Insomnia is a common sleep disorder without effective therapy and can affect a person's life.The mechanism of the disease is not completely understood.Hence,there is a need to understand the targets related to ins...Insomnia is a common sleep disorder without effective therapy and can affect a person's life.The mechanism of the disease is not completely understood.Hence,there is a need to understand the targets related to insomnia,in order to develop innovative therapies and new compounds.Recently,increasing interest has been focused on complementary and alternative medicines for treating or preventing insomnia.Research into their molecular components has revealed that their sedative and sleep-promoting properties rely on the interactions with various neurotransmitter systems in the brain.In this review,the role of 5-hydroxytryptamine(5-HT)in insomnia development is summarized,while a systematic analysis of studies is conducted to assess the mechanisms of herbal medicines on different 5-HT receptors subtypes,in order to provide reference for subsequent research.展开更多
Flavonoids are a large group of phenolic secondary metabolites havinga wide range of biochemical and pharmacological effects.Quantitative analysis of flavonoid profiles in the genus Actinidia,which has not been intens...Flavonoids are a large group of phenolic secondary metabolites havinga wide range of biochemical and pharmacological effects.Quantitative analysis of flavonoid profiles in the genus Actinidia,which has not been intensively conducted,is useful to a better understanding of the pattern and distribution of flavonoids.In the present work,a liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI-MS/MS)method was developed to profile the flavonoids,which was then used to determine the dynamic change of 17 biologically active flavonoids in the leaves of Actinidia valvata at the main growing stages,including glucuronides and acylated di-and triglycosides of flavonoids.The contents of flavonoid triglycosides were significantly higher than other flavonoids.The highest concentrations of kaemperol glycosides were observed in June,while other flavonoids showed highest concentrations in October.On the other hand,the contents of four isorhamnetin glycosides were increased sharply in September to October.The flavonoid profiles seem to be related to temperature,UV-B,and water deficit.Further studies are required to examine the functions of flavonoids in the Actinidia valvata and the underlying molecular mechanisms of actions.展开更多
通过文献计量与知识图谱可视化手段,聚焦全球“传统手工艺数字化”研究领域,全面分析近24年来,传统手工艺数字化研究成果现状、研究热点及发展态势,以及未来方向。以2000—2024年的Scopus和Web of Science及中国知网(CNKI)数据库相关文...通过文献计量与知识图谱可视化手段,聚焦全球“传统手工艺数字化”研究领域,全面分析近24年来,传统手工艺数字化研究成果现状、研究热点及发展态势,以及未来方向。以2000—2024年的Scopus和Web of Science及中国知网(CNKI)数据库相关文献为研究数据源。采用CiteSpace与Bibliometrix文献计量分析工具,首先通过年发文量变化揭示研究成果全球导向;再通过关键词聚类及高影响力文献分析,深入洞察其演变规律;最后结合专题地图与关键词时区分析,梳理传统手工艺数字化领域未来发展方向。全球传统手工艺数字化研究整体发文量呈现波动上升状态,其研究发展可分为初步探索、政策推动、数字化转型三个阶段,主要侧重三个方面:传统手工艺数字化转型研究,手工艺数字化虚拟平台开发与传播研究,手工艺活态传承与产业应用研究。本研究通过多维度分析得出,传统手工艺数字化研究将进一步向多模态设计创新、文化基因价值认同、具身沉浸感知趋势发展,本研究分析为该领域研究发展及未来研究方向提供参照性内容。展开更多
According to China Chemical Fiber Industry Association, during the first half year of 2014, China＇s chemical fiber output has been keeping steady, the benefit has been turning better in comparison to the first quarte...According to China Chemical Fiber Industry Association, during the first half year of 2014, China＇s chemical fiber output has been keeping steady, the benefit has been turning better in comparison to the first quarter of this year, the new production of polyester amounted to 2.62 million tons, upstream suffered imbalance between supply and demand, and some large enterprises have been afflicted with capital chain issues etc. The association forecasts annual production will reach 43500 thousand tons, up by 6% roughly, the gross profit will increase over last year and the operational quality will improve.展开更多
基金supported by the National Natural Science Foundation of China(Nos.82174091,82122066,81973291,and 82003909)the National Key R&D Program of China(No.2022YFC2704603).
文摘Insomnia is a common sleep disorder without effective therapy and can affect a person's life.The mechanism of the disease is not completely understood.Hence,there is a need to understand the targets related to insomnia,in order to develop innovative therapies and new compounds.Recently,increasing interest has been focused on complementary and alternative medicines for treating or preventing insomnia.Research into their molecular components has revealed that their sedative and sleep-promoting properties rely on the interactions with various neurotransmitter systems in the brain.In this review,the role of 5-hydroxytryptamine(5-HT)in insomnia development is summarized,while a systematic analysis of studies is conducted to assess the mechanisms of herbal medicines on different 5-HT receptors subtypes,in order to provide reference for subsequent research.
基金financially supported by National Natural Science Foundation of China(Nos.81102336 and U1203104)Special Project of Biological Medicine of Science and Technology Commission of Shanghai Municipality(No.10431900500)
文摘Flavonoids are a large group of phenolic secondary metabolites havinga wide range of biochemical and pharmacological effects.Quantitative analysis of flavonoid profiles in the genus Actinidia,which has not been intensively conducted,is useful to a better understanding of the pattern and distribution of flavonoids.In the present work,a liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI-MS/MS)method was developed to profile the flavonoids,which was then used to determine the dynamic change of 17 biologically active flavonoids in the leaves of Actinidia valvata at the main growing stages,including glucuronides and acylated di-and triglycosides of flavonoids.The contents of flavonoid triglycosides were significantly higher than other flavonoids.The highest concentrations of kaemperol glycosides were observed in June,while other flavonoids showed highest concentrations in October.On the other hand,the contents of four isorhamnetin glycosides were increased sharply in September to October.The flavonoid profiles seem to be related to temperature,UV-B,and water deficit.Further studies are required to examine the functions of flavonoids in the Actinidia valvata and the underlying molecular mechanisms of actions.
文摘通过文献计量与知识图谱可视化手段,聚焦全球“传统手工艺数字化”研究领域,全面分析近24年来,传统手工艺数字化研究成果现状、研究热点及发展态势,以及未来方向。以2000—2024年的Scopus和Web of Science及中国知网(CNKI)数据库相关文献为研究数据源。采用CiteSpace与Bibliometrix文献计量分析工具,首先通过年发文量变化揭示研究成果全球导向;再通过关键词聚类及高影响力文献分析,深入洞察其演变规律;最后结合专题地图与关键词时区分析,梳理传统手工艺数字化领域未来发展方向。全球传统手工艺数字化研究整体发文量呈现波动上升状态,其研究发展可分为初步探索、政策推动、数字化转型三个阶段,主要侧重三个方面:传统手工艺数字化转型研究,手工艺数字化虚拟平台开发与传播研究,手工艺活态传承与产业应用研究。本研究通过多维度分析得出,传统手工艺数字化研究将进一步向多模态设计创新、文化基因价值认同、具身沉浸感知趋势发展,本研究分析为该领域研究发展及未来研究方向提供参照性内容。
文摘According to China Chemical Fiber Industry Association, during the first half year of 2014, China＇s chemical fiber output has been keeping steady, the benefit has been turning better in comparison to the first quarter of this year, the new production of polyester amounted to 2.62 million tons, upstream suffered imbalance between supply and demand, and some large enterprises have been afflicted with capital chain issues etc. The association forecasts annual production will reach 43500 thousand tons, up by 6% roughly, the gross profit will increase over last year and the operational quality will improve.
