M50 steel,commonly utilized in aircraft engine bearings,is susceptible to friction-induced failures,particularly in high-temperature service conditions.To address this issue,various strategies have been proposed,with ...M50 steel,commonly utilized in aircraft engine bearings,is susceptible to friction-induced failures,particularly in high-temperature service conditions.To address this issue,various strategies have been proposed,with laser shock peening(LSP)garnering significant attention due to its deeper residual stress penetration and excellent surface integrity,whereas the underlying strengthening mechanisms have not yet been fully elucidated.In this study,we systematically investigate the impact of LSP treatment on the tribological properties of M50 steel at temperatures of 25 and 300℃,alongside elucidating the relevant micro-mechanisms.Microstructural analysis reveals that laser impact strengthening primarily arises from dislocation proliferation,resulting in a surface hardness increase of approximately 14%and the formation of a substantial compressive stress layer reaching a maximum value of about 1200 MPa,with a depth of around 2 mm.Friction test results demonstrate reduced coefficients of friction and wear rates following LSP treatment at both temperatures.Notably,a more pronounced reduction is observed at 300℃,with values decreasing by 41.4%and 55.8%,respectively.The enhanced performance is attributed to the synergistic interplay of compressive residual stresses,work-hardening layers,increased density of dislocations,and substantial microstructure refinement.展开更多
Micro light sources are crucial tools for studying the interactions between light and matter at the micro/nanoscale,encompassing diverse applications across multiple disciplines.Despite numerous studies on reducing th...Micro light sources are crucial tools for studying the interactions between light and matter at the micro/nanoscale,encompassing diverse applications across multiple disciplines.Despite numerous studies on reducing the size of micro light sources and enhancing optical resolution,the efficient and simple fabrication of ultra-high-resolution micro light sources remains challenging due to its reliance on precise micro-nano processing technology and advanced processing equipment.In this study,a simple approach for the efficient fabrication of submicron light sources is proposed,namely shadow-assisted sidewall emission(SASE)technology.The SASE utilizes the widely adopted UV photolithography process,employing metal shadow modulation to precisely control the emission of light from polymer sidewalls,thereby obtaining photoluminescent light sources with submicron line widths.The SASE eliminates the need for complex and cumbersome manufacturing procedures.The effects of process parameters,including exposure dose,development time,and metal film thickness,on the linewidth of sources are investigated on detail.It is successfully demonstrated red,green,and blue submicron light sources.Finally,their potential application in the field of optical anti-counterfeiting is also demonstrated.We believe that the SASE proposed in this work provides a novel approach for the preparation and application of micro light sources.展开更多
Objective:The trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy(HIPEC)with cisplatin for patients with locally advanced gastric cancer(LAGC).Methods:Between March 20...Objective:The trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy(HIPEC)with cisplatin for patients with locally advanced gastric cancer(LAGC).Methods:Between March 2015 and November 2016,a phase Ⅱ clinical trial was performed.Fifty consecutive patients with LAGC were randomly assigned to two groups:the experimental group(radical gastrectomy+HIPEC with cisplatin+adjuvant chemotherapy)and the control group(radical gastrectomy+adjuvant chemotherapy).Survival rates were closely monitored.Results:The 5-year overall survival(OS)rate of all patients was 80.0%.The 5-year OS rate in the experimental group was lower than that in the control group,at 75.8%and 88.2%,respectively,with no statistical significance.In addition,5-year recurrence-free survival(RFS)rates of patients who underwent HIPEC or not were also 75.8%and 88.2%,respectively.In the multivariate analysis,only pT stage[risk ratio(RR)=7.079,P=0.018]was significantly associated with prognosis.The most common recurrence pattern was peritoneal recurrence in both groups.The experimental group had a lower incidence of peritoneal recurrence than the control group with no statistical significance.Conclusions:This trial clearly revealed that prophylactic HIPEC with cisplatin neither decrease the risk of peritoneal recurrence nor improve the prognosis of patients with LAGC.Thus,HIPEC with cisplatin is not recommended as a prophylactic treatment for peritoneal recurrence of LAGC after radical gastrectomy.展开更多
Thermal barrier coating(TBC)is crucial for the performance of turbine blades at high temperatures;however,it degrades the microstructure of single-crystal superalloy(SX),thereby reducing creep life.Despite this,the de...Thermal barrier coating(TBC)is crucial for the performance of turbine blades at high temperatures;however,it degrades the microstructure of single-crystal superalloy(SX),thereby reducing creep life.Despite this,the degradation mechanisms associated with the complex multi-layer damage and inter-layer diffusion behavior for TBC/SX systems have not yet been fully elucidated.In this study,using integrated experimental efforts and multiscale characterization techniques,the creep degradation mechanisms of TBC/SX systems at 900℃/500 MPa,980℃/300 MPa,and 1050℃/160 MPa are systematically investigated.Results demonstrate that the creep degradation from TBC intensifies with increasing temperature(T)and stress(σ)ratio(T/σ),exhibiting significant dependency on these two factors,and primarily reduces lifespan of the steady-state stage,with minimal effects on the accelerating stage.During creep deformation,the cracking behavior caused by thermally grown oxide(TGO)beneath the top coat(TC)layer,voids resulting from internal oxidation and interdiffusion in the bond coat(BC)layer,and the recrystallization growth driven by the sandblasting process in the secondary reaction zone(SRZ)are temperature-sensitive damages.In contrast,the initiation and propagation of cracks associated with the topologically close-packed(TCP)phases in the SRZ exhibit pronounced stress sensitivity.Furthermore,the formation of the substrate diffusion zone(SDZ)and the decomposition ofγ/γ′interfacial dislocation networks driven by the Cr-Ru diffusion,as well as the increased stacking fault energy in theγ′phase due to Co loss,are responsible for the acceleration of steady-state creep rate at 1050℃/160 MPa.This work provides a comprehensive and in-depth understanding of the degradation mechanisms under thermal-mechanical coupling in TBC/SX systems,offering new insights into targeted design optimization for multilayered coatings.展开更多
Since the first laparoscopic radical surgery for early gastric cancer 30 years ago, there has been a gradual shift from“open” to “minimally invasive” surgery for gastric cancer. This transition is due to advanceme...Since the first laparoscopic radical surgery for early gastric cancer 30 years ago, there has been a gradual shift from“open” to “minimally invasive” surgery for gastric cancer. This transition is due to advancements in refined anatomy, enlarged field of view, faster recovery, and comparable oncological outcomes. Several high-quality clinical studies have demonstrated the safety and effectiveness of laparoscopy in the treatment of both early and locally advanced gastric cancer. The role of perioperative chemotherapy in managing locally advanced gastric cancer has been widely recognized, and there have been continuous breakthroughs in the exploration of targeted therapy and immunotherapy for perioperative treatment. Additionally, the application of indocyanine green near-infrared imaging technology, 3D laparoscopic technology, and robotic surgery systems has further improved the accuracy and minimally invasive nature of gastric cancer surgeries. Looking ahead, the field of minimally invasive surgery for gastric cancer is expected to become more standardized, resulting in a significant enhancement in the quality of life for gastric cancer patients.展开更多
A metal-insulator-metal(MIM)-based arc-shaped resonator coupled with a rectangular stub(MARS) structure is proposed. This structure can generate two tunable Fano resonances originating from two different mechanisms. T...A metal-insulator-metal(MIM)-based arc-shaped resonator coupled with a rectangular stub(MARS) structure is proposed. This structure can generate two tunable Fano resonances originating from two different mechanisms. The structure has the advantage of being sensitive to the refractive index, and this feature makes it favorable for application in various microsensors. The relationship between the structural parameters and Fano resonance is researched using the finite element method(FEM) based on the software COMSOL Multiphysics 5.4. The simulation reveals that the sensitivity reaches1900 nm/refractive index unit(RIU), and the figure of merit(FOM) is 23.75.展开更多
Topological materials have aroused great interest in recent years,especially when magnetism is involved.Pressure can effectively tune the topological states and possibly induce superconductivity.Here we report the hig...Topological materials have aroused great interest in recent years,especially when magnetism is involved.Pressure can effectively tune the topological states and possibly induce superconductivity.Here we report the high-pressure study of topological semimetals XCd_(2)Sb_(2)(X=Eu and Yb),which have the same crystal structure.In antiferromagnetic(AFM)Weyl semimetal EuCd_(2)Sb_(2),the Néel temperature(TN)increases from 7.4 K at ambient pressure to 50.9 K at 14.9 GPa.When pressure is above 14.9 GPa,the AFM peak of resistance disappears,indicating a non-magnetic state.In paramagnetic Dirac semimetal candidate YbCd_(2)Sb_(2),pressure-induced superconductivity appears at 1.94 GPa,then Tc reaches to a maximum of 1.67 K at 5.22 GPa and drops to zero at about 30 GPa,displaying a dome-shaped temperature–pressure phase diagram.High-pressure x-ray diffraction measurement demonstrates that a crystalline-to-amorphous phase transition occurs at about 16 GPa in YbCd_(2)Sb_(2),revealing the robustness of pressure-induced superconductivity against structural instability.Similar structural phase transition may also occur in EuCd_(2)Sb_(2),causing the disappearance of magnetism.Our results show that XCd_(2)Sb_(2)(X=Eu and Yb)is a novel platform for exploring the interplay among magnetism,topology,and superconductivity.展开更多
Small molecule peptides and their derivatives are an emerging class of supramolecular hydrogelators that have attracted rapidly growing interest in the fields of drug delivery and regenerative medicine due to their in...Small molecule peptides and their derivatives are an emerging class of supramolecular hydrogelators that have attracted rapidly growing interest in the fields of drug delivery and regenerative medicine due to their inherent biodegradability and biocompatibility, as well as versatility in molecular design and ease of synthesis. Built upon the directional, intermolecular interactions such as hydrogen bonding and π-π stacking, peptide-based molecular units can associate in aqueous solution into filamentous assemblies of various sizes and shapes. Under appropriate conditions, these filamentous assemblies can percolate into a 3D network with materials properties tailorable for specific biomedical applications. In this review, we survey the literature published over the past three years in the development of peptide-based hydrogelators for biomedical applications. We highlight several representative examples and center our discussion on the fundamentals of molecular design, assembly, and gelation conditions.展开更多
Characterization of Fermi surface of the BaSn3 superconductor(Tc~ 4.4K)by de Haas–van Alphen(dHvA)effect measurement reveals its non-trivial topological properties.Analysis of non-zero Berry phase is supported by the...Characterization of Fermi surface of the BaSn3 superconductor(Tc~ 4.4K)by de Haas–van Alphen(dHvA)effect measurement reveals its non-trivial topological properties.Analysis of non-zero Berry phase is supported by the ab initio calculations,which reveals a type-II Dirac point setting and tilting along the high symmetric K–H line of the Brillouin zone,about 0.13 eV above the Fermi level,and other two type-I Dirac points on the high symmetric Г–A direction,but slightly far below the Fermi level.The results demonstrate BaSn3 as an excellent example hosting multiple Dirac fermions and an outstanding platform for studying the interplay between nontrivial topological states and superconductivity.展开更多
Cerasus Campanulata is one of several species belonging to the Prunoideae focke,a subfamily of the flowering plant Rosaceae.We investigated the details of its chloroplast genome which may reveal its genus independent ...Cerasus Campanulata is one of several species belonging to the Prunoideae focke,a subfamily of the flowering plant Rosaceae.We investigated the details of its chloroplast genome which may reveal its genus independent of morphological determination.Here,we determined the complete chloroplast(cp)genome sequence of C.campanulata and performed sequence analysis to reveal the presence of 18 forward repeats,20 palindrome repeats,2 complement repeats,4 reverse repeats and 93 simple sequence repeats(SSRs).We additionally performed a comparative study of C.campanulata and seven other Prunoideae focke species.Then,maximum parsimony(MP)and maximum likelihood(ML)phylogenetic analyses were carried out in the little part of Rosaceae,respectively.The results strongly support a position of C.campanulata as a member of the Cerasus in the Rosaceae family.Moreover,the complete cp genome can be used for plant phylogenetic and evolutionary studies that will provide insight into the degree of gene conservation.展开更多
Wearable sensors are pivotal for point-of-care diagnostics,yet their application in extreme conditions is rarely conducted.In this work,we present a wearable pH sensor using tungsten oxide aerogel(TOA)as the sensing m...Wearable sensors are pivotal for point-of-care diagnostics,yet their application in extreme conditions is rarely conducted.In this work,we present a wearable pH sensor using tungsten oxide aerogel(TOA)as the sensing material.With the advantages of large specific surface area,high porosity and interconnected network structures,TOA not only provides excellent pH sensing performance but also demonstrates remarkable structural and sensing stability.The potentiometric pH sensor exhibits a high sensitivity(−63.70 mV/pH),a low detectable limit(0.05)and a superior stability(maintained over 50,000 s).Integrated with a Bluetooth module,the wearable sensor achieves non-invasive and real-time pH monitoring on the human skin with minimal deviation(1.91%)compared to the commercial pH meter.More importantly,the anti-impact behaviors of the TOA-based sensing materials and chip,along with the pH wearable sensor on a pig exhibit an outstanding shock-resistance ability,with variations no more than 7.17%under an impact of 118.38 kPa.Therefore,this study shows great promise for the aerogel-based personalized health management in the extreme environment.展开更多
By reviewing the development of “three-high” oil and gas well testing technology of Sinopec in recent years, this paper systematically summarizes the application of “three-high” oil and gas well testing technology...By reviewing the development of “three-high” oil and gas well testing technology of Sinopec in recent years, this paper systematically summarizes the application of “three-high” oil and gas well testing technology of Sinopec in engineering optimization design technology, and high temperature and high pressure testing technology, high pressure and high temperature transformation completion integration technology. Major progress has been made in seven aspects: plug removal and re-production technology of production wells in high acid gas fields;wellbore preparation technology of ultra-deep, high-pressure, and high-temperature oil and gas wells;surface metering technology;and supporting tool development technology. This paper comprehensively analyzes the challenges faced by the “three-high” oil and gas well production testing technology in four aspects: downhole tools, production testing technology, safe production testing, and the development of low-cost production test tools. Four development directions are put forward: 1) Improve ultra-deep oil and gas testing technology and strengthen integrated geological engineering research. 2) Deepen oil and gas well integrity evaluation technology to ensure the life cycle of oil and gas wells. 3) Carry out high-end, customized, and intelligent research on oil test tools to promote the low-cost and efficient development of ultra deep reservoirs. 4) Promote the fully automatic control of the surface metering process to realize the safe development of “three-high” reservoirs.展开更多
AIM To introduce an innovative intracorporeal anastomosis technique named overlapped delta-shaped anastomosis(ODA)for colon cancer cases undergoing totally laparoscopic colectomy(TLC)and to assess its feasibility and ...AIM To introduce an innovative intracorporeal anastomosis technique named overlapped delta-shaped anastomosis(ODA)for colon cancer cases undergoing totally laparoscopic colectomy(TLC)and to assess its feasibility and safety. METHODS From January 2016 to March 2017,a total of 20consecutive patients with colon cancer accepted TLC and the ODA technique at our medical center.Patient demographics,operative outcomes,perioperative complications,and pathological results were collected and analyzed. RESULTS We successfully completed TLC and the ODA procedure in all 20 cases,including 6(30%)males and 14(70%)females.In total,11(55%),2(10%),and 7(35%)cases accepted right hemicolectomy,transverse hemicolectomy,and left hemicolectomy,respectively.None of the surgeries were converted to an open operation.Mean operative time was 178.5 min,and mean estimated blood loss was 58.5 m L.Mean time to first flatus was 2.5 d,and mean postoperative hospitalization duration was 6.8 d.No severe complications occurred,such as anastomotic leakage,snastomotic stenosis,anastomotic bleeding,and wound infection,except for one case who suffered from an abdominal infection and another case who suffered from gastric paralysis syndrome.Tumor recurrence was not observed in any patient during the follow-up period. CONCLUSION The ODA technique for colon cancer cases undergoing TLC appears to be safe and feasible,although our current results need to be verified in further studies.展开更多
Objective： This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer.Methods： Patients with clinical...Objective： This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer.Methods： Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen（oxaliplatin 85 mg/m2 and irinotecan 150 mg/m2, combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m2 by 44 h infusion or capecitabine 1 g/m2 or S-1 40–60 mg b.i.d orally d 1–10, repeated at 2-week intervals） for 4 cycles. Complete mesocolic excision was scheduled 2–6 weeks after completion of neoadjuvant treatment and followed by a further 6 cycles of FOLFOXIRI or XELOX. Primary outcome measures of this stage II trial were feasibility, safety, tolerance and efficacy of neoadjuvant treatment.Results： All 23 patients received neoadjuvant chemotherapy and underwent surgery. Twenty-one patients（91.3%） had reductions in tumor volume after neoadjuvant treatment, and 13 patients（56.5%） had grade 3–4toxicity. No patients had severe complications from surgery. Preoperative therapy resulted in significant downstaging of T-stage and N-stage compared with the baseline clinical stage including one pathological complete response.Conclusions： Neoadjuvant triple chemotherapy has high activity and acceptable toxicity and perioperative morbidity, and is feasible, tolerable and effective for locally advanced resectable colon cancer.展开更多
This study aims to explore the effect and mechanism of Jiao-tai-wan （JTW） on systemic and tissue-specific inflammation and insulin resistance in obesity-resistant （OR） rats with chronic partial sleep deprivation ...This study aims to explore the effect and mechanism of Jiao-tai-wan （JTW） on systemic and tissue-specific inflammation and insulin resistance in obesity-resistant （OR） rats with chronic partial sleep deprivation （PSD）. OR rats with PSD were orally given JTW and Estazolam for 4 weeks. The amount of food intake and metabolic parameters such as body weight increase rate, fasting plasma glucose （FPG）, fasting insulin （FINS）, homeostasis model assessment-insulin resistance （HOMA-IR） and plasma inflammatory markers were measured. The expression levels of circadian proteins cryptochrome 1 （Cryl） and cryptochrome 2 （Cry2） in hypothalamus, adipose and liver tissues were also determined. Meanwhile, the mRNA expression of inflammatory markers, activity of nuclear factor kappa B （NF-κB） p65 protein, as well as the expression levels of insulin signaling pathway proteins in hypothalamus, adipose and liver tissues were measured. Additionally, cyclic adenosine 3＇, 5＇-monophosphate （cAMP） and activity of vasodilator-stimulated phosphoprotein （VASP） in hypothalamus tissue were measured. JTW significantly decreased the body weight increase rate and food intake, ameliorated systemic inflammation and insulin resistance. JTW effectively ameliorated inflammation and increased PI3K/AKT signaling activation in hypothalamus, adipose and liver. Interestingly, all these changes were associated with the up-regulation of circadian gene Cryl and Cry2 protein expression. We also found that in hypothalamus tissue of PSD rats, down-regulation of Cryl and Cry2 activated cAMP/PKA signaling and then led to inflammation, while JTW inhibited this signaling. These results suggested that JTW has the beneficial effect on ameliorating inflammation and insulin resistance in partially sleep-deprived rats by up-regulating Cry expression.展开更多
Complete understanding of the evolution behaviors of the microstructures and intermetallic compounds(IMCs)along the interface materials flow path in friction stir welding(FSW)of dissimilar Al to Mg alloys is of great ...Complete understanding of the evolution behaviors of the microstructures and intermetallic compounds(IMCs)along the interface materials flow path in friction stir welding(FSW)of dissimilar Al to Mg alloys is of great significance.In this study,conventional FSW and ultrasonic vibration enhanced FSW(UVeFSW)experiments of Al/Mg alloys were performed,and the instantaneous evolution features of the interface materials around the tool were"frozen"by using the"sudden stop"and simultaneous cooling techniques.The microstructures and IMCs formation at different locations around the exit hole were observed and characterized by scanning electron microscope,energy dispersive spectrometer and transmission elec-tron microscope.It was found that before the materials started to deposit near the back of the tool,“IMC+Mg+IMC+Al”multilayer microstructure and simple IMC layer with(β+γ)sequentially emerged on the Al/Mg interface.With the application of ultrasonic vibration,the multi-layered interface structure only appeared at the middle stage of materials flow around the pin,and ultrasonic vibration just began to play a suppression role on the growth of two sub-layers IMC at a position where the materials deposit.With assistance of ultrasonic vibration in UVeFSW,the tool drove a larger volume of Mg alloy to move toward the retreating side,and the final IMCs thickness was thinner than that in FSW.展开更多
AIM:To investigate the correlation between peri-operative fluid therapy and early-phase recovery after liver transplantation(LT) by retrospectively reviewing 102 consecutive recipients.METHODS:Based on whether or not ...AIM:To investigate the correlation between peri-operative fluid therapy and early-phase recovery after liver transplantation(LT) by retrospectively reviewing 102 consecutive recipients.METHODS:Based on whether or not the patients had pulmonary complications,the patients were categorized into non-pulmonary and pulmonary groups.Twentyeight peri-operative variables were analyzed in both groups to screen for the factors related to the occurrence of early pulmonary complications.RESULTS:The starting hemoglobin(Hb) value,an intra-operative transfusion > 100 mL/kg,and a fluid balance ≤-14 mL/kg on the first day and the second or third day post-operatively were significant factors for early pulmonary complications.The extubation time,time to initial passage of flatus,or intensive care unit length of stay were significantly prolonged in patients who had not received an intra-operative transfusion ≤ 100 mL/kg or a fluid balance ≤-14 mL/kg on the first day and the second or the third day post-operatively.Moreover,these patients had poorer results in arterial blood gas analysis.CONCLUSION:It is important to offer a precise and individualized fluid therapy during the peri-operative period to the patients undergoing LT for cirrhosis-associated hepatocellular carcinoma.展开更多
Prostate cancer is the most common malignancy in the reproductive system of older males.Androgen deprivation therapy(ADT)is an important treatment for prostate cancer patients?However,almost all prostate cancer patien...Prostate cancer is the most common malignancy in the reproductive system of older males.Androgen deprivation therapy(ADT)is an important treatment for prostate cancer patients?However,almost all prostate cancer patients unavoidably progress to the castration-resistant stage after ADT treatment.Recent studies have shown that tumor-associated immune cells play major roles in the initiation,progression,and metastasis of prostate cancer.Various phenotypes of tumor-associated immune cells have tumor-promoting or antitumor functions mediated by interacting with tumor cells.Here,we review the current knowledge of tumorassociated immune cells in prostate cancer.展开更多
Non-alcoholic steatohepatitis(NASH)is a severe form of non-alcoholic fatty liver disease without effective treatment.The traditional Chinese medicine formulation Pien Tze Huang(PTH)can suppress inflammatory diseases.H...Non-alcoholic steatohepatitis(NASH)is a severe form of non-alcoholic fatty liver disease without effective treatment.The traditional Chinese medicine formulation Pien Tze Huang(PTH)can suppress inflammatory diseases.Here,we evaluate the effects of PTH on the evolution of NASH and its underlying mechanisms.We found that PTH prevented the development of steatohepatitis induced by various dietary models,including a high-fat high-cholesterol(HFHC)diet,choline-deficient high-fat diet(CD-HFD),and methionine-and choline-deficient(MCD)diet,along with significant suppression of liver injury,hepatic triglyceride,and lipid peroxidation.Moreover,ten days of PTH treatment after the onset of NASH significantly ameliorated MCD diet-induced steatosis and liver injury in mice.Through the metagenomic sequencing of stool samples,we found that PTH administration restored the gut microbiota with enrichment of probiotics including Lactobacillus acidophilus(L.acidophilus),Lactobacillus plantarum,Lactococcus lactis,and Bacillus subtilis.The enriched L.acidophilus prevented MCD diet-induced steatohepatitis.In addition,PTH restored the gut barrier function in mice with steatohepatitis,as evidenced by reduced intestinal permeability,decreased serum lipopolysaccharides(LPS)level,and increased epithelial tightjunction protein E-cadherin expression.Our metabolomic analysis via liquid chromatography-mass spectrometry profiling identified the alteration in the metabolism of bile acids in the portal vein of PTHtreated mice.We further confirmed that an intact gut microbiota is necessary for PTH to exhibit antisteatohepatitis effects.In conclusion,PTH protects against steatohepatitis development by modulating the gut microbiota and metabolites.PTH is a potential promising prophylactic and therapeutic option for patients with NASH.展开更多
基金supported by the National Science and Technology Major Project of China(No.2017-VII-0003-0096)the National Natural Science Foundation of China(Grant Nos.52205240 and 52201140)+2 种基金the Young Elite Scientist Sponsorship Program by CAST(Grant No.YESS20200321)the Natural Science Foundation for Youths of Shaanxi Province(No.2023-JC-QN-0521)the China Postdoctoral Science Foundation(Grant No.2022M723874).
文摘M50 steel,commonly utilized in aircraft engine bearings,is susceptible to friction-induced failures,particularly in high-temperature service conditions.To address this issue,various strategies have been proposed,with laser shock peening(LSP)garnering significant attention due to its deeper residual stress penetration and excellent surface integrity,whereas the underlying strengthening mechanisms have not yet been fully elucidated.In this study,we systematically investigate the impact of LSP treatment on the tribological properties of M50 steel at temperatures of 25 and 300℃,alongside elucidating the relevant micro-mechanisms.Microstructural analysis reveals that laser impact strengthening primarily arises from dislocation proliferation,resulting in a surface hardness increase of approximately 14%and the formation of a substantial compressive stress layer reaching a maximum value of about 1200 MPa,with a depth of around 2 mm.Friction test results demonstrate reduced coefficients of friction and wear rates following LSP treatment at both temperatures.Notably,a more pronounced reduction is observed at 300℃,with values decreasing by 41.4%and 55.8%,respectively.The enhanced performance is attributed to the synergistic interplay of compressive residual stresses,work-hardening layers,increased density of dislocations,and substantial microstructure refinement.
基金supported by Natural Science Foundation of the Fujian Province,China(2024J010016)the National Key R&D Program of China(2021YFB3600400)Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Project(2020ZZ113,2021ZZ130)。
文摘Micro light sources are crucial tools for studying the interactions between light and matter at the micro/nanoscale,encompassing diverse applications across multiple disciplines.Despite numerous studies on reducing the size of micro light sources and enhancing optical resolution,the efficient and simple fabrication of ultra-high-resolution micro light sources remains challenging due to its reliance on precise micro-nano processing technology and advanced processing equipment.In this study,a simple approach for the efficient fabrication of submicron light sources is proposed,namely shadow-assisted sidewall emission(SASE)technology.The SASE utilizes the widely adopted UV photolithography process,employing metal shadow modulation to precisely control the emission of light from polymer sidewalls,thereby obtaining photoluminescent light sources with submicron line widths.The SASE eliminates the need for complex and cumbersome manufacturing procedures.The effects of process parameters,including exposure dose,development time,and metal film thickness,on the linewidth of sources are investigated on detail.It is successfully demonstrated red,green,and blue submicron light sources.Finally,their potential application in the field of optical anti-counterfeiting is also demonstrated.We believe that the SASE proposed in this work provides a novel approach for the preparation and application of micro light sources.
基金supported by the National Nature Science Foundation of China(No.81402308)Science Foundation of Peking University Cancer Hospital(No.2021-24)+2 种基金Natural Science Foundation of Beijing Municipal(No.7242020)Science Foundation of Peking University Cancer Hospital(No.BJCH2025GG04)the National Nature Science Foundation of China(No.82173151).
文摘Objective:The trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy(HIPEC)with cisplatin for patients with locally advanced gastric cancer(LAGC).Methods:Between March 2015 and November 2016,a phase Ⅱ clinical trial was performed.Fifty consecutive patients with LAGC were randomly assigned to two groups:the experimental group(radical gastrectomy+HIPEC with cisplatin+adjuvant chemotherapy)and the control group(radical gastrectomy+adjuvant chemotherapy).Survival rates were closely monitored.Results:The 5-year overall survival(OS)rate of all patients was 80.0%.The 5-year OS rate in the experimental group was lower than that in the control group,at 75.8%and 88.2%,respectively,with no statistical significance.In addition,5-year recurrence-free survival(RFS)rates of patients who underwent HIPEC or not were also 75.8%and 88.2%,respectively.In the multivariate analysis,only pT stage[risk ratio(RR)=7.079,P=0.018]was significantly associated with prognosis.The most common recurrence pattern was peritoneal recurrence in both groups.The experimental group had a lower incidence of peritoneal recurrence than the control group with no statistical significance.Conclusions:This trial clearly revealed that prophylactic HIPEC with cisplatin neither decrease the risk of peritoneal recurrence nor improve the prognosis of patients with LAGC.Thus,HIPEC with cisplatin is not recommended as a prophylactic treatment for peritoneal recurrence of LAGC after radical gastrectomy.
基金supported by the National Science and Technology Major Project of China(No.J2019-Ⅲ-0008-0051)the National Natural Science Foundation of China(Nos.52201140,52375225,and 92360307)the Natural Science Foundation for Youths of Shaanxi Province(No.2023-JC-QN-0521).
文摘Thermal barrier coating(TBC)is crucial for the performance of turbine blades at high temperatures;however,it degrades the microstructure of single-crystal superalloy(SX),thereby reducing creep life.Despite this,the degradation mechanisms associated with the complex multi-layer damage and inter-layer diffusion behavior for TBC/SX systems have not yet been fully elucidated.In this study,using integrated experimental efforts and multiscale characterization techniques,the creep degradation mechanisms of TBC/SX systems at 900℃/500 MPa,980℃/300 MPa,and 1050℃/160 MPa are systematically investigated.Results demonstrate that the creep degradation from TBC intensifies with increasing temperature(T)and stress(σ)ratio(T/σ),exhibiting significant dependency on these two factors,and primarily reduces lifespan of the steady-state stage,with minimal effects on the accelerating stage.During creep deformation,the cracking behavior caused by thermally grown oxide(TGO)beneath the top coat(TC)layer,voids resulting from internal oxidation and interdiffusion in the bond coat(BC)layer,and the recrystallization growth driven by the sandblasting process in the secondary reaction zone(SRZ)are temperature-sensitive damages.In contrast,the initiation and propagation of cracks associated with the topologically close-packed(TCP)phases in the SRZ exhibit pronounced stress sensitivity.Furthermore,the formation of the substrate diffusion zone(SDZ)and the decomposition ofγ/γ′interfacial dislocation networks driven by the Cr-Ru diffusion,as well as the increased stacking fault energy in theγ′phase due to Co loss,are responsible for the acceleration of steady-state creep rate at 1050℃/160 MPa.This work provides a comprehensive and in-depth understanding of the degradation mechanisms under thermal-mechanical coupling in TBC/SX systems,offering new insights into targeted design optimization for multilayered coatings.
基金funded by the Scientific Research Foundation of Peking University Cancer Hospital (No: 2022-9)。
文摘Since the first laparoscopic radical surgery for early gastric cancer 30 years ago, there has been a gradual shift from“open” to “minimally invasive” surgery for gastric cancer. This transition is due to advancements in refined anatomy, enlarged field of view, faster recovery, and comparable oncological outcomes. Several high-quality clinical studies have demonstrated the safety and effectiveness of laparoscopy in the treatment of both early and locally advanced gastric cancer. The role of perioperative chemotherapy in managing locally advanced gastric cancer has been widely recognized, and there have been continuous breakthroughs in the exploration of targeted therapy and immunotherapy for perioperative treatment. Additionally, the application of indocyanine green near-infrared imaging technology, 3D laparoscopic technology, and robotic surgery systems has further improved the accuracy and minimally invasive nature of gastric cancer surgeries. Looking ahead, the field of minimally invasive surgery for gastric cancer is expected to become more standardized, resulting in a significant enhancement in the quality of life for gastric cancer patients.
基金supported in part by the National Natural Science Foundation of China (Grant Nos. 61875250 and 61975189)the Zhejiang Provincial Natural Science Foundation of China (Grant Nos. LD21F050001 and Y21F040001)+3 种基金the Key Research Project by Department of Water Resources of Zhejiang Province (Grant No. RA2101)the Key Research and Development Project of Zhejiang Province (Grant No. 2021C03019)the Key R&D Projects of Shanxi Province (Grant Nos. 201903D421032 and 01804D131038)the Scientific Research Foundation of Zhejiang University of Water Resources and Electric Power (Grant No. xky2022032)。
文摘A metal-insulator-metal(MIM)-based arc-shaped resonator coupled with a rectangular stub(MARS) structure is proposed. This structure can generate two tunable Fano resonances originating from two different mechanisms. The structure has the advantage of being sensitive to the refractive index, and this feature makes it favorable for application in various microsensors. The relationship between the structural parameters and Fano resonance is researched using the finite element method(FEM) based on the software COMSOL Multiphysics 5.4. The simulation reveals that the sensitivity reaches1900 nm/refractive index unit(RIU), and the figure of merit(FOM) is 23.75.
基金the National Natural Science Foundation of China(Grant No.12174064)the Shanghai Municipal Science and Technology Major Project(Grant No.2019SHZDZX01)the research fund from the State Key Laboratory of Surface Physics and Department of Physics,Fudan University(Grant No.KF202009)。
文摘Topological materials have aroused great interest in recent years,especially when magnetism is involved.Pressure can effectively tune the topological states and possibly induce superconductivity.Here we report the high-pressure study of topological semimetals XCd_(2)Sb_(2)(X=Eu and Yb),which have the same crystal structure.In antiferromagnetic(AFM)Weyl semimetal EuCd_(2)Sb_(2),the Néel temperature(TN)increases from 7.4 K at ambient pressure to 50.9 K at 14.9 GPa.When pressure is above 14.9 GPa,the AFM peak of resistance disappears,indicating a non-magnetic state.In paramagnetic Dirac semimetal candidate YbCd_(2)Sb_(2),pressure-induced superconductivity appears at 1.94 GPa,then Tc reaches to a maximum of 1.67 K at 5.22 GPa and drops to zero at about 30 GPa,displaying a dome-shaped temperature–pressure phase diagram.High-pressure x-ray diffraction measurement demonstrates that a crystalline-to-amorphous phase transition occurs at about 16 GPa in YbCd_(2)Sb_(2),revealing the robustness of pressure-induced superconductivity against structural instability.Similar structural phase transition may also occur in EuCd_(2)Sb_(2),causing the disappearance of magnetism.Our results show that XCd_(2)Sb_(2)(X=Eu and Yb)is a novel platform for exploring the interplay among magnetism,topology,and superconductivity.
基金financially supported by the National Science Foundation(No.DMR 1255281)
文摘Small molecule peptides and their derivatives are an emerging class of supramolecular hydrogelators that have attracted rapidly growing interest in the fields of drug delivery and regenerative medicine due to their inherent biodegradability and biocompatibility, as well as versatility in molecular design and ease of synthesis. Built upon the directional, intermolecular interactions such as hydrogen bonding and π-π stacking, peptide-based molecular units can associate in aqueous solution into filamentous assemblies of various sizes and shapes. Under appropriate conditions, these filamentous assemblies can percolate into a 3D network with materials properties tailorable for specific biomedical applications. In this review, we survey the literature published over the past three years in the development of peptide-based hydrogelators for biomedical applications. We highlight several representative examples and center our discussion on the fundamentals of molecular design, assembly, and gelation conditions.
基金Supported by the National Natural Science Foundation of China(Grant No.11874264)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDA18000000)+3 种基金the Starting Grant of Shanghai Tech University,the Shenzhen Peacock Team Plan(Grant No.KQTD20170809110344233)the Bureau of Industry and Information Technology of Shenzhen through the Graphene Manufacturing Innovation Center(Grant No.201901161514)the Key Scientific Research Projects of Higher Institutions in Henan Province(19A140018)Analytical Instrumentation Center,SPST,Shanghai Tech University(Grant No.SPST-AIC10112914).
文摘Characterization of Fermi surface of the BaSn3 superconductor(Tc~ 4.4K)by de Haas–van Alphen(dHvA)effect measurement reveals its non-trivial topological properties.Analysis of non-zero Berry phase is supported by the ab initio calculations,which reveals a type-II Dirac point setting and tilting along the high symmetric K–H line of the Brillouin zone,about 0.13 eV above the Fermi level,and other two type-I Dirac points on the high symmetric Г–A direction,but slightly far below the Fermi level.The results demonstrate BaSn3 as an excellent example hosting multiple Dirac fermions and an outstanding platform for studying the interplay between nontrivial topological states and superconductivity.
基金This work was supported by key research and development plan of Foundation of Jiangsu Forestry Bureau(LYKJ[2017]42),Jiangsu Province(BE2017376)the Nature Science Foundation of China(31770715)the Qinglan project of Jiangsu Province,and Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Cerasus Campanulata is one of several species belonging to the Prunoideae focke,a subfamily of the flowering plant Rosaceae.We investigated the details of its chloroplast genome which may reveal its genus independent of morphological determination.Here,we determined the complete chloroplast(cp)genome sequence of C.campanulata and performed sequence analysis to reveal the presence of 18 forward repeats,20 palindrome repeats,2 complement repeats,4 reverse repeats and 93 simple sequence repeats(SSRs).We additionally performed a comparative study of C.campanulata and seven other Prunoideae focke species.Then,maximum parsimony(MP)and maximum likelihood(ML)phylogenetic analyses were carried out in the little part of Rosaceae,respectively.The results strongly support a position of C.campanulata as a member of the Cerasus in the Rosaceae family.Moreover,the complete cp genome can be used for plant phylogenetic and evolutionary studies that will provide insight into the degree of gene conservation.
基金supported by the National Natural Science Foundation of China(Nos.22374119 and 22274127)the Research Fund of the State Key Laboratory of Solidification Processing(NPU),China(No.2021-QZ-01)+1 种基金the Key Project of Natural Science Fund of Shaanxi Province(Nos.2023-JC-ZD-06 and 2024JC-YBQN-0636)the Open Project of the State Key Laboratory of Transducer Technology(No.SKT2307).
文摘Wearable sensors are pivotal for point-of-care diagnostics,yet their application in extreme conditions is rarely conducted.In this work,we present a wearable pH sensor using tungsten oxide aerogel(TOA)as the sensing material.With the advantages of large specific surface area,high porosity and interconnected network structures,TOA not only provides excellent pH sensing performance but also demonstrates remarkable structural and sensing stability.The potentiometric pH sensor exhibits a high sensitivity(−63.70 mV/pH),a low detectable limit(0.05)and a superior stability(maintained over 50,000 s).Integrated with a Bluetooth module,the wearable sensor achieves non-invasive and real-time pH monitoring on the human skin with minimal deviation(1.91%)compared to the commercial pH meter.More importantly,the anti-impact behaviors of the TOA-based sensing materials and chip,along with the pH wearable sensor on a pig exhibit an outstanding shock-resistance ability,with variations no more than 7.17%under an impact of 118.38 kPa.Therefore,this study shows great promise for the aerogel-based personalized health management in the extreme environment.
文摘By reviewing the development of “three-high” oil and gas well testing technology of Sinopec in recent years, this paper systematically summarizes the application of “three-high” oil and gas well testing technology of Sinopec in engineering optimization design technology, and high temperature and high pressure testing technology, high pressure and high temperature transformation completion integration technology. Major progress has been made in seven aspects: plug removal and re-production technology of production wells in high acid gas fields;wellbore preparation technology of ultra-deep, high-pressure, and high-temperature oil and gas wells;surface metering technology;and supporting tool development technology. This paper comprehensively analyzes the challenges faced by the “three-high” oil and gas well production testing technology in four aspects: downhole tools, production testing technology, safe production testing, and the development of low-cost production test tools. Four development directions are put forward: 1) Improve ultra-deep oil and gas testing technology and strengthen integrated geological engineering research. 2) Deepen oil and gas well integrity evaluation technology to ensure the life cycle of oil and gas wells. 3) Carry out high-end, customized, and intelligent research on oil test tools to promote the low-cost and efficient development of ultra deep reservoirs. 4) Promote the fully automatic control of the surface metering process to realize the safe development of “three-high” reservoirs.
基金Supported by the Central Level and Public Welfare Basal Research Fund of Chinese Academy of Medical Sciences,No.2016ZX310020
文摘AIM To introduce an innovative intracorporeal anastomosis technique named overlapped delta-shaped anastomosis(ODA)for colon cancer cases undergoing totally laparoscopic colectomy(TLC)and to assess its feasibility and safety. METHODS From January 2016 to March 2017,a total of 20consecutive patients with colon cancer accepted TLC and the ODA technique at our medical center.Patient demographics,operative outcomes,perioperative complications,and pathological results were collected and analyzed. RESULTS We successfully completed TLC and the ODA procedure in all 20 cases,including 6(30%)males and 14(70%)females.In total,11(55%),2(10%),and 7(35%)cases accepted right hemicolectomy,transverse hemicolectomy,and left hemicolectomy,respectively.None of the surgeries were converted to an open operation.Mean operative time was 178.5 min,and mean estimated blood loss was 58.5 m L.Mean time to first flatus was 2.5 d,and mean postoperative hospitalization duration was 6.8 d.No severe complications occurred,such as anastomotic leakage,snastomotic stenosis,anastomotic bleeding,and wound infection,except for one case who suffered from an abdominal infection and another case who suffered from gastric paralysis syndrome.Tumor recurrence was not observed in any patient during the follow-up period. CONCLUSION The ODA technique for colon cancer cases undergoing TLC appears to be safe and feasible,although our current results need to be verified in further studies.
文摘Objective： This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer.Methods： Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen（oxaliplatin 85 mg/m2 and irinotecan 150 mg/m2, combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m2 by 44 h infusion or capecitabine 1 g/m2 or S-1 40–60 mg b.i.d orally d 1–10, repeated at 2-week intervals） for 4 cycles. Complete mesocolic excision was scheduled 2–6 weeks after completion of neoadjuvant treatment and followed by a further 6 cycles of FOLFOXIRI or XELOX. Primary outcome measures of this stage II trial were feasibility, safety, tolerance and efficacy of neoadjuvant treatment.Results： All 23 patients received neoadjuvant chemotherapy and underwent surgery. Twenty-one patients（91.3%） had reductions in tumor volume after neoadjuvant treatment, and 13 patients（56.5%） had grade 3–4toxicity. No patients had severe complications from surgery. Preoperative therapy resulted in significant downstaging of T-stage and N-stage compared with the baseline clinical stage including one pathological complete response.Conclusions： Neoadjuvant triple chemotherapy has high activity and acceptable toxicity and perioperative morbidity, and is feasible, tolerable and effective for locally advanced resectable colon cancer.
基金This study was supported by National Natural Science Foundation of China （No. 81373871 and No. 81473637）.
文摘This study aims to explore the effect and mechanism of Jiao-tai-wan （JTW） on systemic and tissue-specific inflammation and insulin resistance in obesity-resistant （OR） rats with chronic partial sleep deprivation （PSD）. OR rats with PSD were orally given JTW and Estazolam for 4 weeks. The amount of food intake and metabolic parameters such as body weight increase rate, fasting plasma glucose （FPG）, fasting insulin （FINS）, homeostasis model assessment-insulin resistance （HOMA-IR） and plasma inflammatory markers were measured. The expression levels of circadian proteins cryptochrome 1 （Cryl） and cryptochrome 2 （Cry2） in hypothalamus, adipose and liver tissues were also determined. Meanwhile, the mRNA expression of inflammatory markers, activity of nuclear factor kappa B （NF-κB） p65 protein, as well as the expression levels of insulin signaling pathway proteins in hypothalamus, adipose and liver tissues were measured. Additionally, cyclic adenosine 3＇, 5＇-monophosphate （cAMP） and activity of vasodilator-stimulated phosphoprotein （VASP） in hypothalamus tissue were measured. JTW significantly decreased the body weight increase rate and food intake, ameliorated systemic inflammation and insulin resistance. JTW effectively ameliorated inflammation and increased PI3K/AKT signaling activation in hypothalamus, adipose and liver. Interestingly, all these changes were associated with the up-regulation of circadian gene Cryl and Cry2 protein expression. We also found that in hypothalamus tissue of PSD rats, down-regulation of Cryl and Cry2 activated cAMP/PKA signaling and then led to inflammation, while JTW inhibited this signaling. These results suggested that JTW has the beneficial effect on ameliorating inflammation and insulin resistance in partially sleep-deprived rats by up-regulating Cry expression.
基金This work was financially supported by the National Natural Science Foundation of China(No.52035005).
文摘Complete understanding of the evolution behaviors of the microstructures and intermetallic compounds(IMCs)along the interface materials flow path in friction stir welding(FSW)of dissimilar Al to Mg alloys is of great significance.In this study,conventional FSW and ultrasonic vibration enhanced FSW(UVeFSW)experiments of Al/Mg alloys were performed,and the instantaneous evolution features of the interface materials around the tool were"frozen"by using the"sudden stop"and simultaneous cooling techniques.The microstructures and IMCs formation at different locations around the exit hole were observed and characterized by scanning electron microscope,energy dispersive spectrometer and transmission elec-tron microscope.It was found that before the materials started to deposit near the back of the tool,“IMC+Mg+IMC+Al”multilayer microstructure and simple IMC layer with(β+γ)sequentially emerged on the Al/Mg interface.With the application of ultrasonic vibration,the multi-layered interface structure only appeared at the middle stage of materials flow around the pin,and ultrasonic vibration just began to play a suppression role on the growth of two sub-layers IMC at a position where the materials deposit.With assistance of ultrasonic vibration in UVeFSW,the tool drove a larger volume of Mg alloy to move toward the retreating side,and the final IMCs thickness was thinner than that in FSW.
基金Supported by Grants from the Bureau of Science and Technology of Guangxi Zhuang Autonomous Region,No.0342014
文摘AIM:To investigate the correlation between peri-operative fluid therapy and early-phase recovery after liver transplantation(LT) by retrospectively reviewing 102 consecutive recipients.METHODS:Based on whether or not the patients had pulmonary complications,the patients were categorized into non-pulmonary and pulmonary groups.Twentyeight peri-operative variables were analyzed in both groups to screen for the factors related to the occurrence of early pulmonary complications.RESULTS:The starting hemoglobin(Hb) value,an intra-operative transfusion > 100 mL/kg,and a fluid balance ≤-14 mL/kg on the first day and the second or third day post-operatively were significant factors for early pulmonary complications.The extubation time,time to initial passage of flatus,or intensive care unit length of stay were significantly prolonged in patients who had not received an intra-operative transfusion ≤ 100 mL/kg or a fluid balance ≤-14 mL/kg on the first day and the second or the third day post-operatively.Moreover,these patients had poorer results in arterial blood gas analysis.CONCLUSION:It is important to offer a precise and individualized fluid therapy during the peri-operative period to the patients undergoing LT for cirrhosis-associated hepatocellular carcinoma.
文摘Prostate cancer is the most common malignancy in the reproductive system of older males.Androgen deprivation therapy(ADT)is an important treatment for prostate cancer patients?However,almost all prostate cancer patients unavoidably progress to the castration-resistant stage after ADT treatment.Recent studies have shown that tumor-associated immune cells play major roles in the initiation,progression,and metastasis of prostate cancer.Various phenotypes of tumor-associated immune cells have tumor-promoting or antitumor functions mediated by interacting with tumor cells.Here,we review the current knowledge of tumorassociated immune cells in prostate cancer.
基金supported by the National Natural Science Foundation of China(82103355 and 82222901)Research Grants Council-General Research Fund(RGC-GRF+2 种基金14117422)Health and Medical Research Fund,Hong Kong(08191336)Vice-Chancellor’s Discretionary Fund CUHK.
文摘Non-alcoholic steatohepatitis(NASH)is a severe form of non-alcoholic fatty liver disease without effective treatment.The traditional Chinese medicine formulation Pien Tze Huang(PTH)can suppress inflammatory diseases.Here,we evaluate the effects of PTH on the evolution of NASH and its underlying mechanisms.We found that PTH prevented the development of steatohepatitis induced by various dietary models,including a high-fat high-cholesterol(HFHC)diet,choline-deficient high-fat diet(CD-HFD),and methionine-and choline-deficient(MCD)diet,along with significant suppression of liver injury,hepatic triglyceride,and lipid peroxidation.Moreover,ten days of PTH treatment after the onset of NASH significantly ameliorated MCD diet-induced steatosis and liver injury in mice.Through the metagenomic sequencing of stool samples,we found that PTH administration restored the gut microbiota with enrichment of probiotics including Lactobacillus acidophilus(L.acidophilus),Lactobacillus plantarum,Lactococcus lactis,and Bacillus subtilis.The enriched L.acidophilus prevented MCD diet-induced steatohepatitis.In addition,PTH restored the gut barrier function in mice with steatohepatitis,as evidenced by reduced intestinal permeability,decreased serum lipopolysaccharides(LPS)level,and increased epithelial tightjunction protein E-cadherin expression.Our metabolomic analysis via liquid chromatography-mass spectrometry profiling identified the alteration in the metabolism of bile acids in the portal vein of PTHtreated mice.We further confirmed that an intact gut microbiota is necessary for PTH to exhibit antisteatohepatitis effects.In conclusion,PTH protects against steatohepatitis development by modulating the gut microbiota and metabolites.PTH is a potential promising prophylactic and therapeutic option for patients with NASH.
