Rock bolting has firmly used as the coal mine roof reinforcement in underground coal mine. The bolting effect of fully grouted rebar bolt is closely related to the bolt surface profile. This paper provides an experime...Rock bolting has firmly used as the coal mine roof reinforcement in underground coal mine. The bolting effect of fully grouted rebar bolt is closely related to the bolt surface profile. This paper provides an experimental study to confirm that bolt rib internal length has great influence on bolting effect. Pull-out tests were conducted using rebar bolt with different rib spacings of 12, 24, 36 and 48 mm representatively from steel tube and from concrete. Results show that peak load increases 25.3% for bolt with large rib spacing. For pull out using concrete block, the increment of peak load between large and small rib spacing is not significant, but the bolt with large rib spacing has great absorption of deformational energy than small rib spacing bolt. This study provides experimental evidence towards optimum design of rock bolt for understand coal mining industry.展开更多
OBJECTIVE To predict the potential targets of hyperoside(Hyp)on improving ischemia/reperfusion injury by network pharmacology,and explore its possible mechanism combined with related literature.METHODS The action targ...OBJECTIVE To predict the potential targets of hyperoside(Hyp)on improving ischemia/reperfusion injury by network pharmacology,and explore its possible mechanism combined with related literature.METHODS The action targets of Hyp and ischemia/reperfusion injury were obtained by TCMSP,Swiss Target Prediction,Pharm Mapper,Similarity ensemble approach,Online Mendelian Inheritance in Man,DisGENT and database.The common targets of drugs and diseases were screened by Omishare and STRING database respectively,and the protein-protein interaction(PPI)network map was constructed.Then the interaction network between Hyp and disease targets was constructed by Cytoscape software and topological cross-linking analysis was carried out.Then the interaction network between Hyp and disease targets was constructed and cross-linked analysis was carried out by using Cytoscape software.The gene ontology(GO)of the core target was analyzed by David database,and then the related pathways of the core target were enriched by KEGG database.RESULTS A total of 54 GO enrichment processes were obtained by GO enrichment analysis of 44 common genes,including 38 biological processes(BP),15 cell composition(CC)processes,and 1 molecular functional(MF)process.43 items were obtained by signal pathway enrichment analysis in KEGG database.CONCLUSION It is suggested that the mechanism of Hyp may be related to PI3K-Akt,RAP1,RAS,VEGF and other signal transduction pathways.The above results laid a theoretical foundation for the study of the mechanism and clinical application of the treatment of ischemia/reperfusion injury.展开更多
基金Financial supports for this work,provided by the Open Projects of Research Center of Coal Resources Safe Mining and Clean Utilization,Liaoning of China (No.LNTU15KF02)
文摘Rock bolting has firmly used as the coal mine roof reinforcement in underground coal mine. The bolting effect of fully grouted rebar bolt is closely related to the bolt surface profile. This paper provides an experimental study to confirm that bolt rib internal length has great influence on bolting effect. Pull-out tests were conducted using rebar bolt with different rib spacings of 12, 24, 36 and 48 mm representatively from steel tube and from concrete. Results show that peak load increases 25.3% for bolt with large rib spacing. For pull out using concrete block, the increment of peak load between large and small rib spacing is not significant, but the bolt with large rib spacing has great absorption of deformational energy than small rib spacing bolt. This study provides experimental evidence towards optimum design of rock bolt for understand coal mining industry.
基金National Natural Science Foundation of China(81170148)and Major Project of Natural Science Foundation of the Department of Education of Anhui Province(KJ2019ZD32)。
文摘OBJECTIVE To predict the potential targets of hyperoside(Hyp)on improving ischemia/reperfusion injury by network pharmacology,and explore its possible mechanism combined with related literature.METHODS The action targets of Hyp and ischemia/reperfusion injury were obtained by TCMSP,Swiss Target Prediction,Pharm Mapper,Similarity ensemble approach,Online Mendelian Inheritance in Man,DisGENT and database.The common targets of drugs and diseases were screened by Omishare and STRING database respectively,and the protein-protein interaction(PPI)network map was constructed.Then the interaction network between Hyp and disease targets was constructed by Cytoscape software and topological cross-linking analysis was carried out.Then the interaction network between Hyp and disease targets was constructed and cross-linked analysis was carried out by using Cytoscape software.The gene ontology(GO)of the core target was analyzed by David database,and then the related pathways of the core target were enriched by KEGG database.RESULTS A total of 54 GO enrichment processes were obtained by GO enrichment analysis of 44 common genes,including 38 biological processes(BP),15 cell composition(CC)processes,and 1 molecular functional(MF)process.43 items were obtained by signal pathway enrichment analysis in KEGG database.CONCLUSION It is suggested that the mechanism of Hyp may be related to PI3K-Akt,RAP1,RAS,VEGF and other signal transduction pathways.The above results laid a theoretical foundation for the study of the mechanism and clinical application of the treatment of ischemia/reperfusion injury.
