Transient receptor potential vanilloid 1(TRPVl) that is known as capsaicin receptor is a non-selective cationion channel[1]. TRPV1 can regulate Ca2+ influx, participate in a variety of physiological and pathological p...Transient receptor potential vanilloid 1(TRPVl) that is known as capsaicin receptor is a non-selective cationion channel[1]. TRPV1 can regulate Ca2+ influx, participate in a variety of physiological and pathological processof tumor[2]. One such agent is Capsazepine (CPZ) that is now widely used as a selective vanilloid type 1 receptor(TRPV1) antagonist. CPZ can be directly actived on the capsaicin receptor, blocked its biological effects, and abolishedosteosarcoma-induced hyperalgesia when administered subcutaneously at doses ranging from 3 to 10 mg/kg,blocked calcium channels[3]. However, the mechanisms underlying the anticancer effects of CPZ have not fully beenunderstood. Whether CPZ can induce apoptosis of human hepatocellular carcinoma cell line HepG2 is not known.Therefore, the objective of the study reported here was to determine whether CPZ can enhance radiation sensitivityin HepG2 cell, and impact on cell proliferation.展开更多
Bonding quality at the interface of solid propellant grains is crucial for the reliability and safety of solid rocket motors.Although bonding reliability is influenced by numerous factors,the lack of quantitative char...Bonding quality at the interface of solid propellant grains is crucial for the reliability and safety of solid rocket motors.Although bonding reliability is influenced by numerous factors,the lack of quantitative characterization of interface debonding mechanisms and the challenge of identifying key factors have made precise control of process variables difficult,resulting in unpredictable failure risks.This paper presents an improved fuzzy failure probability evaluation method that combines fuzzy fault tree analysis with expert knowledge,transforming process data into fuzzy failure probability to accurately assess debonding probabilities.The predictive model is constructed through a general regression neural network and optimized using the particle swarm optimization algorithm.Sensitivity analysis is conducted to identify key decision variables,including normal force,grain rotation speed,and adhesive weight,which are verified experimentally.Compared with classical models,the maximum error margin of the constructed reliability prediction model is only 0.02%,and it has high stability.The experimental results indicate that the main factors affecting debonding are processing roughness and coating uniformity.Controlling the key decision variable as the median resulted in a maximum increase of 200.7%in bonding strength.The feasibility of the improved method has been verified,confirming that identifying key decision variables has the ability to improve bonding reliability.The proposed method simplifies the evaluation of propellant interface bonding reliability under complex conditions by quantifying the relationship between process parameters and failure risk,enabling targeted management of key decision variables.展开更多
In recent years, sarcopenia, as a progressive muscular atrophy and weakness, has become one of the common diseases in the elderly. Although its cause is not fully understood, a growing body of research suggests that e...In recent years, sarcopenia, as a progressive muscular atrophy and weakness, has become one of the common diseases in the elderly. Although its cause is not fully understood, a growing body of research suggests that epigenetic mechanisms play an important role in the pathogenesis of sarcopenia. The purpose of this review is to summarize the current research progress in the epigenetics of sarcopenia, focusing on the role of DNA methylation, RNA methylation and non-coding RNA in the pathogenesis of sarcopenia. While exploring the epigenetic mechanism of sarcopenia, this study will also look into the application prospect of epigenetics in the treatment strategy of sarcopenia, which will provide new ideas and directions for the treatment of sarcopenia.展开更多
有机肥种类繁多,特点各异。顺应现代农业发展趋势的液体有机肥备受推崇,厘清研究现状以及关注热点,对有机肥的选用及今后相关研究方向具有重要指导意义。为系统把握液体有机肥的研究现状与热点,以指导科学选用及明确未来研究方向,基于...有机肥种类繁多,特点各异。顺应现代农业发展趋势的液体有机肥备受推崇,厘清研究现状以及关注热点,对有机肥的选用及今后相关研究方向具有重要指导意义。为系统把握液体有机肥的研究现状与热点,以指导科学选用及明确未来研究方向,基于文献计量法,以“液体有机肥”为主题,对中国知网CNKI和Web of science数据库中的文献进行检索分析,重点对年度论文发表量、文献类型、主题分布、研究层次、机构分布等方面进行统计分析。结果表明,中外关于液体有机肥大规模研究始于21世纪前后;中文核心期刊论文占整体研究量的20%,英文期刊论文占整体的89%,表明国内在液体有机肥方面的深入系统核心研究相对不足;现有研究内容主要偏向液体有机肥应用效果、施用技术与产品研发,研究目的更倾向于验证新产品肥效、促进新产品的推广应用,而对它作用机理以及生态、环境方面效应的系统研究较为欠缺。本研究认为,未来可就液体有机肥的作用机制及其对生态环境方面的影响作更深入研究。展开更多
目的:探究乳腺癌病人婚姻质量的影响因素。方法:检索Cochrane Library、PubMed、EMbase、Web of Science、中国生物医学文献数据库、中国知网、万方数据库和维普数据库中关于乳腺癌病人婚姻质量的队列研究、病例对照研究和横断面研究。...目的:探究乳腺癌病人婚姻质量的影响因素。方法:检索Cochrane Library、PubMed、EMbase、Web of Science、中国生物医学文献数据库、中国知网、万方数据库和维普数据库中关于乳腺癌病人婚姻质量的队列研究、病例对照研究和横断面研究。采用Stata14.0软件对数据进行Meta分析。结果:共纳入15篇文献,总样本量为3 906例。乳腺癌病人婚姻质量的影响因素包括文化程度[OR=1.67,95%CI(1.00,2.80),P=0.05]、家庭经济收入[OR=12.21,95%CI(9.20,16.21),P<0.001]、婚姻状况[OR=2.10,95%CI(1.41,3.14),P<0.001]、医疗费用来源[OR=2.65,95%CI(2.34,3.00),P<0.001]、承担家务情况[OR=2.14,95%CI(1.67,4.29),P=0.032]、病程[OR=3.12,95%CI(2.08,4.70),P<0.001]、婚姻满意度[OR=3.55,95%CI(3.08,4.09),P<0.001]、性生活体验[OR=2.82,95%CI(2.40,3.33),P<0.001]、社会支持[OR=1.74,95%CI(1.35,2.23),P=0.032]。结论:乳腺癌严重影响女性病人的婚姻质量,护理人员应提高对乳腺癌病人婚姻质量的认识水平和重视程度,制订全程、精细和个性化的心理干预措施,以预防乳腺癌病人婚姻焦虑。展开更多
Acute kidney injury(AKI)is a critical condition with limited effective therapies.Akkermansia muciniphila(A.muciniphila)is a probiotic with multiple beneficial effects,including the regulation of epithelial cell tight ...Acute kidney injury(AKI)is a critical condition with limited effective therapies.Akkermansia muciniphila(A.muciniphila)is a probiotic with multiple beneficial effects,including the regulation of epithelial cell tight junctions.Since renal pathophysiology is associated with gut barrier integrity,we hypothesized that A.muciniphila may have preventive effects on AKI.We established a lipopolysaccharide(LPS)-induced AKI mouse model to evaluate the effects of A.muciniphila.Our findings showed that pretreatment with A.muciniphila significantly attenuated kidney injury,as evidenced by reduced serum creatinine and urea nitrogen levels,alongside decreased tubular necrosis and apoptosis.A.muciniphila preserved intestinal barrier integrity and induced marked shifts in gut microbial ecology and the metabolome.A.muciniphila notably induced an increase in the relative abundance of the phylum Proteobacteria while decreasing in that of the phylum Bacteroidetes.At the genus level,Prevotella,Faecalibaculum,Moraxella,and Lactobacillus were more abundant in A.muciniphilapretreated mice.Metabolomic analysis revealed that A.muciniphila altered the gut metabolome,with changes involving pathways such as tyrosine metabolism,alanine/aspartate/glutamate homeostasis,cancer-related carbon flux,and GABAergic synaptic signaling.In conclusion,our findings indicate that A.muciniphila exerts renoprotective effects by modulating the gut-kidney axis,thereby establishing a foundation for future studies to explore the connection between gut microbiota and AKI.展开更多
基金Key Program of National Natural Science Foundation of China (U1432248), National Natural Science Foundationof China (11175222, 11205219) , Western Talent Program of Chinese Academy of Sciences (Y260230XB0).
文摘Transient receptor potential vanilloid 1(TRPVl) that is known as capsaicin receptor is a non-selective cationion channel[1]. TRPV1 can regulate Ca2+ influx, participate in a variety of physiological and pathological processof tumor[2]. One such agent is Capsazepine (CPZ) that is now widely used as a selective vanilloid type 1 receptor(TRPV1) antagonist. CPZ can be directly actived on the capsaicin receptor, blocked its biological effects, and abolishedosteosarcoma-induced hyperalgesia when administered subcutaneously at doses ranging from 3 to 10 mg/kg,blocked calcium channels[3]. However, the mechanisms underlying the anticancer effects of CPZ have not fully beenunderstood. Whether CPZ can induce apoptosis of human hepatocellular carcinoma cell line HepG2 is not known.Therefore, the objective of the study reported here was to determine whether CPZ can enhance radiation sensitivityin HepG2 cell, and impact on cell proliferation.
基金supported in part by the Equipment Development Pre-research Project funded by Equipment Development Department,PRC under Grant No.50923010501Fundamental Research Program of Shenyang Institute of Automation(SIA),Chinese Academy of Sciencess under Grant No.355060201。
文摘Bonding quality at the interface of solid propellant grains is crucial for the reliability and safety of solid rocket motors.Although bonding reliability is influenced by numerous factors,the lack of quantitative characterization of interface debonding mechanisms and the challenge of identifying key factors have made precise control of process variables difficult,resulting in unpredictable failure risks.This paper presents an improved fuzzy failure probability evaluation method that combines fuzzy fault tree analysis with expert knowledge,transforming process data into fuzzy failure probability to accurately assess debonding probabilities.The predictive model is constructed through a general regression neural network and optimized using the particle swarm optimization algorithm.Sensitivity analysis is conducted to identify key decision variables,including normal force,grain rotation speed,and adhesive weight,which are verified experimentally.Compared with classical models,the maximum error margin of the constructed reliability prediction model is only 0.02%,and it has high stability.The experimental results indicate that the main factors affecting debonding are processing roughness and coating uniformity.Controlling the key decision variable as the median resulted in a maximum increase of 200.7%in bonding strength.The feasibility of the improved method has been verified,confirming that identifying key decision variables has the ability to improve bonding reliability.The proposed method simplifies the evaluation of propellant interface bonding reliability under complex conditions by quantifying the relationship between process parameters and failure risk,enabling targeted management of key decision variables.
文摘In recent years, sarcopenia, as a progressive muscular atrophy and weakness, has become one of the common diseases in the elderly. Although its cause is not fully understood, a growing body of research suggests that epigenetic mechanisms play an important role in the pathogenesis of sarcopenia. The purpose of this review is to summarize the current research progress in the epigenetics of sarcopenia, focusing on the role of DNA methylation, RNA methylation and non-coding RNA in the pathogenesis of sarcopenia. While exploring the epigenetic mechanism of sarcopenia, this study will also look into the application prospect of epigenetics in the treatment strategy of sarcopenia, which will provide new ideas and directions for the treatment of sarcopenia.
文摘有机肥种类繁多,特点各异。顺应现代农业发展趋势的液体有机肥备受推崇,厘清研究现状以及关注热点,对有机肥的选用及今后相关研究方向具有重要指导意义。为系统把握液体有机肥的研究现状与热点,以指导科学选用及明确未来研究方向,基于文献计量法,以“液体有机肥”为主题,对中国知网CNKI和Web of science数据库中的文献进行检索分析,重点对年度论文发表量、文献类型、主题分布、研究层次、机构分布等方面进行统计分析。结果表明,中外关于液体有机肥大规模研究始于21世纪前后;中文核心期刊论文占整体研究量的20%,英文期刊论文占整体的89%,表明国内在液体有机肥方面的深入系统核心研究相对不足;现有研究内容主要偏向液体有机肥应用效果、施用技术与产品研发,研究目的更倾向于验证新产品肥效、促进新产品的推广应用,而对它作用机理以及生态、环境方面效应的系统研究较为欠缺。本研究认为,未来可就液体有机肥的作用机制及其对生态环境方面的影响作更深入研究。
文摘目的:探究乳腺癌病人婚姻质量的影响因素。方法:检索Cochrane Library、PubMed、EMbase、Web of Science、中国生物医学文献数据库、中国知网、万方数据库和维普数据库中关于乳腺癌病人婚姻质量的队列研究、病例对照研究和横断面研究。采用Stata14.0软件对数据进行Meta分析。结果:共纳入15篇文献,总样本量为3 906例。乳腺癌病人婚姻质量的影响因素包括文化程度[OR=1.67,95%CI(1.00,2.80),P=0.05]、家庭经济收入[OR=12.21,95%CI(9.20,16.21),P<0.001]、婚姻状况[OR=2.10,95%CI(1.41,3.14),P<0.001]、医疗费用来源[OR=2.65,95%CI(2.34,3.00),P<0.001]、承担家务情况[OR=2.14,95%CI(1.67,4.29),P=0.032]、病程[OR=3.12,95%CI(2.08,4.70),P<0.001]、婚姻满意度[OR=3.55,95%CI(3.08,4.09),P<0.001]、性生活体验[OR=2.82,95%CI(2.40,3.33),P<0.001]、社会支持[OR=1.74,95%CI(1.35,2.23),P=0.032]。结论:乳腺癌严重影响女性病人的婚姻质量,护理人员应提高对乳腺癌病人婚姻质量的认识水平和重视程度,制订全程、精细和个性化的心理干预措施,以预防乳腺癌病人婚姻焦虑。
基金funded by the National Natural Science Foundation of China(Grant No.82470766 to H.M.)the Jiangsu Provincial Medical Key Discipline(Laboratory)Cultivation Unit(Grant No.JSDW202206 to C.X.)the First Affiliated Hospital of Nanjing Medical University Clinical Capacity Enhancement Project(Grant No.JSPH-MC-2022-18 to C.X.).
文摘Acute kidney injury(AKI)is a critical condition with limited effective therapies.Akkermansia muciniphila(A.muciniphila)is a probiotic with multiple beneficial effects,including the regulation of epithelial cell tight junctions.Since renal pathophysiology is associated with gut barrier integrity,we hypothesized that A.muciniphila may have preventive effects on AKI.We established a lipopolysaccharide(LPS)-induced AKI mouse model to evaluate the effects of A.muciniphila.Our findings showed that pretreatment with A.muciniphila significantly attenuated kidney injury,as evidenced by reduced serum creatinine and urea nitrogen levels,alongside decreased tubular necrosis and apoptosis.A.muciniphila preserved intestinal barrier integrity and induced marked shifts in gut microbial ecology and the metabolome.A.muciniphila notably induced an increase in the relative abundance of the phylum Proteobacteria while decreasing in that of the phylum Bacteroidetes.At the genus level,Prevotella,Faecalibaculum,Moraxella,and Lactobacillus were more abundant in A.muciniphilapretreated mice.Metabolomic analysis revealed that A.muciniphila altered the gut metabolome,with changes involving pathways such as tyrosine metabolism,alanine/aspartate/glutamate homeostasis,cancer-related carbon flux,and GABAergic synaptic signaling.In conclusion,our findings indicate that A.muciniphila exerts renoprotective effects by modulating the gut-kidney axis,thereby establishing a foundation for future studies to explore the connection between gut microbiota and AKI.
基金supported by the National Natural Science Foundation of China(No.82270127)the Fundamental Research Fund for the Central Universities of Central South University(No.2021zzts0085)。
