Neurokinin-1 receptor(NK1R),a member of the G protein-coupled receptor(GPCR)family,contributes to multiple pathological processes,including pain,chronic inflammation,and cancer(Gutierrez et al.,2019;Robinson et al.,20...Neurokinin-1 receptor(NK1R),a member of the G protein-coupled receptor(GPCR)family,contributes to multiple pathological processes,including pain,chronic inflammation,and cancer(Gutierrez et al.,2019;Robinson et al.,2023).Current reports and our previous work have proven that NK1R is highly expressed in many cancer cells,such as colorectal cancer and leukemia,and that targeted blocking of NK1R can effectively inhibit tumor cell proliferation(Li XQ et al.,2013;Li JY et al.,2016;Ge et al.,2019;Shi et al.,2021).展开更多
基金supported by the National Natural Science Foundation of China(No.32201092)the Zhejiang Provincial Natural Science Foundation of China(No.LTGY24H180008).
文摘Neurokinin-1 receptor(NK1R),a member of the G protein-coupled receptor(GPCR)family,contributes to multiple pathological processes,including pain,chronic inflammation,and cancer(Gutierrez et al.,2019;Robinson et al.,2023).Current reports and our previous work have proven that NK1R is highly expressed in many cancer cells,such as colorectal cancer and leukemia,and that targeted blocking of NK1R can effectively inhibit tumor cell proliferation(Li XQ et al.,2013;Li JY et al.,2016;Ge et al.,2019;Shi et al.,2021).
