Titanium(Ti)and its alloys are frequently utilized as critical components in a variety of engineering ap-plications because of their high specific strength and excellent corrosion resistance.Compared to conven-tional ...Titanium(Ti)and its alloys are frequently utilized as critical components in a variety of engineering ap-plications because of their high specific strength and excellent corrosion resistance.Compared to conven-tional surface strengthening technologies,laser shock peening(LSP)has increasingly attracted attention from researchers and industries,since it significantly improves the surface strength,biocompatibility,fa-tigue resistance,and anti-corrosion ability of Ti and its alloys.Despite numerous studies that have been carried out to elucidate the effects of LSP on microstructural evolution and mechanical properties of Ti and its alloys in recent years,a comprehensive review of recent advancements in the field of Ti and its alloys subjected to LSP is still lacking.In this review,the standard LSP and the novel process designs of LSP assisted by thermal,cryogenic,electropulsing and magnetic fields are discussed and compared.Microstructural evolution,with focuses on the dislocation dynamics,deformation twinning,grain refine-ment and surface amorphization,during LSP processing of Ti alloys is reviewed.Furthermore,the en-hanced engineering performance of the L SP-processed(L SPed)Ti alloys,including surface hardness,wear resistance,fatigue life and corrosion resistance are summarized.Finally,this review concludes by present-ing an overview of the current challenges encountered in this field and offering insights into anticipated future trends.展开更多
Four cynipid gall wasps belonging to three genera are reported with descriptions of their host plants and galls,i.e.,Belizinella vicina Kovalev,1965,Cerroneuroterus folimargo(Monzen,1954),C.monseni(Dettmer,1934)and Ne...Four cynipid gall wasps belonging to three genera are reported with descriptions of their host plants and galls,i.e.,Belizinella vicina Kovalev,1965,Cerroneuroterus folimargo(Monzen,1954),C.monseni(Dettmer,1934)and Neuroterus hakonensis Ashmead,1904.The genus Belizinella and three species,B.vicina,C.monseni and N.hakonensis,are recorded in China for the first time.The species B.vicina is redescribed for the missing or incongruent features from its original description.In addition,the gall host for Ufo rufiventris Wang,Guo,Wang,Pujade-Villar&Chen is also recorded here for the first time.展开更多
Graphene and carbon nanotube(CNT) are representative carbon nanomaterials which have aroused numerous research interest due to their extraordinary material properties and promising application potentials,especially in...Graphene and carbon nanotube(CNT) are representative carbon nanomaterials which have aroused numerous research interest due to their extraordinary material properties and promising application potentials,especially in the energy storage and conversion areas.However,the agglomeration happening in these materials has largely blocked their applications.Hybridization of CNT with graphene can,on one hand,prevent the agglomeration behavior,on the other hand,generate a synergistic effect between them with enhanced physical and chemical properties.There have been many studies conducted to find out the suitable approaches to synthesize graphene/CNT composites,and realize the application potentials of these structures.Based on the recent advances,this paper reviews the current research progress that has been achieved in synthesizing graphene/CNT composites,and the energy-related applications.Through this review,we aim at stimulating more significant research on this subject.展开更多
Location estimation of underwater sensor networks(USNs)has become a critical technology,due to its fundamental role in the sensing,communication and control of ocean volume.However,the asynchronous clock,security atta...Location estimation of underwater sensor networks(USNs)has become a critical technology,due to its fundamental role in the sensing,communication and control of ocean volume.However,the asynchronous clock,security attack and mobility characteristics of underwater environment make localization much more challenging as compared with terrestrial sensor networks.This paper is concerned with a privacy-preserving asynchronous localization issue for USNs.Particularly,a hybrid network architecture that includes surface buoys,anchor nodes,active sensor nodes and ordinary sensor nodes is constructed.Then,an asynchronous localization protocol is provided,through which two privacy-preserving localization algorithms are designed to estimate the locations of active and ordinary sensor nodes.It is worth mentioning that,the proposed localization algorithms reveal disguised positions to the network,while they do not adopt any homomorphic encryption technique.More importantly,they can eliminate the effect of asynchronous clock,i.e.,clock skew and offset.The performance analyses for the privacy-preserving asynchronous localization algorithms are also presented.Finally,simulation and experiment results reveal that the proposed localization approach can avoid the leakage of position information,while the location accuracy can be significantly enhanced as compared with the other works.展开更多
Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precurs...Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are lacking.Here,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to DM.Analysis of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT groups.In addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.展开更多
A simple and sensitive high performance liquid chromatography with fluorescence detection （HPLC-FD） has been developed for simultaneous quantification of doxorubicin （DOX） and its dipeptide conjugate prodrug （PDO...A simple and sensitive high performance liquid chromatography with fluorescence detection （HPLC-FD） has been developed for simultaneous quantification of doxorubicin （DOX） and its dipeptide conjugate prodrug （PDOX） in mice plasma. The chromatographic separation was carried out on an Amethyst C18-H column with gradient mobile phase of 0.1% formic acid and 0.1% formic acid in acetonitrile at a flow rate of 1.0 mL/min. The excitation and emission wavelengths were set at 490 and 550 nm, respectively. The method was comprehensively validated. The limits of detection were low up to 5.0 ng/mL for DOX and 25.0 ng/mL for PDOX. And the limits of quantification were low up to 12.5 ng/mL for DOX and 50 ng/mL for PDOX, which were lower than those for most of the current methods. The calibration curves showed good linearity （R2 〉 0.999） over the concentration ranges. The extraction recoveries ranged from 84.0% to 88.2% for DOX and from 85.4% to 89.2% for PDOX. Satisfactory intra-day and inter-day precisions were achieved with RSDs less than 9.1%. The results show that the developed HPLC-FD method is accurate, reliable and will be helpful for preclinical pharmacokinetic study of DOX and PDOX.展开更多
Bi layer formation in Cu/Sn-58Bi/Cu solder joints was investigated with different current densities and solder thickness. Uniform and continuous Bi layers were formed at the anode interface which indicated that Bi was...Bi layer formation in Cu/Sn-58Bi/Cu solder joints was investigated with different current densities and solder thickness. Uniform and continuous Bi layers were formed at the anode interface which indicated that Bi was the main diffusing species migrating from the cathode to the anode. The electromigration force and Joule heating took on the main driving forces for Bi diffusion and migration. In addition, two appearance types of Bi layers, planar-type and groove-type, were found during current stressing. The morphology and thickness of Bi layers were affected by current density and current stressing time.展开更多
In order to effectively achieve torque demand in electric vehicles （EVs）, this paper presents a torque control strategy based on model predictive control （MPC） for permanent magnet synchronous motor （PMSM） drive...In order to effectively achieve torque demand in electric vehicles （EVs）, this paper presents a torque control strategy based on model predictive control （MPC） for permanent magnet synchronous motor （PMSM） driven by a two-level three-phase inverter. A centralized control strategy is established in the MPC framework to track the torque demand and reduce energy loss, by directly optimizing the switch states of inverter. To fast determine the optimal control sequence in predictive process, a searching tree is built to look for optimal inputs by dynamic programming （DP） algorithm on the basis of the principle of optimality. Then we design a pruning method to check the candidate inputs that can enter the next predictive loop in order to decrease the computational burden of evaluation of input sequences. Finally, the simulation results on different conditions indicate that the proposed strategy can achieve a tradeoff between control performance and computational efficiency.展开更多
Underwater data collection is an importance part in the process of network monitoring,network management and intrusion detection.However,the limited-energy of nodes is a major challenge to collect underwater data.The ...Underwater data collection is an importance part in the process of network monitoring,network management and intrusion detection.However,the limited-energy of nodes is a major challenge to collect underwater data.The solution of this problem are not only in the hands of network topology but in the hands of path of autonomous underwater vehicle(AUV).With the problem in hand,an energy-efficient data collection scheme is designed for mobile underwater network.Especially,the data collection scheme is divided into two phases,i.e.,routing algorithm design for sensor nodes and path planing for AUV.With consideration of limited-energy and network robustness,Q-learning based dynamic routing algorithm is designed in the first phase to optimize the routing selection of nodes,through which a potential-game based optimal rigid graph method is proposed to balance the trade-off between the energy consumption and the network robustness.With the collected data,Q-learning based path planning strategy is proposed for AUV in the second phase to find the desired path to gather the data from data collector,then a mode-free tracking controller is developed to track the desired path accurately.Finally,the performance analysis and simulation results reveal that the proposed approach can guarantee energy-efficient and improve network stability.展开更多
The Chinese medicine Extractum trametes robiniophila murr(ETRM)is the extract of a type of fungus.Recent studies have suggested that ETRM efficiently improves the effacement of podocyte foot processes in adriamycin(AD...The Chinese medicine Extractum trametes robiniophila murr(ETRM)is the extract of a type of fungus.Recent studies have suggested that ETRM efficiently improves the effacement of podocyte foot processes in adriamycin(ADR)-induced nephrotic rats.In the present study,we aimed to assess whether ETRM modulated the actin rearrangements of podocytes and involved signaling molecules,includingα-actinin-4 and nephrin.Podocytes were treated with ADR(0.5μmol/L),ADR(0.5μmol/L)+dexamethasone(Dex)(1μmol/L),ADR(0.5μmol/L)+ETRM(10 mg/mL).The F-actin in the podocytes was stained by fluorescent phallotoxins and observed by confocal microscopy.The expression levels ofα-actinin-4 and nephrin were tested by real-time PCR and Western blotting analysis.The administration of ETRM could significantly prevent ADR-treated podocytes from actin rearrangement.Both ETRM and Dex could stabilize podocyte actin cytoskeletons.Moreover,α-actinin-4 might act as a potential target for ETRM functionality in podocyte actin rearrangements.However,pretreatment with ETRM could not inhibit the up-regulation of nephrin as a result of ADR treatment.ETRM could improve the cytoskeleton stability in ADR-induced actin rearrangement of podocytes via regulatingα-actinin-4 expression.展开更多
Politeness is a social phenomenon, a means to achieve good interpersonal relationships, and a norm imposed by social conventions. Politeness is universal, that is, it can be observed as a phenomenon in all cultures. I...Politeness is a social phenomenon, a means to achieve good interpersonal relationships, and a norm imposed by social conventions. Politeness is universal, that is, it can be observed as a phenomenon in all cultures. It is resorted to by speakers of different languages as a means to an end, and it is recognized as a norm in all societies. Despite its universality, the actual manifestations of politeness, the ways to realize politeness, and the standards differ in different cultures. Politeness is, to some extent, culture-specific.展开更多
Mechanosensitive ion channels(MSCs)are key molecules in the mechano-electrical transduction of arterial baroreceptors.Among them,acid-sensing ion channel 2(ASIC2)and transient receptor potential vanilloid subfamily me...Mechanosensitive ion channels(MSCs)are key molecules in the mechano-electrical transduction of arterial baroreceptors.Among them,acid-sensing ion channel 2(ASIC2)and transient receptor potential vanilloid subfamily member 1(TRPV1)have been studied extensively and documented to play important roles.In this study,experiments using aortic arch-aortic nerve preparations isolated from rats revealed that both ASIC2 and TRPV1 are functionally necessary,as blocking either abrogated nearly all pressure-dependent neural discharge.However,whether ASIC2 and TRPV1 work in coordination remained unclear.So we carried out cell-attached patch-clamp recordings in HEK293T cells co-expressing ASIC2 and TRPV1 and found that inhibition of ASIC2 completely blocked stretch-activated currents while inhibition of TRPV 1 only partially blocked these currents.Immunofluorescence staining of aortic arch-aortic adventitia from rats showed that ASIC2 and TRPV1 are co-localized in the aortic nerve endings,and co-immunoprecipitation assays confirmed that the two proteins form a compact complex in HEK293T cells and in baroreceptors.Moreover,protein modeling analysis,exogenous co-immunoprecipitation assays,and biotin pull-down assays indicated that ASIC2 and TRPV1 interact directly.In summary,our research suggests that ASIC2 and TRPV1 form a compact complex and function synergisti-cally in the mechano-electrical transduction of arterial baroreceptors.The model of synergism between MSCs may have important biological significance beyond ASIC2 and TRPV 1.展开更多
Objective:In this research,we tried to explore how short-term mindfulness(STM)intervention affects adoles-cents’anxiety,depression,and negative and positive emotion during the COVID-19 pandemic.Design:10 classes were...Objective:In this research,we tried to explore how short-term mindfulness(STM)intervention affects adoles-cents’anxiety,depression,and negative and positive emotion during the COVID-19 pandemic.Design:10 classes were divided into experiment groups(5 classes;n=238)and control(5 classes;n=244)randomly.Hospital Anxi-ety and Depression Scale(HADS)and Positive and Negative Affect Schedule(PANAS)were used to measure par-ticipants’dependent variables.In the experiment group,we conducted STM practice interventions every morning in theirfirst class from March to November 2020.No interventions were conducted in the control group.Methods:Paired-sample t-tests were used to identify if a significant difference exists between every time point of the experimental and control groups.Repeated ANOVA and Growth Mixture Model(GMM)were used to analyze the tendency of positive and negative emotions,anxiety,and depression in the experimental group.Results and Conclusions:(1)With the intervention of STM,there was a significant decrease in negative emotions and an increase in positive emotions in the experimental group,whereas there were non-significant differences in the control group.(2)To explore the heterogeneity trajectories of dependent variables,we built a GMM and found there were two latent growth classes in the trajectories.(3)The results of the models showed their trajec-tories were downward,which meant that the levels of anxiety,depression,and negative emotions of participants decreased during the STM training period.Nonetheless,the score of positive affect showed upward in three loops of intervention,which indicated that the level of the participants’positive affect increased through the STM inter-vention.(4)This research indicated that STM should be given increasing consideration to enhance mental health during the worldwide outbreak of COVID-19.展开更多
According to the requirement of New Engineering Disciplines initiated by the Ministry of Education of China,the course of Programming Fundamentals has been reformed in ethnic university to satisfy the standard of New ...According to the requirement of New Engineering Disciplines initiated by the Ministry of Education of China,the course of Programming Fundamentals has been reformed in ethnic university to satisfy the standard of New Engineering Certification.The reform is implemented in teaching content,implementation in both theoretical and experimental classes,teaching assessment and teacher training.展开更多
The development of economic globalization has granted people more opportunities for crosscultural exchanges,and therefore,the demand for English language talents in the society has gradually increased and more require...The development of economic globalization has granted people more opportunities for crosscultural exchanges,and therefore,the demand for English language talents in the society has gradually increased and more requirements for English language talents have also been continuously set out.Therefore,high-quality English language talents who are capable of cultural exchanges and communication are very important.English language films are a very important carrier in English learning.It is a beloved tool for learning English language due to its nature.In addition,the vivid situations,interesting speeches and expressions,and intuitive auditory impacts in the English language films provide very effective materials for college English listening teaching,and have therefore been highly valued by the college English teachers and educators.In view of the above,this article discusses English language films and college English listening teaching.The main purpose is to improve the quality of English listening teaching and students’cross-cultural communication skills.展开更多
This paper first makes an overview of blended teaching mode,and then analyzes the impact of the epidemic on college English teaching and the necessity of carrying out online live teaching.Finally,taking the current si...This paper first makes an overview of blended teaching mode,and then analyzes the impact of the epidemic on college English teaching and the necessity of carrying out online live teaching.Finally,taking the current situation of online teaching in Universities in X city as an example,this paper puts forward some suggestions on blended college English teaching based on online live teaching during the epidemic period,hoping to contribute to the improvement of teaching quality with a modest effort.展开更多
基金supported by the National Key R&D Plan of China(No.2022YFB3705603)the National Natural Science Foundation of China(No.52101046)+1 种基金the Excellent Youth Overseas Project of National Science and Natural Foundation of China,the Baowu Special Metallurgy Cooperation Limited(No.22H010101336)the Medicine-Engineering Interdisciplinary Project of Shanghai Jiao Tong University(No.YG2022QN076).
文摘Titanium(Ti)and its alloys are frequently utilized as critical components in a variety of engineering ap-plications because of their high specific strength and excellent corrosion resistance.Compared to conven-tional surface strengthening technologies,laser shock peening(LSP)has increasingly attracted attention from researchers and industries,since it significantly improves the surface strength,biocompatibility,fa-tigue resistance,and anti-corrosion ability of Ti and its alloys.Despite numerous studies that have been carried out to elucidate the effects of LSP on microstructural evolution and mechanical properties of Ti and its alloys in recent years,a comprehensive review of recent advancements in the field of Ti and its alloys subjected to LSP is still lacking.In this review,the standard LSP and the novel process designs of LSP assisted by thermal,cryogenic,electropulsing and magnetic fields are discussed and compared.Microstructural evolution,with focuses on the dislocation dynamics,deformation twinning,grain refine-ment and surface amorphization,during LSP processing of Ti alloys is reviewed.Furthermore,the en-hanced engineering performance of the L SP-processed(L SPed)Ti alloys,including surface hardness,wear resistance,fatigue life and corrosion resistance are summarized.Finally,this review concludes by present-ing an overview of the current challenges encountered in this field and offering insights into anticipated future trends.
基金supported by the National Natural Science Foundation of China(31472032,31071970)Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars(LR14C040002)。
文摘Four cynipid gall wasps belonging to three genera are reported with descriptions of their host plants and galls,i.e.,Belizinella vicina Kovalev,1965,Cerroneuroterus folimargo(Monzen,1954),C.monseni(Dettmer,1934)and Neuroterus hakonensis Ashmead,1904.The genus Belizinella and three species,B.vicina,C.monseni and N.hakonensis,are recorded in China for the first time.The species B.vicina is redescribed for the missing or incongruent features from its original description.In addition,the gall host for Ufo rufiventris Wang,Guo,Wang,Pujade-Villar&Chen is also recorded here for the first time.
文摘Graphene and carbon nanotube(CNT) are representative carbon nanomaterials which have aroused numerous research interest due to their extraordinary material properties and promising application potentials,especially in the energy storage and conversion areas.However,the agglomeration happening in these materials has largely blocked their applications.Hybridization of CNT with graphene can,on one hand,prevent the agglomeration behavior,on the other hand,generate a synergistic effect between them with enhanced physical and chemical properties.There have been many studies conducted to find out the suitable approaches to synthesize graphene/CNT composites,and realize the application potentials of these structures.Based on the recent advances,this paper reviews the current research progress that has been achieved in synthesizing graphene/CNT composites,and the energy-related applications.Through this review,we aim at stimulating more significant research on this subject.
基金supported in part by the National Natural Science Foundation of China(61873345,61973263)the Youth Talent Support Program of Hebei(BJ2018050,BJ2020031)+2 种基金the Teturned Overseas Chinese Scholar Foundation of Hebei(C201829)the Natural Science Foundation of Hebei(F2020203002)the Postgraduate Innovation Fund Project of Hebei(CXZZSS2019047)。
文摘Location estimation of underwater sensor networks(USNs)has become a critical technology,due to its fundamental role in the sensing,communication and control of ocean volume.However,the asynchronous clock,security attack and mobility characteristics of underwater environment make localization much more challenging as compared with terrestrial sensor networks.This paper is concerned with a privacy-preserving asynchronous localization issue for USNs.Particularly,a hybrid network architecture that includes surface buoys,anchor nodes,active sensor nodes and ordinary sensor nodes is constructed.Then,an asynchronous localization protocol is provided,through which two privacy-preserving localization algorithms are designed to estimate the locations of active and ordinary sensor nodes.It is worth mentioning that,the proposed localization algorithms reveal disguised positions to the network,while they do not adopt any homomorphic encryption technique.More importantly,they can eliminate the effect of asynchronous clock,i.e.,clock skew and offset.The performance analyses for the privacy-preserving asynchronous localization algorithms are also presented.Finally,simulation and experiment results reveal that the proposed localization approach can avoid the leakage of position information,while the location accuracy can be significantly enhanced as compared with the other works.
基金supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202001)the National Natural Science Foundation of China(82104835).
文摘Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are lacking.Here,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to DM.Analysis of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT groups.In addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.
基金supported by the National Natural Science Foundation of China (Grant nos. 21375101, 81573384 and 91417301)Natural Science Foundation of Hubei Province, China (No. 2014CFA077)Innovation Seed Fund and Translational Medical Research Fund of Wuhan University School of Medicine, China
文摘A simple and sensitive high performance liquid chromatography with fluorescence detection （HPLC-FD） has been developed for simultaneous quantification of doxorubicin （DOX） and its dipeptide conjugate prodrug （PDOX） in mice plasma. The chromatographic separation was carried out on an Amethyst C18-H column with gradient mobile phase of 0.1% formic acid and 0.1% formic acid in acetonitrile at a flow rate of 1.0 mL/min. The excitation and emission wavelengths were set at 490 and 550 nm, respectively. The method was comprehensively validated. The limits of detection were low up to 5.0 ng/mL for DOX and 25.0 ng/mL for PDOX. And the limits of quantification were low up to 12.5 ng/mL for DOX and 50 ng/mL for PDOX, which were lower than those for most of the current methods. The calibration curves showed good linearity （R2 〉 0.999） over the concentration ranges. The extraction recoveries ranged from 84.0% to 88.2% for DOX and from 85.4% to 89.2% for PDOX. Satisfactory intra-day and inter-day precisions were achieved with RSDs less than 9.1%. The results show that the developed HPLC-FD method is accurate, reliable and will be helpful for preclinical pharmacokinetic study of DOX and PDOX.
基金supported by the China Postdoctoral Science Foundation (No. 20100480250)the Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education(No. KZ200910005004)
文摘Bi layer formation in Cu/Sn-58Bi/Cu solder joints was investigated with different current densities and solder thickness. Uniform and continuous Bi layers were formed at the anode interface which indicated that Bi was the main diffusing species migrating from the cathode to the anode. The electromigration force and Joule heating took on the main driving forces for Bi diffusion and migration. In addition, two appearance types of Bi layers, planar-type and groove-type, were found during current stressing. The morphology and thickness of Bi layers were affected by current density and current stressing time.
基金This work was supported by the NSFC Projects of International Cooperation and Exchanges （No. 61520106008）, the National Natural Science Foundation of China （Nos. 61503149, U1564207） and the Graduate Innovation Fund of Jilin University （No. 2016093）.
文摘In order to effectively achieve torque demand in electric vehicles （EVs）, this paper presents a torque control strategy based on model predictive control （MPC） for permanent magnet synchronous motor （PMSM） driven by a two-level three-phase inverter. A centralized control strategy is established in the MPC framework to track the torque demand and reduce energy loss, by directly optimizing the switch states of inverter. To fast determine the optimal control sequence in predictive process, a searching tree is built to look for optimal inputs by dynamic programming （DP） algorithm on the basis of the principle of optimality. Then we design a pruning method to check the candidate inputs that can enter the next predictive loop in order to decrease the computational burden of evaluation of input sequences. Finally, the simulation results on different conditions indicate that the proposed strategy can achieve a tradeoff between control performance and computational efficiency.
基金Supported by the National Natural Science Foundation of China(61873345,62222314)the Distinguished Young Foundation of Hebei Province(F2022203001)+2 种基金the Central Guidance Local Foundation of Hebei Province(226Z3201G)the three-three-three Foundation of Hebei Province(C20221019)the Open Fund Project of Key Laboratory of Ocean Observation Technology,MNR(2021klootA02).
文摘Underwater data collection is an importance part in the process of network monitoring,network management and intrusion detection.However,the limited-energy of nodes is a major challenge to collect underwater data.The solution of this problem are not only in the hands of network topology but in the hands of path of autonomous underwater vehicle(AUV).With the problem in hand,an energy-efficient data collection scheme is designed for mobile underwater network.Especially,the data collection scheme is divided into two phases,i.e.,routing algorithm design for sensor nodes and path planing for AUV.With consideration of limited-energy and network robustness,Q-learning based dynamic routing algorithm is designed in the first phase to optimize the routing selection of nodes,through which a potential-game based optimal rigid graph method is proposed to balance the trade-off between the energy consumption and the network robustness.With the collected data,Q-learning based path planning strategy is proposed for AUV in the second phase to find the desired path to gather the data from data collector,then a mode-free tracking controller is developed to track the desired path accurately.Finally,the performance analysis and simulation results reveal that the proposed approach can guarantee energy-efficient and improve network stability.
基金The National Natural Science Foundation of China(Grant No.81660130)the Natural Science Foundation of Gansu Province,China(Grant No.18JR3RA045).
文摘The Chinese medicine Extractum trametes robiniophila murr(ETRM)is the extract of a type of fungus.Recent studies have suggested that ETRM efficiently improves the effacement of podocyte foot processes in adriamycin(ADR)-induced nephrotic rats.In the present study,we aimed to assess whether ETRM modulated the actin rearrangements of podocytes and involved signaling molecules,includingα-actinin-4 and nephrin.Podocytes were treated with ADR(0.5μmol/L),ADR(0.5μmol/L)+dexamethasone(Dex)(1μmol/L),ADR(0.5μmol/L)+ETRM(10 mg/mL).The F-actin in the podocytes was stained by fluorescent phallotoxins and observed by confocal microscopy.The expression levels ofα-actinin-4 and nephrin were tested by real-time PCR and Western blotting analysis.The administration of ETRM could significantly prevent ADR-treated podocytes from actin rearrangement.Both ETRM and Dex could stabilize podocyte actin cytoskeletons.Moreover,α-actinin-4 might act as a potential target for ETRM functionality in podocyte actin rearrangements.However,pretreatment with ETRM could not inhibit the up-regulation of nephrin as a result of ADR treatment.ETRM could improve the cytoskeleton stability in ADR-induced actin rearrangement of podocytes via regulatingα-actinin-4 expression.
文摘Politeness is a social phenomenon, a means to achieve good interpersonal relationships, and a norm imposed by social conventions. Politeness is universal, that is, it can be observed as a phenomenon in all cultures. It is resorted to by speakers of different languages as a means to an end, and it is recognized as a norm in all societies. Despite its universality, the actual manifestations of politeness, the ways to realize politeness, and the standards differ in different cultures. Politeness is, to some extent, culture-specific.
基金by the National Natural Science Foundation of China(31871147 and 31371162)the Science and Technology Development Program of Beijing Municipal Education Commission(KZ202010025038).
文摘Mechanosensitive ion channels(MSCs)are key molecules in the mechano-electrical transduction of arterial baroreceptors.Among them,acid-sensing ion channel 2(ASIC2)and transient receptor potential vanilloid subfamily member 1(TRPV1)have been studied extensively and documented to play important roles.In this study,experiments using aortic arch-aortic nerve preparations isolated from rats revealed that both ASIC2 and TRPV1 are functionally necessary,as blocking either abrogated nearly all pressure-dependent neural discharge.However,whether ASIC2 and TRPV1 work in coordination remained unclear.So we carried out cell-attached patch-clamp recordings in HEK293T cells co-expressing ASIC2 and TRPV1 and found that inhibition of ASIC2 completely blocked stretch-activated currents while inhibition of TRPV 1 only partially blocked these currents.Immunofluorescence staining of aortic arch-aortic adventitia from rats showed that ASIC2 and TRPV1 are co-localized in the aortic nerve endings,and co-immunoprecipitation assays confirmed that the two proteins form a compact complex in HEK293T cells and in baroreceptors.Moreover,protein modeling analysis,exogenous co-immunoprecipitation assays,and biotin pull-down assays indicated that ASIC2 and TRPV1 interact directly.In summary,our research suggests that ASIC2 and TRPV1 form a compact complex and function synergisti-cally in the mechano-electrical transduction of arterial baroreceptors.The model of synergism between MSCs may have important biological significance beyond ASIC2 and TRPV 1.
基金Regional Science Fund Project of Northwest Normal University,Grant No.31660281.
文摘Objective:In this research,we tried to explore how short-term mindfulness(STM)intervention affects adoles-cents’anxiety,depression,and negative and positive emotion during the COVID-19 pandemic.Design:10 classes were divided into experiment groups(5 classes;n=238)and control(5 classes;n=244)randomly.Hospital Anxi-ety and Depression Scale(HADS)and Positive and Negative Affect Schedule(PANAS)were used to measure par-ticipants’dependent variables.In the experiment group,we conducted STM practice interventions every morning in theirfirst class from March to November 2020.No interventions were conducted in the control group.Methods:Paired-sample t-tests were used to identify if a significant difference exists between every time point of the experimental and control groups.Repeated ANOVA and Growth Mixture Model(GMM)were used to analyze the tendency of positive and negative emotions,anxiety,and depression in the experimental group.Results and Conclusions:(1)With the intervention of STM,there was a significant decrease in negative emotions and an increase in positive emotions in the experimental group,whereas there were non-significant differences in the control group.(2)To explore the heterogeneity trajectories of dependent variables,we built a GMM and found there were two latent growth classes in the trajectories.(3)The results of the models showed their trajec-tories were downward,which meant that the levels of anxiety,depression,and negative emotions of participants decreased during the STM training period.Nonetheless,the score of positive affect showed upward in three loops of intervention,which indicated that the level of the participants’positive affect increased through the STM inter-vention.(4)This research indicated that STM should be given increasing consideration to enhance mental health during the worldwide outbreak of COVID-19.
基金supported by the Scientific Research Foundation of Inner Mongolia of China(KCBJ2018029)the CRP of CAS Key Laboratory of Solar Activity of National Astronomical Observatories(KLSA201905).
文摘According to the requirement of New Engineering Disciplines initiated by the Ministry of Education of China,the course of Programming Fundamentals has been reformed in ethnic university to satisfy the standard of New Engineering Certification.The reform is implemented in teaching content,implementation in both theoretical and experimental classes,teaching assessment and teacher training.
文摘The development of economic globalization has granted people more opportunities for crosscultural exchanges,and therefore,the demand for English language talents in the society has gradually increased and more requirements for English language talents have also been continuously set out.Therefore,high-quality English language talents who are capable of cultural exchanges and communication are very important.English language films are a very important carrier in English learning.It is a beloved tool for learning English language due to its nature.In addition,the vivid situations,interesting speeches and expressions,and intuitive auditory impacts in the English language films provide very effective materials for college English listening teaching,and have therefore been highly valued by the college English teachers and educators.In view of the above,this article discusses English language films and college English listening teaching.The main purpose is to improve the quality of English listening teaching and students’cross-cultural communication skills.
文摘This paper first makes an overview of blended teaching mode,and then analyzes the impact of the epidemic on college English teaching and the necessity of carrying out online live teaching.Finally,taking the current situation of online teaching in Universities in X city as an example,this paper puts forward some suggestions on blended college English teaching based on online live teaching during the epidemic period,hoping to contribute to the improvement of teaching quality with a modest effort.
