Recently,piezocatalysis has attracted considerable attention as a new type of renewable mechanical energy conversion technology,which relies on the strain induced polarization of the piezoelectric material.This new te...Recently,piezocatalysis has attracted considerable attention as a new type of renewable mechanical energy conversion technology,which relies on the strain induced polarization of the piezoelectric material.This new technology has been extensively applied in the applications of water splitting,water remediation,gas purification and tumor therapy.Despite the rapid development in the piezo-catalysis,the utilization of piezoelectric materials for synthetic purpose is still under exploration.Piezoelectric means to promote or-ganic reactions expand the scope of piezoelectrically mediated reactions and show successes in both organic and polymer synthesis.Herein,we provide a comprehensive review on recent progress of piezoelectrically mediated reactions,catalytic mechanisms and applications in the last few years.The limitations and future directions of this area are also discussed.We believe this review will provide new insights into the underlying mechanism of piezoelectric mediated electron transfer process and guide the design of new chemistry.展开更多
In the field of cancer therapy,inhibiting autophagy has emerged as a promising strategy.However,pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1(PD-L1),enabling tumor i...In the field of cancer therapy,inhibiting autophagy has emerged as a promising strategy.However,pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1(PD-L1),enabling tumor immune evasion.To address this issue,we developed innovative ROS-responsive cationic poly(ethylene imine)(PEI)nanogels using selenol chemistry-mediated multicomponent reaction(MCR)technology.This procedure involved simple mixing of low-molecular-weight PEI(LMW PEI),γ-selenobutylacetone(γ-SBL),and poly(ethylene glycol)methacrylate(PEGMA).Through high-throughput screening,we constructed a library of AxSeyOz nanogels and identified the optimized A1.8Se3O0.5/siPD-L1 nanogels,which exhibited a size of approximately 200 nm,excellent colloidal stability,and the most effective PD-L1 silencing efficacy.These nanogels demonstrated enhanced uptake by tumor cells,excellent oxidative degradation ability,and inhibited autophagy by alkalinizing lysosomes.The A1.8Se3O0.5/siPD-L1 nanogels significantly downregulated PD-L1 expression and increased the expression of major histocompatibility complex class I(MHC-I),resulting in robust proliferation of specific CD8+T cells and a decrease in MC38 tumor growth.As a result,the A1.8Se3O0.5/siPD-L1 nanogels inhibited tumor growth through self-inhibition of autophagy,upregulation of MHC-I,and downregulation of PD-L1.Designed with dynamic diselenide bonds,the A1.8Se3O0.5/siPD-L1 nanogels showed synergistic antitumor efficacy through self-inhibition of autophagy and prevention of immune escape.展开更多
基金supported by the National Natural Science Foundation of China(22101195 and 21925107)the Natural Science Foundation of liangsu Province(BK20210732)+2 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Program of Innovative Research Team of Soochow UniversityWe thank Dr.Bo Tang for the helpful discussion and support from the Special Key Project of Technology Innovation and Application Development of Chongqing(No.cstc2020jscx-dxwtBx0025).
文摘Recently,piezocatalysis has attracted considerable attention as a new type of renewable mechanical energy conversion technology,which relies on the strain induced polarization of the piezoelectric material.This new technology has been extensively applied in the applications of water splitting,water remediation,gas purification and tumor therapy.Despite the rapid development in the piezo-catalysis,the utilization of piezoelectric materials for synthetic purpose is still under exploration.Piezoelectric means to promote or-ganic reactions expand the scope of piezoelectrically mediated reactions and show successes in both organic and polymer synthesis.Herein,we provide a comprehensive review on recent progress of piezoelectrically mediated reactions,catalytic mechanisms and applications in the last few years.The limitations and future directions of this area are also discussed.We believe this review will provide new insights into the underlying mechanism of piezoelectric mediated electron transfer process and guide the design of new chemistry.
基金National Natural Science Foundation of China(No.21971177,82072051)Natural Science Foundation of the Jiangsu Higher Education Institution of China(No.22KJA150004)+2 种基金Priority Academic Program Development(PAPD)of Jiangsu Higher Education InstitutionsJiangsu Key Laboratory of Advanced Functional Polymers Design and Application,Soochow UniversitySuzhou Key Laboratory of Macromolecular Design and Precision Synthesis and the Program of Innovative Research Team of Soochow University.
文摘In the field of cancer therapy,inhibiting autophagy has emerged as a promising strategy.However,pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1(PD-L1),enabling tumor immune evasion.To address this issue,we developed innovative ROS-responsive cationic poly(ethylene imine)(PEI)nanogels using selenol chemistry-mediated multicomponent reaction(MCR)technology.This procedure involved simple mixing of low-molecular-weight PEI(LMW PEI),γ-selenobutylacetone(γ-SBL),and poly(ethylene glycol)methacrylate(PEGMA).Through high-throughput screening,we constructed a library of AxSeyOz nanogels and identified the optimized A1.8Se3O0.5/siPD-L1 nanogels,which exhibited a size of approximately 200 nm,excellent colloidal stability,and the most effective PD-L1 silencing efficacy.These nanogels demonstrated enhanced uptake by tumor cells,excellent oxidative degradation ability,and inhibited autophagy by alkalinizing lysosomes.The A1.8Se3O0.5/siPD-L1 nanogels significantly downregulated PD-L1 expression and increased the expression of major histocompatibility complex class I(MHC-I),resulting in robust proliferation of specific CD8+T cells and a decrease in MC38 tumor growth.As a result,the A1.8Se3O0.5/siPD-L1 nanogels inhibited tumor growth through self-inhibition of autophagy,upregulation of MHC-I,and downregulation of PD-L1.Designed with dynamic diselenide bonds,the A1.8Se3O0.5/siPD-L1 nanogels showed synergistic antitumor efficacy through self-inhibition of autophagy and prevention of immune escape.
