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基于FXR-MRP2/BSEP通路探究车前子水提物对环磷酰胺致大鼠肝损伤的保护作用及机制研究 被引量:6
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作者 陈浩 赵威 +4 位作者 俞浩 刘汉珍 马世堂 宓穗卿 王宁生 《中药药理与临床》 CAS CSCD 北大核心 2018年第5期85-90,共6页
目的:观察车前子水提物对肿瘤化疗药物环磷酰胺引起的大鼠肝损伤的保护作用,并探究基于FXR-MRP2/BSEP通路探究车前子水提物发挥保护作用的机制。方法:将70只雌雄各半的SD大鼠,随机分为空白对照组、肝损模型组、优思弗组(阳性对照,100 mg... 目的:观察车前子水提物对肿瘤化疗药物环磷酰胺引起的大鼠肝损伤的保护作用,并探究基于FXR-MRP2/BSEP通路探究车前子水提物发挥保护作用的机制。方法:将70只雌雄各半的SD大鼠,随机分为空白对照组、肝损模型组、优思弗组(阳性对照,100 mg/kg)、车前子水提物10g生药/kg、5g生药/kg、2.5生药/kg剂量组、京尼平苷酸200mg/kg等7组,每组10只。空白对照组和肝损伤模型组灌胃给予0.5%的羧甲基纤维素钠,其他组灌胃给予相应药物,连续给药10天,除空白对照组,其余各组第3天腹腔注射环磷酰胺200mg/kg 1次。末次给药后,分离肝组织和腹主动脉取血,测定血清谷丙转氨酶(GPT)、谷草酶(GOT)和碱性磷酸酶(ALP)活性以及总胆红素(TB)、直接胆红素(DB)和总胆汁酸(TBA)的含量; Western Blot检测肝组织法尼醇-X受体(FXR)、多药耐药蛋白2(MRP2)、胆盐输出泵(BSEP)的表达; RT-PCR法检测FXR、MRP2、BSEP的基因表达量;苏木素伊红(HE)染色进行肝组织病理组织形态学观察。结果:与肝损伤模型组相比,车前子水提物10g生药/kg、5g生药/kg剂量组、京尼平苷酸200mg/kg明显对抗环磷酰胺引起的大鼠血清中GOT、GPT和ALP的升高,明显改善肝损伤引起的血清中TB、DB、和TBA的含量升高,并缓解环磷酰胺引起的肝组织病变,肝组织中FXR、BSEP和MRP2的蛋白表达量明显升高,肝组织中FXR、BSEP和MRP2的mRNA的表达量显著升高。结论:车前子水提物对环磷酰胺引起大鼠肝损伤具有保护作用,其活性物质可能是京尼平苷酸,其发挥作用的机制可能与上调核受体FXR来改善胆汁酸微循环有关。 展开更多
关键词 车前子 京尼平苷酸 环磷酰胺 肝损伤 法尼醇-X受体
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Management of Chinese Foreign Direct Investment:"One Belt, One Road" Across Eurasia to Africa and Europe Amidst Maritime Tensions in the South China Sea Region
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作者 David A. Jones hanzhen liu 《International Relations and Diplomacy》 2017年第8期486-500,共15页
Outward Foreign Direct Investment (OFDI) from the People's Republic of China ("China") has been expandingworldwide, much as Inward Foreign Direct Investment (IFDI) from the world into China has burgeoned, at ... Outward Foreign Direct Investment (OFDI) from the People's Republic of China ("China") has been expandingworldwide, much as Inward Foreign Direct Investment (IFDI) from the world into China has burgeoned, at leastuntil very recently. Global FDI declined worldwide in 2014, with China's IFDI declining less than many placeselsewhere, resulting in China overtaking the United States as the world's most attractive location for FDI for thefirst time since 2003, before India overtook China in 2015 (Iyengar, 2015). In 2014, meanwhile, for the first time,China's OFDI exceeded its IFDI, rendering it a net exporter of FDI, signaling the end of the approach to the end ofChina as a developing nation (Yao & Wang, 2014). What does this mean? More than anything else, one mustconsider two factors in assessing China's 21st century foreign ambitions: Is its One Belt, One Road (OBOR) ageopolitical tetrahedron as some allege, if so, economically or militarily? Is its maritime policy across the WesternPacific Rim of Asia aimed at constructing a fleet of surface cruisers and submarines to wage a guerre de course(war of the chase), much as German vice admiral Wolfgang Wegener urged Imperial Germany to do in world War Ithen Nazi Germany to do in World War II, in an effort to dominate merchant sea routes thereby disrupting supplieswithout recourse to a "balanced fleet" such as Britain possessed in World Wars I and II and the United Statesoperates currently? Both China's "New Silk Road" and the "New Maritime Silk Route" are at the root of ageopolitical tetrahedron. Chinese domination of the South China Sea and to a lesser extent of the East China Searegions signals its potential guerre de course strategy. Is there an antidote to conflict in Asia, if so, what is it? 展开更多
关键词 China guerre de course strategy NEW SILK Road NEW MARITIME SILK Route
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