BACKGROUND Mild cognitive impairment(MCI)and subjective cognitive decline(SCD)are risk indicators for dementia and require ongoing management.Traditional Korean medicine(TKM)commonly employs acupuncture and herbal med...BACKGROUND Mild cognitive impairment(MCI)and subjective cognitive decline(SCD)are risk indicators for dementia and require ongoing management.Traditional Korean medicine(TKM)commonly employs acupuncture and herbal medicine for cognitive impairment;yet,clinical research on acupotomy is lacking.Although most TKM treatments occur in primary care,the research is largely hospital-based.This registry was established to systematically collect real-world data on the clinical progress,efficacy,and safety of TKM with acupotomy for patients with MCI or SCD in primary care.It is hypothesized that TKM with acupotomy improves cognitive function and is safe for these patients.AIM To establish an MCI or SCD registry of patients receiving TKM,including acupotomy,to analyze its clinical efficacy and safety.METHODS This observational registry study will be conducted across 22 medical institutions;approximately 500 participants will be recruited.Data—sociodemographic information,medication history,height,weight,vital signs,and assessment questionnaires(Montreal Cognitive Assessment-Korean,short form of Korean-Everyday Cognition,Numeric Rating Scale,Korean version of the Insomnia Severity Index)—will be collected at 3-month intervals over a year.This study will also document the TKM treatment administered and any adverse events.Routine TKM procedures will be followed,with acupuncture and acupotomy administered as per protocol;treatments including herbal medicine,Chuna therapy,and moxibustion may be administered at the practitioner’s discretion.RESULTS The registry will capture a wide range of real-world clinical data regarding demographic profiles,treatment processes,and adverse events.This detailed documentation is expected to clarify patient characteristics,evaluate the clinical course,and identify factors that may affect cognitive improvement in patients with MCI and SCD.CONCLUSION This research may provide evidence supporting acupotomy for cognitive impairment in primary care by confirming its efficacy and safety,providing preliminary evidence for TKM-based interventions aimed at improving cognitive function.展开更多
Background:Patients with cancer are confronted not only with physical changes and pain but also with significant psychological challenges,including distress,anxiety,and depression,as a consequence of their diagnosis a...Background:Patients with cancer are confronted not only with physical changes and pain but also with significant psychological challenges,including distress,anxiety,and depression,as a consequence of their diagnosis and treatment.This study aimed to identify the factors influencing anxiety or depression in patientswith cancer,examine the relationship between the duration since cancer diagnosis and psychological state,and explore the association between these factors and the use of Korean medicine(KM).Methods:This study utilized data from the 2018 Korea Health Panel spanning 2008 to 2018.The analysis focused on adult participants(aged 19 and above)diagnosed with cancer who responded to their psychological state(i.e.,anxiety or depression)and the duration since their cancer diagnosis.The dependent variables were the presence of anxiety or depression and the utilization of KM.Descriptive statistics and multiple logistic regression analysis were used to investigate factors influencing these variables.Results:A total of 773 participants were included in the final analysis,of whom 214 reported prior KM experience.Multiple logistic regression analysis indicated that the likelihood of experiencing anxiety or depression decreased as the duration since cancer diagnosis increased.Factors associated with anxiety or depression in patients with cancer included sex(odds ratio[OR]=2.06),number of chronic diseases(OR=1.17),Charlson Comorbidity Index score(CCI score of 2:OR=1.60),and EQ-5D(EuroQol Five Dimensions Questionnaire)index(OR<0.001).Cancer patients without anxiety or depression were more likely to use KM if they had been diagnosed within three years,were female(OR=2.11),and had a higher number of chronic conditions(OR=1.20).In contrast,patients with anxiety or depression were more likely to utilizeKMif theyhadbeendiagnosed formore thanfive years(OR=6.30)and resided in urban areas.Conclusions:The results suggest that patterns of KM utilization among patients with cancer are associated with their psychological state.Future research should focus on identifying direct correlations between psychological factors and KM use in patients with cancer.展开更多
Conductive fibers are essential for wearable electronics,especially in electronic textiles(e-textiles)used as skin-interfaced sensors and interconnects.Achieving sustainable e-textiles with integrated toughness,waterp...Conductive fibers are essential for wearable electronics,especially in electronic textiles(e-textiles)used as skin-interfaced sensors and interconnects.Achieving sustainable e-textiles with integrated toughness,waterproofing,and washability remains challenging.We present waterproof conductive tough fibers(CTFs)fabricated via a scalable,continuous capillary tube-assisted coating(CTAC)process.The multilayered CTFs demonstrate a conductivity of 6.42 kS/cm,Young’s modulus of 6.22 MPa,toughness of 9.40×10^(5)J/m^(3),and 70%strain at break.With lengths exceeding 20 m,a native oxide layer on the eutectic gallium-indium(EGaIn)shell ensures reliable waterproofing with the IPX8 standard.They also maintain consistent performance for 24 days water immersion and repeated washing up to 100 cycles,showing superior resistance retention compared to the EGaIn-absence fibers.As a proof-of-concept,they enable wireless power transfer and reliable monitoring of electrocardiogram and electromyogram signals,establishing a robust platform for sustainable e-textiles.展开更多
To accurately probe the tactile information on soft skin,it is critical for the pressure sensing array to be free of noise and inter-taxel crosstalk,irrespective of the measurement condition.However,on dynamically mov...To accurately probe the tactile information on soft skin,it is critical for the pressure sensing array to be free of noise and inter-taxel crosstalk,irrespective of the measurement condition.However,on dynamically moving and soft surfaces,which are common conditions for on-skin and robotic applications,obtaining precise measurement without compromising the sensing performance is a significant challenge due to mechanical coupling between the sensors and with the moving surface.In this work,multi-level architectural design of micro-pyramids and trapezoid-shaped mechanical barrier array was implemented to enable accurate spatiotemporal tactile sensing on soft surfaces under dynamic deformations.Trade-off relationship between limit of detection and bending insensitivity was discovered,which was overcome by employing micropores in barrier structures.Finally,in-situ pressure mapping on dynamically moving soft surfaces without signal distortion is demonstrated while human skin and/or soft robots are performing complicated tasks such as reading Braille and handling the artificial organs.展开更多
Realizing highly immersive tactile interactions requires a skin-integrated,untethered,high-definition tactile transducer devices that can record and generate tactile stimuli.However,the rigid and bulky form factor,and...Realizing highly immersive tactile interactions requires a skin-integrated,untethered,high-definition tactile transducer devices that can record and generate tactile stimuli.However,the rigid and bulky form factor,and insufficient resolution of existing actuators are hindering the reproduction of sophisticated tactile sensations and immersive user experiences.Here,we demonstrate an ultraflexible tactile interface with high spatial resolution of 1.8 mm for telehaptic communication on human skin.Dual mechanism sensors and sub-mm scale piezoceramic actuators are designed to record and generate the static and dynamic pressures in a wide frequency range(1 Hz to 1 kHz).Moreover,actuators are integrated on ultra-flexible substrate with chessboard pattern to minimize stress during mechanical deformations.Finally,remote transmissions of various tactile stimuli,such as shapes,textures,and vibration patterns were demonstrated by the telehaptic system with low latency(<1.55 ms)and high fidelity as proven by the shorttime Fourier-transform analysis.展开更多
基金Supported by The Korea Health Technology Project through the Korea Health Industry Development Institute,funded by the Ministry of Health and Welfare,Republic of Korea,No.RS-2023-KH138802.
文摘BACKGROUND Mild cognitive impairment(MCI)and subjective cognitive decline(SCD)are risk indicators for dementia and require ongoing management.Traditional Korean medicine(TKM)commonly employs acupuncture and herbal medicine for cognitive impairment;yet,clinical research on acupotomy is lacking.Although most TKM treatments occur in primary care,the research is largely hospital-based.This registry was established to systematically collect real-world data on the clinical progress,efficacy,and safety of TKM with acupotomy for patients with MCI or SCD in primary care.It is hypothesized that TKM with acupotomy improves cognitive function and is safe for these patients.AIM To establish an MCI or SCD registry of patients receiving TKM,including acupotomy,to analyze its clinical efficacy and safety.METHODS This observational registry study will be conducted across 22 medical institutions;approximately 500 participants will be recruited.Data—sociodemographic information,medication history,height,weight,vital signs,and assessment questionnaires(Montreal Cognitive Assessment-Korean,short form of Korean-Everyday Cognition,Numeric Rating Scale,Korean version of the Insomnia Severity Index)—will be collected at 3-month intervals over a year.This study will also document the TKM treatment administered and any adverse events.Routine TKM procedures will be followed,with acupuncture and acupotomy administered as per protocol;treatments including herbal medicine,Chuna therapy,and moxibustion may be administered at the practitioner’s discretion.RESULTS The registry will capture a wide range of real-world clinical data regarding demographic profiles,treatment processes,and adverse events.This detailed documentation is expected to clarify patient characteristics,evaluate the clinical course,and identify factors that may affect cognitive improvement in patients with MCI and SCD.CONCLUSION This research may provide evidence supporting acupotomy for cognitive impairment in primary care by confirming its efficacy and safety,providing preliminary evidence for TKM-based interventions aimed at improving cognitive function.
基金supported by a grant of the R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(grant number:RS-2023-KH139376).
文摘Background:Patients with cancer are confronted not only with physical changes and pain but also with significant psychological challenges,including distress,anxiety,and depression,as a consequence of their diagnosis and treatment.This study aimed to identify the factors influencing anxiety or depression in patientswith cancer,examine the relationship between the duration since cancer diagnosis and psychological state,and explore the association between these factors and the use of Korean medicine(KM).Methods:This study utilized data from the 2018 Korea Health Panel spanning 2008 to 2018.The analysis focused on adult participants(aged 19 and above)diagnosed with cancer who responded to their psychological state(i.e.,anxiety or depression)and the duration since their cancer diagnosis.The dependent variables were the presence of anxiety or depression and the utilization of KM.Descriptive statistics and multiple logistic regression analysis were used to investigate factors influencing these variables.Results:A total of 773 participants were included in the final analysis,of whom 214 reported prior KM experience.Multiple logistic regression analysis indicated that the likelihood of experiencing anxiety or depression decreased as the duration since cancer diagnosis increased.Factors associated with anxiety or depression in patients with cancer included sex(odds ratio[OR]=2.06),number of chronic diseases(OR=1.17),Charlson Comorbidity Index score(CCI score of 2:OR=1.60),and EQ-5D(EuroQol Five Dimensions Questionnaire)index(OR<0.001).Cancer patients without anxiety or depression were more likely to use KM if they had been diagnosed within three years,were female(OR=2.11),and had a higher number of chronic conditions(OR=1.20).In contrast,patients with anxiety or depression were more likely to utilizeKMif theyhadbeendiagnosed formore thanfive years(OR=6.30)and resided in urban areas.Conclusions:The results suggest that patterns of KM utilization among patients with cancer are associated with their psychological state.Future research should focus on identifying direct correlations between psychological factors and KM use in patients with cancer.
基金funded by the Ministry of Science and ICT(MSIT)(Grant No.IITP-2023-2020-0-01461,RS-2023-00213089,RS-2024-00403639,RS-2024-00403163)funded by the Ministry of Trade,Industry and Energy(MOTIE)(Grant No.P0017805,RS-2022-00154781)funded by the Ministry of Education(MOE)(Grant No.RS-2023-00220077).
文摘Conductive fibers are essential for wearable electronics,especially in electronic textiles(e-textiles)used as skin-interfaced sensors and interconnects.Achieving sustainable e-textiles with integrated toughness,waterproofing,and washability remains challenging.We present waterproof conductive tough fibers(CTFs)fabricated via a scalable,continuous capillary tube-assisted coating(CTAC)process.The multilayered CTFs demonstrate a conductivity of 6.42 kS/cm,Young’s modulus of 6.22 MPa,toughness of 9.40×10^(5)J/m^(3),and 70%strain at break.With lengths exceeding 20 m,a native oxide layer on the eutectic gallium-indium(EGaIn)shell ensures reliable waterproofing with the IPX8 standard.They also maintain consistent performance for 24 days water immersion and repeated washing up to 100 cycles,showing superior resistance retention compared to the EGaIn-absence fibers.As a proof-of-concept,they enable wireless power transfer and reliable monitoring of electrocardiogram and electromyogram signals,establishing a robust platform for sustainable e-textiles.
基金supported by Institute for Information&Communications Technology Promotion (IITP)grant funded by the Korea government (MSIT,Grant No.2020-0-00003,Development of high piezoelectric coefficient composite and ultra-low power multilayered piezoelectric sensor/actuator multi-functional module,Grant No.2022-0-00025,Development of soft-suit technology to support human motor ability,and Grant No.2022-0-00020,Imperceptible on-skin sensor devices for musculoskeletal monitoring and rehabilitation)the KAIST UP Program.
文摘To accurately probe the tactile information on soft skin,it is critical for the pressure sensing array to be free of noise and inter-taxel crosstalk,irrespective of the measurement condition.However,on dynamically moving and soft surfaces,which are common conditions for on-skin and robotic applications,obtaining precise measurement without compromising the sensing performance is a significant challenge due to mechanical coupling between the sensors and with the moving surface.In this work,multi-level architectural design of micro-pyramids and trapezoid-shaped mechanical barrier array was implemented to enable accurate spatiotemporal tactile sensing on soft surfaces under dynamic deformations.Trade-off relationship between limit of detection and bending insensitivity was discovered,which was overcome by employing micropores in barrier structures.Finally,in-situ pressure mapping on dynamically moving soft surfaces without signal distortion is demonstrated while human skin and/or soft robots are performing complicated tasks such as reading Braille and handling the artificial organs.
基金supported by the Institute for Information&Communications Technology Promotion (IITP) grant funded by the Korean government (MSIT) (Grant No.2020-0-00003,Development of High Piezoelectric Coefficient Composite and Ultra-low Power Multi-layered Piezoelectric Sensor/Actuator Multi-functional Module and Grant No.2017-0-00048,Development of Core Technologies for Tactile Input/Output Panels in Skintronics).
文摘Realizing highly immersive tactile interactions requires a skin-integrated,untethered,high-definition tactile transducer devices that can record and generate tactile stimuli.However,the rigid and bulky form factor,and insufficient resolution of existing actuators are hindering the reproduction of sophisticated tactile sensations and immersive user experiences.Here,we demonstrate an ultraflexible tactile interface with high spatial resolution of 1.8 mm for telehaptic communication on human skin.Dual mechanism sensors and sub-mm scale piezoceramic actuators are designed to record and generate the static and dynamic pressures in a wide frequency range(1 Hz to 1 kHz).Moreover,actuators are integrated on ultra-flexible substrate with chessboard pattern to minimize stress during mechanical deformations.Finally,remote transmissions of various tactile stimuli,such as shapes,textures,and vibration patterns were demonstrated by the telehaptic system with low latency(<1.55 ms)and high fidelity as proven by the shorttime Fourier-transform analysis.
