Silicon nanowires(SiNWs)have been used in a wide variety of applications over the past few decades due to their excellent material properties.The only drawback is the high production cost of SiNWs.The preparation of S...Silicon nanowires(SiNWs)have been used in a wide variety of applications over the past few decades due to their excellent material properties.The only drawback is the high production cost of SiNWs.The preparation of SiNWs from photovoltaic waste silicon(WSi)powders,which are high-volume industrial wastes,not only avoids the secondary energy consumption and environmental pollution caused by complicated recycling methods,but also realizes its high-value utilization.Herein,we present a method to rapidly convert photovoltaic WSi powders into SiNWs products.The flash heating and quenching provided by carbothermal shock induce the production of free silicon atoms from the WSi powders,which are rapidly reorganized and assembled into SiNWs during the vapor-phase process.This method allows for the one-step composite of SiNWs and carbon cloth(CC)and the formation of SiC at the interface of the silicon(Si)and carbon(C)contact to create a stable chemical connection.The obtained SiNWs-CC(SiNWs@CC)composites can be directly used as lithium anodes,exhibiting high initial coulombic efficiency(86.4%)and stable cycling specific capacity(2437.4 mA h g^(-1)at 0.5 A g^(-1)after 165 cycles).In addition,various SiNWs@C composite electrodes are easily prepared using this method.展开更多
The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set inco...The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set incorporating innovative fault labels to train a U-Net-structured CNN model,enabling effective identification of small-scale strike-slip faults through seismic data interpretation.Based on the CNN faults,we analyze the distribution patterns of small-scale strike-slip faults.The small-scale strike-slip faults can be categorized into NNW-trending and NE-trending groups with strike lengths ranging 200–5000 m.The development intensity of small-scale strike-slip faults in the Lower Yingshan Member notably exceeds that in the Upper Member.The Lower and Upper Yingshan members are two distinct mechanical layers with contrasting brittleness characteristics,separated by a low-brittleness layer.The superior brittleness of the Lower Yingshan Member enhances the development intensity of small-scale strike-slip faults compared to the upper member,while the low-brittleness layer exerts restrictive effects on vertical fault propagation.Fracture-vug systems formed by interactions of two or more small-scale strike-slip faults demonstrate larger sizes than those controlled by individual faults.All fracture-vug system sizes show positive correlations with the vertical extents of associated small-scale strike-slip faults,particularly intersection and approaching fracture-vug systems exhibit accelerated size increases proportional to the vertical extents.展开更多
Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently understood.As potent anti-i...Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently understood.As potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet known.In the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of action.In vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial polarization.Lipopolysaccharide,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were administered.RNA-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of dexamethasone.The Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our hypothesis.High-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain injury.Thus dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in vivo.Glucocorticoid receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain injury.Additionally,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is the GR/JAK1/STAT3 pathway.Overactivation of glucocorticoid receptor by high-dose dexamethasone reduced the expression of M2 microglia,which plays an antiinflammatory role.In contrast,inhibiting the activation of glucocorticoid receptor reduced the number of apoptotic glia and neurons and decreased the loss of dendritic spines after traumatic brain injury.Dexamethasone may exe rt its neurotoxic effects by inhibiting M2 microglia through the GR/JAK1/STAT3 signaling pathway.展开更多
Antifungal resistance is the leading cause of antifungal treatment failure in invasive candidiasis.Metabolic rewiring could become a new insight to account for antifungal resistance as to find innovative clinical ther...Antifungal resistance is the leading cause of antifungal treatment failure in invasive candidiasis.Metabolic rewiring could become a new insight to account for antifungal resistance as to find innovative clinical therapies.Here,we show that dynamic surface-enhanced Raman spectroscopy is a promising tool to identify the metabolic differences between fluconazole(Diflucan)-resistant and fluconazole(Diflucan)-sensitive Candida albicans through the signatures of biochemical components and complemented with machine learning algorithms and two-dimensional correlation spectroscopy,an underlying resistance mechanism,that is,the change of purine metabolites induced the resistance of Candida albicans has been clarified yet never reported anywhere.We hope the integrated methodology introduced in this work could be beneficial for the interpretation of cellular regulation,propelling the development of targeted antifungal therapies and diagnostic tools for more efficient management of severe antifungal resistance.展开更多
Solid-state batteries(SSBs)with thermal stable solid-state electrolytes(SSEs)show intrinsic capacity and great potential in energy density improvement.SSEs play critical role,however,their low ionic conductivity at ro...Solid-state batteries(SSBs)with thermal stable solid-state electrolytes(SSEs)show intrinsic capacity and great potential in energy density improvement.SSEs play critical role,however,their low ionic conductivity at room temperature and high brittleness hinder their further development.In this paper,polypropylene(PP)-polyvinylidene fluoride(PVDF)-Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP)-Lithium bis(trifluoromethane sulphonyl)imide(LiTFSI)multi-layered composite solid electrolyte(CSE)is prepared by a simple separator coating strategy.The incorporation of LATP nanoparticle fillers and high concentration LiTFSI not only reduces the crystallinity of PVDF,but also forms a solvation structure,which contributes to high ionic conductivity in a wide temperature.In addition,using a PP separator as the supporting film,the mechanical strength of the electrolyte was improved and the growth of lithium dendrites are effectively inhibited.The results show that the CSE prepared in this paper has a high ionic conductivity of 6.38×10^(-4)S/cm at room temperature and significantly improves the mechanical properties,the tensile strength reaches 11.02 MPa.The cycle time of Li/Li symmetric cell assembled by CSE at room temperature can exceed 800 h.The Li/LFP full cell can cycle over 800 cycles and the specific capacity of Li/LFP full cell can still reach 120 m Ah/g after 800 cycles at 2 C.This CSE has good cycle stability and excellent mechanical strength at room temperature,which provides an effective method to improve the performance of solid electrolytes under moderate condition.展开更多
High-voltage LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)cathodes are critical for enhancing the energy density of lithium-ion batteries(LIBs).The development of binders compatible with high-voltage NCM811 cathode material...High-voltage LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)cathodes are critical for enhancing the energy density of lithium-ion batteries(LIBs).The development of binders compatible with high-voltage NCM811 cathode materials is crucial to enhance the electrochemical performance of LIBs.However,the traditional fluoropolymer binder,poly(vinylidene difluoride)(PVDF),can potentially leach components or break down into poly(fluoroalkyl substances)(PFAS)chemicals,thereby contributing to PFAS contamination.A novel fluorine-free polymer,polysulfone-polyamide-polyimide(SPIO),was designed and synthesized as a binder for NCM811 cathodes.The SPIO binder exhibits exceptional mechanical properties and superior electrochemical characteristics.The cathode film fabricated with SPIO demonstrated a remarkable delamination force of 8 N(390 N·m^(-1)),indicating robust adhesion.The Li‖NCM811 cell incorporating the SPIO binder retained 80%of its initial capacity after 300 cycles at a current density of 0.2 C.In comparison,the control cells assem bled with the PVDF binder retained only 52%of their capacities under the same cycling conditions.Furthermore,the SPIO binder exhibited improved compatibility with the electrolyte.Transmission electron microscopy analysis of the cathode films after 100 cycles revealed the formation of a unifo rm,dense,and continuous chemical-electrochemical interface(CEI)by the SPIO binder on the surface of the NCM811 particles,which significantly contributed to the enhancement of the electrochemical performance.These results highlight the potential of SPIO as an advanced binder material for high-perfo rmance lithium-ion batteries.展开更多
A novel hydroxy late-rich functionalized biosorbent by grafting citric acid on the decrystallized Dicranopteris dichotoma stem(DDS) was prepared.The obtained g-DDS-3 exhibits good hydrophilicity,thermal stability and ...A novel hydroxy late-rich functionalized biosorbent by grafting citric acid on the decrystallized Dicranopteris dichotoma stem(DDS) was prepared.The obtained g-DDS-3 exhibits good hydrophilicity,thermal stability and superior adsorption performance for Ce^(3+).The effects of citric acid dosage,pH and initial Ce^(3+)concentration on the adsorption experiments were investigated.The maximum adsorption capacity(Langmuir model) of Ce^(3+)by g-DDS-3 is 131.0 mg/g at pH of 7.0,which surpasses that of most previously reported biomass-based materials.Adsorption kinetic results indicate that the adsorption process conforms to the pseudo-second-order model and can achieve equilibrium quickly.By analyzing the adsorption mechanism,we find that carboxyl groups are uniformly distributed on the surface of g-DDS-3 post modification,which provides abundant adsorption sites,and the adsorption is primarily driven by the ion exchange between Ce^(3+)and carboxyl groups protons.In addition,the adsorption-desorption experiments suggest that the g-DDS-3 has excellent recyclability since the adsorption capacity still remain above 90% after five cycles.These findings prove that carboxylate-rich modified D.dichotoma has great potential for application in the effective separation and recovery of Ce^(3+)from leaching tailings.展开更多
Gallic acid(GA),a plant phenol ubiquitously present in fruits and vegetables,has demonstrated efficacy in ameliorating ulcerative colitis(UC).Despite previous reports,the precise mechanism of GA's therapeutic acti...Gallic acid(GA),a plant phenol ubiquitously present in fruits and vegetables,has demonstrated efficacy in ameliorating ulcerative colitis(UC).Despite previous reports,the precise mechanism of GA's therapeutic action remains elusive.Herein,the present study aims to delineate the mechanism underlying the anti-UC effects of GA by focusing on the interplay of gut microbiota,microbial and host cometabolites,and gut immune regulation.The findings revealed that GA treatment improved the colitis symptoms and systematic inflammatory response,reliant on gut microbiota,as evidenced by microbiota depletion and fecal microbiota transplantation.According to the 16S r DNA sequencing results,GA altered the gut microbiota community structure and upregulated the biosynthesis of secondary bile acids(SBAs).Metabolomics and flow cytometry(FCS)analysis revealed a substantial increase in SBAs production,including ursodeoxycholic acid(UDCA),lithocholic acid(LCA),3-oxo-lithocholic acid(3-oxo-LCA)and iso-allolithocholic acid(Isoallo LCA),which further upregulated the proportion of regulatory T(Treg)cells and downregulated the proportion of T helper type 17(Th17)cells in the colon,ultimately resulting in an improved Treg/Th17 balance.Further FCS and real-time quantitative PCR assays provided mechanistic insights,demonstrating that UDCA and Isoallo LCA facilitate Treg cell differentiation through the upregulation of nuclear hormone receptor 4A1(NR4A1).This research elucidated that GA effectively mitigates colitis by modulating the Treg/Th17 balance,facilitated by the enhanced synthesis of microbiota-derived SBAs.These insights unveil innovative pathways through which GA exerts its anti-UC effects,emphasizing the potential therapeutic benefits of incorporating a GAenriched diet into UC management.展开更多
This paper is a synthetic use of carbon isotope composition,Rock-Eval data,organic petrology,element composition of kerogen,major and trace elements,and biomarker characteristic of the Permian Pingdiquan(P_(2)p)source...This paper is a synthetic use of carbon isotope composition,Rock-Eval data,organic petrology,element composition of kerogen,major and trace elements,and biomarker characteristic of the Permian Pingdiquan(P_(2)p)source rocks in the Wucaiwan sag,Junggar Basin,China as proxies(1)for evaluations of hydrocarbon potential,organic matter(OM)composition and thermal maturity of the OM in the source rocks,(2)for reconstruction of paleodepositional environment,and(3)for analysis of controlling factor of organic carbon accumulation.The P_(2)p Formation developed good-excellent source rocks with thermal maturity of OM ranging from low-mature to mature stages.The OM was mainly composed of C_(3)terrestrial higher plants and aquatic organisms including aerobic bacteria,green sulfur bacteria,saltwater and fresh algae,Sphagnum moss species,submerged macrophytes,Nymphaea,and aquatic pollen taxa.The proportion of terrestrial higher plants decreased and that of aquatic organisms increased from margin to center of the sag.The benthic water within reducing environment and brackishwater column were superposed by periodic/occasional fresh-water influx(e.g.,rainfall and river drain),which led to fresh-water conditions and well oxygenating in the water column during overturn process.The whole study area developed lacustrine source rocks without seawater intrusion.During periodic/occasional fresh-water influx periods with plenty of terrestrial plant inputs,the paleoredox conditions of the sag were relatively oxic in the shallow fresh-water which experienced strong oxidation and decomposition of OM,therefore were not conducive for the OM preservation.However,the overall middle primary productivity made up for this deficiency,and was the main controlling factor on the organic carbon accumulation.A suitable supply from terrestrial inputs can promote biotic paleoproductivity,and a relatively high sedimentation rate can reduce oxidation and decomposition times of OM.On the contrary,during the intervals of the fresh-water influxes,relatively reducing conditions are a more important controlling factor on the OM accumulation in the case that the decrease of the terrestrial biotic source.展开更多
Developing cost-effective and high-activity catalysts for the methanolysis of ammonia borane(AB)has attracted great attention in the field of hydrogen energy recently.Besides the modification of the electronic structu...Developing cost-effective and high-activity catalysts for the methanolysis of ammonia borane(AB)has attracted great attention in the field of hydrogen energy recently.Besides the modification of the electronic structure of the catalysts,external factors such as visible light irradiation can improve the efficiency of hydrogen production as well.In the present study,a Z-scheme heterostructured VO-Cu_(0.5)Ni_(0.5)O catalysts were constructed by introducing a plenteous phase interface and oxygen vacancy(Vo).The catalytic activity of as-prepared VO-Cu_(0.5)Ni_(0.5)O toward AB methanolysis has been improved dramatically with the assistance of visible light irradiation.The turnover frequency(TOF)under visible light irradiation was measured to be 29_(mol)H_(2)·mol_(cat.)^(-1)·min^(-1),which is 1.4 times larger than the TOF in the absence of visible light.Systematic characterization experiments and density functional theory(DFT)calculations were conducted to unveil the causation of enhanced catalytic activity.The results demonstrated that the enhancement of the catalytic activity of VO-Cu_(0.5)Ni_(0.5)O originated from the electronic structure modification induced by the formation of heterojunctions,the introduction of oxygen vacancies,and the assistance of visible light cooperatively.The formation of heterojunction and the introduction of oxygen vacancies provoked the upshift of the d-band center;while the visible light irradiation induced the photogenerated electrons to transfer from Cu to Ni sites at the interface.Such electron structure modulation is beneficial for the construction of abundant active sites,thereby enhancing the adsorption of methanol on the Ni sites,which is considered as the rate-determine step for the methanolysis of AB.The strong interaction between Ni and O weakened the O-H bond of methanol,accelerating the methanolysis of AB.These results demonstrate the utilization of combined heterojunction,oxygen vacancy,and visible light to explore highly active AB methanolysis catalysts,which should shed light on the exploration of more effective catalysts for AB methanolysis.展开更多
Algal copper uptake(i.e.,Cu bioavailability)in the euphotic zone plays a vital role in algal photosynthesis and respiration,affecting the primary productivity and the source and sink of atmospheric carbon.Algal Cu upt...Algal copper uptake(i.e.,Cu bioavailability)in the euphotic zone plays a vital role in algal photosynthesis and respiration,affecting the primary productivity and the source and sink of atmospheric carbon.Algal Cu uptake is controlled by natural dissolved organic Cu(DOCu)speciation(i.e.,complexed with the dissolved organic matter)that conventionally could be tested by model prediction or molecular-level characterizations in the lab,while DOCu uptake are hardly directly assessed.Thus,the new chemistrybiology insight into the mechanisms of the Cu uptake process in algae is urgent.The DOCu speciation transformation(organic DOCu to free Cu(II)ions),enzymatic reduction-induced valence change(reduction of free Cu(II)to Cu(I)ions),and algal Cu uptake at the algae-water interface are imitated.Herein,an intelligent system with DOCu colorimetric sensor is developed for real-time monitoring of newly generated Cu(I)ions.Deep learning with whole sample image-based characterization and powerful feature extraction capabilities facilitates colorimetric measurement.In this context,the Cu bioavailability with 7 kinds of organic ligands(e.g.,amino acids,organic acids,carbohydrates)can be predicted by the mimetic intelligent biosensor within 15.0min,i.e.,the DOCu uptake and speciation is successfully predicted and streamlined by the biomimetic approach.展开更多
Gastrodin(GAS),the principal bioactive composition of Gastrodia elata Blume,has potential for pharmaceutical applications.Several studies in recent years have shown that GAS may enhance neurotrophic benefits,reduce in...Gastrodin(GAS),the principal bioactive composition of Gastrodia elata Blume,has potential for pharmaceutical applications.Several studies in recent years have shown that GAS may enhance neurotrophic benefits,reduce inflammation,and act as an antioxidant.In this study,we sought to identify the molecular mechanisms underlying the protective benefits of GAS against colitis induced by dextran sodium sulfate(DSS)in mice.GAS(200 mg/kg)significantly ameliorated the severity of colitis in mice caused by DSS,as evidenced by an increase in colon length,a reduction in disease activity index,a decrease in tissue damage,and a reduction in body weight loss.Additionally,GAS inhibited DSS-induced hyperactivation of inflammation-related NF-κB signaling pathways to reduce the production of inflammatory mediators,thereby mitigating the inflammatory response in mice.Furthermore,the administration of GAS restored the function of the gastrointestinal barrier by increasing the count of goblet cells,as well as the levels of tight junction associated proteins,including Zonula occludens-1(ZO-1),Occludin,and Claudin-3.GAS also influenced the overall richness of the gut microbiota,as shown by 16S rRNA sequencing analysis,consequently boosting the proliferative rate of probiotic species,such as Lachnospiraceae and Muribaculaceae,while reducing the richness of harmful bacteria including Escherichia_Shigella,Enterobacteriaceae,Bacteroidaceae,and Bacteroides.GAS(200 mg/kg)alleviated ulcerative colitis(UC)by modulating gut dysbiosis,as demonstrated by a fecal microbial transplantation(FMT)test.Furthermore,inflammatory damage induced by lipopolysaccharide(LPS)was averted in RAW264.7 cells by GAS administration,hence preventing the NF-κB signaling pathway from being activated in these experimental conditions conducted in vitro.Overall,the data indicate that GAS treatment effectively reduces colitis caused by DSS by regulating gut microbiota,suppressing inflammation,and preserving the mucosal barrier integrity.展开更多
Employing multiple metals for synergistic electronic structure regulation emerges as a promising approach to develop highly efficient and robust electrocatalysts for hydrogen evolution at ampere levels.In this study,a...Employing multiple metals for synergistic electronic structure regulation emerges as a promising approach to develop highly efficient and robust electrocatalysts for hydrogen evolution at ampere levels.In this study,a series of Schreibersite-type intermetallic compounds,particularly Mo_(2)Fe_(0.8)Ru_(0.2)P,are synthesized through high-temperature solid-phase synthesis.Experimental results demonstrate that the integration of Ru significantly improves the kinetics of proton adsorption and desorption during the hydrogen evolution reaction(HER).Additionally,density functional theory(DFT)calculations and X-ray absorption near edge structure(XANES)analyses effectively corroborate the pronounced d-orbital hybridization of Fe within the structure,which facilitates the transfer of hydroxide ions and the maintenance of material durability during alkaline HER processes.Remarkably,Mo_(2)Fe_(0.8)Ru_(0.2)P exhibits superior alkaline HER activity,characterized by an overpotential of merely 48 mV at a current density of 10 mA cm^(-2).After prolonged operation of 1000 h at high current densities(1.1 A cm^(-2)),the activity decline remains minimal,under 4%(with overpotential increasing from 258 mV to 268 mV).These results demonstrate the potential of strategically combining metallic elements to design high-performance industrial-grade electrocatalysts.展开更多
The relentless pursuit of advanced X-ray detection technologies has been significantly bolstered by the emergence of metal halides perovskites(MHPs)and their derivatives,which possess remarkable light yield and X-ray ...The relentless pursuit of advanced X-ray detection technologies has been significantly bolstered by the emergence of metal halides perovskites(MHPs)and their derivatives,which possess remarkable light yield and X-ray sensitivity.This comprehensive review delves into cutting-edge approaches for optimizing MHP scintillators performances by enhancing intrinsic physical properties and employing engineering radioluminescent(RL)light strategies,underscoring their potential for developing materials with superior high-resolution X-ray detection and imaging capabilities.We initially explore into recent research focused on strategies to effectively engineer the intrinsic physical properties of MHP scintillators,including light yield and response times.Additionally,we explore innovative engineering strategies involving stacked structures,waveguide effects,chiral circularly polarized luminescence,increased transparency,and the fabrication of flexile MHP scintillators,all of which effectively manage the RL light to achieve high-resolution and high-contrast X-ray imaging.Finally,we provide a roadmap for advancing next-generation MHP scintillators,highlighting their transformative potential in high-performance X-ray detection systems.展开更多
As a new type of pollutant,the harm caused by microplastics(MPs)to organisms has been the research focus.Recently,the proportion of MPs ingested through the digestive tract has gradually increased with the popularity ...As a new type of pollutant,the harm caused by microplastics(MPs)to organisms has been the research focus.Recently,the proportion of MPs ingested through the digestive tract has gradually increased with the popularity of fast-food products,such as takeout.The damage to the digestive system has attracted increasing attention.We reviewed the literature regarding toxicity of MPs and observed that they have different effects on multiple organs of the digestive system.The mechanism may be related to the toxic effects of MPs themselves,interactions with various substances in the biological body,and participation in various signaling pathways to induce adverse reactions as a carrier of toxins to increase the time and amount of body absorption.Based on the toxicity mechanism of MPs,we propose specific suggestions to provide a theoretical reference for the government and relevant departments.展开更多
The quest for sustainable energy solutions has intensified the need for efficient water electrolysis techniques,pivotal for hydrogen production.However,developing effective bifunctional electrocatalysts capable of dri...The quest for sustainable energy solutions has intensified the need for efficient water electrolysis techniques,pivotal for hydrogen production.However,developing effective bifunctional electrocatalysts capable of driving the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)remains a formidable challenge.Addressing this,we introduce a novel built-in electric field(BEF)strategy to synthesize NiCoP–Co nanoarrays directly on Ti_(3)C_(2)T_(x) MXene substrates(NiCoP–Co/MXene).This approach leverages a significant work function difference(ΔΦ),propelling these nanoarrays as adept bifunctional electrocatalysts for comprehensive water splitting.MXene,in this process,plays a dual role.It acts as a conductive support,enhancing the catalyst’s overall conductivity,and facilitates an effective charge transport pathway,ensuring efficient charge transfer.Our study reveals that the BEF induces an electric field at the interface,prompting charge transfer from Co to NiCoP.This transfer modulates asymmetric charge distributions,which intricately control intermediates’adsorption and desorption dynamics.Such regulation is crucial for enhancing the reaction kinetics of both HER and OER.Furthermore,under oxidative conditions,the NiCoP–Co/MXene catalyst undergoes a structural metamorphosis into Ni(Co)oxides/hydroxides/MXene,increasing OER performance.This research demonstrates the BEF’s role in fine-tuning interfacial charge redistribution and underscores its potential in crafting more sophisticated electrocatalytic designs.The insights gained here could pave the way for the next generation of electrocatalysis,with far-reaching implications for energy conversion and storage technologies.展开更多
Based on the rapid advancements in nanomaterials and nanotechnology,the Nanofluidic Reverse Electrodialysis(NRED)has attracted significant attention as an innovative and promising energy conversion strategy for extrac...Based on the rapid advancements in nanomaterials and nanotechnology,the Nanofluidic Reverse Electrodialysis(NRED)has attracted significant attention as an innovative and promising energy conversion strategy for extracting sustainable and clean energy fromthe salinity gradient energy.However,the scarcity of research investigating the intricate multi-factor coupling effects on the energy conversion performance,especially the trade-offs between ion selectivity and mass transfer in nanochannels,of NRED poses a great challenge to achieving breakthroughs in energy conversion processes.This numerical study innovatively investigates the multi-factor coupling effect of three critical operational factors,including the nanochannel configuration,the temperature field,and the concentration difference,on the energy conversion processes of NRED.In this work,a dimensionless amplitude parameter s is introduced to emulate the randomly varied wall configuration of nanochannels that inherently occur in practical applications,thereby enhancing the realism and applicability of our analysis.Numerical results reveal that the application of a temperature gradient,which is oriented in opposition to the concentration gradient,enhances the ion transportation and selectivity simultaneously,leading to an enhancement in both output power and energy conversion efficiency.Additionally,the increased fluctuation of the nanochannel wall from s=0 to s=0.08 improves ion selectivity yet raises ion transport resistance,resulting in an enhancement in output power and energy conversion efficiency but a slight reduction in current.Furthermore,with increasing the concentration ratio cH/cL from 10 to 1000,either within a fixed temperature field or at a constant dimensionless amplitude,the maximumpower consistently attains its optimal value at a concentration ratio of 100 but the cation transfer number experiences amonotonic decrease across this entire range of concentration ratios.Finally,uponmodifying the operational parameters fromthe baseline condition of s=0,c_(H)/c_(L)=10,andΔT=0 K to the targetedconditionof s=0.08,c_(H)/c_(L)=50,andΔT=25 K,there is a concerted improvement observed in the open-circuit potential,short-circuit current,andmaximumpower,with respective increments of 8.86%,204.97%,and 232.01%,but a reduction in cation transfer number with a notable decrease of 15.37%.展开更多
Reconstructing the trajectories of charged particles in high-energy physics experiments is a complex task,particularly for long-lived particles.At the future Super Tau-Charm Facility(STCF),such particles are expected ...Reconstructing the trajectories of charged particles in high-energy physics experiments is a complex task,particularly for long-lived particles.At the future Super Tau-Charm Facility(STCF),such particles are expected to appear in several key benchmark physics processes.A Common Tracking Software was used to reconstruct the trajectories of long-lived particles,revealing that the track-finding performance of the widely used combinatorial Kalman filter is limited by its seeding algorithm.This limitation can be mitigated by guiding the combinatorial Kalman filter using initial tracks provided by the Hough transform.The track-finding performance of the combined Hough transform and combinatorial Kalman filter was evaluated using the process J∕ψ→Λ(→pπ−)Λ(→pπ+)at STCF.展开更多
With the rapid development of lithium batteries,it’s of great significance to ensure the safe use of it.An ultrasound imaging system based on fiber optic ultrasound sensor has been developed to monitor the internal c...With the rapid development of lithium batteries,it’s of great significance to ensure the safe use of it.An ultrasound imaging system based on fiber optic ultrasound sensor has been developed to monitor the internal changes of lithium batteries.Based on Fabry-Perot interferometer(FPI)structure which is made of a glass plate and an optical fiber pigtail,the ultrasound imaging system possesses a high sensitivity of 558 mV/kPa at 500 kHz with the noise equivalent pressure(NEP)of only 63.5 mPa.For the frequency response,the ultrasound sensitivity is higher than 13.1 mV/kPa within the frequency range from 50 kHz to 1 MHz.Meanwhile,the battery imaging system based on the proposed sensor has a superior resolution as high as 0.5 mm.The performance of battery safety monitoring is verified,in which three commercial lithium-ion ferrous phosphate/graphite(LFP||Gr)batteries are imaged and the state of health(SOH)for different batteries is obtained.Besides,the wetting process of an anode-free lithium metal batteries(AFLMB)is clearly observed via the proposed system,in which the formation process of the pouch cell is analyzed and the gas-related"unwetting"condition is discovered,representing a significant advancement in battery health monitoring field.In the future,the commercial usage can be realized when sensor array and artificial intelligence technology are adopted.展开更多
Anxiety disorders,characterized by persistent apprehension,somatic symptoms and fatigue,are leading causes of disability worldwide.The burgeoning therapeutic potential of aerobic exercise has gained prominence as a le...Anxiety disorders,characterized by persistent apprehension,somatic symptoms and fatigue,are leading causes of disability worldwide.The burgeoning therapeutic potential of aerobic exercise has gained prominence as a leading non-pharmacological strategy,with evidence supporting its effectiveness in alleviating anxiety across diverse conditions.This review synthesizes current research to clarify the molecular mechanisms through which aerobic exercise ameliorates anxiety in terms of the effects of exercise on the hypothalamic–pituitary–adrenal(HPA)axis,the hepatic-brain axis and epigenetics;electroencephalographic alterations;inflammatory pathways;the balance between oxidative and nitrogenous stress;various substances,such as brain-derived neurotrophic factor(BDNF),atrial natriuretic peptide(ANP),and opioid peptides;and the 5-HT2C receptor and cannabinoid receptor type-1(CB1R),among others,reflecting the positive modulatory effects of aerobic exercise on anxiety.As a non-pharmacological intervention,aerobic exercise has been demonstrated to be useful in a variety of medical applications and has considerable potential for ameliorating symptoms of anxiety.展开更多
基金partially funded by the National Natural Science Foundation of China(52074255,52274412)。
文摘Silicon nanowires(SiNWs)have been used in a wide variety of applications over the past few decades due to their excellent material properties.The only drawback is the high production cost of SiNWs.The preparation of SiNWs from photovoltaic waste silicon(WSi)powders,which are high-volume industrial wastes,not only avoids the secondary energy consumption and environmental pollution caused by complicated recycling methods,but also realizes its high-value utilization.Herein,we present a method to rapidly convert photovoltaic WSi powders into SiNWs products.The flash heating and quenching provided by carbothermal shock induce the production of free silicon atoms from the WSi powders,which are rapidly reorganized and assembled into SiNWs during the vapor-phase process.This method allows for the one-step composite of SiNWs and carbon cloth(CC)and the formation of SiC at the interface of the silicon(Si)and carbon(C)contact to create a stable chemical connection.The obtained SiNWs-CC(SiNWs@CC)composites can be directly used as lithium anodes,exhibiting high initial coulombic efficiency(86.4%)and stable cycling specific capacity(2437.4 mA h g^(-1)at 0.5 A g^(-1)after 165 cycles).In addition,various SiNWs@C composite electrodes are easily prepared using this method.
基金supported by the National Natural Science Foundation of China(No.U21B2062).
文摘The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set incorporating innovative fault labels to train a U-Net-structured CNN model,enabling effective identification of small-scale strike-slip faults through seismic data interpretation.Based on the CNN faults,we analyze the distribution patterns of small-scale strike-slip faults.The small-scale strike-slip faults can be categorized into NNW-trending and NE-trending groups with strike lengths ranging 200–5000 m.The development intensity of small-scale strike-slip faults in the Lower Yingshan Member notably exceeds that in the Upper Member.The Lower and Upper Yingshan members are two distinct mechanical layers with contrasting brittleness characteristics,separated by a low-brittleness layer.The superior brittleness of the Lower Yingshan Member enhances the development intensity of small-scale strike-slip faults compared to the upper member,while the low-brittleness layer exerts restrictive effects on vertical fault propagation.Fracture-vug systems formed by interactions of two or more small-scale strike-slip faults demonstrate larger sizes than those controlled by individual faults.All fracture-vug system sizes show positive correlations with the vertical extents of associated small-scale strike-slip faults,particularly intersection and approaching fracture-vug systems exhibit accelerated size increases proportional to the vertical extents.
基金supported by research grants from the Ningbo Science and Technology Plan Project,No.2022Z143hezuo(to BL)the National Natural Science Foundation of China,No.82201520(to XD)。
文摘Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently understood.As potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet known.In the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of action.In vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial polarization.Lipopolysaccharide,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were administered.RNA-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of dexamethasone.The Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our hypothesis.High-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain injury.Thus dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in vivo.Glucocorticoid receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain injury.Additionally,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is the GR/JAK1/STAT3 pathway.Overactivation of glucocorticoid receptor by high-dose dexamethasone reduced the expression of M2 microglia,which plays an antiinflammatory role.In contrast,inhibiting the activation of glucocorticoid receptor reduced the number of apoptotic glia and neurons and decreased the loss of dendritic spines after traumatic brain injury.Dexamethasone may exe rt its neurotoxic effects by inhibiting M2 microglia through the GR/JAK1/STAT3 signaling pathway.
基金supported by grants from the National Natural Science Foundation of China(Nos.22074015 and 82074428)Youth Talent Cultivation Initiation Fund of Zhongda Hospital,Southeast University(No.CZXM-GSP-RC110)to Hao Li+1 种基金Evidence-Based Capacity Building for TCM Specialty Therapies for Skin Diseases of National Administration of TCMInnovative Team Projects of Shanghai Municipal Commission of Health(No.2022CX011)to Fulun Li.
文摘Antifungal resistance is the leading cause of antifungal treatment failure in invasive candidiasis.Metabolic rewiring could become a new insight to account for antifungal resistance as to find innovative clinical therapies.Here,we show that dynamic surface-enhanced Raman spectroscopy is a promising tool to identify the metabolic differences between fluconazole(Diflucan)-resistant and fluconazole(Diflucan)-sensitive Candida albicans through the signatures of biochemical components and complemented with machine learning algorithms and two-dimensional correlation spectroscopy,an underlying resistance mechanism,that is,the change of purine metabolites induced the resistance of Candida albicans has been clarified yet never reported anywhere.We hope the integrated methodology introduced in this work could be beneficial for the interpretation of cellular regulation,propelling the development of targeted antifungal therapies and diagnostic tools for more efficient management of severe antifungal resistance.
基金supported by National Natural Science Foundation of China(No.22209075)。
文摘Solid-state batteries(SSBs)with thermal stable solid-state electrolytes(SSEs)show intrinsic capacity and great potential in energy density improvement.SSEs play critical role,however,their low ionic conductivity at room temperature and high brittleness hinder their further development.In this paper,polypropylene(PP)-polyvinylidene fluoride(PVDF)-Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP)-Lithium bis(trifluoromethane sulphonyl)imide(LiTFSI)multi-layered composite solid electrolyte(CSE)is prepared by a simple separator coating strategy.The incorporation of LATP nanoparticle fillers and high concentration LiTFSI not only reduces the crystallinity of PVDF,but also forms a solvation structure,which contributes to high ionic conductivity in a wide temperature.In addition,using a PP separator as the supporting film,the mechanical strength of the electrolyte was improved and the growth of lithium dendrites are effectively inhibited.The results show that the CSE prepared in this paper has a high ionic conductivity of 6.38×10^(-4)S/cm at room temperature and significantly improves the mechanical properties,the tensile strength reaches 11.02 MPa.The cycle time of Li/Li symmetric cell assembled by CSE at room temperature can exceed 800 h.The Li/LFP full cell can cycle over 800 cycles and the specific capacity of Li/LFP full cell can still reach 120 m Ah/g after 800 cycles at 2 C.This CSE has good cycle stability and excellent mechanical strength at room temperature,which provides an effective method to improve the performance of solid electrolytes under moderate condition.
基金supported by the Shenzhen Science and Technology Program(No.JCYJ20220818100407016)the National Natural Science Foundation of China(No.22275059)+1 种基金Guangdong Special Support Program(No.2021TX06L775)high-level special funds(No.G03050K002)。
文摘High-voltage LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)cathodes are critical for enhancing the energy density of lithium-ion batteries(LIBs).The development of binders compatible with high-voltage NCM811 cathode materials is crucial to enhance the electrochemical performance of LIBs.However,the traditional fluoropolymer binder,poly(vinylidene difluoride)(PVDF),can potentially leach components or break down into poly(fluoroalkyl substances)(PFAS)chemicals,thereby contributing to PFAS contamination.A novel fluorine-free polymer,polysulfone-polyamide-polyimide(SPIO),was designed and synthesized as a binder for NCM811 cathodes.The SPIO binder exhibits exceptional mechanical properties and superior electrochemical characteristics.The cathode film fabricated with SPIO demonstrated a remarkable delamination force of 8 N(390 N·m^(-1)),indicating robust adhesion.The Li‖NCM811 cell incorporating the SPIO binder retained 80%of its initial capacity after 300 cycles at a current density of 0.2 C.In comparison,the control cells assem bled with the PVDF binder retained only 52%of their capacities under the same cycling conditions.Furthermore,the SPIO binder exhibited improved compatibility with the electrolyte.Transmission electron microscopy analysis of the cathode films after 100 cycles revealed the formation of a unifo rm,dense,and continuous chemical-electrochemical interface(CEI)by the SPIO binder on the surface of the NCM811 particles,which significantly contributed to the enhancement of the electrochemical performance.These results highlight the potential of SPIO as an advanced binder material for high-perfo rmance lithium-ion batteries.
基金Project supported by the National Key R&D Program of China (2021YFC2901500)National Natural Science Foundation of China(22208349)+1 种基金Shandong Provincial Natural Science Youth Fund (ZR2022QB244)Shandong Energy Institute Innovation Fund (SEII202107, SEII202133)。
文摘A novel hydroxy late-rich functionalized biosorbent by grafting citric acid on the decrystallized Dicranopteris dichotoma stem(DDS) was prepared.The obtained g-DDS-3 exhibits good hydrophilicity,thermal stability and superior adsorption performance for Ce^(3+).The effects of citric acid dosage,pH and initial Ce^(3+)concentration on the adsorption experiments were investigated.The maximum adsorption capacity(Langmuir model) of Ce^(3+)by g-DDS-3 is 131.0 mg/g at pH of 7.0,which surpasses that of most previously reported biomass-based materials.Adsorption kinetic results indicate that the adsorption process conforms to the pseudo-second-order model and can achieve equilibrium quickly.By analyzing the adsorption mechanism,we find that carboxyl groups are uniformly distributed on the surface of g-DDS-3 post modification,which provides abundant adsorption sites,and the adsorption is primarily driven by the ion exchange between Ce^(3+)and carboxyl groups protons.In addition,the adsorption-desorption experiments suggest that the g-DDS-3 has excellent recyclability since the adsorption capacity still remain above 90% after five cycles.These findings prove that carboxylate-rich modified D.dichotoma has great potential for application in the effective separation and recovery of Ce^(3+)from leaching tailings.
基金funded by the National Natural Science Foundation of China(82174104 and 22104158)Guangzhou Science and Technology Program(2023B03J1382)+2 种基金Nansha Science and Technology Program(2022ZD004)Science and Technology Innovation Strategy of Guangdong Province(2020A1111350001)Natural Science Foundation of Hunan Province(2021JJ40041)。
文摘Gallic acid(GA),a plant phenol ubiquitously present in fruits and vegetables,has demonstrated efficacy in ameliorating ulcerative colitis(UC).Despite previous reports,the precise mechanism of GA's therapeutic action remains elusive.Herein,the present study aims to delineate the mechanism underlying the anti-UC effects of GA by focusing on the interplay of gut microbiota,microbial and host cometabolites,and gut immune regulation.The findings revealed that GA treatment improved the colitis symptoms and systematic inflammatory response,reliant on gut microbiota,as evidenced by microbiota depletion and fecal microbiota transplantation.According to the 16S r DNA sequencing results,GA altered the gut microbiota community structure and upregulated the biosynthesis of secondary bile acids(SBAs).Metabolomics and flow cytometry(FCS)analysis revealed a substantial increase in SBAs production,including ursodeoxycholic acid(UDCA),lithocholic acid(LCA),3-oxo-lithocholic acid(3-oxo-LCA)and iso-allolithocholic acid(Isoallo LCA),which further upregulated the proportion of regulatory T(Treg)cells and downregulated the proportion of T helper type 17(Th17)cells in the colon,ultimately resulting in an improved Treg/Th17 balance.Further FCS and real-time quantitative PCR assays provided mechanistic insights,demonstrating that UDCA and Isoallo LCA facilitate Treg cell differentiation through the upregulation of nuclear hormone receptor 4A1(NR4A1).This research elucidated that GA effectively mitigates colitis by modulating the Treg/Th17 balance,facilitated by the enhanced synthesis of microbiota-derived SBAs.These insights unveil innovative pathways through which GA exerts its anti-UC effects,emphasizing the potential therapeutic benefits of incorporating a GAenriched diet into UC management.
基金financially supported by the National Natural Science Foundation of China(NSFC)(No.42202154)the Science Foundation of China University of Petroleum,Beijing(No.ZX20220074)。
文摘This paper is a synthetic use of carbon isotope composition,Rock-Eval data,organic petrology,element composition of kerogen,major and trace elements,and biomarker characteristic of the Permian Pingdiquan(P_(2)p)source rocks in the Wucaiwan sag,Junggar Basin,China as proxies(1)for evaluations of hydrocarbon potential,organic matter(OM)composition and thermal maturity of the OM in the source rocks,(2)for reconstruction of paleodepositional environment,and(3)for analysis of controlling factor of organic carbon accumulation.The P_(2)p Formation developed good-excellent source rocks with thermal maturity of OM ranging from low-mature to mature stages.The OM was mainly composed of C_(3)terrestrial higher plants and aquatic organisms including aerobic bacteria,green sulfur bacteria,saltwater and fresh algae,Sphagnum moss species,submerged macrophytes,Nymphaea,and aquatic pollen taxa.The proportion of terrestrial higher plants decreased and that of aquatic organisms increased from margin to center of the sag.The benthic water within reducing environment and brackishwater column were superposed by periodic/occasional fresh-water influx(e.g.,rainfall and river drain),which led to fresh-water conditions and well oxygenating in the water column during overturn process.The whole study area developed lacustrine source rocks without seawater intrusion.During periodic/occasional fresh-water influx periods with plenty of terrestrial plant inputs,the paleoredox conditions of the sag were relatively oxic in the shallow fresh-water which experienced strong oxidation and decomposition of OM,therefore were not conducive for the OM preservation.However,the overall middle primary productivity made up for this deficiency,and was the main controlling factor on the organic carbon accumulation.A suitable supply from terrestrial inputs can promote biotic paleoproductivity,and a relatively high sedimentation rate can reduce oxidation and decomposition times of OM.On the contrary,during the intervals of the fresh-water influxes,relatively reducing conditions are a more important controlling factor on the OM accumulation in the case that the decrease of the terrestrial biotic source.
基金supported the Natural Science Foundation of Guangdong Province(Nos.2022A1515140085,2022A1515111022 and 2022A1515110275)the Major and Special Project in the Field of Intelligent Manufacturing of the Universities in Guangdong Province(No.2020ZDZX2067)+2 种基金the Natural Science Foundation of Huizhou University(No.HZU202004)the Professorial and Doctoral Scientific Research Foundation of Huizhou University(No.2020JB046)the Open Project Program of Guangdong Provincial Key Laboratory of Electronic Functional Materials and Devices,Huizhou University(No.EFMDN2021004M).
文摘Developing cost-effective and high-activity catalysts for the methanolysis of ammonia borane(AB)has attracted great attention in the field of hydrogen energy recently.Besides the modification of the electronic structure of the catalysts,external factors such as visible light irradiation can improve the efficiency of hydrogen production as well.In the present study,a Z-scheme heterostructured VO-Cu_(0.5)Ni_(0.5)O catalysts were constructed by introducing a plenteous phase interface and oxygen vacancy(Vo).The catalytic activity of as-prepared VO-Cu_(0.5)Ni_(0.5)O toward AB methanolysis has been improved dramatically with the assistance of visible light irradiation.The turnover frequency(TOF)under visible light irradiation was measured to be 29_(mol)H_(2)·mol_(cat.)^(-1)·min^(-1),which is 1.4 times larger than the TOF in the absence of visible light.Systematic characterization experiments and density functional theory(DFT)calculations were conducted to unveil the causation of enhanced catalytic activity.The results demonstrated that the enhancement of the catalytic activity of VO-Cu_(0.5)Ni_(0.5)O originated from the electronic structure modification induced by the formation of heterojunctions,the introduction of oxygen vacancies,and the assistance of visible light cooperatively.The formation of heterojunction and the introduction of oxygen vacancies provoked the upshift of the d-band center;while the visible light irradiation induced the photogenerated electrons to transfer from Cu to Ni sites at the interface.Such electron structure modulation is beneficial for the construction of abundant active sites,thereby enhancing the adsorption of methanol on the Ni sites,which is considered as the rate-determine step for the methanolysis of AB.The strong interaction between Ni and O weakened the O-H bond of methanol,accelerating the methanolysis of AB.These results demonstrate the utilization of combined heterojunction,oxygen vacancy,and visible light to explore highly active AB methanolysis catalysts,which should shed light on the exploration of more effective catalysts for AB methanolysis.
基金supported by the National Natural Science Foundation of China(No.22074058,S.Li).
文摘Algal copper uptake(i.e.,Cu bioavailability)in the euphotic zone plays a vital role in algal photosynthesis and respiration,affecting the primary productivity and the source and sink of atmospheric carbon.Algal Cu uptake is controlled by natural dissolved organic Cu(DOCu)speciation(i.e.,complexed with the dissolved organic matter)that conventionally could be tested by model prediction or molecular-level characterizations in the lab,while DOCu uptake are hardly directly assessed.Thus,the new chemistrybiology insight into the mechanisms of the Cu uptake process in algae is urgent.The DOCu speciation transformation(organic DOCu to free Cu(II)ions),enzymatic reduction-induced valence change(reduction of free Cu(II)to Cu(I)ions),and algal Cu uptake at the algae-water interface are imitated.Herein,an intelligent system with DOCu colorimetric sensor is developed for real-time monitoring of newly generated Cu(I)ions.Deep learning with whole sample image-based characterization and powerful feature extraction capabilities facilitates colorimetric measurement.In this context,the Cu bioavailability with 7 kinds of organic ligands(e.g.,amino acids,organic acids,carbohydrates)can be predicted by the mimetic intelligent biosensor within 15.0min,i.e.,the DOCu uptake and speciation is successfully predicted and streamlined by the biomimetic approach.
基金financial support from the Project of Health Research Talents of Jilin Province(2023SCZ21)the Department of Science and Technology of Jilin Province(20220202076NC,20220202088NC).
文摘Gastrodin(GAS),the principal bioactive composition of Gastrodia elata Blume,has potential for pharmaceutical applications.Several studies in recent years have shown that GAS may enhance neurotrophic benefits,reduce inflammation,and act as an antioxidant.In this study,we sought to identify the molecular mechanisms underlying the protective benefits of GAS against colitis induced by dextran sodium sulfate(DSS)in mice.GAS(200 mg/kg)significantly ameliorated the severity of colitis in mice caused by DSS,as evidenced by an increase in colon length,a reduction in disease activity index,a decrease in tissue damage,and a reduction in body weight loss.Additionally,GAS inhibited DSS-induced hyperactivation of inflammation-related NF-κB signaling pathways to reduce the production of inflammatory mediators,thereby mitigating the inflammatory response in mice.Furthermore,the administration of GAS restored the function of the gastrointestinal barrier by increasing the count of goblet cells,as well as the levels of tight junction associated proteins,including Zonula occludens-1(ZO-1),Occludin,and Claudin-3.GAS also influenced the overall richness of the gut microbiota,as shown by 16S rRNA sequencing analysis,consequently boosting the proliferative rate of probiotic species,such as Lachnospiraceae and Muribaculaceae,while reducing the richness of harmful bacteria including Escherichia_Shigella,Enterobacteriaceae,Bacteroidaceae,and Bacteroides.GAS(200 mg/kg)alleviated ulcerative colitis(UC)by modulating gut dysbiosis,as demonstrated by a fecal microbial transplantation(FMT)test.Furthermore,inflammatory damage induced by lipopolysaccharide(LPS)was averted in RAW264.7 cells by GAS administration,hence preventing the NF-κB signaling pathway from being activated in these experimental conditions conducted in vitro.Overall,the data indicate that GAS treatment effectively reduces colitis caused by DSS by regulating gut microbiota,suppressing inflammation,and preserving the mucosal barrier integrity.
基金supported by Research Grants of the NRF(2023R1A2C2003823,RS-2024-00405818)funded by the National Research Foundation under the Ministry of Science,ICT&Future,Korea。
文摘Employing multiple metals for synergistic electronic structure regulation emerges as a promising approach to develop highly efficient and robust electrocatalysts for hydrogen evolution at ampere levels.In this study,a series of Schreibersite-type intermetallic compounds,particularly Mo_(2)Fe_(0.8)Ru_(0.2)P,are synthesized through high-temperature solid-phase synthesis.Experimental results demonstrate that the integration of Ru significantly improves the kinetics of proton adsorption and desorption during the hydrogen evolution reaction(HER).Additionally,density functional theory(DFT)calculations and X-ray absorption near edge structure(XANES)analyses effectively corroborate the pronounced d-orbital hybridization of Fe within the structure,which facilitates the transfer of hydroxide ions and the maintenance of material durability during alkaline HER processes.Remarkably,Mo_(2)Fe_(0.8)Ru_(0.2)P exhibits superior alkaline HER activity,characterized by an overpotential of merely 48 mV at a current density of 10 mA cm^(-2).After prolonged operation of 1000 h at high current densities(1.1 A cm^(-2)),the activity decline remains minimal,under 4%(with overpotential increasing from 258 mV to 268 mV).These results demonstrate the potential of strategically combining metallic elements to design high-performance industrial-grade electrocatalysts.
基金supported by the National Nature Science Foundation of China(NSFC)(U2241236,1220041913,52473253)the National Key Research and Development Program of China(2022ZDZX0007)+1 种基金Fundamental Research Open Subject Grant Program of Yantai Advanced Materials and Green Manufacturing Laboratory of Shandong Province(AMGM2024F15)Yunnan Major Scientific and Technological Projects(202402AB080011).
文摘The relentless pursuit of advanced X-ray detection technologies has been significantly bolstered by the emergence of metal halides perovskites(MHPs)and their derivatives,which possess remarkable light yield and X-ray sensitivity.This comprehensive review delves into cutting-edge approaches for optimizing MHP scintillators performances by enhancing intrinsic physical properties and employing engineering radioluminescent(RL)light strategies,underscoring their potential for developing materials with superior high-resolution X-ray detection and imaging capabilities.We initially explore into recent research focused on strategies to effectively engineer the intrinsic physical properties of MHP scintillators,including light yield and response times.Additionally,we explore innovative engineering strategies involving stacked structures,waveguide effects,chiral circularly polarized luminescence,increased transparency,and the fabrication of flexile MHP scintillators,all of which effectively manage the RL light to achieve high-resolution and high-contrast X-ray imaging.Finally,we provide a roadmap for advancing next-generation MHP scintillators,highlighting their transformative potential in high-performance X-ray detection systems.
文摘As a new type of pollutant,the harm caused by microplastics(MPs)to organisms has been the research focus.Recently,the proportion of MPs ingested through the digestive tract has gradually increased with the popularity of fast-food products,such as takeout.The damage to the digestive system has attracted increasing attention.We reviewed the literature regarding toxicity of MPs and observed that they have different effects on multiple organs of the digestive system.The mechanism may be related to the toxic effects of MPs themselves,interactions with various substances in the biological body,and participation in various signaling pathways to induce adverse reactions as a carrier of toxins to increase the time and amount of body absorption.Based on the toxicity mechanism of MPs,we propose specific suggestions to provide a theoretical reference for the government and relevant departments.
基金supported by Guangdong Basic and Applied Basic Research Foundation(Nos.2021A1515010261 and 2023A1515140153)Guangdong Special Innovative Projects of General Universities(No.2022KTSCX136)+1 种基金the Major and Special Project in the Field of Intelligent Manufacturing of the Universities in Guangdong Province(No.2020ZDZX2067)the Innovative Team Project of the Universities in Guangdong Province(No.2023KCXTD035).
文摘The quest for sustainable energy solutions has intensified the need for efficient water electrolysis techniques,pivotal for hydrogen production.However,developing effective bifunctional electrocatalysts capable of driving the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)remains a formidable challenge.Addressing this,we introduce a novel built-in electric field(BEF)strategy to synthesize NiCoP–Co nanoarrays directly on Ti_(3)C_(2)T_(x) MXene substrates(NiCoP–Co/MXene).This approach leverages a significant work function difference(ΔΦ),propelling these nanoarrays as adept bifunctional electrocatalysts for comprehensive water splitting.MXene,in this process,plays a dual role.It acts as a conductive support,enhancing the catalyst’s overall conductivity,and facilitates an effective charge transport pathway,ensuring efficient charge transfer.Our study reveals that the BEF induces an electric field at the interface,prompting charge transfer from Co to NiCoP.This transfer modulates asymmetric charge distributions,which intricately control intermediates’adsorption and desorption dynamics.Such regulation is crucial for enhancing the reaction kinetics of both HER and OER.Furthermore,under oxidative conditions,the NiCoP–Co/MXene catalyst undergoes a structural metamorphosis into Ni(Co)oxides/hydroxides/MXene,increasing OER performance.This research demonstrates the BEF’s role in fine-tuning interfacial charge redistribution and underscores its potential in crafting more sophisticated electrocatalytic designs.The insights gained here could pave the way for the next generation of electrocatalysis,with far-reaching implications for energy conversion and storage technologies.
基金funded by the National Natural Science Foundation of China[52106246]the Postgraduate Research&Practice innovation Program of Jiangsu Province[KYCX24_1641].
文摘Based on the rapid advancements in nanomaterials and nanotechnology,the Nanofluidic Reverse Electrodialysis(NRED)has attracted significant attention as an innovative and promising energy conversion strategy for extracting sustainable and clean energy fromthe salinity gradient energy.However,the scarcity of research investigating the intricate multi-factor coupling effects on the energy conversion performance,especially the trade-offs between ion selectivity and mass transfer in nanochannels,of NRED poses a great challenge to achieving breakthroughs in energy conversion processes.This numerical study innovatively investigates the multi-factor coupling effect of three critical operational factors,including the nanochannel configuration,the temperature field,and the concentration difference,on the energy conversion processes of NRED.In this work,a dimensionless amplitude parameter s is introduced to emulate the randomly varied wall configuration of nanochannels that inherently occur in practical applications,thereby enhancing the realism and applicability of our analysis.Numerical results reveal that the application of a temperature gradient,which is oriented in opposition to the concentration gradient,enhances the ion transportation and selectivity simultaneously,leading to an enhancement in both output power and energy conversion efficiency.Additionally,the increased fluctuation of the nanochannel wall from s=0 to s=0.08 improves ion selectivity yet raises ion transport resistance,resulting in an enhancement in output power and energy conversion efficiency but a slight reduction in current.Furthermore,with increasing the concentration ratio cH/cL from 10 to 1000,either within a fixed temperature field or at a constant dimensionless amplitude,the maximumpower consistently attains its optimal value at a concentration ratio of 100 but the cation transfer number experiences amonotonic decrease across this entire range of concentration ratios.Finally,uponmodifying the operational parameters fromthe baseline condition of s=0,c_(H)/c_(L)=10,andΔT=0 K to the targetedconditionof s=0.08,c_(H)/c_(L)=50,andΔT=25 K,there is a concerted improvement observed in the open-circuit potential,short-circuit current,andmaximumpower,with respective increments of 8.86%,204.97%,and 232.01%,but a reduction in cation transfer number with a notable decrease of 15.37%.
基金supported by the National Natural Science Foundation of China(Nos.12375194,12341504,12375197,12025502)。
文摘Reconstructing the trajectories of charged particles in high-energy physics experiments is a complex task,particularly for long-lived particles.At the future Super Tau-Charm Facility(STCF),such particles are expected to appear in several key benchmark physics processes.A Common Tracking Software was used to reconstruct the trajectories of long-lived particles,revealing that the track-finding performance of the widely used combinatorial Kalman filter is limited by its seeding algorithm.This limitation can be mitigated by guiding the combinatorial Kalman filter using initial tracks provided by the Hough transform.The track-finding performance of the combined Hough transform and combinatorial Kalman filter was evaluated using the process J∕ψ→Λ(→pπ−)Λ(→pπ+)at STCF.
基金supports from China National Funds for Distinguished Young Scientists(62425505)National Natural Science Foundation of China(U22A20206)+1 种基金the China Postdoctoral Science Foundation(2023M731188)the Fundamental Research Funds for the Central Universities(2024BRA012).
文摘With the rapid development of lithium batteries,it’s of great significance to ensure the safe use of it.An ultrasound imaging system based on fiber optic ultrasound sensor has been developed to monitor the internal changes of lithium batteries.Based on Fabry-Perot interferometer(FPI)structure which is made of a glass plate and an optical fiber pigtail,the ultrasound imaging system possesses a high sensitivity of 558 mV/kPa at 500 kHz with the noise equivalent pressure(NEP)of only 63.5 mPa.For the frequency response,the ultrasound sensitivity is higher than 13.1 mV/kPa within the frequency range from 50 kHz to 1 MHz.Meanwhile,the battery imaging system based on the proposed sensor has a superior resolution as high as 0.5 mm.The performance of battery safety monitoring is verified,in which three commercial lithium-ion ferrous phosphate/graphite(LFP||Gr)batteries are imaged and the state of health(SOH)for different batteries is obtained.Besides,the wetting process of an anode-free lithium metal batteries(AFLMB)is clearly observed via the proposed system,in which the formation process of the pouch cell is analyzed and the gas-related"unwetting"condition is discovered,representing a significant advancement in battery health monitoring field.In the future,the commercial usage can be realized when sensor array and artificial intelligence technology are adopted.
基金supported by the National Natural Science Foundation of China(No.82405550 and No.82374584).
文摘Anxiety disorders,characterized by persistent apprehension,somatic symptoms and fatigue,are leading causes of disability worldwide.The burgeoning therapeutic potential of aerobic exercise has gained prominence as a leading non-pharmacological strategy,with evidence supporting its effectiveness in alleviating anxiety across diverse conditions.This review synthesizes current research to clarify the molecular mechanisms through which aerobic exercise ameliorates anxiety in terms of the effects of exercise on the hypothalamic–pituitary–adrenal(HPA)axis,the hepatic-brain axis and epigenetics;electroencephalographic alterations;inflammatory pathways;the balance between oxidative and nitrogenous stress;various substances,such as brain-derived neurotrophic factor(BDNF),atrial natriuretic peptide(ANP),and opioid peptides;and the 5-HT2C receptor and cannabinoid receptor type-1(CB1R),among others,reflecting the positive modulatory effects of aerobic exercise on anxiety.As a non-pharmacological intervention,aerobic exercise has been demonstrated to be useful in a variety of medical applications and has considerable potential for ameliorating symptoms of anxiety.
