OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were...OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were randomly assigned(n = 10/group) to a control group(C) or one of three moxa smoke concentration groups(% opacity): low(L1; 0.4%), medium(M1; 2%), and high(H1; 15%). Mice in the latter three groups were exposed to moxa smoke in a dynamic gas exposure cabinet for 20 min per day for7 days. Mice in control group were placed in the same cabinet without any intervention. For the sleep experiments, another 50 mice were divided into five groups of 10 mice each: a saline-injected control group, L1 + pentobarbital sodium(PS)-injected group, M1+PS group, H1(15%)+PS group,and a positive control group(10 mg/kg, chlorpromazine, p.o.). The weight, general activities, locomotor activities, rotarod performance, sleep duration,and sleeping rate induced by a subthreshold dose of pentobarbital sodium were recorded in the mice,and the composition of moxa smoke was analyzed using headspace gas chromatography(GC-HS).RESULTS: A low concentration of smoke significantly decreased the frequency of locomotor activities and the time for which the mice remaining on the rotarod; however, a high smoke concentration significantly prolonged the pentobarbital-induced sleeping time and sleeping rate.CONCLUSION: The concentration-dependent relaxing effects of moxa smoke on the Central Nervous System(CNS) were confirmed. Moreover, GC-HS analysis showed that the component present in the highest concentration in moxa smoke was eucalyp-tol, an essential oil well recognized for its soothing effects on the CNS. This may therefore be accountable for the sedative effects of moxa smoke.展开更多
Phase engineering of molybdenum disulfide(MoS_(2))can achieve phase transformation from the semiconducting phase(2H-MoS_(2))with poor conductivity to the metallic phase(1T-MoS_(2))with superior electrochemical propert...Phase engineering of molybdenum disulfide(MoS_(2))can achieve phase transformation from the semiconducting phase(2H-MoS_(2))with poor conductivity to the metallic phase(1T-MoS_(2))with superior electrochemical properties.Therefore,it is desirable to prepare high concentration 1T-MoS_(2)by simple and facile methods.In this work,MoS_(2)with high concentration of 1T phase is successfully prepared by one-pot hydrothermal synthesis through the synergistic effect of HNO_(3)and CH_(3)CH_(2)OH,which is stable for more than half of a year.The as-synthesized MoS_(2)shows high capacitance of 392Fg^(-1)at 1A g^(-1)as used for supercapacitors electrodes,and displays excellent capacitance retention(83%after 10,000 cycles).Asymmetric supercapacitors(ASCs)devices assembled by the as-synthesized MoS_(2)and MnO_(2)on carbon cloths,exhibit high energy and power densities(0.194 m Wh cm^(-2)and 13.466 mW cm^(-2)).These results shed a light to realize 1T phase MoS_(2)through the synergistic effect in hydrothermal processing.展开更多
Hepatology encompasses various aspects,such as metabolic-associated fatty liver disease,viral hepatitis,alcoholic liver disease,liver cirrhosis,liver failure,liver tumors,and liver transplantation.The global epidemiol...Hepatology encompasses various aspects,such as metabolic-associated fatty liver disease,viral hepatitis,alcoholic liver disease,liver cirrhosis,liver failure,liver tumors,and liver transplantation.The global epidemiological situation of liver diseases is grave,posing a substantial threat to human health and quality of life.Characterized by high incidence and mortality rates,liver diseases have emerged as a prominent global public health concern.In recent years,the rapid advan-cement of artificial intelligence(AI),deep learning,and radiomics has transfor-med medical research and clinical practice,demonstrating considerable potential in hepatology.AI is capable of automatically detecting abnormal cells in liver tissue sections,enhancing the accu-racy and efficiency of pathological diagnosis.Deep learning models are able to extract features from computed tomography and magnetic resonance imaging images to facilitate liver disease classification.Machine learning models are capable of integrating clinical data to forecast disease progression and treatment responses,thus supporting clinical decision-making for personalized medicine.Through the analysis of imaging data,laboratory results,and genomic information,AI can assist in diagnosis,forecast disease progression,and optimize treatment plans,thereby improving clinical outcomes for liver disease patients.This minireview intends to comprehensively summarize the state-of-the-art theories and applications of AI in hepatology,explore the opportunities and challenges it presents in clinical practice,basic research,and translational medicine,and propose future research directions to guide the advancement of hepatology and ultimately improve patient outcomes.展开更多
Intervertebral disc degeneration is a leading cause of lower back pain and is characterized by pathological processes such as nucleus pulposus cell apoptosis,extracellular matrix imbalance,and annulus fibrosus rupture...Intervertebral disc degeneration is a leading cause of lower back pain and is characterized by pathological processes such as nucleus pulposus cell apoptosis,extracellular matrix imbalance,and annulus fibrosus rupture.These pathological changes result in disc height loss and functional decline,potentially leading to disc herniation.This comprehensive review aimed to address the current challenges in intervertebral disc degeneration treatment by evaluating the regenerative potential of stem cell-based therapies,with a particular focus on emerging technologies such as exosomes and gene vector systems.Through mechanisms such as differentiation,paracrine effects,and immunomodulation,stem cells facilitate extracellular matrix repair and reduce nucleus pulposus cell apoptosis.Despite recent advancements,clinical applications are hindered by challenges such as hypoxic disc environments and immune rejection.By analyzing recent preclinical and clinical findings,this review provided insights into optimizing stem cell therapy to overcome these obstacles and highlighted future directions in the field.展开更多
Anion exchange membrane fuel cells(AEMFCs),regarded as a promising alternative to proton exchange membrane fuel cells(PEMFCs),have garnered increasing attention because of their cost-effectiveness by using the non-nob...Anion exchange membrane fuel cells(AEMFCs),regarded as a promising alternative to proton exchange membrane fuel cells(PEMFCs),have garnered increasing attention because of their cost-effectiveness by using the non-noble metal catalysts and hydrocarbon-based ionomers as membrane[1].However,despite of extensive researches on non-noble metal catalysts such as Co[2].展开更多
To address the problems of low accuracy by the CONWEP model and poor efficiency by the Coupled Eulerian-Lagrangian(CEL)method in predicting close-range air blast loads of cylindrical charges,a neural network-based sim...To address the problems of low accuracy by the CONWEP model and poor efficiency by the Coupled Eulerian-Lagrangian(CEL)method in predicting close-range air blast loads of cylindrical charges,a neural network-based simulation(NNS)method with higher accuracy and better efficiency was proposed.The NNS method consisted of three main steps.First,the parameters of blast loads,including the peak pressures and impulses of cylindrical charges with different aspect ratios(L/D)at different stand-off distances and incident angles were obtained by two-dimensional numerical simulations.Subsequently,incident shape factors of cylindrical charges with arbitrary aspect ratios were predicted by a neural network.Finally,reflected shape factors were derived and implemented into the subroutine of the ABAQUS code to modify the CONWEP model,including modifications of impulse and overpressure.The reliability of the proposed NNS method was verified by related experimental results.Remarkable accuracy improvement was acquired by the proposed NNS method compared with the unmodified CONWEP model.Moreover,huge efficiency superiority was obtained by the proposed NNS method compared with the CEL method.The proposed NNS method showed good accuracy when the scaled distance was greater than 0.2 m/kg^(1/3).It should be noted that there is no need to generate a new dataset again since the blast loads satisfy the similarity law,and the proposed NNS method can be directly used to simulate the blast loads generated by different cylindrical charges.The proposed NNS method with high efficiency and accuracy can be used as an effective method to analyze the dynamic response of structures under blast loads,and it has significant application prospects in designing protective structures.展开更多
Objective Patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection frequently develop central nervous system damage,yet the mechanisms driving this pathology remain unclear.This study investi...Objective Patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection frequently develop central nervous system damage,yet the mechanisms driving this pathology remain unclear.This study investigated the primary pathways and key factors underlying brain tissue damage induced by the SARS-CoV-2 beta variant(lineage B.1.351).Methods K18-hACE2 and C57BL/6 mice were intranasally infected with the SARS-CoV-2 beta variant.Viral replication,pathological phenotypes,and brain transcriptomes were analyzed.Gene Ontology(GO)analysis was performed to identify altered pathways.Expression changes of host genes were verified using reverse transcription-quantitative polymerase chain reaction and Western blot.Results Pathological alterations were observed in the lungs of both mouse strains.However,only K18-hACE2 mice exhibited elevated viral RNA loads and infectious titers in the brain at 3 days post-infection,accompanied by neuropathological injury and weight loss.GO analysis of infected K18-hACE2 brain tissue revealed significant dysregulation of genes associated with innate immunity and antiviral defense responses,including type I interferons,pro-inflammatory cytokines,Toll-like receptor signaling components,and interferon-stimulated genes.Neuroinflammation was evident,alongside activation of apoptotic and pyroptotic pathways.Furthermore,altered neural cell marker expression suggested viral-induced neuroglial activation,resulting in caspase 4 and lipocalin 2 release and disruption of neuronal molecular networks.Conclusion These findings elucidate mechanisms of neuropathogenicity associated with the SARS-CoV-2 beta variant and highlight therapeutic targets to mitigate COVID-19-related neurological dysfunction.展开更多
This paper investigates the active traveling wave vibration control of an elastic supported rotating porous aluminium conical shell(CS)under impact loading.Piezoelectric smart materials in the form of micro fiber comp...This paper investigates the active traveling wave vibration control of an elastic supported rotating porous aluminium conical shell(CS)under impact loading.Piezoelectric smart materials in the form of micro fiber composites(MFCs)are used as actuators and sensors.To this end,a metal pore truncated CS with MFCs attached to its surface is considered.Adding artificial virtual springs at two edges of the truncated CS achieves various elastic supported boundaries by changing the spring stiffness.Based on the first-order shear deformation theory(FSDT),minimum energy principle,and artificial virtual spring technology,the theoretical formulations considering the electromechanical coupling are derived.The comparison of the natural frequency of the present results with the natural frequencies reported in previous literature evaluates the accuracy of the present approach.To study the vibration control,the integral quadrature method in conjunction with the differential quadrature approximation in the length direction is used to discretize the partial differential dynamical system to form a set of ordinary differential equations.With the aid of the velocity negative feedback method,both the time history and the input control voltage on the actuator are demonstrated to present the effects of velocity feedback gain,pore distribution type,semi-vertex angle,impact loading,and rotational angular velocity on the traveling wave vibration control.展开更多
为研究电子束退火对Li-N共掺杂Zn O薄膜性能的影响,首先利用溶胶-凝胶旋涂法在p型Si(111)衬底上制备Li-N共掺杂的Zn O前驱膜,然后用电子束对前驱膜进行退火。退火时,电子束加速电压10 k V,退火时间5 min,聚焦束流123 m A,束流为0.7~1.9 ...为研究电子束退火对Li-N共掺杂Zn O薄膜性能的影响,首先利用溶胶-凝胶旋涂法在p型Si(111)衬底上制备Li-N共掺杂的Zn O前驱膜,然后用电子束对前驱膜进行退火。退火时,电子束加速电压10 k V,退火时间5 min,聚焦束流123 m A,束流为0.7~1.9 m A,最后得到Li-N共掺杂的Zn O薄膜。XRD谱分析表明,当束流高于1.5 m A之后,薄膜为六方Zn O和立方Zn O的混合多晶薄膜,且有金属Zn生成,导致薄膜有较强的绿光发射。SEM图片分析显示,薄膜的晶粒尺寸随束流增加而增大,当束流高于1.5 m A后,晶粒尺寸变化不大,约为60 nm。光致发光(PL)谱和激光拉曼谱的分析结果证实Li、N元素已掺入Zn O晶格中,PL谱中观察到Li元素掺杂引起的紫光发射,拉曼散射光谱中观察到N替代O位的缺陷振动模式。展开更多
目的:观察益气养阴化浊通络方对高糖诱导的小鼠肾足细胞自噬相关蛋白5(autophagy-related protein 5,ATG5)、B细胞淋巴瘤-2蛋白相互作用中心卷曲螺旋蛋白1(B-cell lymphoma-2-interacting myosin-like coiled-coil protein 1,Beclin-1)...目的:观察益气养阴化浊通络方对高糖诱导的小鼠肾足细胞自噬相关蛋白5(autophagy-related protein 5,ATG5)、B细胞淋巴瘤-2蛋白相互作用中心卷曲螺旋蛋白1(B-cell lymphoma-2-interacting myosin-like coiled-coil protein 1,Beclin-1)及B淋巴细胞瘤-2基因/腺病毒E1B相互作用蛋白3(B-cell lymphoma-2/adenovirus E1 B interacting protein 3,BNIP3)表达的影响,探讨其对自噬的作用。方法:选取Wistar大鼠,分别灌胃20,40,80 g·kg^(-1)益气养阴化浊通络方及生理盐水,制备低、中、高浓度含药血清和空白血清。体外培养小鼠肾足细胞,分为正常对照组、高糖组、益气养阴化浊通络方低、中、高剂量组和雷帕霉素组。CCK-8法检测细胞增殖,细胞划痕检测细胞迁移能力,qRT-PCR和Western blot检测微管相关蛋白1轻链3B(microtubule-associated protein 1 light chain 3 B,LC3B)、ATG5、Beclin-1及BNIP3 mRNA和蛋白表达。结果:与空白对照组相比,高糖组足细胞增殖减弱,迁移能力增强,LC3B、ATG5、Beclin-1及BNIP3 mRNA和蛋白表达显著减弱;与HG组相比,益气养阴化浊通络方低、中、高剂量含药血清组及雷帕霉素组均可促进足细胞增殖,抑制足细胞迁移,明显促进LC3B、ATG5、Beclin-1及BNIP3 mRNA和蛋白表达。结论:益气养阴化浊通络方能够促进高糖诱导的小鼠肾足细胞自噬,调节足细胞增殖及迁移。展开更多
According to folk usage of Aconitum carmichaelii Debx., the present study was designed to determine the feasibility of the stems and leaves of Aconitum carmichaelii Debx. as a new medicinal resource. Fourteen alkaloid...According to folk usage of Aconitum carmichaelii Debx., the present study was designed to determine the feasibility of the stems and leaves of Aconitum carmichaelii Debx. as a new medicinal resource. Fourteen alkaloids in mother roots, fibrous roots, stems, and leaves of Aconitum carmichaelii Debx. were measured by HPLC-MS/MS. And multivariate analysis methods, such as clustering analysis and principal component analysis, were applied to analyze the difference among various parts. In addition, the acute toxicity, analgesia, and anti-inflammatory tests were carried out. The results suggested that the contents of alkaloids in mother roots and fibrous roots were approximate, but those of leaves and stems were different from mother roots and fibrous roots. The results of the acute toxicity testing demonstrated the toxicity of fibrous root was strongest, and mother roots were slightly less toxic than fibrous roots. The stems and leaves were far less toxic than mother and fibrous roots. In addition, the analgesia and inflammatory tests showed the effects of the various tissues had no difference each other. These results provided a basis for developing new complementary and alternative treatments for rheumatoid arthritis patients. Simultaneously, the approach may also turn wastes into treasure and promote the development of circular economy.展开更多
According to the characteristics of comprehensive mechanized heading face, established the mathematical model of single-phase air flow with κ-ε two equations model, and have established κ-ε-θ-κp mathematic model...According to the characteristics of comprehensive mechanized heading face, established the mathematical model of single-phase air flow with κ-ε two equations model, and have established κ-ε-θ-κp mathematic model to solve two-phase flow of gas and particles in dust space with eulerian-eulerian method and eulerian-lagrangian method. Numerical solution of gas-particle two-phase flow was put forward based on collocated grid SIMPLE algorithm. Moreover, numerical simulation of dust concentration in fully mechanized caving face was carded out by using Fluent software. Finally, when in forced-exhaust ventilation circumstance, drawer type fan drum have less dust absorption, and most of dust spread to the other site; the dust concentration is inversely proportional to the distance from tunneling head, and the dust concentration has already diffused to decrease below 102 mg/m3 at the position ofx=12 m. Dust are more focused on relative side（in the range about y from 0 to 2 meter） of roadway space of press-ventilated fan drum, especially between tunneling place and drawer type fan drum; the roadway with road header have a higher dust concentration. These conclusions provide reliable theory basis for the dust prevention in comprehensive mechanized heading face.展开更多
This article reviews the research progress of rehabilitation treatment and nursing care of patients with neurogenic bladder after spinal cord injury,in order to provide reference for the rehabilitation treatment and n...This article reviews the research progress of rehabilitation treatment and nursing care of patients with neurogenic bladder after spinal cord injury,in order to provide reference for the rehabilitation treatment and nursing care of patients.We reviewed recent medical literature on patients with neurogenic bladder,focusing on neurogenic bladder caused by spinal cord injury.We analyzed 30 recent of publications in patients with neurogenic bladder after spinal cord injury,in addition to reviewing and evaluating the commonly used rehabilitation nursing methods for neurogenic bladder.Psychological counseling is a vital aspect which cannot be neglected in the process of neurogenic bladder rehabilitation.Hitherto,the commonly used drug and surgical treatments may have negatively impacted the mental health of patients in varying degrees.However,in clinical practice,applying intermittent catheterization in patients who have neurogenic bladder with spinal cord injury may help improve patients’life quality,mitigate psychological burden,and reduce negative emotions.展开更多
A self-healing and recyclable carbon tube/epoxy adhesive was prepared by epoxy monomer with Diels-Alder （DA） bonds, diethylenetriamine and polyethyleneimine modified multi-wall carbon nanotubes （MWCNTs）. The self-...A self-healing and recyclable carbon tube/epoxy adhesive was prepared by epoxy monomer with Diels-Alder （DA） bonds, diethylenetriamine and polyethyleneimine modified multi-wall carbon nanotubes （MWCNTs）. The self-healing and recyclable ability was attained by thermally reversible Diels-Alder reaction between furan and maleimide in the epoxy monomer. By controlling the molar ratio of furfuryl glycidyl ether and 4,4＇-methylenebis（N-phenylmaleimide）, the glass transition temperature and mechanical properties of MWCNTs/epoxy adhesives were varied. The self-healing properties of MWCNTs/epoxy polymers were evaluated by lap shear experiment and the results showed that the MWCNTs/epoxy adhesives exhibited enhanced mechanical properties and excellent self-healing ability under heat stimulus. The healing efficiency was related to the molecule mobility and the conversion of DA reaction between furan and maleimide. The MWCNTs/epoxy adhesives also displayed excellent recyclable ability by transforming into soluble polymer under heating. These materials offer a wide range of possibilities to produce materials with healing and recyclable ability and have the potential to bring great benefits to our daily lives by enhancing the safety, performance, and lifetime of products.展开更多
BACKGROUND Liver failure has high mortality and poor prognosis,and establishing new reliable markers for predicting its prognosis is necessary.Mucosal-associated invariant T(MAIT)cells are a novel population of innate...BACKGROUND Liver failure has high mortality and poor prognosis,and establishing new reliable markers for predicting its prognosis is necessary.Mucosal-associated invariant T(MAIT)cells are a novel population of innate-like lymphocytes involved in inflammatory liver disease,and their potential role in liver failure remains unclear.AIM To investigate alteration of circulating MAIT cells and assess its prognostic value in patients with hepatitis B virus(HBV)-related liver failure.METHODS We recruited 55 patients with HBV-related liver failure,48 patients with chronic hepatitis B and 40 healthy controls(HCs)from Nantong Third People’s Hospital Affiliated to Nantong University.Peripheral blood mononuclear cells were isolated,and the percentage and number of circulating MAIT cells were detected by flow cytometry.Plasma levels of interleukin(IL)-7,IL-12p70,IL-18 and interferon-αwere measured by Luminex assay.RESULTS Circulating MAIT cells were significantly decreased in HBV-related liver failure patients(percentage:2.00±1.22 vs 5.19±1.27%,P<0.0001;number:5.47±4.93 vs 84.43±19.59,P<0.0001)compared with HCs.More importantly,there was a significant reduction of MAIT cells in patients with middle/late-stage compared with early-stage liver failure.Circulating MAIT cells partially recovered after disease improvement,both in percentage(4.01±1.21 vs 2.04±0.95%,P<0.0001)and in cell count(17.24±8.56 vs 7.41±4.99,P<0.0001).The proportion(2.29±1.01 vs 1.58±1.38%,P<0.05)and number(7.30±5.70 vs 2.94±1.47,P<0.001)of circulating MAIT cells were significantly higher in the survival group than in the dead/liver transplantation group,and the Kaplan–Meier curve showed that lower expression of circulating MAIT cells(both percentage and cell count)predicted poor overall survival(P<0.01).Also,the levels of IL-12(20.26±5.42 pg/mL vs 17.76±2.79 pg/mL,P=0.01)and IL-18(1470.05±1525.38 pg/mL vs 362.99±109.64 pg/mL,P<0.0001)were dramatically increased in HBV-related liver failure patients compared with HCs.CONCLUSION Circulating MAIT cells may play an important role in the process of HBV-related liver failure and can be an important prognostic marker.展开更多
Developing wheat that acquires and uses phosphorus(P)more efficiently is a promising and low-cost solution for increasing grain yield and reducing P-related environmental impacts.The present study identified agronomic...Developing wheat that acquires and uses phosphorus(P)more efficiently is a promising and low-cost solution for increasing grain yield and reducing P-related environmental impacts.The present study identified agronomic and physiological traits that contribute to genetic variation in the P acquisition,remobilization,and utilization efficiency of 11 wheat cultivars from southwest China grown in P-deficient purple lithomorphic soil(Olsen P=4.7)with balanced(75 kg P ha^(−1))and excess P(120 kg P ha^(−1))supplies.On average,soil P deficiency(–P)reduced root P uptake(17.0%–60.8%),P remobilization(33.9%–52.8%),dry mass yield(11.5%–39.2%),and grain yield(17.7%–54.4%).Balanced P(+P)increased grain yield via increased plant biomass rather than increased HI.–P increased phosphorus uptake efficiency(PUpE,4.5-fold),phosphorus utilization efficiency(PUtE,1.25-fold),and phosphorus use efficiency(PUE,5.4-fold)compared with those under+P,and PUtE explained most(58.1%–60.8%)of the genetic variation in PUE under both–P and+P.The high root P uptake of P-efficient cultivars under–P was regulated by root surface area and root length density in the 0–10 cm soil layer but not in the 10–20 and 20–40 cm soil layers,suggesting that a topsoil foraging strategy is a more economical approach than deeper root exploration for increasing P uptake.Root P uptake before anthesis and P remobilization after anthesis were critical for increasing the PUtE of wheat,given that P-efficient cultivars showed higher Pn(net photosynthetic rate)and sucrose levels than P-inefficient cultivars.Pn reduction by–P resulted from decreased Gs and Ci,and high evapotranspiration under+P increased shoot P%by increasing root P uptake.Genetic variation in the source-to-sink ratio was observed in consequence of a+P-induced allometric increase in sucrose in leaves and kernels.Owing to these beneficial effects,+P increased the kernel N and P yields of the 11 cultivars by 9.9%–52.4%and 12.3%–48.8%,respectively.The findings of this study could help improve wheat in future breeding efforts and P management by identifying desirable Pefficient phenotypes in P-deficient farming systems.展开更多
The inferior conductivity and drastic volume expansion of silicon still remain the bottleneck in achieving high energy density Lithium-ion Batteries(LIBs).The design of the three-dimensional structure of electrodes by...The inferior conductivity and drastic volume expansion of silicon still remain the bottleneck in achieving high energy density Lithium-ion Batteries(LIBs).The design of the three-dimensional structure of electrodes by compositing silicon and carbon materials has been employed to tackle the above challenges,however,the exorbitant costs and the uncertainty of the conductive structure persist,leaving ample room for improvement.Herein,silicon nanoparticles were innovatively composited with eco-friendly biochar sourced from cotton to fabricate a 3D globally consecutive conductive network.The network serves a dual purpose:enhancing overall electrode conductivity and serving as a scaffold to maintain electrode integrity.The conductivity of the network was further augmented by introducing P-doping at the optimum doping temperature of 350℃.Unlike the local conductive sites formed by the mere mixing of silicon and conductive agents,the consecutive network can affirm the improvement of the conductivity at a macro level.Moreover,first-principle calculations further validated that the rapid diffusion of Li^(+)is attributed to the tailored electronic microstructure and charge rearrangement of the fiber.The prepared consecutive conductive Si@P-doped carbonized cotton fiber anode outperforms the inconsecutive Si@Graphite anode in both cycling performance(capacity retention of 1777.15 mAh g^(-1) vs.682.56 mAh g^(-1) after 150 cycles at 0.3 C)and rate performance(1244.24 mAh g^(-1) vs.370.28 mAh g^(-1) at 2.0 C).The findings of this study may open up new avenues for the development of globally interconnected conductive networks in Si-based anodes,thereby enabling the fabrication of high-performance LIBs.展开更多
基金Supported by the National Natural Science Foundation of China:Effect of Moxibustion on"Longevity Gene"SIRT1 Regulation in Aged Mice(No.81403449)NSFC Project:Effect of Moxibustion and its Therapeutic Factors on Mitochondrial Energy Metabolism and Apotosis Pathyway in APP/PS1Transgenic Alzheimer's Disease Mouse Model(No.81574068)National Program on Key Basic Research Project(973 Program):the Study of Components and Mechanisms of Artemisia and the Product and Moxibustion and Safety Evaluation(No.2009CB522906)
文摘OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were randomly assigned(n = 10/group) to a control group(C) or one of three moxa smoke concentration groups(% opacity): low(L1; 0.4%), medium(M1; 2%), and high(H1; 15%). Mice in the latter three groups were exposed to moxa smoke in a dynamic gas exposure cabinet for 20 min per day for7 days. Mice in control group were placed in the same cabinet without any intervention. For the sleep experiments, another 50 mice were divided into five groups of 10 mice each: a saline-injected control group, L1 + pentobarbital sodium(PS)-injected group, M1+PS group, H1(15%)+PS group,and a positive control group(10 mg/kg, chlorpromazine, p.o.). The weight, general activities, locomotor activities, rotarod performance, sleep duration,and sleeping rate induced by a subthreshold dose of pentobarbital sodium were recorded in the mice,and the composition of moxa smoke was analyzed using headspace gas chromatography(GC-HS).RESULTS: A low concentration of smoke significantly decreased the frequency of locomotor activities and the time for which the mice remaining on the rotarod; however, a high smoke concentration significantly prolonged the pentobarbital-induced sleeping time and sleeping rate.CONCLUSION: The concentration-dependent relaxing effects of moxa smoke on the Central Nervous System(CNS) were confirmed. Moreover, GC-HS analysis showed that the component present in the highest concentration in moxa smoke was eucalyp-tol, an essential oil well recognized for its soothing effects on the CNS. This may therefore be accountable for the sedative effects of moxa smoke.
基金supported by the National Key R&D Program of China(Nos.2016YFA0401801)Natural Science Foundation of Anhui Province(No.1608085QE107)the Users with Excellence Program of Hefei Science Center CAS(No.2021HSC-UE009)。
文摘Phase engineering of molybdenum disulfide(MoS_(2))can achieve phase transformation from the semiconducting phase(2H-MoS_(2))with poor conductivity to the metallic phase(1T-MoS_(2))with superior electrochemical properties.Therefore,it is desirable to prepare high concentration 1T-MoS_(2)by simple and facile methods.In this work,MoS_(2)with high concentration of 1T phase is successfully prepared by one-pot hydrothermal synthesis through the synergistic effect of HNO_(3)and CH_(3)CH_(2)OH,which is stable for more than half of a year.The as-synthesized MoS_(2)shows high capacitance of 392Fg^(-1)at 1A g^(-1)as used for supercapacitors electrodes,and displays excellent capacitance retention(83%after 10,000 cycles).Asymmetric supercapacitors(ASCs)devices assembled by the as-synthesized MoS_(2)and MnO_(2)on carbon cloths,exhibit high energy and power densities(0.194 m Wh cm^(-2)and 13.466 mW cm^(-2)).These results shed a light to realize 1T phase MoS_(2)through the synergistic effect in hydrothermal processing.
文摘Hepatology encompasses various aspects,such as metabolic-associated fatty liver disease,viral hepatitis,alcoholic liver disease,liver cirrhosis,liver failure,liver tumors,and liver transplantation.The global epidemiological situation of liver diseases is grave,posing a substantial threat to human health and quality of life.Characterized by high incidence and mortality rates,liver diseases have emerged as a prominent global public health concern.In recent years,the rapid advan-cement of artificial intelligence(AI),deep learning,and radiomics has transfor-med medical research and clinical practice,demonstrating considerable potential in hepatology.AI is capable of automatically detecting abnormal cells in liver tissue sections,enhancing the accu-racy and efficiency of pathological diagnosis.Deep learning models are able to extract features from computed tomography and magnetic resonance imaging images to facilitate liver disease classification.Machine learning models are capable of integrating clinical data to forecast disease progression and treatment responses,thus supporting clinical decision-making for personalized medicine.Through the analysis of imaging data,laboratory results,and genomic information,AI can assist in diagnosis,forecast disease progression,and optimize treatment plans,thereby improving clinical outcomes for liver disease patients.This minireview intends to comprehensively summarize the state-of-the-art theories and applications of AI in hepatology,explore the opportunities and challenges it presents in clinical practice,basic research,and translational medicine,and propose future research directions to guide the advancement of hepatology and ultimately improve patient outcomes.
基金Supported by Henan Province Key Research and Development Program,No.231111311000Henan Provincial Science and Technology Research Project,No.232102310411+2 种基金Henan Province Medical Science and Technology Key Project,No.LHGJ20220566 and No.LHGJ20240365Henan Province Medical Education Research Project,No.WJLX2023079Zhengzhou Medical and Health Technology Innovation Guidance Program,No.2024YLZDJH022.
文摘Intervertebral disc degeneration is a leading cause of lower back pain and is characterized by pathological processes such as nucleus pulposus cell apoptosis,extracellular matrix imbalance,and annulus fibrosus rupture.These pathological changes result in disc height loss and functional decline,potentially leading to disc herniation.This comprehensive review aimed to address the current challenges in intervertebral disc degeneration treatment by evaluating the regenerative potential of stem cell-based therapies,with a particular focus on emerging technologies such as exosomes and gene vector systems.Through mechanisms such as differentiation,paracrine effects,and immunomodulation,stem cells facilitate extracellular matrix repair and reduce nucleus pulposus cell apoptosis.Despite recent advancements,clinical applications are hindered by challenges such as hypoxic disc environments and immune rejection.By analyzing recent preclinical and clinical findings,this review provided insights into optimizing stem cell therapy to overcome these obstacles and highlighted future directions in the field.
基金supported by the National Natural Science Foundation of China(Nos.22162014 and U24A2044).
文摘Anion exchange membrane fuel cells(AEMFCs),regarded as a promising alternative to proton exchange membrane fuel cells(PEMFCs),have garnered increasing attention because of their cost-effectiveness by using the non-noble metal catalysts and hydrocarbon-based ionomers as membrane[1].However,despite of extensive researches on non-noble metal catalysts such as Co[2].
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52271317 and 52071149)the Fundamental Research Funds for the Central Universities(HUST:2019kfy XJJS007)。
文摘To address the problems of low accuracy by the CONWEP model and poor efficiency by the Coupled Eulerian-Lagrangian(CEL)method in predicting close-range air blast loads of cylindrical charges,a neural network-based simulation(NNS)method with higher accuracy and better efficiency was proposed.The NNS method consisted of three main steps.First,the parameters of blast loads,including the peak pressures and impulses of cylindrical charges with different aspect ratios(L/D)at different stand-off distances and incident angles were obtained by two-dimensional numerical simulations.Subsequently,incident shape factors of cylindrical charges with arbitrary aspect ratios were predicted by a neural network.Finally,reflected shape factors were derived and implemented into the subroutine of the ABAQUS code to modify the CONWEP model,including modifications of impulse and overpressure.The reliability of the proposed NNS method was verified by related experimental results.Remarkable accuracy improvement was acquired by the proposed NNS method compared with the unmodified CONWEP model.Moreover,huge efficiency superiority was obtained by the proposed NNS method compared with the CEL method.The proposed NNS method showed good accuracy when the scaled distance was greater than 0.2 m/kg^(1/3).It should be noted that there is no need to generate a new dataset again since the blast loads satisfy the similarity law,and the proposed NNS method can be directly used to simulate the blast loads generated by different cylindrical charges.The proposed NNS method with high efficiency and accuracy can be used as an effective method to analyze the dynamic response of structures under blast loads,and it has significant application prospects in designing protective structures.
基金supported by the National Key Research and Development Program of China(2023YFC3041500).
文摘Objective Patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection frequently develop central nervous system damage,yet the mechanisms driving this pathology remain unclear.This study investigated the primary pathways and key factors underlying brain tissue damage induced by the SARS-CoV-2 beta variant(lineage B.1.351).Methods K18-hACE2 and C57BL/6 mice were intranasally infected with the SARS-CoV-2 beta variant.Viral replication,pathological phenotypes,and brain transcriptomes were analyzed.Gene Ontology(GO)analysis was performed to identify altered pathways.Expression changes of host genes were verified using reverse transcription-quantitative polymerase chain reaction and Western blot.Results Pathological alterations were observed in the lungs of both mouse strains.However,only K18-hACE2 mice exhibited elevated viral RNA loads and infectious titers in the brain at 3 days post-infection,accompanied by neuropathological injury and weight loss.GO analysis of infected K18-hACE2 brain tissue revealed significant dysregulation of genes associated with innate immunity and antiviral defense responses,including type I interferons,pro-inflammatory cytokines,Toll-like receptor signaling components,and interferon-stimulated genes.Neuroinflammation was evident,alongside activation of apoptotic and pyroptotic pathways.Furthermore,altered neural cell marker expression suggested viral-induced neuroglial activation,resulting in caspase 4 and lipocalin 2 release and disruption of neuronal molecular networks.Conclusion These findings elucidate mechanisms of neuropathogenicity associated with the SARS-CoV-2 beta variant and highlight therapeutic targets to mitigate COVID-19-related neurological dysfunction.
基金Supported by the National Natural Science Foundation of China(Nos.12272056 and 11832002)。
文摘This paper investigates the active traveling wave vibration control of an elastic supported rotating porous aluminium conical shell(CS)under impact loading.Piezoelectric smart materials in the form of micro fiber composites(MFCs)are used as actuators and sensors.To this end,a metal pore truncated CS with MFCs attached to its surface is considered.Adding artificial virtual springs at two edges of the truncated CS achieves various elastic supported boundaries by changing the spring stiffness.Based on the first-order shear deformation theory(FSDT),minimum energy principle,and artificial virtual spring technology,the theoretical formulations considering the electromechanical coupling are derived.The comparison of the natural frequency of the present results with the natural frequencies reported in previous literature evaluates the accuracy of the present approach.To study the vibration control,the integral quadrature method in conjunction with the differential quadrature approximation in the length direction is used to discretize the partial differential dynamical system to form a set of ordinary differential equations.With the aid of the velocity negative feedback method,both the time history and the input control voltage on the actuator are demonstrated to present the effects of velocity feedback gain,pore distribution type,semi-vertex angle,impact loading,and rotational angular velocity on the traveling wave vibration control.
文摘为研究电子束退火对Li-N共掺杂Zn O薄膜性能的影响,首先利用溶胶-凝胶旋涂法在p型Si(111)衬底上制备Li-N共掺杂的Zn O前驱膜,然后用电子束对前驱膜进行退火。退火时,电子束加速电压10 k V,退火时间5 min,聚焦束流123 m A,束流为0.7~1.9 m A,最后得到Li-N共掺杂的Zn O薄膜。XRD谱分析表明,当束流高于1.5 m A之后,薄膜为六方Zn O和立方Zn O的混合多晶薄膜,且有金属Zn生成,导致薄膜有较强的绿光发射。SEM图片分析显示,薄膜的晶粒尺寸随束流增加而增大,当束流高于1.5 m A后,晶粒尺寸变化不大,约为60 nm。光致发光(PL)谱和激光拉曼谱的分析结果证实Li、N元素已掺入Zn O晶格中,PL谱中观察到Li元素掺杂引起的紫光发射,拉曼散射光谱中观察到N替代O位的缺陷振动模式。
文摘目的:观察益气养阴化浊通络方对高糖诱导的小鼠肾足细胞自噬相关蛋白5(autophagy-related protein 5,ATG5)、B细胞淋巴瘤-2蛋白相互作用中心卷曲螺旋蛋白1(B-cell lymphoma-2-interacting myosin-like coiled-coil protein 1,Beclin-1)及B淋巴细胞瘤-2基因/腺病毒E1B相互作用蛋白3(B-cell lymphoma-2/adenovirus E1 B interacting protein 3,BNIP3)表达的影响,探讨其对自噬的作用。方法:选取Wistar大鼠,分别灌胃20,40,80 g·kg^(-1)益气养阴化浊通络方及生理盐水,制备低、中、高浓度含药血清和空白血清。体外培养小鼠肾足细胞,分为正常对照组、高糖组、益气养阴化浊通络方低、中、高剂量组和雷帕霉素组。CCK-8法检测细胞增殖,细胞划痕检测细胞迁移能力,qRT-PCR和Western blot检测微管相关蛋白1轻链3B(microtubule-associated protein 1 light chain 3 B,LC3B)、ATG5、Beclin-1及BNIP3 mRNA和蛋白表达。结果:与空白对照组相比,高糖组足细胞增殖减弱,迁移能力增强,LC3B、ATG5、Beclin-1及BNIP3 mRNA和蛋白表达显著减弱;与HG组相比,益气养阴化浊通络方低、中、高剂量含药血清组及雷帕霉素组均可促进足细胞增殖,抑制足细胞迁移,明显促进LC3B、ATG5、Beclin-1及BNIP3 mRNA和蛋白表达。结论:益气养阴化浊通络方能够促进高糖诱导的小鼠肾足细胞自噬,调节足细胞增殖及迁移。
基金supported by the Sichuan Provincial Administration of Traditional Chinese Medicine Research Project(No.2018NQ008)
文摘According to folk usage of Aconitum carmichaelii Debx., the present study was designed to determine the feasibility of the stems and leaves of Aconitum carmichaelii Debx. as a new medicinal resource. Fourteen alkaloids in mother roots, fibrous roots, stems, and leaves of Aconitum carmichaelii Debx. were measured by HPLC-MS/MS. And multivariate analysis methods, such as clustering analysis and principal component analysis, were applied to analyze the difference among various parts. In addition, the acute toxicity, analgesia, and anti-inflammatory tests were carried out. The results suggested that the contents of alkaloids in mother roots and fibrous roots were approximate, but those of leaves and stems were different from mother roots and fibrous roots. The results of the acute toxicity testing demonstrated the toxicity of fibrous root was strongest, and mother roots were slightly less toxic than fibrous roots. The stems and leaves were far less toxic than mother and fibrous roots. In addition, the analgesia and inflammatory tests showed the effects of the various tissues had no difference each other. These results provided a basis for developing new complementary and alternative treatments for rheumatoid arthritis patients. Simultaneously, the approach may also turn wastes into treasure and promote the development of circular economy.
基金Supported by the National Natural Science Foundation of China （51074100） the National Natural Science Foundation of Shan dong province （ZR2OIOEM016）
文摘According to the characteristics of comprehensive mechanized heading face, established the mathematical model of single-phase air flow with κ-ε two equations model, and have established κ-ε-θ-κp mathematic model to solve two-phase flow of gas and particles in dust space with eulerian-eulerian method and eulerian-lagrangian method. Numerical solution of gas-particle two-phase flow was put forward based on collocated grid SIMPLE algorithm. Moreover, numerical simulation of dust concentration in fully mechanized caving face was carded out by using Fluent software. Finally, when in forced-exhaust ventilation circumstance, drawer type fan drum have less dust absorption, and most of dust spread to the other site; the dust concentration is inversely proportional to the distance from tunneling head, and the dust concentration has already diffused to decrease below 102 mg/m3 at the position ofx=12 m. Dust are more focused on relative side（in the range about y from 0 to 2 meter） of roadway space of press-ventilated fan drum, especially between tunneling place and drawer type fan drum; the roadway with road header have a higher dust concentration. These conclusions provide reliable theory basis for the dust prevention in comprehensive mechanized heading face.
文摘This article reviews the research progress of rehabilitation treatment and nursing care of patients with neurogenic bladder after spinal cord injury,in order to provide reference for the rehabilitation treatment and nursing care of patients.We reviewed recent medical literature on patients with neurogenic bladder,focusing on neurogenic bladder caused by spinal cord injury.We analyzed 30 recent of publications in patients with neurogenic bladder after spinal cord injury,in addition to reviewing and evaluating the commonly used rehabilitation nursing methods for neurogenic bladder.Psychological counseling is a vital aspect which cannot be neglected in the process of neurogenic bladder rehabilitation.Hitherto,the commonly used drug and surgical treatments may have negatively impacted the mental health of patients in varying degrees.However,in clinical practice,applying intermittent catheterization in patients who have neurogenic bladder with spinal cord injury may help improve patients’life quality,mitigate psychological burden,and reduce negative emotions.
基金financially supported by the National Natural Science Foundation of China(Nos.51573172,11405149 and 51401187)the Science and Technology Planning Project of Sichuan Province(No.SCXSDTR15001)Director’s Funds of China Academy of Engineering Physics(No.SJZ201506)
文摘A self-healing and recyclable carbon tube/epoxy adhesive was prepared by epoxy monomer with Diels-Alder （DA） bonds, diethylenetriamine and polyethyleneimine modified multi-wall carbon nanotubes （MWCNTs）. The self-healing and recyclable ability was attained by thermally reversible Diels-Alder reaction between furan and maleimide in the epoxy monomer. By controlling the molar ratio of furfuryl glycidyl ether and 4,4＇-methylenebis（N-phenylmaleimide）, the glass transition temperature and mechanical properties of MWCNTs/epoxy adhesives were varied. The self-healing properties of MWCNTs/epoxy polymers were evaluated by lap shear experiment and the results showed that the MWCNTs/epoxy adhesives exhibited enhanced mechanical properties and excellent self-healing ability under heat stimulus. The healing efficiency was related to the molecule mobility and the conversion of DA reaction between furan and maleimide. The MWCNTs/epoxy adhesives also displayed excellent recyclable ability by transforming into soluble polymer under heating. These materials offer a wide range of possibilities to produce materials with healing and recyclable ability and have the potential to bring great benefits to our daily lives by enhancing the safety, performance, and lifetime of products.
基金Supported by National Natural Science Foundation of China,No.81600449Nantong Science and Technology Bureau,No.MS22018007,No.MSZ18130,and No.JCZ18036+2 种基金Six Peak Talents in Jiangsu Province,No.YY-177Project of Jiangsu Province Youth Medical Talent Development,No.QNRC2016400and Project of Nantong Youth Medical Talent Development,No.05.
文摘BACKGROUND Liver failure has high mortality and poor prognosis,and establishing new reliable markers for predicting its prognosis is necessary.Mucosal-associated invariant T(MAIT)cells are a novel population of innate-like lymphocytes involved in inflammatory liver disease,and their potential role in liver failure remains unclear.AIM To investigate alteration of circulating MAIT cells and assess its prognostic value in patients with hepatitis B virus(HBV)-related liver failure.METHODS We recruited 55 patients with HBV-related liver failure,48 patients with chronic hepatitis B and 40 healthy controls(HCs)from Nantong Third People’s Hospital Affiliated to Nantong University.Peripheral blood mononuclear cells were isolated,and the percentage and number of circulating MAIT cells were detected by flow cytometry.Plasma levels of interleukin(IL)-7,IL-12p70,IL-18 and interferon-αwere measured by Luminex assay.RESULTS Circulating MAIT cells were significantly decreased in HBV-related liver failure patients(percentage:2.00±1.22 vs 5.19±1.27%,P<0.0001;number:5.47±4.93 vs 84.43±19.59,P<0.0001)compared with HCs.More importantly,there was a significant reduction of MAIT cells in patients with middle/late-stage compared with early-stage liver failure.Circulating MAIT cells partially recovered after disease improvement,both in percentage(4.01±1.21 vs 2.04±0.95%,P<0.0001)and in cell count(17.24±8.56 vs 7.41±4.99,P<0.0001).The proportion(2.29±1.01 vs 1.58±1.38%,P<0.05)and number(7.30±5.70 vs 2.94±1.47,P<0.001)of circulating MAIT cells were significantly higher in the survival group than in the dead/liver transplantation group,and the Kaplan–Meier curve showed that lower expression of circulating MAIT cells(both percentage and cell count)predicted poor overall survival(P<0.01).Also,the levels of IL-12(20.26±5.42 pg/mL vs 17.76±2.79 pg/mL,P=0.01)and IL-18(1470.05±1525.38 pg/mL vs 362.99±109.64 pg/mL,P<0.0001)were dramatically increased in HBV-related liver failure patients compared with HCs.CONCLUSION Circulating MAIT cells may play an important role in the process of HBV-related liver failure and can be an important prognostic marker.
基金support from the Sichuan Province Science and Technology Support Program(2021YJ0504,2021YFYZ0002)National Key Research and Development Program of China(2016YFD0300406)+1 种基金Special Fund for Agro-scientific Research in the Public Interest(20150312705)Crops Breeding Project in Sichuan Province(2016NYZ0051,22ZDZX0018).
文摘Developing wheat that acquires and uses phosphorus(P)more efficiently is a promising and low-cost solution for increasing grain yield and reducing P-related environmental impacts.The present study identified agronomic and physiological traits that contribute to genetic variation in the P acquisition,remobilization,and utilization efficiency of 11 wheat cultivars from southwest China grown in P-deficient purple lithomorphic soil(Olsen P=4.7)with balanced(75 kg P ha^(−1))and excess P(120 kg P ha^(−1))supplies.On average,soil P deficiency(–P)reduced root P uptake(17.0%–60.8%),P remobilization(33.9%–52.8%),dry mass yield(11.5%–39.2%),and grain yield(17.7%–54.4%).Balanced P(+P)increased grain yield via increased plant biomass rather than increased HI.–P increased phosphorus uptake efficiency(PUpE,4.5-fold),phosphorus utilization efficiency(PUtE,1.25-fold),and phosphorus use efficiency(PUE,5.4-fold)compared with those under+P,and PUtE explained most(58.1%–60.8%)of the genetic variation in PUE under both–P and+P.The high root P uptake of P-efficient cultivars under–P was regulated by root surface area and root length density in the 0–10 cm soil layer but not in the 10–20 and 20–40 cm soil layers,suggesting that a topsoil foraging strategy is a more economical approach than deeper root exploration for increasing P uptake.Root P uptake before anthesis and P remobilization after anthesis were critical for increasing the PUtE of wheat,given that P-efficient cultivars showed higher Pn(net photosynthetic rate)and sucrose levels than P-inefficient cultivars.Pn reduction by–P resulted from decreased Gs and Ci,and high evapotranspiration under+P increased shoot P%by increasing root P uptake.Genetic variation in the source-to-sink ratio was observed in consequence of a+P-induced allometric increase in sucrose in leaves and kernels.Owing to these beneficial effects,+P increased the kernel N and P yields of the 11 cultivars by 9.9%–52.4%and 12.3%–48.8%,respectively.The findings of this study could help improve wheat in future breeding efforts and P management by identifying desirable Pefficient phenotypes in P-deficient farming systems.
基金supported by the National Natural Science Foundation of China(No.12205252)the Basic Public Welfare Re-search Special Project of Zhejiang Province(No.LZY22B040001)+4 种基金the Quzhou Science and Technology Plan Project(No.2022K39)Science and Technology Project of Quzhou Research Institute,Zhejiang University(Nos.IZQ2021KJ2032,IZQ2022KJ3014,and IZQ2022KJ3002)Independent scientific Research Project of Quzhou Research Institute,Zhejiang University(No.IZQ2021RCZX007)New“115 talents”Project ofQuzhou,National Nature Science Foundation of China(No.52172244)Fundamental Research Funds for the Central University(No.226202200053).
文摘The inferior conductivity and drastic volume expansion of silicon still remain the bottleneck in achieving high energy density Lithium-ion Batteries(LIBs).The design of the three-dimensional structure of electrodes by compositing silicon and carbon materials has been employed to tackle the above challenges,however,the exorbitant costs and the uncertainty of the conductive structure persist,leaving ample room for improvement.Herein,silicon nanoparticles were innovatively composited with eco-friendly biochar sourced from cotton to fabricate a 3D globally consecutive conductive network.The network serves a dual purpose:enhancing overall electrode conductivity and serving as a scaffold to maintain electrode integrity.The conductivity of the network was further augmented by introducing P-doping at the optimum doping temperature of 350℃.Unlike the local conductive sites formed by the mere mixing of silicon and conductive agents,the consecutive network can affirm the improvement of the conductivity at a macro level.Moreover,first-principle calculations further validated that the rapid diffusion of Li^(+)is attributed to the tailored electronic microstructure and charge rearrangement of the fiber.The prepared consecutive conductive Si@P-doped carbonized cotton fiber anode outperforms the inconsecutive Si@Graphite anode in both cycling performance(capacity retention of 1777.15 mAh g^(-1) vs.682.56 mAh g^(-1) after 150 cycles at 0.3 C)and rate performance(1244.24 mAh g^(-1) vs.370.28 mAh g^(-1) at 2.0 C).The findings of this study may open up new avenues for the development of globally interconnected conductive networks in Si-based anodes,thereby enabling the fabrication of high-performance LIBs.
