Trophoblast stem cells(TSCs)are placental progenitors derived from the trophectoderm or the extraembryonic ectoderm.Recently,human TSCs were established via a specific culture system[1].However,the process by which hu...Trophoblast stem cells(TSCs)are placental progenitors derived from the trophectoderm or the extraembryonic ectoderm.Recently,human TSCs were established via a specific culture system[1].However,the process by which human TSCs further differentiate into terminal trophoblasts that mimic placental development remains obscure and interesting.Hence,the development of a suitable celltool to robustly study the mechanism underlying the self-renewal or differentiation of human TSCs is urgently needed.Mammalian haploid cells resemble their diploid counterparts but have a single genome,which is widely used in the genetic screening of many biological processes.However,no haploid cells for an extraembryonic lineage in humans have been derived.展开更多
The thyroid is an essential endocrine organ in human body,and thyroid hormones(THs)are pivotal signaling molecules and mediators in various physiological processes.THs,particularly in their free form,play a critical r...The thyroid is an essential endocrine organ in human body,and thyroid hormones(THs)are pivotal signaling molecules and mediators in various physiological processes.THs,particularly in their free form,play a critical role in regulating body temperature and in the metabolism of lipid and glucose,making the maintenance of TH levels crucial for human health.THs undergo a series of metabolic processes,producing TH metabolites(THMs).THMs are significant in endocrine regulation,such as 3,5-diiothyronine(3,5-T2)and 3-iodothyronamine(3-T1AM),which exhibit activities akin to THs.The production and distribution of THMs are intricately linked to the function of specific organs and tissues,highlighting the need for advanced research into the determination and mechanisms of THMs in body.Exposure to endocrine disrupting chemicals(EDCs)can significantly affect the levels of thyroid stimulating hormone(TSH)and THs.This review utilizes machine learning to analyze epidemiological data,identifying potential EDCs that pose risks of hyperthyroidism and hypothyroidism.Additionally,it delves into the toxicological mechanisms of these EDCs,examining their effects on TH production,binding processes,related proteins,and metabolic enzymes.This approach effectively bridges the gap between epidemiological studies and toxicological researches,laying the groundwork for future research trends.By integrating epidemiological studies with machine learning,this review offers insightful perspectives on the potential risks associated with chemical exposure and underscores the necessity for further research in understanding the impact of EDCs on TH metabolism and TH-related health effects.展开更多
The adverse effect of ambient PM_(2.5) exposure on very early pregnancy(VEP)remains controversial among epidemiological studies but is supported by toxicological evidence.We adopted a multicenter retrospective cohort ...The adverse effect of ambient PM_(2.5) exposure on very early pregnancy(VEP)remains controversial among epidemiological studies but is supported by toxicological evidence.We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM_(2.5) exposure on the VEP using the in vitro fertilization and embryo transfer platform and high-resolution PM_(2.5) data in China.We first investigated the association between PM_(2.5) exposure 1 week before and 1 week after the embryo transfer date and VEP.The average PM_(2.5) concentrations of the 2 weeks were approximately 47μg/m^(3).The pooled results revealed a negative association between women’s accumulated PM_(2.5) exposure during the 2 weeks near the day of embryo transfer and success odds of VEP with the relative risk of 0.999(95%CI:0.997-0.999)at each increase of 10μg/m3.The women with the fresh cycle or one transplanted embryo were considered as a vulnerable population.Furthermore,seven periods for the fresh cycle and five periods for the frozen cycle from 85 days before oocyte retrieval to the day of gestational sac detection by ultrasound detection were defined.For these exposure periods,no association between the average PM_(2.5) exposure and VEP risk was identified.Our study provided large-scale population evidence for the association between PM_(2.5) exposure near embryo transfer day and VEP and identified vulnerable populations among women undergoing in vitro fertilization-embryo transfer.展开更多
基金supported by the National Key Research and Development Program of China(2023YFC2705900)the Fundamental Research Funds for the Central Universities(63223030)+1 种基金the National Natural Science Foundation of China(82371671,82201840,and 82301879)the Natural Science Foundation of Tianjin City(22JCZDJC00480).
文摘Trophoblast stem cells(TSCs)are placental progenitors derived from the trophectoderm or the extraembryonic ectoderm.Recently,human TSCs were established via a specific culture system[1].However,the process by which human TSCs further differentiate into terminal trophoblasts that mimic placental development remains obscure and interesting.Hence,the development of a suitable celltool to robustly study the mechanism underlying the self-renewal or differentiation of human TSCs is urgently needed.Mammalian haploid cells resemble their diploid counterparts but have a single genome,which is widely used in the genetic screening of many biological processes.However,no haploid cells for an extraembryonic lineage in humans have been derived.
基金funded by the National Natural Science Foundation of China(42277425,42161134001,U22A20614)“the Fundamental Research Funds for the Central Universities”,Nankai University(63171109)+4 种基金sponsored by Tianjin Health Research Project(TJWJ2023MS028)Tianjin Science and Technology planning project(21JCZDJC00330)National Clinical Key Discipline Cohort Study Project(GJZDZKZBDL 2022-)Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-043A)Ministry of Education,China(T2017002).
文摘The thyroid is an essential endocrine organ in human body,and thyroid hormones(THs)are pivotal signaling molecules and mediators in various physiological processes.THs,particularly in their free form,play a critical role in regulating body temperature and in the metabolism of lipid and glucose,making the maintenance of TH levels crucial for human health.THs undergo a series of metabolic processes,producing TH metabolites(THMs).THMs are significant in endocrine regulation,such as 3,5-diiothyronine(3,5-T2)and 3-iodothyronamine(3-T1AM),which exhibit activities akin to THs.The production and distribution of THMs are intricately linked to the function of specific organs and tissues,highlighting the need for advanced research into the determination and mechanisms of THMs in body.Exposure to endocrine disrupting chemicals(EDCs)can significantly affect the levels of thyroid stimulating hormone(TSH)and THs.This review utilizes machine learning to analyze epidemiological data,identifying potential EDCs that pose risks of hyperthyroidism and hypothyroidism.Additionally,it delves into the toxicological mechanisms of these EDCs,examining their effects on TH production,binding processes,related proteins,and metabolic enzymes.This approach effectively bridges the gap between epidemiological studies and toxicological researches,laying the groundwork for future research trends.By integrating epidemiological studies with machine learning,this review offers insightful perspectives on the potential risks associated with chemical exposure and underscores the necessity for further research in understanding the impact of EDCs on TH metabolism and TH-related health effects.
基金National Key Research&Development Program of Ministry of Science and Technology of China,No.2023YFC3708305(ZPB),2022YFE0134900(JL),and 2022YFC2704404(QL)National Natural Science Foundation of China,No.42077390(BW),41771527(BW)Yunnan Major Scientific and Technological Projects,No.202202AG050019(BP).
文摘The adverse effect of ambient PM_(2.5) exposure on very early pregnancy(VEP)remains controversial among epidemiological studies but is supported by toxicological evidence.We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM_(2.5) exposure on the VEP using the in vitro fertilization and embryo transfer platform and high-resolution PM_(2.5) data in China.We first investigated the association between PM_(2.5) exposure 1 week before and 1 week after the embryo transfer date and VEP.The average PM_(2.5) concentrations of the 2 weeks were approximately 47μg/m^(3).The pooled results revealed a negative association between women’s accumulated PM_(2.5) exposure during the 2 weeks near the day of embryo transfer and success odds of VEP with the relative risk of 0.999(95%CI:0.997-0.999)at each increase of 10μg/m3.The women with the fresh cycle or one transplanted embryo were considered as a vulnerable population.Furthermore,seven periods for the fresh cycle and five periods for the frozen cycle from 85 days before oocyte retrieval to the day of gestational sac detection by ultrasound detection were defined.For these exposure periods,no association between the average PM_(2.5) exposure and VEP risk was identified.Our study provided large-scale population evidence for the association between PM_(2.5) exposure near embryo transfer day and VEP and identified vulnerable populations among women undergoing in vitro fertilization-embryo transfer.
