BACKGROUND Pulsatile tinnitus(PT)is a potentially disabling symptom that has received increasing attention.Multiple causes of PT have been confirmed by targeted treatment.However,dynamic changes of related structures ...BACKGROUND Pulsatile tinnitus(PT)is a potentially disabling symptom that has received increasing attention.Multiple causes of PT have been confirmed by targeted treatment.However,dynamic changes of related structures in PT patients with multiple causes after stenting for ipsilateral transverse sinus stenosis(TSS)have not been previously reported.We report such a case and present postoperative computed tomography venography(CTV)follow-up findings to demonstrate the decreased sigmoid sinus diverticulum and bone remodeling.CASE SUMMARY A 45-year-old man suffered from left-sided PT for 15 years that was occasionally accompanied by headache and dizziness.Pre-operative CTV revealed left-sided sigmoid sinus wall anomalies(SSWAs),TSS,outflow dominance,large posterior condylar emissary vein,and an empty sella turcica.A cerebrospinal fluid pressure of 270 mmH2O was further detected.The sound disappeared immediately after stenting for ipsilateral TSS,with no recurrence during 2 years of follow-up.After the procedure,the patient underwent four consecutive CTV examinations.The diverticulum decreased 6 mo after the procedure with new bone remodeling.The density of the remodeled bone was further increased 1 year later,and a hardened edge was formed 2 years later.CONCLUSION PT associated with SSWAs,TSS,and idiopathic intracranial hypertension can be cured by stenting for TSS alone.And bone remodeling around SSWAs is a more significant finding.展开更多
BACKGROUND Pulsatile tinnitus(PT)is an annoying sound that can be eliminated with targeted treatment of the cause.However,the causes of PT have not been fully elucidated.CASE SUMMARY A 38-year-old woman with right-sid...BACKGROUND Pulsatile tinnitus(PT)is an annoying sound that can be eliminated with targeted treatment of the cause.However,the causes of PT have not been fully elucidated.CASE SUMMARY A 38-year-old woman with right-sided objective PT underwent preoperative computed tomography arteriography and venography(CTA/V).A 3.8 mm vine diploic vein(DV),which passed through the mastoid air cells posteriorly in a dehiscent canal and was continuous with the transverse-sigmoid sinus,was thought to be the causative finding.Four-dimensional flow magnetic resonance(4D flow MR)imaging showed that the blood in the DV flowed toward the transverse-sigmoid sinus.The closer the blood was to the transverse-sigmoid sinus,the higher the velocity.No vortex or turbulence was found in the DV or adjacent transverse sinus.The sound was eliminated immediately after ligation of the DV with no recurrence during a three-month follow-up.No flow signal of the DV was noted on postoperative 4D flow MR.CONCLUSION A DV may be a treatable cause of PT.CTA/V and 4D flow MR could be utilized to determine the morphological and hemodynamic characteristics of the DV.展开更多
Introduction:Brain age prediction using neuroimaging data and machine learning algorithms holds significant promise for gaining insights into the development of neurodegenerative diseases.The estimation of brain age m...Introduction:Brain age prediction using neuroimaging data and machine learning algorithms holds significant promise for gaining insights into the development of neurodegenerative diseases.The estimation of brain age may be influenced not only by the imaging modality but also by multidomain clinical factors.However,the degree to which various clinical factors in individuals are associated with brain structure,as well as the comprehensive relationship between these factors and brain aging,is not yet clear.Methods:In this study,multimodal brain magnetic resonance imaging data and longitudinal clinical information were collected from 964 participants in a population-based cohort with 16 years of follow-up in northern China.We developed a machine learning-based algorithm to predict multimodal brain age and compared the estimated brain age gap(BAG)differences among the 5 groups characterized by varying exposures to these high-risk clinical factors.We then estimated modality-specific brain age in the hypertension group based on hypertension-related regional imaging metrics.Results:The results revealed a significantly larger BAG estimated from multimodal neuroimaging in subjects with 4 or 5 risk factors compared to other groups,suggesting an acceleration of brain aging under cumulative exposure to multiple risk factors.The estimated T1-based BAG exhibited a significantly higher level in the hypertensive subjects compared to the normotensive individuals.Conclusion:Our study provides valuable insights into a range of health factors across lifestyle,metabolism,and social context that are reflective of brain aging and also contributes to the advancement of interventions and public health initiatives targeted at the general population aimed at promoting brain health.展开更多
Background:The cumulative effect of body mass index(BMI)on brain health remains ill-deffned.The effects of overweight on brain health across different age groups need clariffcation.We analyzed the effect of cumulative...Background:The cumulative effect of body mass index(BMI)on brain health remains ill-deffned.The effects of overweight on brain health across different age groups need clariffcation.We analyzed the effect of cumulative BMI on neuroimaging features of brain health in adults of different ages.Methods:This study was based on a multicenter,community-based cohort study.We modeled the trajectories of BMI over 16 years to evaluate cumulative exposure.Multimodality neuroimaging data were collected once for volumetric measurements of the brain macrostructure,white matter hyperintensity(WMH),and brain microstructure.We used a generalized linear model to evaluate the association between cumulative BMI and neuroimaging features.Two-sample Mendelian randomization analysis was performed using summary level of BMI genetic data from 681,275 individuals and neuroimaging genetic data from 33,224 individuals to analyze the causal relationships.Results:Clinical and neuroimaging data were obtained from 1,074 adults(25 to 83 years).For adults aged under 45 years,brain volume differences in participants with a cumulative BMI of>26.2 kg/m^(2) corresponded to 12.0 years[95%conffdence interval(CI),3.0 to 20.0]of brain aging.Differences in WMH were statistically substantial for participants aged over 60 years,with a 6.0-ml(95%CI,1.5 to 10.5)larger volume.Genetic analysis indicated causal relationships between high BMI and smaller gray matter and higher fractional anisotropy in projection ffbers.Conclusion:High cumulative BMI is associated with smaller brain volume,larger volume of white matter lesions,and abnormal microstructural integrity.Adults younger than 45 years are suggested to maintain their BMI below 26.2 kg/m^(2) for better brain health.Trial Registration:This study was registered on clinicaltrials.gov(Clinical Indicators and Brain Image Data:A Cohort Study Based on Kailuan Cohort;No.NCT05453877;https://clinicaltrials.gov/ct2/show/NCT05453877).展开更多
The filtration performance of the moving bed granular filter with axial flow (MBGF-AF) is investigated through a large cold experiment. The effect of different operation parameters on the filtration performance (colle...The filtration performance of the moving bed granular filter with axial flow (MBGF-AF) is investigated through a large cold experiment. The effect of different operation parameters on the filtration performance (collection efficiency, pressure drop) of the axial-flow moving bed filter is investigated in combination with the dust deposition effect and the mechanism of trapping dust by the capturing particles. The results show that the collection efficiency of MBGF-AF is enhanced by decreasing the superficial gas velocity, increasing the inlet dust concentration properly, or decreasing the moving velocity of the capturing particles. A model covering the above operation parameters is established to calculate the collection efficiency of the moving bed granular filter. It is used in a wide range of operating parameters for the MBGFs.展开更多
To the Editor:Non-arteritic anterior ischemic optic neuropathy(NAION),characterized by a sudden onset of unilateral painless visual loss and a swollen optic disc,is the most common form of acute optic neuropathy in pa...To the Editor:Non-arteritic anterior ischemic optic neuropathy(NAION),characterized by a sudden onset of unilateral painless visual loss and a swollen optic disc,is the most common form of acute optic neuropathy in patients over 50 years of age.[1]The pathogenesis of NAION remains unclear,but most histopathological studies support the concept of vasculopathic occlusion in the region of the short posterior ciliary arteries.[2]Functional magnetic resonance imaging(fMRI)is one of the most widely used non-invasive techniques for measuring brain function over time in vivo.To the best of our knowledge,only one study has investigated the effects of stimulating the affected eye in the extra-visual areas in NAION in humans.[3]However,this previous study only examined task-state fMRI,and lacked a measure of resting-state fMRI(rs-fMRI).Thus,it remains unclear whether regional spontaneous brain changes are limited to the visual system.展开更多
Introduction Upper abdominal magnetic resonance(MR)imaging is appropriate for body composition analysis.111 Especially for individuals with obesity,it is of great value to quantify the hepatic proton density fat fract...Introduction Upper abdominal magnetic resonance(MR)imaging is appropriate for body composition analysis.111 Especially for individuals with obesity,it is of great value to quantify the hepatic proton density fat fraction(PDFF)and the amount of abdominal adipose tissue during clinical evaluation and for research on obesity-related risks.Analytical results may be used to determine the optimal choice of surgical procedure and evaluate treatment outcomes.Multiple artificial intelligence(Al)algorithms and systems have been developed for the automated measurement of body composition.The basis of Al development and application is to have uniform standards for clinical data acquisition and management.The uneven quality ofMR images is one ofthe major obstacles to Al system development and analytical results.A standardized process of MR scanning and clinical data management is urgently needed.展开更多
基金The Beijing Scholar 2015and the National Natural Science Foundation of China,No.61931013,No.81701644,and No.61801311.
文摘BACKGROUND Pulsatile tinnitus(PT)is a potentially disabling symptom that has received increasing attention.Multiple causes of PT have been confirmed by targeted treatment.However,dynamic changes of related structures in PT patients with multiple causes after stenting for ipsilateral transverse sinus stenosis(TSS)have not been previously reported.We report such a case and present postoperative computed tomography venography(CTV)follow-up findings to demonstrate the decreased sigmoid sinus diverticulum and bone remodeling.CASE SUMMARY A 45-year-old man suffered from left-sided PT for 15 years that was occasionally accompanied by headache and dizziness.Pre-operative CTV revealed left-sided sigmoid sinus wall anomalies(SSWAs),TSS,outflow dominance,large posterior condylar emissary vein,and an empty sella turcica.A cerebrospinal fluid pressure of 270 mmH2O was further detected.The sound disappeared immediately after stenting for ipsilateral TSS,with no recurrence during 2 years of follow-up.After the procedure,the patient underwent four consecutive CTV examinations.The diverticulum decreased 6 mo after the procedure with new bone remodeling.The density of the remodeled bone was further increased 1 year later,and a hardened edge was formed 2 years later.CONCLUSION PT associated with SSWAs,TSS,and idiopathic intracranial hypertension can be cured by stenting for TSS alone.And bone remodeling around SSWAs is a more significant finding.
基金Supported by National Natural Science Foundation of China,No.61931013 and No.61801311.
文摘BACKGROUND Pulsatile tinnitus(PT)is an annoying sound that can be eliminated with targeted treatment of the cause.However,the causes of PT have not been fully elucidated.CASE SUMMARY A 38-year-old woman with right-sided objective PT underwent preoperative computed tomography arteriography and venography(CTA/V).A 3.8 mm vine diploic vein(DV),which passed through the mastoid air cells posteriorly in a dehiscent canal and was continuous with the transverse-sigmoid sinus,was thought to be the causative finding.Four-dimensional flow magnetic resonance(4D flow MR)imaging showed that the blood in the DV flowed toward the transverse-sigmoid sinus.The closer the blood was to the transverse-sigmoid sinus,the higher the velocity.No vortex or turbulence was found in the DV or adjacent transverse sinus.The sound was eliminated immediately after ligation of the DV with no recurrence during a three-month follow-up.No flow signal of the DV was noted on postoperative 4D flow MR.CONCLUSION A DV may be a treatable cause of PT.CTA/V and 4D flow MR could be utilized to determine the morphological and hemodynamic characteristics of the DV.
基金supported by Grant No.62206165(L.W.),No.62376150(J.J.),No.62171297(H.L.),and No.82020108013(J.J.)from the National Natural Science Foundation of ChinaGrant No.7242267(H.L.)from the Beijing Natural Science Foundation+1 种基金Grant No.2022ZD021600 from Science and Technology Innovation 2030-Major Projects(J.J.)Grant No.XTCX-KJ-2023-37 from the Shanghai Industrial Collaborative Innovation Project(J.J.).
文摘Introduction:Brain age prediction using neuroimaging data and machine learning algorithms holds significant promise for gaining insights into the development of neurodegenerative diseases.The estimation of brain age may be influenced not only by the imaging modality but also by multidomain clinical factors.However,the degree to which various clinical factors in individuals are associated with brain structure,as well as the comprehensive relationship between these factors and brain aging,is not yet clear.Methods:In this study,multimodal brain magnetic resonance imaging data and longitudinal clinical information were collected from 964 participants in a population-based cohort with 16 years of follow-up in northern China.We developed a machine learning-based algorithm to predict multimodal brain age and compared the estimated brain age gap(BAG)differences among the 5 groups characterized by varying exposures to these high-risk clinical factors.We then estimated modality-specific brain age in the hypertension group based on hypertension-related regional imaging metrics.Results:The results revealed a significantly larger BAG estimated from multimodal neuroimaging in subjects with 4 or 5 risk factors compared to other groups,suggesting an acceleration of brain aging under cumulative exposure to multiple risk factors.The estimated T1-based BAG exhibited a significantly higher level in the hypertensive subjects compared to the normotensive individuals.Conclusion:Our study provides valuable insights into a range of health factors across lifestyle,metabolism,and social context that are reflective of brain aging and also contributes to the advancement of interventions and public health initiatives targeted at the general population aimed at promoting brain health.
基金supported by the National Natural Science Foundation of China(62171297 and 61931013)Natural Science Foundation of Beijing Municipality(7242267)Beijing Scholars Program([2015]160).
文摘Background:The cumulative effect of body mass index(BMI)on brain health remains ill-deffned.The effects of overweight on brain health across different age groups need clariffcation.We analyzed the effect of cumulative BMI on neuroimaging features of brain health in adults of different ages.Methods:This study was based on a multicenter,community-based cohort study.We modeled the trajectories of BMI over 16 years to evaluate cumulative exposure.Multimodality neuroimaging data were collected once for volumetric measurements of the brain macrostructure,white matter hyperintensity(WMH),and brain microstructure.We used a generalized linear model to evaluate the association between cumulative BMI and neuroimaging features.Two-sample Mendelian randomization analysis was performed using summary level of BMI genetic data from 681,275 individuals and neuroimaging genetic data from 33,224 individuals to analyze the causal relationships.Results:Clinical and neuroimaging data were obtained from 1,074 adults(25 to 83 years).For adults aged under 45 years,brain volume differences in participants with a cumulative BMI of>26.2 kg/m^(2) corresponded to 12.0 years[95%conffdence interval(CI),3.0 to 20.0]of brain aging.Differences in WMH were statistically substantial for participants aged over 60 years,with a 6.0-ml(95%CI,1.5 to 10.5)larger volume.Genetic analysis indicated causal relationships between high BMI and smaller gray matter and higher fractional anisotropy in projection ffbers.Conclusion:High cumulative BMI is associated with smaller brain volume,larger volume of white matter lesions,and abnormal microstructural integrity.Adults younger than 45 years are suggested to maintain their BMI below 26.2 kg/m^(2) for better brain health.Trial Registration:This study was registered on clinicaltrials.gov(Clinical Indicators and Brain Image Data:A Cohort Study Based on Kailuan Cohort;No.NCT05453877;https://clinicaltrials.gov/ct2/show/NCT05453877).
基金supported by National Natural Science Foundation of China(U1862202).
文摘The filtration performance of the moving bed granular filter with axial flow (MBGF-AF) is investigated through a large cold experiment. The effect of different operation parameters on the filtration performance (collection efficiency, pressure drop) of the axial-flow moving bed filter is investigated in combination with the dust deposition effect and the mechanism of trapping dust by the capturing particles. The results show that the collection efficiency of MBGF-AF is enhanced by decreasing the superficial gas velocity, increasing the inlet dust concentration properly, or decreasing the moving velocity of the capturing particles. A model covering the above operation parameters is established to calculate the collection efficiency of the moving bed granular filter. It is used in a wide range of operating parameters for the MBGFs.
基金supported by grants from the Basic Scientific Research Program from Beijing Univers让y of Chinese Medicine(No.2015-JYB-JSMS107)the Capital Characteristic Clinical Project(No.Z171100001017206).
文摘To the Editor:Non-arteritic anterior ischemic optic neuropathy(NAION),characterized by a sudden onset of unilateral painless visual loss and a swollen optic disc,is the most common form of acute optic neuropathy in patients over 50 years of age.[1]The pathogenesis of NAION remains unclear,but most histopathological studies support the concept of vasculopathic occlusion in the region of the short posterior ciliary arteries.[2]Functional magnetic resonance imaging(fMRI)is one of the most widely used non-invasive techniques for measuring brain function over time in vivo.To the best of our knowledge,only one study has investigated the effects of stimulating the affected eye in the extra-visual areas in NAION in humans.[3]However,this previous study only examined task-state fMRI,and lacked a measure of resting-state fMRI(rs-fMRI).Thus,it remains unclear whether regional spontaneous brain changes are limited to the visual system.
基金supported by the National Natural Science Foundation of China(No.62171297)the Capital's Funds for Health Improvement and Research(No.2020-1-2021)the Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(No.ZYLX202101)。
文摘Introduction Upper abdominal magnetic resonance(MR)imaging is appropriate for body composition analysis.111 Especially for individuals with obesity,it is of great value to quantify the hepatic proton density fat fraction(PDFF)and the amount of abdominal adipose tissue during clinical evaluation and for research on obesity-related risks.Analytical results may be used to determine the optimal choice of surgical procedure and evaluate treatment outcomes.Multiple artificial intelligence(Al)algorithms and systems have been developed for the automated measurement of body composition.The basis of Al development and application is to have uniform standards for clinical data acquisition and management.The uneven quality ofMR images is one ofthe major obstacles to Al system development and analytical results.A standardized process of MR scanning and clinical data management is urgently needed.
