies are known for their effectiveness in treating a variety of gastric diseases,although the mechanisms underlying these effects are not fully understood.This study tested the effectiveness of electroacupuncture(EA)at acupoints Zhongwan(RN12)and Weishu(BL21)for managing gastric motility disorder(GMD)and investigated the underlying mechanisms involved.Methods A GMD model was used to evaluate the impact of EA on various aspects of gastric function including the amplitude of gastric motility,electrogastrogram,food intake,and the rate of gastric emptying.Immunofluorescence techniques were used to explore the activation of spinal neurons by EA,specifically examining the presence of cholera toxin B subunit(CTB)-positive neurons and fibers emanating from acupoints RN12 and BL21.The stimulation ofγ-aminobutyric acid(GABA)-ergic neurons in the spinal dorsal horn,the inhibition of sympathetic preganglionic neurons in the spinal lateral horn,and their collective effects on the activity of sympathetic nerves were examined.Results EA at RN12 and BL21 significantly improved gastric motility compromised by GMD.Notably,EA activated spinal neurons,with CTB-positive neurons and fibers from RN12 and BL21 being detectable in both the dorsal root ganglia and the spinal dorsal horn.Further analysis revealed that EA at these acupoints not only stimulated GABAergic neurons in the spinal dorsal horn but also suppressed sympathetic preganglionic neurons in the spinal lateral horn,effectively reducing excessive activity of sympathetic nerves triggered by GMD.Conclusion EA treatment at RN12 and BL21 effectively enhances gastric motility in a GMD model.The therapeutic efficacy of this approach is attributed to the activation of spinal neurons and the modulation of the spinal GABAergic-sympathetic pathway,providing a neurobiological foundation for the role of acupuncture in treating gastric disorders.展开更多
Aiming at reducing the dust pollution during the tunneling process and improving the application efficiency of air curtain dust prevention technology,according to the changes of radial jet velocity(v_(r)),axial extrac...Aiming at reducing the dust pollution during the tunneling process and improving the application efficiency of air curtain dust prevention technology,according to the changes of radial jet velocity(v_(r)),axial extraction velocity(v_(e))and extraction distance(L)in the formation process of air curtain,the numerical simulation method was used to analyze the rules of airflow structure evolution and the diffusion characteristics of dust particles in fully mechanized excavation tunnel.The results indicate that as v_(r) and v_(e) increase,the migration path of the wall jet of the air curtain changes into an axial direction;as L decreases,the migration distance increases accordingly.These phenomena make the airflow distribution in the working face tends to be uniform.The dust diffusion distance reduces as well,wherein,the range of the discrete area of dust particles decreases sharply,until all dust particles are concentrated in the accumulation area.On this basis,the v_(r),v_(e) and L were optimized and applied in the 63_(up) 08 fully mechanized working face.By the application of the optimal parameters,the average dust removal efficiency at the driver’s position increased by 71%.The dust concentration was reduced and the working environment had been improved effectively.展开更多
This paper aims to numerically explore the characteristics of unsteady cavitating flow around a NACA0015 hydrofoil,with a focus on vorticity attributes.The simulation utilizes a homogeneous mixture model coupled with ...This paper aims to numerically explore the characteristics of unsteady cavitating flow around a NACA0015 hydrofoil,with a focus on vorticity attributes.The simulation utilizes a homogeneous mixture model coupled with a filter-based density correction turbulence model and a modified Zwart cavitation model.The study investigates the dynamic cavitation features of the thermal fluid around the hydrofoil at various incoming flow velocities.It systematically elucidates the evolution of cavitation and vortex dynamics corresponding to each velocity condition.The results indicate that with increasing incoming flow velocity,distinct cavitation processes take place in the flow field.展开更多
The hot deformation behavior of the premium GH4738 alloy was investigated in the temperature range of 1313 to 1353 K at strain rates of 0.01 to 1 s^(−1)using the hot compression test.To accurately predict flow stress,...The hot deformation behavior of the premium GH4738 alloy was investigated in the temperature range of 1313 to 1353 K at strain rates of 0.01 to 1 s^(−1)using the hot compression test.To accurately predict flow stress,three novel strain compensation constitutive equations were developed and rigorously assessed.The results indicate that the power function model(correlation coefficients r=0.98544)demonstrates greater prediction accuracy compared to other functions,with a calculated average activation energy of 507.968 kJ mol−1.Additionally,electron backscattered diffraction technology and transmission electron microscopy were used to analyze the evolution of the alloy microstructure during dynamic recrystallization under different deformation conditions.The results show that under high-temperature and large deformation conditions,the dislocation density and the degree of grain rotation increase,which promotes the formation and growth of new recrystallized grains,so that recrystallization is completed when the deformation amount reaches 30%.Besides,the increase in the temperature not only enhances the thermal activation mechanism,but also improves the grain size uniformity and texture consistency.Meanwhile,the carbide inhibits grain overgrowth by pinning grain boundaries,maintaining a fine and uniform grain structure of the alloy,and thereby improving the plasticity of the material.展开更多
Drug overdose is a common reason for emergency department admissions.Although pharmacobezoars due to drug overdose are rare,they can increase the length of hospital stay and risk of mortality.^([1]) Currently,no clear...Drug overdose is a common reason for emergency department admissions.Although pharmacobezoars due to drug overdose are rare,they can increase the length of hospital stay and risk of mortality.^([1]) Currently,no clear procedure for the management of gastric pharmacobezoars exists.We report a case of a patient with pharmacobezoars caused by high-dose oral drug poisoning.The patient recovered completely after gastroscopy,gastric lavage,and symptomatic treatments.展开更多
Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and al...Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.展开更多
In pursuit of more efficient and stable electrochemical energy storage materials,composite materials consisting of metal oxides and graphene oxide have garnered significant attention due to their unique structures and...In pursuit of more efficient and stable electrochemical energy storage materials,composite materials consisting of metal oxides and graphene oxide have garnered significant attention due to their unique structures and exceptional properties.Graphene oxide(GO),a two-dimensional material with an extremely high specific surface area and excellent conductivity,offers new possibilities for enhancing the electrochemical performance of metal oxides.In this work,we synthesized met-al-organic framework(MOF)and GO composites by regulating the amount of GO,and successfully prepared composites of metal oxides supported by nitrogen-doped carbon frameworks and GO through a simple one-step calcination process.Based on the electrochemical tests,the optimal amount of GO was determined.This research will provide new insights into and directions for designing and synthesizing metal oxide and graphene oxide composite materials with an ideal electro-chemical performance.展开更多
Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modi...Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd（III） ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd（III） ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd（III） ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity （rl） of the hybrid nano-suitcases is reported as 44.4 L/（mmol-s）, which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos.12074213 and 11574108)the Major Basic Program of Natural Science Foundation of Shandong Province (Grant No.ZR2021ZD01)the Natural Science Foundation of Shandong Province (Grant No.ZR2023MA082)。
文摘In recent years,the research on superconductivity in one-dimensional(1D)materials has been attracting increasing attention due to its potential applications in low-dimensional nanodevices.However,the critical temperature(T_(c))of 1D superconductors is low.In this work,we theoretically investigate the possible high T_(c) superconductivity of(5,5)carbon nanotube(CNT).The pristine(5,5)CNT is a Dirac semimetal and can be modulated into a semiconductor by full hydrogenation.Interestingly,by further hole doping,it can be regulated into a metallic state with the sp3-hybridized𝜎electrons metalized,and a giant Kohn anomaly appears in the optical phonons.The two factors together enhance the electron–phonon coupling,and lead to high-T_(c) superconductivity.When the hole doping concentration of hydrogenated-(5,5)CNT is 2.5 hole/cell,the calculated T_(c) is 82.3 K,exceeding the boiling point of liquid nitrogen.Therefore,the predicted hole-doped hydrogenated-(5,5)CNT provides a new platform for 1D high-T_(c) superconductivity and may have potential applications in 1D nanodevices.
基金supported by the National Natural Science Foundation of China (NSFC)Projects (Nos.42205105,42121004,and 42077190)the Science and Technology Project of Shaoguan (No.210811164532141)+3 种基金the National Key R&D Program of China (2022YFC3700604)the Science and Technology Program of Guangzhou City (No.202201010400)the Fundamental Research Funds for the Central Universities (No.21622319)the Research Center of Low Carbon Economy for Guangzhou Region (No.22JNZS50).
文摘Emission characteristics of biogenic volatile organic compounds(BVOCs)from dominant tree species in the subtropical pristine forests of China are extremely limited.Here we conducted in situ field measurements of BVOCs emissions from representative mature evergreen trees by using dynamic branch enclosures at four altitude gradients(600-1690ma.s.l.)in the Nanling Mountains of southern China.Composition characteristics as well as seasonal and altitudinal variations were analyzed.Standardized emission rates and canopyscale emission factors were then calculated.Results showed that BVOCs emission intensities in the wet season were generally higher than those in the dry season.Monoterpenes were the dominant BVOCs emitted from most broad-leaved trees,accounting for over 70%of the total.Schima superba,Yushania basihirsuta and Altingia chinensis had relatively high emission intensities and secondary pollutant formation potentials.The localized emission factors of isoprene were comparable to the defaults in the Model of Emissions of Gases and Aerosols fromNature(MEGAN),while emission factors of monoterpenes and sesquiterpenes were 2 to 58 times of those in the model.Our results can be used to update the current BVOCs emission inventory in MEGAN,thereby reducing the uncertainties of BVOCs emission estimations in forested regions of southern China.
基金supported by National Key R&D Program of China(2023YFD1301200)China Agriculture Research Systems(CARS-40-K11)+2 种基金Beijing Agriculture Innovation Consortium(BAIC06-2024-G05)Strategic Priority Research Program of the National Center of Technology Innovation for Pigs(NCTIP-XD/C08)The Chinese Academy of Agricultural Science and Technology Innovation Project(ASTIP-IAS-12)。
文摘Background Caffeic acid(CA)and its derivative,chlorogenic acid(CGA),have shown promise in preventing and alleviating fatty liver disease.CA,compared to CGA,has much lower production costs and higher bioavailability,making it a potentially superior feed additive.However,the efficacy,mechanistic differences,and comparative impacts of CA and CGA on fatty liver disease in laying hens remain unclear.This study aimed to evaluate and compare the effects of CA and CGA on production performance,egg quality,and fatty liver disease in laying hens.Results A total of 1,44061-week-old Hyline Brown laying hens were randomly divided into 8 groups and fed diets supplemented with basal diet,25,50,100 and 200 mg/kg of CA,and 100,200 and 400 mg/kg of CGA(CON,CA25,CA50,CA100,CA200,CGA100,CGA200 and CGA400,respectively)for 12 weeks.Both CA and CGA improved production performance and egg quality,while reducing markers of hepatic damage and lipid accumulation.CA and CGA significantly decreased TG,TC,and LDL-C levels and increased T-SOD activity.Transcriptomic and proteomic analyses revealed that CA and CGA reduced hepatic lipid accumulation through downregulation of lipid biosynthesis-related genes(ACLY,ACACA,FASN,and SCD1)and enhanced lipid transport and oxidation genes(FABPs,CD36,CPT1A,ACOX1,and SCP2).Of note,low-dose CA25 exhibited equivalent efficacy to the higher dose CGA100 group in alleviating fatty liver conditions.Mechanistically,CA and CGA alleviated lipid accumulation via activation of the ADPN-AMPK-PPARαsignaling pathway.Conclusions This study demonstrates that dietary CA and CGA effectively improve laying performance,egg quality,and hepatic lipid metabolism in laying hens,with CA potentially being more economical and efficient.Transcriptomic and proteomic evidence highlight shared mechanisms between CA25 and CGA100.These findings provide a foundation for CA and CGA as therapeutic agents for fatty liver disease and related metabolic diseases in hens,and also offer insights into the targeted modification of CGA(including the isomer of CGA)into CA,thereby providing novel strategies for the efficient utilization of CGA.Highlights(1)Dietary CA and CGA improve fatty liver,laying performance and egg quality.(2)Lower dose of CA25 achieves the equivalent improvement as CGA100 or CGA200.(3)CA and CGA mediate the ADPN-AMPK-PPARαpathway to alleviate fatty liver.
基金supported by the National Key R&D Plan of China(No.2022YFB3705603)the National Natural Science Foundation of China(No.52101046)+1 种基金the Excellent Youth Overseas Project of National Science and Natural Foundation of China,the Baowu Special Metallurgy Cooperation Limited(No.22H010101336)the Medicine-Engineering Interdisciplinary Project of Shanghai Jiao Tong University(No.YG2022QN076).
文摘Titanium(Ti)and its alloys are frequently utilized as critical components in a variety of engineering ap-plications because of their high specific strength and excellent corrosion resistance.Compared to conven-tional surface strengthening technologies,laser shock peening(LSP)has increasingly attracted attention from researchers and industries,since it significantly improves the surface strength,biocompatibility,fa-tigue resistance,and anti-corrosion ability of Ti and its alloys.Despite numerous studies that have been carried out to elucidate the effects of LSP on microstructural evolution and mechanical properties of Ti and its alloys in recent years,a comprehensive review of recent advancements in the field of Ti and its alloys subjected to LSP is still lacking.In this review,the standard LSP and the novel process designs of LSP assisted by thermal,cryogenic,electropulsing and magnetic fields are discussed and compared.Microstructural evolution,with focuses on the dislocation dynamics,deformation twinning,grain refine-ment and surface amorphization,during LSP processing of Ti alloys is reviewed.Furthermore,the en-hanced engineering performance of the L SP-processed(L SPed)Ti alloys,including surface hardness,wear resistance,fatigue life and corrosion resistance are summarized.Finally,this review concludes by present-ing an overview of the current challenges encountered in this field and offering insights into anticipated future trends.
基金supported by the National Key Research and Development Program of China(No.2017YFC1502504)the National Natural Science Foundation of China(No.41877531).
文摘With the increasing severity of arsenic(As)pollution,quantifying the environmental behavior of pollutant based on numerical model has become an important approach to determine the potential impacts and finalize the precise control strategies.Taking the industrialintensive Jinsha River Basin as typical area,a two-dimensional hydrodynamic water quality model coupled with Soil andWater Assessment Tool(SWAT)model was developed to accurately simulate the watershed-scale distribution and transport of As in the terrestrial and aquatic environment at high spatial and temporal resolution.The effects of hydro-climate change,hydropower station construction and non-point source emissions on Aswere quantified based on the coupled model.The result indicated that higher As concentration areas mainly centralized in urban districts and concentration slowly decreased from upstream to downstream.Due to the enhanced rainfall,the As concentration was significantly higher during the rainy season than the dry season.Hydro-climate change and the construction of hydropower station not only affected the dissolved As concentration,but also affected the adsorption and desorption of As in sediment.Furthermore,As concentration increased with the input of non-point source pollution,with the maximum increase about 30%,resulting that non-point sources contributed important pollutant impacts to waterways.The coupled model used in pollutant behavior analysis is generalwith high potential application to predict and mitigate water pollution.
基金supported by the Anhui Province Scientific Research Planning Project(No.2023AH050851 and No.2022AH050438)National Natural Science Foundation of China(No.81904095,No.82205274 and No.82101483)+2 种基金Research Project of Xin’an Medical and Chinese Medicine Modernization Research Institute(No.2023CXMMTCM016)Anhui University of Chinese Medicine 2018–2019 High-level Talents Introduction Support Plan(No.2019rcyb002)Excellent Youth Project of Anhui Universities of China(No.2022AH030065).
文摘Objective Acupuncture therapies are known for their effectiveness in treating a variety of gastric diseases,although the mechanisms underlying these effects are not fully understood.This study tested the effectiveness of electroacupuncture(EA)at acupoints Zhongwan(RN12)and Weishu(BL21)for managing gastric motility disorder(GMD)and investigated the underlying mechanisms involved.Methods A GMD model was used to evaluate the impact of EA on various aspects of gastric function including the amplitude of gastric motility,electrogastrogram,food intake,and the rate of gastric emptying.Immunofluorescence techniques were used to explore the activation of spinal neurons by EA,specifically examining the presence of cholera toxin B subunit(CTB)-positive neurons and fibers emanating from acupoints RN12 and BL21.The stimulation ofγ-aminobutyric acid(GABA)-ergic neurons in the spinal dorsal horn,the inhibition of sympathetic preganglionic neurons in the spinal lateral horn,and their collective effects on the activity of sympathetic nerves were examined.Results EA at RN12 and BL21 significantly improved gastric motility compromised by GMD.Notably,EA activated spinal neurons,with CTB-positive neurons and fibers from RN12 and BL21 being detectable in both the dorsal root ganglia and the spinal dorsal horn.Further analysis revealed that EA at these acupoints not only stimulated GABAergic neurons in the spinal dorsal horn but also suppressed sympathetic preganglionic neurons in the spinal lateral horn,effectively reducing excessive activity of sympathetic nerves triggered by GMD.Conclusion EA treatment at RN12 and BL21 effectively enhances gastric motility in a GMD model.The therapeutic efficacy of this approach is attributed to the activation of spinal neurons and the modulation of the spinal GABAergic-sympathetic pathway,providing a neurobiological foundation for the role of acupuncture in treating gastric disorders.
基金financially supported by the Natural Science Foundation of Shandong Province(ZR2020QE124,ZR2023ME031 and ZR2023ME012)Innovation Achievement Cultivation Project of Qingdao University of Technology(CLZ2022-002)National Natural Science Foundation of China(52404222 and 52374209).
文摘Aiming at reducing the dust pollution during the tunneling process and improving the application efficiency of air curtain dust prevention technology,according to the changes of radial jet velocity(v_(r)),axial extraction velocity(v_(e))and extraction distance(L)in the formation process of air curtain,the numerical simulation method was used to analyze the rules of airflow structure evolution and the diffusion characteristics of dust particles in fully mechanized excavation tunnel.The results indicate that as v_(r) and v_(e) increase,the migration path of the wall jet of the air curtain changes into an axial direction;as L decreases,the migration distance increases accordingly.These phenomena make the airflow distribution in the working face tends to be uniform.The dust diffusion distance reduces as well,wherein,the range of the discrete area of dust particles decreases sharply,until all dust particles are concentrated in the accumulation area.On this basis,the v_(r),v_(e) and L were optimized and applied in the 63_(up) 08 fully mechanized working face.By the application of the optimal parameters,the average dust removal efficiency at the driver’s position increased by 71%.The dust concentration was reduced and the working environment had been improved effectively.
文摘This paper aims to numerically explore the characteristics of unsteady cavitating flow around a NACA0015 hydrofoil,with a focus on vorticity attributes.The simulation utilizes a homogeneous mixture model coupled with a filter-based density correction turbulence model and a modified Zwart cavitation model.The study investigates the dynamic cavitation features of the thermal fluid around the hydrofoil at various incoming flow velocities.It systematically elucidates the evolution of cavitation and vortex dynamics corresponding to each velocity condition.The results indicate that with increasing incoming flow velocity,distinct cavitation processes take place in the flow field.
基金supported by the National Key R&D Program of China(No.2021YFB3700403).
文摘The hot deformation behavior of the premium GH4738 alloy was investigated in the temperature range of 1313 to 1353 K at strain rates of 0.01 to 1 s^(−1)using the hot compression test.To accurately predict flow stress,three novel strain compensation constitutive equations were developed and rigorously assessed.The results indicate that the power function model(correlation coefficients r=0.98544)demonstrates greater prediction accuracy compared to other functions,with a calculated average activation energy of 507.968 kJ mol−1.Additionally,electron backscattered diffraction technology and transmission electron microscopy were used to analyze the evolution of the alloy microstructure during dynamic recrystallization under different deformation conditions.The results show that under high-temperature and large deformation conditions,the dislocation density and the degree of grain rotation increase,which promotes the formation and growth of new recrystallized grains,so that recrystallization is completed when the deformation amount reaches 30%.Besides,the increase in the temperature not only enhances the thermal activation mechanism,but also improves the grain size uniformity and texture consistency.Meanwhile,the carbide inhibits grain overgrowth by pinning grain boundaries,maintaining a fine and uniform grain structure of the alloy,and thereby improving the plasticity of the material.
基金supported by the Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-007A)Beijing Union Medical Foundation-Rui E Emergency Medicine Research Funding (PUMF01010010-2024-18)。
文摘Drug overdose is a common reason for emergency department admissions.Although pharmacobezoars due to drug overdose are rare,they can increase the length of hospital stay and risk of mortality.^([1]) Currently,no clear procedure for the management of gastric pharmacobezoars exists.We report a case of a patient with pharmacobezoars caused by high-dose oral drug poisoning.The patient recovered completely after gastroscopy,gastric lavage,and symptomatic treatments.
基金supported by China Postdoctoral Science Foundation(2022M722674)Peixian Science and Technology Plan Project(P202410)Xuzhou Medical Reserve Talents Project(XWRCHT20220009).
文摘Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.
基金supported by the National Natural Science Foundation of China(51971157)Shenzhen Science and Technology Program(JCYJ20210324115412035,JCYJ202103-24123202008,JCYJ20210324122803009 and ZDS-YS20210813095534001)Guangdong Foundation for Basic and Applied Basic Research Program(2021A1515110880).
文摘In pursuit of more efficient and stable electrochemical energy storage materials,composite materials consisting of metal oxides and graphene oxide have garnered significant attention due to their unique structures and exceptional properties.Graphene oxide(GO),a two-dimensional material with an extremely high specific surface area and excellent conductivity,offers new possibilities for enhancing the electrochemical performance of metal oxides.In this work,we synthesized met-al-organic framework(MOF)and GO composites by regulating the amount of GO,and successfully prepared composites of metal oxides supported by nitrogen-doped carbon frameworks and GO through a simple one-step calcination process.Based on the electrochemical tests,the optimal amount of GO was determined.This research will provide new insights into and directions for designing and synthesizing metal oxide and graphene oxide composite materials with an ideal electro-chemical performance.
基金financially supported by the National Natural Science Foundation of China(Nos.21374061,81371703 and 81501571)the Marie Curie International Incoming Fellowship of the EU+2 种基金the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning“Shu Guang”project supported by Shanghai Municipal Education CommissionShanghai Education Development Foundation
文摘Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd（III） ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd（III） ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd（III） ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity （rl） of the hybrid nano-suitcases is reported as 44.4 L/（mmol-s）, which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.
