Background and Objectives:This study investigated the iodine status of pregnant women at an average altitude of approximately 2000 meters in Qujing,China.The relationship between iodine and thyroid function in differe...Background and Objectives:This study investigated the iodine status of pregnant women at an average altitude of approximately 2000 meters in Qujing,China.The relationship between iodine and thyroid function in different trimesters as well as adverse pregnancy and fetal outcomes were also investigated.Methods and Study Design:A total of 1,025 pregnant women who were admitted to Qujing Affiliated Hospital of Kunming Medical Univer sity from January 2019 to August 2021 were included.Urinary iodine concentration(UIC)was detected by color imetric method,and serum thyroid function was detected by chemiluminescence.Among them,537 pregnant women were followed up to analyze the association of iodine with adverse pregnancy and fetal outcomes.Re sults:The median UIC was 127μg/L.Serum triiodothyronine,thyroxine,free triiodothyronine,and free thyrox ine were negatively associated with urinary iodine concentration in the first and second trimesters of pregnancy.The proportion of pregnant women testing positive for thyroid peroxidase antibody(TPO-Ab)and the prevalence of thyroid autoimmunity(TAI)increased significantly in more-than-adequate iodine and excess iodine groups.Logistic regression analysis showed maternal iodine was not associated with adverse pregnancy and fetal out comes.Conclusions:Mild iodine deficiency is common among pregnant women in plateau areas of China.The relationship between iodine and thyroid function is significant in the first and second trimesters of pregnancy,es pecially in those with moderate to severe iodine deficiency.Abnormal iodine level in pregnant women was not significantly associated with adverse pregnancy and fetal outcomes in areas with predominantly mild iodine defi ciency.展开更多
基金supported by Yunnan Province Basic Re search Special Program-Kunming Medical University Joint Special Program-Superficial Program(202101AY070001-226)Yunnan Provincial Science and Technology Talents and Plat form Program(202305AD160002)Kunming Medical Uni versity"14th Five-Year Plan"Key Discipline Construction Pro jects.The funders supported the costs of this study.
文摘Background and Objectives:This study investigated the iodine status of pregnant women at an average altitude of approximately 2000 meters in Qujing,China.The relationship between iodine and thyroid function in different trimesters as well as adverse pregnancy and fetal outcomes were also investigated.Methods and Study Design:A total of 1,025 pregnant women who were admitted to Qujing Affiliated Hospital of Kunming Medical Univer sity from January 2019 to August 2021 were included.Urinary iodine concentration(UIC)was detected by color imetric method,and serum thyroid function was detected by chemiluminescence.Among them,537 pregnant women were followed up to analyze the association of iodine with adverse pregnancy and fetal outcomes.Re sults:The median UIC was 127μg/L.Serum triiodothyronine,thyroxine,free triiodothyronine,and free thyrox ine were negatively associated with urinary iodine concentration in the first and second trimesters of pregnancy.The proportion of pregnant women testing positive for thyroid peroxidase antibody(TPO-Ab)and the prevalence of thyroid autoimmunity(TAI)increased significantly in more-than-adequate iodine and excess iodine groups.Logistic regression analysis showed maternal iodine was not associated with adverse pregnancy and fetal out comes.Conclusions:Mild iodine deficiency is common among pregnant women in plateau areas of China.The relationship between iodine and thyroid function is significant in the first and second trimesters of pregnancy,es pecially in those with moderate to severe iodine deficiency.Abnormal iodine level in pregnant women was not significantly associated with adverse pregnancy and fetal outcomes in areas with predominantly mild iodine defi ciency.
