目的探讨冠状动脉粥样硬化性心脏病(CHD)合并心房颤动(AF)的危险因素及其与残余胆固醇(RC)的相关性。方法回顾性分析徐州市中心医院心血管诊疗中心2022年10月至2023年10月确诊为CHD的患者816例,通过回顾医院信息系统中的病例资料,根据...目的探讨冠状动脉粥样硬化性心脏病(CHD)合并心房颤动(AF)的危险因素及其与残余胆固醇(RC)的相关性。方法回顾性分析徐州市中心医院心血管诊疗中心2022年10月至2023年10月确诊为CHD的患者816例,通过回顾医院信息系统中的病例资料,根据患者既往及住院期间是否合并AF分为CHD合并AF组(n=144)和CHD无AF组(n=672),比较两组患者临床基本信息、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、RC水平、个人史和既往史等,通过logistic回归分析CHD患者合并AF的影响因素,采用受试者工作特征曲线(ROC)分析RC对CHD合并AF的诊断意义。结果CHD合并AF组RC水平低于CHD无AF组[0.30(-0.28,0.55)mmol/L vs 0.57(0.28,0.97)mmol/L],差异有统计学意义(Z=7.929,P<0.01);logistic回归分析显示,增高的RC是CHD患者AF发生的保护因素(OR=0.30,P<0.05);RC与AF患者症状严重程度呈负相关(r=-0.290,P<0.05)。结论低RC水平是CHD合并AF的危险因素,RC对CHD患者并发AF以及AF症状的严重程度具有一定预测价值。展开更多
Runoff observation uncertainty is a key unsolved issue in the hydrology community.Existing studies mainly focused on observation uncertainty sources and their impacts on simulation performance,but the impacts on chang...Runoff observation uncertainty is a key unsolved issue in the hydrology community.Existing studies mainly focused on observation uncertainty sources and their impacts on simulation performance,but the impacts on changes of flow regime characteristics remained rare.This study detects temporal changes in 16 flow regime metrics from five main components(i.e.,magnitude,frequency of events,variability,duration,and timing),and evaluates the effects of observation uncertainty on trends of flow regime metrics by adopting a normal distribution error model and using uncertainty width,significant change rate of slopes,coefficient of variation,and degree of deviation.The daily runoff series from 1971 to 2020 at five hydrological stations(i.e.,Huangheyan,Tangnaihai,and Lanzhou in the Yellow River Source Region,Xianyang in the Weihe River Catchment,and Heishiguan in the Yiluo River Catchment)in the water conservation zone of Yellow River are collected for our study.Results showed that:(1)Flow regimes showed significant increases in the low flow magnitude,and significant decreases in the high and average flow magnitude,variability and duration at all the five stations.The magnitude,variability and duration metrics decreased significantly,and the frequency metrics increased significantly at Heishiguan.The low flow magnitude and timing metrics increased significantly,while the high flow magnitude,frequency and variability metrics decreased significantly at Xianyang.The low flow magnitude and high flow timing metrics increased significantly,while the low flow frequency,high flow magnitude and variability metrics decreased significantly in the Yellow River Source Region.(2)Observation uncertainty remarkably impacted the changes of 28.75% of total flow regime metrics at all the stations.The trends of 11.25% of total metrics changed from significance to insignificance,while those of 17.5% of total metrics changed from insignificance to significance.For the rest metrics,the trends remained the same,i.e.,significant(18.75%)and insignificant(52.50%)trends.(3)Observation uncertainty had the greatest impacts on the frequency metrics,especially at Xianyang,followed by duration,variability,timing and magnitude metrics.展开更多
文摘目的探讨冠状动脉粥样硬化性心脏病(CHD)合并心房颤动(AF)的危险因素及其与残余胆固醇(RC)的相关性。方法回顾性分析徐州市中心医院心血管诊疗中心2022年10月至2023年10月确诊为CHD的患者816例,通过回顾医院信息系统中的病例资料,根据患者既往及住院期间是否合并AF分为CHD合并AF组(n=144)和CHD无AF组(n=672),比较两组患者临床基本信息、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、RC水平、个人史和既往史等,通过logistic回归分析CHD患者合并AF的影响因素,采用受试者工作特征曲线(ROC)分析RC对CHD合并AF的诊断意义。结果CHD合并AF组RC水平低于CHD无AF组[0.30(-0.28,0.55)mmol/L vs 0.57(0.28,0.97)mmol/L],差异有统计学意义(Z=7.929,P<0.01);logistic回归分析显示,增高的RC是CHD患者AF发生的保护因素(OR=0.30,P<0.05);RC与AF患者症状严重程度呈负相关(r=-0.290,P<0.05)。结论低RC水平是CHD合并AF的危险因素,RC对CHD患者并发AF以及AF症状的严重程度具有一定预测价值。
基金National Key Research and Development Program of China,No.2021YFC3201102National Natural Science Foundation of China,No.42071041,No.42171047。
文摘Runoff observation uncertainty is a key unsolved issue in the hydrology community.Existing studies mainly focused on observation uncertainty sources and their impacts on simulation performance,but the impacts on changes of flow regime characteristics remained rare.This study detects temporal changes in 16 flow regime metrics from five main components(i.e.,magnitude,frequency of events,variability,duration,and timing),and evaluates the effects of observation uncertainty on trends of flow regime metrics by adopting a normal distribution error model and using uncertainty width,significant change rate of slopes,coefficient of variation,and degree of deviation.The daily runoff series from 1971 to 2020 at five hydrological stations(i.e.,Huangheyan,Tangnaihai,and Lanzhou in the Yellow River Source Region,Xianyang in the Weihe River Catchment,and Heishiguan in the Yiluo River Catchment)in the water conservation zone of Yellow River are collected for our study.Results showed that:(1)Flow regimes showed significant increases in the low flow magnitude,and significant decreases in the high and average flow magnitude,variability and duration at all the five stations.The magnitude,variability and duration metrics decreased significantly,and the frequency metrics increased significantly at Heishiguan.The low flow magnitude and timing metrics increased significantly,while the high flow magnitude,frequency and variability metrics decreased significantly at Xianyang.The low flow magnitude and high flow timing metrics increased significantly,while the low flow frequency,high flow magnitude and variability metrics decreased significantly in the Yellow River Source Region.(2)Observation uncertainty remarkably impacted the changes of 28.75% of total flow regime metrics at all the stations.The trends of 11.25% of total metrics changed from significance to insignificance,while those of 17.5% of total metrics changed from insignificance to significance.For the rest metrics,the trends remained the same,i.e.,significant(18.75%)and insignificant(52.50%)trends.(3)Observation uncertainty had the greatest impacts on the frequency metrics,especially at Xianyang,followed by duration,variability,timing and magnitude metrics.
