Cytomegalovirus(CMV)is frequently detected in inflammatory bowel tissue,especially in corticosteroid-refractory patients,and it has been blamed for adverse outcomes.However,the first acquisition of CMV does not involv...Cytomegalovirus(CMV)is frequently detected in inflammatory bowel tissue,especially in corticosteroid-refractory patients,and it has been blamed for adverse outcomes.However,the first acquisition of CMV does not involve the colon.In particular in the colonic mucosa,which evolved due to the gut microbial relationship,CMV promotes inflammation via recruited monocytes and not through replication in resident macrophages.Whether CMV is the last straw in the process of mucosal inflammation,a doomed agent,or an innocent bystander is a difficult question that remains elusive.With this work,we will try to review the relationship between intestinal mucosa and CMV in the framework of basic virological principles.展开更多
文摘Cytomegalovirus(CMV)is frequently detected in inflammatory bowel tissue,especially in corticosteroid-refractory patients,and it has been blamed for adverse outcomes.However,the first acquisition of CMV does not involve the colon.In particular in the colonic mucosa,which evolved due to the gut microbial relationship,CMV promotes inflammation via recruited monocytes and not through replication in resident macrophages.Whether CMV is the last straw in the process of mucosal inflammation,a doomed agent,or an innocent bystander is a difficult question that remains elusive.With this work,we will try to review the relationship between intestinal mucosa and CMV in the framework of basic virological principles.
