Basophils,which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation,have been neglected by researchers in the past decades.Previous studies have revealed their vit...Basophils,which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation,have been neglected by researchers in the past decades.Previous studies have revealed their vital roles in allergic diseases and parasitic infections.Intriguingly,recent studies even reported that basophils might be associated with cancer development,as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers.However,it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components;the answer may depend on the tumor biology and the microenvironment.Herein,we reviewed the role of basophils in cancers,and highlighted some potential and promising therapeutic strategies.展开更多
Background:Limited knowledge and guidelines exist for invasive intraductal papillary mucinous neoplasm(IPMN).This study aims to explore the significance of lymph node involvement on adjuvant chemotherapy(ACT)for invas...Background:Limited knowledge and guidelines exist for invasive intraductal papillary mucinous neoplasm(IPMN).This study aims to explore the significance of lymph node involvement on adjuvant chemotherapy(ACT)for invasive IPMN.Materials and methods:Patients diagnosed with invasive IPMN were selected from both the Surveillance,Epidemiology,and End Results(SEER)database and our hospital.Kaplan-Meier analysis,Cox proportional hazards model,and propensity score matching(PSM)were used in this study.Results:In the SEER group,multivariate analysis involving 775 patients revealed that several factors including age,tumor differentiation,the American Joint Committee on Cancer(AJCC)T staging,N staging,and tumor node metastasis classification(TNM)stage significantly influenced overall survival(OS)and cancer-specific survival(CSS).Turning to the Zhongshan Hospital group(ZS group),which had 94 recruited patients,multivariate analysis for OS,CSS,and recurrence-free survival(RFS)showed that AJCC N staging emerged as the most significant risk factor,with hazard ratio(HR)values of 4.664,4.955,and 3.175,respectively.In subgroup analysis,ACT provided survival advantages for patients with positive lymph node metastasis(LNM).In a PSM analysis focused on patients with positive LNM,the comparison revealed that ACT emerged as a critical factor influencing both OS and CSS(both P<.005).Especially,these patients younger than 60 years old or those with AJCC-T2-N+staging were found to get apparently benefit from ACT as revealed by our subgroup interaction analysis.Conclusion:LNM plays a pivotal role in the management of invasive IPMN patients who underwent surgery,and ACT might be a beneficial therapeutic option for individuals concurrent with LNM,particularly among those younger than 60 years old,or with AJCC-T2-N+staging.展开更多
基金supported by the Shanghai Sailing Program(No.21YF1407100)the China Postdoctoral Science Foundation(No.2021M690037)+1 种基金the National Natural Science Foundation of China(Nos.82103409 and 81773068)the National Key R&D Program of China(No.2019YFC1315902)。
文摘Basophils,which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation,have been neglected by researchers in the past decades.Previous studies have revealed their vital roles in allergic diseases and parasitic infections.Intriguingly,recent studies even reported that basophils might be associated with cancer development,as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers.However,it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components;the answer may depend on the tumor biology and the microenvironment.Herein,we reviewed the role of basophils in cancers,and highlighted some potential and promising therapeutic strategies.
基金supported by grants from the Shanghai Municipal Health Commission(201940019)National Natural Science Foundation of China(82103417,81827807,81972218,81972257,82103409,82173116,82273382,82272929)+5 种基金Shanghai ShenKang Hospital Development Centre Project(SHDC2020CR2017B)Program of Shanghai Academic/Technology Research Leader(23XD1400600)China Postdoctoral Science Foundation(2021M690037)Shanghai Sailing Program(21YF1407100)Science and Technology Planning Project of Yunnan Province(202305AF150148)Shanghai Municipal Health Commission(20224Y0307).
文摘Background:Limited knowledge and guidelines exist for invasive intraductal papillary mucinous neoplasm(IPMN).This study aims to explore the significance of lymph node involvement on adjuvant chemotherapy(ACT)for invasive IPMN.Materials and methods:Patients diagnosed with invasive IPMN were selected from both the Surveillance,Epidemiology,and End Results(SEER)database and our hospital.Kaplan-Meier analysis,Cox proportional hazards model,and propensity score matching(PSM)were used in this study.Results:In the SEER group,multivariate analysis involving 775 patients revealed that several factors including age,tumor differentiation,the American Joint Committee on Cancer(AJCC)T staging,N staging,and tumor node metastasis classification(TNM)stage significantly influenced overall survival(OS)and cancer-specific survival(CSS).Turning to the Zhongshan Hospital group(ZS group),which had 94 recruited patients,multivariate analysis for OS,CSS,and recurrence-free survival(RFS)showed that AJCC N staging emerged as the most significant risk factor,with hazard ratio(HR)values of 4.664,4.955,and 3.175,respectively.In subgroup analysis,ACT provided survival advantages for patients with positive lymph node metastasis(LNM).In a PSM analysis focused on patients with positive LNM,the comparison revealed that ACT emerged as a critical factor influencing both OS and CSS(both P<.005).Especially,these patients younger than 60 years old or those with AJCC-T2-N+staging were found to get apparently benefit from ACT as revealed by our subgroup interaction analysis.Conclusion:LNM plays a pivotal role in the management of invasive IPMN patients who underwent surgery,and ACT might be a beneficial therapeutic option for individuals concurrent with LNM,particularly among those younger than 60 years old,or with AJCC-T2-N+staging.
